| Tag |
Content |
| WERAM ID |
WERAM-Scp-0009 |
| Ensembl Protein ID |
SPAC1952.05.1:pep |
| Uniprot Accession |
Q9UUK2; GCN5_SCHPO
|
| Genbank Protein ID |
NP_594807.1
|
| Protein Name |
Histone acetyltransferase gcn5 |
| Genbank Nucleotide ID |
NM_001020236.2
|
| Gene Name |
GCN5;SPAC1952.05 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HAT |
GCN5 |
N-acetyltransferase |
H2BK11; H2BK16; H3K9; H3K14; H3K18; H3K36; H4K8; H4K16 |
K |
26223950; 18022374
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
GCN5 |
1.60e-67 |
224.6 |
123 |
272 |
| Ac_Reader |
Bromodomain |
9.70e-26 |
87.8 |
360 |
430 |
|
| Organism |
Schizosaccharomyces pombe |
| NCBI Taxa ID |
284812 |
Functional Description
(View)Functional Description
Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, and with a lower preference histone H4 to form H4K8ac and H4K16ac. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity). |
Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, and with a lower preference histone H4 to form H4K8ac and H4K16ac. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).
|
| Domain Profile |
HAT GCN5
GCN5.txt 2 leksrvdevllvlvglqkvfeaqlprmkkeyiarlladrkhkslvvikkdngvvggitfrlfeeegfvEvvycavaskervkGyGkrLlnhl 93
++++++ +++++l+gl+++f++qlp+m+keyi+rl++dr+h s++++k++ +vvggit+r+fe++gf+E+v+ca+as+e+v+GyG++L+nhl
SPAC1952.05.1:pep 123 VSNDDTADSMIMLTGLKNIFMKQLPKMPKEYITRLIYDRNHLSMTIVKDNLHVVGGITYRPFEQRGFAEIVFCAIASNEQVRGYGSHLMNHL 214
57889999************************************************************************************ PP
GCN5.txt 94 kevarktrrikffLTfadneaigyfkkqgfskeiklpksstigyikeyegatllecel 151
k+++r t++i++fLT+adn+aigyfkkqgf+kei+l+ks+++gyik+yeg+tl++c++
SPAC1952.05.1:pep 215 KDYVRGTTTIQHFLTYADNYAIGYFKKQGFTKEITLDKSIWVGYIKDYEGGTLMQCTM 272
********************************************************87 PP
Ac_Reader Bromodomain
BROMO.txt 1 kehevsepFrepvdpqleipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssvq 72
++h+ s+pF++pv + ++pdYy++i++PmdLst++ rl++++Y+s+eef++D + if+N++ yn+ ++ ++
SPAC1952.05.1:pep 360 QNHPSSWPFMQPVSK-EDVPDYYEVIEHPMDLSTMEFRLRNNQYESVEEFIRDAKYIFDNCRSYNDSNTTYY 430
689************.6************************************************9998776 PP
