| Tag |
Content |
| WERAM ID |
WERAM-Mum-0218 |
| Ensembl Protein ID |
ENSMUSP00000085226.4 |
| Uniprot Accession |
Q8VH37; HDAC8_MOUSE; Q3V270; Q9D0K6
|
| Genbank Protein ID |
NP_001300671.1; NP_081658.1
|
| Protein Name |
Histone deacetylase 8 |
| Genbank Nucleotide ID |
NM_001313742.1; NM_027382.4
|
| Gene Name |
HDAC8 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
Class-I |
Histone deacetylase |
H2A; H2B; H3; H4 |
K |
18292778
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
Class-I |
3.20e-140 |
468.6 |
17 |
323 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (By similarity). |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (By similarity).
|
| Domain Profile |
HDAC Class-I
class-1.txt 4 ayaydedvgeyhygqkhpmkpkrlsltheLvlnyglskkleivkpkkasaeellkfhseeyieflkkvepenaeelskelkkfnvgedc 92
+y+y+++ +++++++ +++pkr+s++h+L+ +y+l+k+++ivkpk as+ee+++fh+++y+++l+kv++e +e+++ ++ ++++g+dc
ENSMUSP00000085226.4 17 VYIYSPE--YVSICDSLVKVPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDEDHP-DSIEYGLGYDC 102
6888888..8899**************************************************************99.6789******* PP
class-1.txt 93 PvfdglfeycqlitGasleaakkLnkkeadiainwaGGlhhakkseasGfcyvnDivlailellkkhkrvlyididlhhGDgveeafyt 181
P ++g+f+y+++i+G++++aa++L+++++++ainw+GG+hhakk+easGfcy+nD vl+il+l++k++r+ly+d+dlhhGDgve+af++
ENSMUSP00000085226.4 103 PATEGIFDYAAAIGGGTITAAQCLIDGKCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFDRILYVDLDLHHGDGVEDAFSF 191
***************************************************************************************** PP
class-1.txt 182 tdrvmtvsfhkygeeffPgtGdlsdvgaekgkyyavnvPlkdgidDesyekifksviskvieafePeavvlqcGaDslagDrlgefnls 270
t++vmtvs+hk++++ffPgtGd+sdvg +kg+yy+vnvP++dgi+De+y++i++sv+++v++af+P+avvlq+GaD++agD++++fn++
ENSMUSP00000085226.4 192 TSKVMTVSLHKFSPGFFPGTGDMSDVGLGKGRYYSVNVPIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMT 280
***************************************************************************************** PP
class-1.txt 271 ikghaecvkfvksfnlpllvlGGGGYtlrnvaRcwtyetavvl 313
g+++c+k+v +++l++l+lGGGGY+l+n+aRcwty+t+v+l
ENSMUSP00000085226.4 281 PVGIGKCLKYVLQWQLATLILGGGGYNLANTARCWTYLTGVIL 323
*****************************************97 PP
|
Protein Sequence
(Fasta) | MEMPEEPANS GHSLPPVYIY SPEYVSICDS LVKVPKRASM VHSLIEAYAL HKQMRIVKPK 60
VASMEEMATF HTDAYLQHLQ KVSQEGDEDH PDSIEYGLGY DCPATEGIFD YAAAIGGGTI 120
TAAQCLIDGK CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFD RILYVDLDLH 180
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDMSDVGLG KGRYYSVNVP IQDGIQDEKY 240
YHICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY VLQWQLATLI 300
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH 360
RIQQILNYIK GNLKHVV 377Protein Fasta Sequence
>ENSMUSP00000085226.4|HDAC8|Mus musculus
