| Tag |
Content |
| WERAM ID |
WERAM-Art-0083 |
| Ensembl Protein ID |
AT3G44750.1 |
| Uniprot Accession |
Q9FVE6; HDT1_ARATH; O22238
|
| Genbank Protein ID |
NP_566872.1
|
| Protein Name |
Histone deacetylase HDT1 |
| Genbank Nucleotide ID |
NM_114344.3
|
| Gene Name |
HDT1;HD2A;HDA3;At3g44750;T32N15.8 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
HD2 |
|
H3K9 |
K |
26689639
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
HD2 |
2.00e-86 |
315 |
|
|
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Required for histone H3 'Lys-9' deacetylation. Involved in rRNA gene silencing in nucleolar dominance. Seems to be implicated in the regulation of genes involved in seeds development. |
Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Required for histone H3 'Lys-9' deacetylation. Involved in rRNA gene silencing in nucleolar dominance. Seems to be implicated in the regulation of genes involved in seeds development.
|
| Domain Profile |
HDAC HD2
Query: 1 MEFWGIEVKSGKPVTVTPEEGILIHVSQASLGECKNKKGEFVPLHVKVGNQNLVLGTLST 60
MEFWGIEVKSGKPVTVTPEEGILIHVSQASLGECKNKKGEFVPLHVKVGNQNLVLGTLST
Sbjct: 1 MEFWGIEVKSGKPVTVTPEEGILIHVSQASLGECKNKKGEFVPLHVKVGNQNLVLGTLST 60
Query: 61 ENIPQLFCDLVFDKEFELSHTWGKGSVYFVGYKTPNIEPQGYSXXXXXXXXXXXXXXXXX 120
ENIPQLFCDLVFDKEFELSHTWGKGSVYFVGYKTPNIEPQGYS
Sbjct: 61 ENIPQLFCDLVFDKEFELSHTWGKGSVYFVGYKTPNIEPQGYSEEEEEEEEEVPAGNAAK 120
Query: 121 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPTPKKPASSKKRANEXXX 180
PTPKKPASSKKRANE
Sbjct: 121 AVAKPKAKPAEVKPAVDDEEDESDSDGMDEDDSDGEDSEEEEPTPKKPASSKKRANETTP 180
Query: 181 XXXXXXXXXXXXXXXQKTDEKKKGGKAANQSPKSASQVSCGSCKKTFNSGNALESHNKAK 240
QKTDEKKKGGKAANQSPKSASQVSCGSCKKTFNSGNALESHNKAK
Sbjct: 181 KAPVSAKKAKVAVTPQKTDEKKKGGKAANQSPKSASQVSCGSCKKTFNSGNALESHNKAK 240
Query: 241 HAAAK 245
HAAAK
Sbjct: 241 HAAAK 245
|
Protein Sequence
(Fasta) | MEFWGIEVKS GKPVTVTPEE GILIHVSQAS LGECKNKKGE FVPLHVKVGN QNLVLGTLST 60
ENIPQLFCDL VFDKEFELSH TWGKGSVYFV GYKTPNIEPQ GYSEEEEEEE EEVPAGNAAK 120
AVAKPKAKPA EVKPAVDDEE DESDSDGMDE DDSDGEDSEE EEPTPKKPAS SKKRANETTP 180
KAPVSAKKAK VAVTPQKTDE KKKGGKAANQ SPKSASQVSC GSCKKTFNSG NALESHNKAK 240
HAAAK 245Protein Fasta Sequence
>AT3G44750.1|HDT1;HD2A;HDA3;At3g44750;T32N15.8|Arabidopsis thaliana
MEFWGIEVKSGKPVTVTPEEGILIHVSQASLGECKNKKGEFVPLHVKVGNQNLVLGTLSTENIPQLFCDLVFDKEFELSHTWGKGSVYFVGYKTPNIEPQGYSEEEEEEEEEVPAGNAAKAVAKPKAKPAEVKPAVDDEEDESDSDGMDEDDSDGEDSEEEEPTPKKPASSKKRANETTPKAPVSAKKAKVAVTPQKTDEKKKGGKAANQSPKSASQVSCGSCKKTFNSGNALESHNKAKHAAAK |
Nucleotide Sequence
(Fasta) | TCTTACATTT TCAGCTGCTC ATAAACCCTA AAAATCCTCT CTTTTTCTCA ACCTTGATTC 60
TTAGCCATGG AGTTCTGGGG AATTGAAGTT AAATCAGGAA AGCCAGTTAC AGTGACTCCT 120
