| Tag |
Content |
| WERAM ID |
WERAM-Art-0090 |
| Ensembl Protein ID |
AT3G54610.1 |
| Uniprot Accession |
Q9AR19; GCN5_ARATH; O22654; Q7G1G9; Q9M1G7
|
| Genbank Protein ID |
NP_567002.1
|
| Protein Name |
Histone acetyltransferase GCN5 |
| Genbank Nucleotide ID |
NM_115318.2
|
| Gene Name |
HAG1;BGT;GCN5;HAT1BGT;At3g54610;T14E10.180;GCN5 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Ac_Reader |
Bromodomain |
Bromodomain |
H3K9; H3K14 |
K |
12466527
|
| HAT |
GCN5 |
N-acetyltransferase |
H3K9; H3K14 |
K |
26689639; 26596766
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HAT |
GCN5 |
1.50e-61 |
207.9 |
223 |
370 |
| Ac_Reader |
Bromodomain |
2.70e-24 |
85.8 |
472 |
543 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
Acetylates histone H3 and ADA2 proteins in vitro. Acetylates 'Lys-14' of histone H3. Acetylation of histones gives a specific tag for epigenetic transcription activation. Operates in concert with certain DNA-binding transcriptional activators. Acts via the formation of large multiprotein complexes that modify the chromatin (By similarity). |
Acetylates histone H3 and ADA2 proteins in vitro. Acetylates 'Lys-14' of histone H3. Acetylation of histones gives a specific tag for epigenetic transcription activation. Operates in concert with certain DNA-binding transcriptional activators. Acts via the formation of large multiprotein complexes that modify the chromatin (By similarity).
|
| Domain Profile |
HAT GCN5
GCN5.txt 3 eksrvdevllvlvglqkvfeaqlprmkkeyiarlladrkhkslvvikkdngvvggitfrlfeeegfvEvvycavaskervkGyGkrLlnhlkevarkt 100
++++ de++++l+gl+++f++qlp+m+keyi rll+drkhks++v++ n vvggit+r++++++f E+ +ca++++e+vkGyG+rL+nhlk++ar++
AT3G54610.1 223 SNDSIDEHMMCLIGLKNIFARQLPNMPKEYIVRLLMDRKHKSVMVLR-GNLVVGGITYRPYHSQKFGEIAFCAITADEQVKGYGTRLMNHLKQHARDV 319
68899******************************************.************************************************** PP
GCN5.txt 101 rrikffLTfadneaigyfkkqgfskeiklpksstigyikeyegatllecel 151
+ +++fLT+adn+a+gyf kqgf+kei+l+k++++g+ik+y+g+ l+ec++
AT3G54610.1 320 DGLTHFLTYADNNAVGYFVKQGFTKEIYLEKDVWHGFIKDYDGGLLMECKI 370
*************************************************97 PP
Ac_Reader Bromodomain
BROMO.txt 1 kehevsepFrepvdpqleipdYydiikePmdLstikerleegn.YsspeefvkDvrlifnNakaynenkssvq 72
+ h +++pF+epvd ++pdYydiik P+dL+ i +r+e+++ Y +++ fv+D r++fnN+++yn++++ ++