MEMPEEPANSGHSLPPVYIYSPEYVSICDSLVKVPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDEDHPDSIEYGLGYDCPATEGIFDYAAAIGGGTITAAQCLIDGKCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFDRILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDMSDVGLGKGRYYSVNVPIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYVLQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV |
Nucleotide Sequence
(Fasta) | GTGCTACTTG TGCCATGAAA AAATTGATCC CAATTGGCAG TTATTTGGTT TTTATATCTG 60
TCAGGCACCT TTTTTGAACT GTGGTCATCA GTAGAAGGCA TCTGGTCTGG AAGGGCCCAT 120
CCATCCCTGT AGTTGGACGA GGGACCAGGG AAACTGTCTC CGGCGATCTA AATAGGAGGG 180
AATGTTGACA AGGGAGCACC GCTGGGGCTG AACAGAGGAG CAGGAACTGG AGCTCAGGCT 240
GAGTCTGAAA ACTGTTGGCT CCAGACTTTG GCTCGCGGAC GGTTGGAAGT GGGAGATGGA 300
GATGCCAGAG GAACCCGCCA ACAGTGGGCA TTCACTACCC CCGGTTTATA TTTACAGTCC 360
CGAGTATGTC AGCATCTGCG ACTCCCTTGT GAAGGTCCCC AAACGGGCCA GTATGGTCCA 420
CTCTCTGATC GAAGCCTATG CCCTGCATAA ACAAATGAGG ATAGTGAAGC CCAAAGTGGC 480
CTCCATGGAG GAGATGGCCA CCTTCCACAC TGATGCCTAT CTGCAACATC TCCAGAAAGT 540
CAGCCAAGAA GGTGATGAGG ACCATCCAGA CTCCATAGAA TATGGACTAG GTTATGACTG 600
CCCAGCCACA GAAGGGATAT TTGACTATGC AGCAGCTATA GGAGGAGGTA CAATCACAGC 660
TGCCCAGTGC CTGATTGACG GGAAGTGTAA AGTAGCCATC AACTGGTCTG GAGGGTGGCA 720
TCATGCAAAG AAAGATGAAG CATCTGGTTT CTGTTATCTC AATGATGCTG TCCTGGGAAT 780
ATTACGATTG CGACGGAAAT TTGACCGTAT TCTCTACGTG GATTTGGATC TACACCATGG 840
AGATGGTGTA GAAGATGCCT TCAGTTTTAC ATCGAAGGTT ATGACTGTGT CCCTGCACAA 900
GTTCTCCCCA GGATTTTTCC CAGGAACAGG TGACATGTCT GATGTTGGCC TGGGGAAAGG 960
ACGGTACTAC AGTGTCAATG TGCCCATTCA GGATGGCATC CAGGATGAGA AGTACTATCA 1020
CATCTGTGAA AGTGTACTAA AAGAAGTGTA CCAGGCCTTC AATCCGAAGG CAGTGGTTTT 1080
ACAGCTGGGA GCAGATACTA TTGCCGGAGA TCCAATGTGT TCCTTTAATA TGACACCAGT 1140
GGGGATCGGC AAGTGTCTGA AGTATGTCCT ACAGTGGCAG CTGGCAACTC TGATTTTAGG 1200
AGGAGGAGGC TATAACCTTG CCAACACGGC TCGTTGCTGG ACATACTTGA CCGGGGTCAT 1260
CCTAGGGAAA ACGCTATCCT CTGAGATCCC AGATCATGAG TTTTTCACAG CATATGGTCC 1320
TGATTATGTG CTGGAAATCA CGCCAAGCTG CCGGCCAGAC CGCAATGAGC CCCACCGAAT 1380
CCAGCAAATC CTCAACTACA TCAAAGGGAA TCTGAAGCAT GTGGTCTAGT TGACAAAAAG 1440
AGATCAGGTT CCCAGAGCTG GGCAGCAGTG CCTATAATGA AGACAGTGTG TTGATGCAAG 1500
CGGTTTGTGG AATTTGTGAC TGCAGGGGAA ATTTGGAAGA AATTACTTCC TGAAAATTTC 1560
CAAGGGGCAC CAAGTGGCAG CTGGCCTCCT GGGGTGAGGA GCCAGGCACC CCGGAGCCAG 1620
GCCTAAGGGG AAGAAGAAGA TAGCCAGTGT TTAAAGTGTT TATTTTAAAA CACAAATGCA 1680
GTTTTTAATG GTTCAAAATT ATTTTTAAGC AAGTTGGGGG GAAGAATTTT ATCTTCATAA 1740
AGGGGACAAG TCAGGAGCTG CAGAAGAGTG GGGTTGGGTA GGGGGGTCAG CAGATGGGCA 1800
GGTTCGGCCC TCGGGGCCAT TTAGATAGAG ACCTGTGGGG GAGGGGTATC AGCAGACTGG 1860
GAGGTAAGGA GGAGTCTACC ACTTTTGTTT TAGTATGATG CACTCCAGTT GTTCTTAATA 1920
AAAGTTTTGA AAATGT
1937Nucleotide Fasta Sequence
>ENSMUSP00000085226.4|Class-I|Mus musculus