GAAGAAGGCA TTCTTATCCA CGTTTCTCAG GCATCGCTTG GAGAATGTAA AAACAAGAAG 180
GGAGAGTTTG TGCCTTTACA TGTAAAGGTT GGGAACCAGA ACTTGGTTCT GGGAACTCTA 240
TCGACTGAGA ACATCCCTCA GCTTTTCTGT GATTTGGTAT TCGACAAGGA GTTTGAGCTT 300
TCTCACACTT GGGGAAAAGG AAGTGTTTAC TTTGTTGGAT ACAAAACTCC CAACATTGAG 360
CCACAAGGCT ATTCTGAGGA AGAAGAGGAA GAAGAGGAAG AAGTTCCTGC TGGGAATGCT 420
GCCAAGGCTG TAGCTAAACC AAAGGCTAAG CCTGCAGAAG TGAAGCCAGC TGTTGATGAT 480
GAAGAGGATG AGTCTGATTC TGACGGAATG GATGAAGATG ATTCTGATGG TGAGGATTCT 540
GAGGAAGAAG AGCCTACACC TAAGAAGCCT GCATCAAGCA AGAAGAGAGC TAATGAAACT 600
ACCCCTAAAG CACCTGTGTC AGCAAAGAAG GCGAAAGTAG CAGTTACTCC TCAGAAAACA 660
GATGAGAAGA AGAAAGGGGG AAAGGCTGCA AACCAGAGCC CAAAGTCGGC CAGTCAAGTC 720
TCATGTGGTT CATGCAAGAA GACTTTCAAC TCAGGGAATG CACTTGAGTC TCACAACAAG 780
GCCAAGCACG CTGCTGCCAA GTGAAGTGGT TTCTTATTAG AGCTTGTGAT TTCTATGGAA 840
TTTTGCCTGT AGTCTTTATG AAACCTTCGG ATTTTCTTAT ATTTTCTTTT GATAACAAGA 900
GTCTTAATGA AAGAGAGCCA GTTGGAGTCT TATTACCACT ATATTTCAAC ATTCTATCTT 960
GGCTCAAATG TGTTAATTTT AGATTCACGT TTTCACCA
999Nucleotide Fasta Sequence
>AT3G44750.1|HD2|Arabidopsis thaliana
TCTTACATTTTCAGCTGCTCATAAACCCTAAAAATCCTCTCTTTTTCTCAACCTTGATTCTTAGCCATGGAGTTCTGGGGAATTGAAGTTAAATCAGGAAAGCCAGTTACAGTGACTCCTGAAGAAGGCATTCTTATCCACGTTTCTCAGGCATCGCTTGGAGAATGTAAAAACAAGAAGGGAGAGTTTGTGCCTTTACATGTAAAGGTTGGGAACCAGAACTTGGTTCTGGGAACTCTATCGACTGAGAACATCCCTCAGCTTTTCTGTGATTTGGTATTCGACAAGGAGTTTGAGCTTTCTCACACTTGGGGAAAAGGAAGTGTTTACTTTGTTGGATACAAAACTCCCAACATTGAGCCACAAGGCTATTCTGAGGAAGAAGAGGAAGAAGAGGAAGAAGTTCCTGCTGGGAATGCTGCCAAGGCTGTAGCTAAACCAAAGGCTAAGCCTGCAGAAGTGAAGCCAGCTGTTGATGATGAAGAGGATGAGTCTGATTCTGACGGAATGGATGAAGATGATTCTGATGGTGAGGATTCTGAGGAAGAAGAGCCTACACCTAAGAAGCCTGCATCAAGCAAGAAGAGAGCTAATGAAACTACCCCTAAAGCACCTGTGTCAGCAAAGAAGGCGAAAGTAGCAGTTACTCCTCAGAAAACAGATGAGAAGAAGAAAGGGGGAAAGGCTGCAAACCAGAGCCCAAAGTCGGCCAGTCAAGTCTCATGTGGTTCATGCAAGAAGACTTTCAACTCAGGGAATGCACTTGAGTCTCACAACAAGGCCAAGCACGCTGCTGCCAAGTGAAGTGGTTTCTTATTAGAGCTTGTGATTTCTATGGAATTTTGCCTGTAGTCTTTATGAAACCTTCGGATTTTCTTATATTTTCTTTTGATAACAAGAGTCTTAATGAAAGAGAGCCAGTTGGAGTCTTATTACCACTATATTTCAACATTCTATCTTGGCTCAAATGTGTTAATTTTAGATTCACGTTTTCACCA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR007087--Znf_C2H2
|
| PROSITE |
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
|
| Pfam |
|
| Gene Ontology |
GO:0005730--C:nucleolus
GO:0016787--F:hydrolase activity
GO:0046872--F:metal ion binding
GO:0016568--P:chromatin modification
GO:0009294--P:DNA mediated transformation
GO:0009944--P:polarity specification of adaxial/abaxial axis
GO:0006355--P:regulation of transcription, DNA-templated
GO:0010162--P:seed dormancy process
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