|
Protein Sequence
(Fasta) | MSNSLNDQTR PPDSSVVDST SSNFPNASND SVHDKPVKQD EQSNPNVREA IANSDGQESL 60
AVKENKDTES SSSHFVPNGV SNSKKRKLVA TDLDVDFDIS SVRVTEKPSV LEEKSGVIQF 120
RVVSNDDTAD SMIMLTGLKN IFMKQLPKMP KEYITRLIYD RNHLSMTIVK DNLHVVGGIT 180
YRPFEQRGFA EIVFCAIASN EQVRGYGSHL MNHLKDYVRG TTTIQHFLTY ADNYAIGYFK 240
KQGFTKEITL DKSIWVGYIK DYEGGTLMQC TMIPKIKYLE ANLILAIQKA AVVSKINRIT 300
RSNVVYPGLD VFKDGPAHIE PSQVPGLMEV GWCKEMEELS KKPRPKPFFA VLEMLFTEMQ 360
NHPSSWPFMQ PVSKEDVPDY YEVIEHPMDL STMEFRLRNN QYESVEEFIR DAKYIFDNCR 420
SYNDSNTTYY KNADRLEKFF QKKLRETEYS HLAD 454Protein Fasta Sequence
>SPAC1952.05.1:pep|GCN5;SPAC1952.05|Schizosaccharomyces pombe
MSNSLNDQTRPPDSSVVDSTSSNFPNASNDSVHDKPVKQDEQSNPNVREAIANSDGQESLAVKENKDTESSSSHFVPNGVSNSKKRKLVATDLDVDFDISSVRVTEKPSVLEEKSGVIQFRVVSNDDTADSMIMLTGLKNIFMKQLPKMPKEYITRLIYDRNHLSMTIVKDNLHVVGGITYRPFEQRGFAEIVFCAIASNEQVRGYGSHLMNHLKDYVRGTTTIQHFLTYADNYAIGYFKKQGFTKEITLDKSIWVGYIKDYEGGTLMQCTMIPKIKYLEANLILAIQKAAVVSKINRITRSNVVYPGLDVFKDGPAHIEPSQVPGLMEVGWCKEMEELSKKPRPKPFFAVLEMLFTEMQNHPSSWPFMQPVSKEDVPDYYEVIEHPMDLSTMEFRLRNNQYESVEEFIRDAKYIFDNCRSYNDSNTTYYKNADRLEKFFQKKLRETEYSHLAD |
Nucleotide Sequence
(Fasta) | CAAAAAATGA AAGCAGAAAA TTCGTAGAGA AGAAATTTTC TAATCTTGCA TCCCAAGTCA 60
AATCATGTAT TTGTGTCTTT AATTAGTAAA TATTAGGATA ATCGTTGATT TGAAGTATTA 120
AAAAATTGAT TGTATTTTGG AGCGCAAATC TGAGATTTTT TTTATAGATT AAAAAATTCT 180
CCTTGATACG GTCATTTTCG GTTGACTTGT GTTCAAACTC TTTCTATAAA AAGAGGTTCT 240
TTTTCTAAGA GAATCCCTGC CGAGTTTCCT TAAGTTTTAG AAAGGTAAAG GGCTGGTCGA 300
CGTCTTTTCA CATTGTTGGT GCCAAAAACA AAATTTTCGA GACAAATAAC TGGGTTCGTG 360
GTGTATATTT TAACAAATTA TCGTTTATTT TAATTTTCTG TATTTCGTTA TTATATACCG 420
TTTTTTCGTG CTCGTTTCAT CTTGTATCGT TCTTGACAAT TTCTGTATCT TCACTTTTTG 480
GATTTATTTG TTTGGATGCG TGGCATAGAA TAATCATGTC GAATTCGTTA AATGATCAAA 540
CACGACCACC CGATTCAAGT GTTGTAGACA GTACATCTTC CAACTTTCCA AATGCGTCAA 600
ACGATAGTGT ACATGATAAA CCGGTAAAAC AGGACGAACA ATCCAATCCA AATGTTCGCG 660
AAGCAATTGC TAATTCCGAT GGACAAGAAT CTTTAGCTGT AAAGGAAAAC AAGGATACGG 720
AAAGCTCATC CTCTCATTTC GTACCTAACG GAGTTTCAAA TTCTAAAAAG AGAAAGCTCG 780
TGGCTACAGA TTTAGATGTT GATTTTGATA TTAGTAGTGT ACGAGTTACT GAAAAGCCAT 840
CTGTATTAGA AGAAAAAAGC GGCGTTATTC AATTTCGTGT TGTTTCTAAC GACGACACCG 900