GTGCTACTTGTGCCATGAAAAAATTGATCCCAATTGGCAGTTATTTGGTTTTTATATCTGTCAGGCACCTTTTTTGAACTGTGGTCATCAGTAGAAGGCATCTGGTCTGGAAGGGCCCATCCATCCCTGTAGTTGGACGAGGGACCAGGGAAACTGTCTCCGGCGATCTAAATAGGAGGGAATGTTGACAAGGGAGCACCGCTGGGGCTGAACAGAGGAGCAGGAACTGGAGCTCAGGCTGAGTCTGAAAACTGTTGGCTCCAGACTTTGGCTCGCGGACGGTTGGAAGTGGGAGATGGAGATGCCAGAGGAACCCGCCAACAGTGGGCATTCACTACCCCCGGTTTATATTTACAGTCCCGAGTATGTCAGCATCTGCGACTCCCTTGTGAAGGTCCCCAAACGGGCCAGTATGGTCCACTCTCTGATCGAAGCCTATGCCCTGCATAAACAAATGAGGATAGTGAAGCCCAAAGTGGCCTCCATGGAGGAGATGGCCACCTTCCACACTGATGCCTATCTGCAACATCTCCAGAAAGTCAGCCAAGAAGGTGATGAGGACCATCCAGACTCCATAGAATATGGACTAGGTTATGACTGCCCAGCCACAGAAGGGATATTTGACTATGCAGCAGCTATAGGAGGAGGTACAATCACAGCTGCCCAGTGCCTGATTGACGGGAAGTGTAAAGTAGCCATCAACTGGTCTGGAGGGTGGCATCATGCAAAGAAAGATGAAGCATCTGGTTTCTGTTATCTCAATGATGCTGTCCTGGGAATATTACGATTGCGACGGAAATTTGACCGTATTCTCTACGTGGATTTGGATCTACACCATGGAGATGGTGTAGAAGATGCCTTCAGTTTTACATCGAAGGTTATGACTGTGTCCCTGCACAAGTTCTCCCCAGGATTTTTCCCAGGAACAGGTGACATGTCTGATGTTGGCCTGGGGAAAGGACGGTACTACAGTGTCAATGTGCCCATTCAGGATGGCATCCAGGATGAGAAGTACTATCACATCTGTGAAAGTGTACTAAAAGAAGTGTACCAGGCCTTCAATCCGAAGGCAGTGGTTTTACAGCTGGGAGCAGATACTATTGCCGGAGATCCAATGTGTTCCTTTAATATGACACCAGTGGGGATCGGCAAGTGTCTGAAGTATGTCCTACAGTGGCAGCTGGCAACTCTGATTTTAGGAGGAGGAGGCTATAACCTTGCCAACACGGCTCGTTGCTGGACATACTTGACCGGGGTCATCCTAGGGAAAACGCTATCCTCTGAGATCCCAGATCATGAGTTTTTCACAGCATATGGTCCTGATTATGTGCTGGAAATCACGCCAAGCTGCCGGCCAGACCGCAATGAGCCCCACCGAATCCAGCAAATCCTCAACTACATCAAAGGGAATCTGAAGCATGTGGTCTAGTTGACAAAAAGAGATCAGGTTCCCAGAGCTGGGCAGCAGTGCCTATAATGAAGACAGTGTGTTGATGCAAGCGGTTTGTGGAATTTGTGACTGCAGGGGAAATTTGGAAGAAATTACTTCCTGAAAATTTCCAAGGGGCACCAAGTGGCAGCTGGCCTCCTGGGGTGAGGAGCCAGGCACCCCGGAGCCAGGCCTAAGGGGAAGAAGAAGATAGCCAGTGTTTAAAGTGTTTATTTTAAAACACAAATGCAGTTTTTAATGGTTCAAAATTATTTTTAAGCAAGTTGGGGGGAAGAATTTTATCTTCATAAAGGGGACAAGTCAGGAGCTGCAGAAGAGTGGGGTTGGGTAGGGGGGTCAGCAGATGGGCAGGTTCGGCCCTCGGGGCCATTTAGATAGAGACCTGTGGGGGAGGGGTATCAGCAGACTGGGAGGTAAGGAGGAGTCTACCACTTTTGTTTTAGTATGATGCACTCCAGTTGTTCTTAATAAAAGTTTTGAAAATGT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR000286--His_deacetylse
IPR003084--His_deacetylse_1
IPR023801--His_deacetylse_dom
|
| PROSITE |
|
| Pfam |
PF00850--Hist_deacetyl
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0000118--C:histone deacetylase complex
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004407--F:histone deacetylase activity
GO:0030544--F:Hsp70 protein binding
GO:0051879--F:Hsp90 protein binding
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0008134--F:transcription factor binding
GO:0016568--P:chromatin modification
GO:0031397--P:negative regulation of protein ubiquitination
GO:0071922--P:regulation of cohesin localization to chromatin
GO:0031647--P:regulation of protein stability
GO:0032204--P:regulation of telomere maintenance
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007062--P:sister chromatid cohesion
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