AT3G54610.1 472 QDHADAWPFKEPVDS-RDVPDYYDIIKDPIDLKVIAKRVESEQyYVTLDMFVADARRMFNNCRTYNSPDTIYY 543
5799***********.6***********************9887999*********************99876 PP
|
Protein Sequence
(Fasta) | MDSHSSHLNA ANRSRSSQTP SPSHSASASV TSSLHKRKLA ATTAANAAAS EDHAPPSSSF 60
PPSSFSADTR DGALTSNDEL ESISARGADT DSDPDESEDI VVDDDEDEFA PEQDQDSSIR 120
TFTAARLDSS SGVNGSSRNT KLKTESSTVK LESSDGGKDG GSSVVGTGVS GTVGGSSISG 180
LVPKDESVKV LAENFQTSGA YIAREEALKR EEQAGRLKFV CYSNDSIDEH MMCLIGLKNI 240
FARQLPNMPK EYIVRLLMDR KHKSVMVLRG NLVVGGITYR PYHSQKFGEI AFCAITADEQ 300
VKGYGTRLMN HLKQHARDVD GLTHFLTYAD NNAVGYFVKQ GFTKEIYLEK DVWHGFIKDY 360
DGGLLMECKI DPKLPYTDLS SMIRQQRKAI DERIRELSNC QNVYPKIEFL KNEAGIPRKI 420
IKVEEIRGLR EAGWTPDQWG HTRFKLFNGS ADMVTNQKQL NALMRALLKT MQDHADAWPF 480
KEPVDSRDVP DYYDIIKDPI DLKVIAKRVE SEQYYVTLDM FVADARRMFN NCRTYNSPDT 540
IYYKCATRLE THFHSKVQAG LQSGAKSQ 568Protein Fasta Sequence
>AT3G54610.1|HAG1;BGT;GCN5;HAT1BGT;At3g54610;T14E10.180;GCN5|Arabidopsis thaliana
MDSHSSHLNAANRSRSSQTPSPSHSASASVTSSLHKRKLAATTAANAAASEDHAPPSSSFPPSSFSADTRDGALTSNDELESISARGADTDSDPDESEDIVVDDDEDEFAPEQDQDSSIRTFTAARLDSSSGVNGSSRNTKLKTESSTVKLESSDGGKDGGSSVVGTGVSGTVGGSSISGLVPKDESVKVLAENFQTSGAYIAREEALKREEQAGRLKFVCYSNDSIDEHMMCLIGLKNIFARQLPNMPKEYIVRLLMDRKHKSVMVLRGNLVVGGITYRPYHSQKFGEIAFCAITADEQVKGYGTRLMNHLKQHARDVDGLTHFLTYADNNAVGYFVKQGFTKEIYLEKDVWHGFIKDYDGGLLMECKIDPKLPYTDLSSMIRQQRKAIDERIRELSNCQNVYPKIEFLKNEAGIPRKIIKVEEIRGLREAGWTPDQWGHTRFKLFNGSADMVTNQKQLNALMRALLKTMQDHADAWPFKEPVDSRDVPDYYDIIKDPIDLKVIAKRVESEQYYVTLDMFVADARRMFNNCRTYNSPDTIYYKCATRLETHFHSKVQAGLQSGAKSQ |
Nucleotide Sequence
(Fasta) | GATTTTCTCA ATCACCTTCA CTATACTGCT TCGATGGACT CTCACTCTTC CCACCTCAAC 60
GCCGCCAATC GTTCCCGCAG TTCTCAGACT CCTTCTCCTT CTCATTCCGC CTCCGCCTCC 120
GTCACTTCTT CTCTCCACAA ACGCAAACTC GCCGCCACCA CGGCAGCGAA TGCAGCCGCT 180
TCTGAAGATC ACGCCCCTCC TTCTTCCTCT TTCCCTCCTT CCTCCTTCTC TGCCGATACT 240
CGCGACGGCG CTTTAACCTC CAACGATGAA CTCGAGAGCA TCTCCGCTCG CGGCGCCGAT 300
ACAGATTCAG ATCCTGATGA ATCAGAGGAT ATAGTCGTGG ATGATGACGA GGACGAATTT 360
GCTCCTGAAC AGGACCAGGA CTCTTCTATC CGCACATTCA CCGCCGCTCG ACTCGATTCC 420
AGCTCTGGAG TCAACGGTTC GAGTCGCAAC ACTAAACTTA AGACGGAAAG CTCCACGGTG 480
AAGCTTGAGA GCTCTGATGG TGGAAAAGAT GGTGGATCAT CTGTGGTTGG GACTGGTGTG 540
AGTGGCACTG TTGGAGGAAG CTCAATCTCA GGGCTCGTGC CAAAGGATGA GTCTGTTAAG 600
GTATTGGCTG AGAATTTCCA GACTAGCGGA GCTTACATTG CCAGAGAAGA GGCTTTGAAA 660