CCGACAGTAT GATCATGTTG ACTGGTTTAA AAAACATATT TATGAAACAA CTTCCTAAAA 960
TGCCAAAAGA ATACATTACG CGGCTAATTT ATGATCGAAA CCATCTTTCA ATGACCATTG 1020
TCAAAGATAA TTTACATGTA GTGGGCGGTA TTACTTATCG TCCATTTGAA CAACGAGGAT 1080
TTGCCGAAAT TGTATTTTGT GCGATTGCTT CCAATGAACA GGTTCGTGGT TATGGTTCTC 1140
ATTTAATGAA TCATTTAAAG GATTATGTCC GTGGAACTAC TACAATTCAG CACTTCTTGA 1200
CATATGCAGA TAACTATGCA ATCGGGTATT TTAAAAAACA AGGATTTACT AAGGAAATTA 1260
CTCTTGACAA GTCTATATGG GTTGGCTATA TTAAGGATTA CGAAGGTGGC ACACTTATGC 1320
AATGCACCAT GATTCCAAAA ATAAAGTATT TAGAAGCTAA TCTGATTTTG GCTATTCAGA 1380
AAGCTGCTGT TGTTTCCAAA ATTAACAGGA TCACTCGGTC GAACGTTGTT TATCCTGGTT 1440
TAGACGTATT CAAAGATGGT CCAGCTCATA TAGAGCCGTC TCAAGTTCCT GGGTTGATGG 1500
AAGTTGGATG GTGCAAGGAA ATGGAAGAGC TCTCCAAAAA GCCCAGACCT AAACCTTTTT 1560
TTGCCGTTTT GGAAATGCTT TTTACAGAAA TGCAAAATCA TCCGTCTTCC TGGCCCTTTA 1620
TGCAACCGGT TAGTAAAGAG GATGTACCCG ATTATTACGA AGTTATTGAA CACCCCATGG 1680
ACCTTTCGAC TATGGAATTT CGGTTGCGTA ACAACCAGTA TGAGTCTGTA GAGGAATTTA 1740
TTCGGGATGC AAAATATATA TTTGATAATT GCCGTTCTTA CAATGACTCC AACACGACTT 1800
ACTATAAAAA TGCCGATAGA TTGGAAAAGT TTTTCCAGAA AAAACTTCGT GAAACTGAGT 1860
ATTCACACTT AGCCGATTAA TCATTTACAT TTATTATCAT CGAAACGTCT ATTCCGAAGT 1920
TTTATTGATT ATAACATATA CATTTCACCT TTTAATTTTT TACACGAATA TCTTTTGTGC 1980
CTTCCAAATA TGCTGGCATA TCAAGAACTG CTAGTGTTTA ATTTTTAGTT TTTTTGTTTA 2040
AAAATATATA TAATTCTATA ATACCAAACA CTCTTTATGT TCCATAATAA CAAATGTA
2099Nucleotide Fasta Sequence
>SPAC1952.05.1:pep|Bromodomain|Schizosaccharomyces pombe
CAAAAAATGAAAGCAGAAAATTCGTAGAGAAGAAATTTTCTAATCTTGCATCCCAAGTCAAATCATGTATTTGTGTCTTTAATTAGTAAATATTAGGATAATCGTTGATTTGAAGTATTAAAAAATTGATTGTATTTTGGAGCGCAAATCTGAGATTTTTTTTATAGATTAAAAAATTCTCCTTGATACGGTCATTTTCGGTTGACTTGTGTTCAAACTCTTTCTATAAAAAGAGGTTCTTTTTCTAAGAGAATCCCTGCCGAGTTTCCTTAAGTTTTAGAAAGGTAAAGGGCTGGTCGACGTCTTTTCACATTGTTGGTGCCAAAAACAAAATTTTCGAGACAAATAACTGGGTTCGTGGTGTATATTTTAACAAATTATCGTTTATTTTAATTTTCTGTATTTCGTTATTATATACCGTTTTTTCGTGCTCGTTTCATCTTGTATCGTTCTTGACAATTTCTGTATCTTCACTTTTTGGATTTATTTGTTTGGATGCGTGGCATAGAATAATCATGTCGAATTCGTTAAATGATCAAACACGACCACCCGATTCAAGTGTTGTAGACAGTACATCTTCCAACTTTCCAAATGCGTCAAACGATAGTGTACATGATAAACCGGTAAAACAGGACGAACAATCCAATCCAAATGTTCGCGAAGCAATTGCTAATTCCGATGGACAAGAATCTTTAGCTGTAAAGGAAAACAAGGATACGGAAAGCTCATCCTCTCATTTCGTACCTAACGGAGTTTCAAATTCTAAAAAGAGAAAGCTCGTGGCTACAGATTTAGATGTTGATTTTGATATTAGTAGTGTACGAGTTACTGAAAAGCCATCTGTATTAGAAGAAAAAAGCGGCGTTATTCAATTTCGTGTTGTTTCTAACGACGACACCGCCGACAGTATGATCATGTTGACTGGTTTAAAAAACATATTTATGAAACAACTTCCTAAAATGCCAAAAGAATACATTACGCGGCTAATTTATGATCGAAACCATCTTTCAATGACCATTGTCAAAGATAATTTACATGTAGTGGGCGGTATTACTTATCGTCCATTTGAACAACGAGGATTTGCCGAAATTGTATTTTGTGCGATTGCTTCCAATGAACAGGTTCGTGGTTATGGTTCTCATTTAATGAATCATTTAAAGGATTATGTCCGTGGAACTACTACAATTCAGCACTTCTTGACATATGCAGATAACTATGCAATCGGGTATTTTAAAAAACAAGGATTTACTAAGGAAATTACTCTTGACAAGTCTATATGGGTTGGCTATATTAAGGATTACGAAGGTGGCACACTTATGCAATGCACCATGATTCCAAAAATAAAGTATTTAGAAGCTAATCTGATTTTGGCTATTCAGAAAGCTGCTGTTGTTTCCAAAATTAACAGGATCACTCGGTCGAACGTTGTTTATCCTGGTTTAGACGTATTCAAAGATGGTCCAGCTCATATAGAGCCGTCTCAAGTTCCTGGGTTGATGGAAGTTGGATGGTGCAAGGAAATGGAAGAGCTCTCCAAAAAGCCCAGACCTAAACCTTTTTTTGCCGTTTTGGAAATGCTTTTTACAGAAATGCAAAATCATCCGTCTTCCTGGCCCTTTATGCAACCGGTTAGTAAAGAGGATGTACCCGATTATTACGAAGTTATTGAACACCCCATGGACCTTTCGACTATGGAATTTCGGTTGCGTAACAACCAGTATGAGTCTGTAGAGGAATTTATTCGGGATGCAAAATATATATTTGATAATTGCCGTTCTTACAATGACTCCAACACGACTTACTATAAAAATGCCGATAGATTGGAAAAGTTTTTCCAGAAAAAACTTCGTGAAACTGAGTATTCACACTTAGCCGATTAATCATTTACATTTATTATCATCGAAACGTCTATTCCGAAGTTTTATTGATTATAACATATACATTTCACCTTTTAATTTTTTACACGAATATCTTTTGTGCCTTCCAAATATGCTGGCATATCAAGAACTGCTAGTGTTTAATTTTTAGTTTTTTTGTTTAAAAATATATATAATTCTATAATACCAAACACTCTTTATGTTCCATAATAACAAATGTA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0010--Activator
KW-0012--Acyltransferase
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR000182--GNAT_dom
|
| PROSITE |
PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51186--GNAT
|
| Pfam |
PF00583--Acetyltransf_1
PF00439--Bromodomain
|
| Gene Ontology |
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0000124--C:SAGA complex
GO:0010484--F:H3 histone acetyltransferase activity
GO:0006338--P:chromatin remodeling
GO:0043966--P:histone H3 acetylation
GO:0060358--P:negative regulation of leucine import
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007131--P:reciprocal meiotic recombination
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