AGAGAGGAGC AAGCAGGACG ACTCAAATTT GTTTGTTACT CAAATGATTC CATTGATGAG 720
CATATGATGT GCTTGATTGG GTTGAAGAAC ATTTTTGCAA GACAGTTACC TAATATGCCC 780
AAGGAGTACA TTGTTCGTCT TCTGATGGAT AGGAAACATA AGTCTGTTAT GGTACTAAGA 840
GGGAATCTAG TTGTAGGTGG TATCACGTAT CGTCCATATC ACAGTCAGAA GTTTGGGGAA 900
ATAGCATTTT GTGCAATCAC AGCAGATGAA CAAGTAAAAG GTTACGGTAC CAGATTGATG 960
AACCACTTGA AACAACATGC ACGTGATGTT GATGGATTGA CGCATTTTCT TACTTATGCT 1020
GACAACAATG CTGTTGGTTA CTTCGTCAAG CAGGGTTTTA CTAAAGAGAT TTACTTGGAG 1080
AAAGATGTAT GGCATGGGTT CATTAAAGAC TATGATGGTG GTCTCCTTAT GGAATGCAAA 1140
ATTGATCCAA AGCTGCCATA TACGGATTTG TCAAGCATGA TACGCCAGCA AAGAAAGGCA 1200
ATTGATGAAA GGATAAGAGA GTTATCAAAC TGTCAGAATG TGTATCCAAA AATTGAGTTT 1260
CTAAAGAATG AAGCTGGAAT TCCTAGAAAG ATTATCAAAG TTGAGGAAAT ACGTGGCTTA 1320
AGGGAAGCTG GTTGGACCCC AGATCAGTGG GGGCACACTC GTTTCAAATT ATTCAATGGT 1380
TCTGCTGATA TGGTGACAAA TCAAAAACAG TTGAATGCAC TCATGCGTGC GCTTTTAAAG 1440
ACAATGCAAG ACCATGCTGA TGCTTGGCCT TTCAAAGAAC CAGTGGATTC TCGCGATGTC 1500
CCTGATTACT ATGACATCAT TAAGGATCCC ATTGATCTGA AGGTAATTGC AAAGAGGGTA 1560
GAGTCGGAAC AGTATTACGT GACATTGGAT ATGTTTGTTG CGGATGCGAG ACGGATGTTT 1620
AACAATTGTA GAACTTACAA CTCCCCCGAT ACCATTTATT ACAAATGTGC AACCAGGTTG 1680
GAAACACACT TCCATAGCAA AGTACAAGCA GGTCTCCAAT CTGGTGCTAA ATCTCAATAG 1740
AAGAAGATGG TAGAGGTTAT ATTAATATCA TTTTCTAGAT CTTTCATTTT AAGATACTTT 1800
CATTGGAACT GGGAATACAT GTATACTATT TTAGGCCCAT GTATACTGGA GCTTAATTGT 1860
TTGTATGTTT TTTTTTCGGA TAGGTAAATA TTTGATTTAG TTAGATTCAG AATGTTTAAG 1920
TTTTTACTTT GTAGGTTAAA TTTGTTCTAT AAAGCTTATT TCCAACTGTA AAGACACATT 1980
TCATTTTACT AAATGTTTCT GATGAAAATC ACATAACC
2019Nucleotide Fasta Sequence
>AT3G54610.1|Bromodomain|Arabidopsis thaliana
GATTTTCTCAATCACCTTCACTATACTGCTTCGATGGACTCTCACTCTTCCCACCTCAACGCCGCCAATCGTTCCCGCAGTTCTCAGACTCCTTCTCCTTCTCATTCCGCCTCCGCCTCCGTCACTTCTTCTCTCCACAAACGCAAACTCGCCGCCACCACGGCAGCGAATGCAGCCGCTTCTGAAGATCACGCCCCTCCTTCTTCCTCTTTCCCTCCTTCCTCCTTCTCTGCCGATACTCGCGACGGCGCTTTAACCTCCAACGATGAACTCGAGAGCATCTCCGCTCGCGGCGCCGATACAGATTCAGATCCTGATGAATCAGAGGATATAGTCGTGGATGATGACGAGGACGAATTTGCTCCTGAACAGGACCAGGACTCTTCTATCCGCACATTCACCGCCGCTCGACTCGATTCCAGCTCTGGAGTCAACGGTTCGAGTCGCAACACTAAACTTAAGACGGAAAGCTCCACGGTGAAGCTTGAGAGCTCTGATGGTGGAAAAGATGGTGGATCATCTGTGGTTGGGACTGGTGTGAGTGGCACTGTTGGAGGAAGCTCAATCTCAGGGCTCGTGCCAAAGGATGAGTCTGTTAAGGTATTGGCTGAGAATTTCCAGACTAGCGGAGCTTACATTGCCAGAGAAGAGGCTTTGAAAAGAGAGGAGCAAGCAGGACGACTCAAATTTGTTTGTTACTCAAATGATTCCATTGATGAGCATATGATGTGCTTGATTGGGTTGAAGAACATTTTTGCAAGACAGTTACCTAATATGCCCAAGGAGTACATTGTTCGTCTTCTGATGGATAGGAAACATAAGTCTGTTATGGTACTAAGAGGGAATCTAGTTGTAGGTGGTATCACGTATCGTCCATATCACAGTCAGAAGTTTGGGGAAATAGCATTTTGTGCAATCACAGCAGATGAACAAGTAAAAGGTTACGGTACCAGATTGATGAACCACTTGAAACAACATGCACGTGATGTTGATGGATTGACGCATTTTCTTACTTATGCTGACAACAATGCTGTTGGTTACTTCGTCAAGCAGGGTTTTACTAAAGAGATTTACTTGGAGAAAGATGTATGGCATGGGTTCATTAAAGACTATGATGGTGGTCTCCTTATGGAATGCAAAATTGATCCAAAGCTGCCATATACGGATTTGTCAAGCATGATACGCCAGCAAAGAAAGGCAATTGATGAAAGGATAAGAGAGTTATCAAACTGTCAGAATGTGTATCCAAAAATTGAGTTTCTAAAGAATGAAGCTGGAATTCCTAGAAAGATTATCAAAGTTGAGGAAATACGTGGCTTAAGGGAAGCTGGTTGGACCCCAGATCAGTGGGGGCACACTCGTTTCAAATTATTCAATGGTTCTGCTGATATGGTGACAAATCAAAAACAGTTGAATGCACTCATGCGTGCGCTTTTAAAGACAATGCAAGACCATGCTGATGCTTGGCCTTTCAAAGAACCAGTGGATTCTCGCGATGTCCCTGATTACTATGACATCATTAAGGATCCCATTGATCTGAAGGTAATTGCAAAGAGGGTAGAGTCGGAACAGTATTACGTGACATTGGATATGTTTGTTGCGGATGCGAGACGGATGTTTAACAATTGTAGAACTTACAACTCCCCCGATACCATTTATTACAAATGTGCAACCAGGTTGGAAACACACTTCCATAGCAAAGTACAAGCAGGTCTCCAATCTGGTGCTAAATCTCAATAGAAGAAGATGGTAGAGGTTATATTAATATCATTTTCTAGATCTTTCATTTTAAGATACTTTCATTGGAACTGGGAATACATGTATACTATTTTAGGCCCATGTATACTGGAGCTTAATTGTTTGTATGTTTTTTTTTCGGATAGGTAAATATTTGATTTAGTTAGATTCAGAATGTTTAAGTTTTTACTTTGTAGGTTAAATTTGTTCTATAAAGCTTATTTCCAACTGTAAAGACACATTTCATTTTACTAAATGTTTCTGATGAAAATCACATAACC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0010--Activator
KW-0012--Acyltransferase
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
--
|
| Interpro |
IPR016181--Acyl_CoA_acyltransferase
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR000182--GNAT_dom
|
| PROSITE |
PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51186--GNAT
|
| Pfam |
PF00583--Acetyltransf_1
PF00439--Bromodomain
|
| Gene Ontology |
GO:0000123--C:histone acetyltransferase complex
GO:0005634--C:nucleus
GO:0016407--F:acetyltransferase activity
GO:0003677--F:DNA binding
GO:0010484--F:H3 histone acetyltransferase activity
GO:0004402--F:histone acetyltransferase activity
GO:0009908--P:flower development
GO:0016573--P:histone acetylation
GO:0043966--P:histone H3 acetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010321--P:regulation of vegetative phase change
GO:0009416--P:response to light stimulus
GO:0010015--P:root morphogenesis
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
