Tag |
Content |
WERAM ID |
WERAM-Hos-0223 |
Ensembl Protein ID |
ENSP00000482224.1 |
Uniprot Accession |
Q6B0I6; KDM4D_HUMAN; B3KPC4; Q0VF39; Q9NT41; Q9NW76 |
Genbank Protein ID |
NP_060509.2 |
Protein Name |
Lysine-specific demethylase 4D |
Genbank Nucleotide ID |
NM_018039.2 |
Gene Name |
KDM4D;JMJD2D |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDM |
JHDM3_JMJD2 |
Jmjc |
H3K9; H3K36 |
K |
20951770; 20889125 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDM |
JHDM3_JMJD2 |
6.50e-89 |
298.5 |
89 |
312 |
|
Organism |
Homo sapiens |
NCBI Taxa ID |
9606 |
Functional Description (View)Functional Description
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. |
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
|
Domain Profile |
HDM JHDM3_JMJD2
JHDM3.txt 46 WhvedmdlysinylhfGapktWyavpseaakrlek 80 +h + + + y h+ + k++ + p+++ ++le+ ENSP00000482224.1 89 YHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLER 123 56666666667899999999988888888777776 PP JHDM3.txt 1 dedveeWnlnklktildsvekelkieieGvntpylyvgmlkttfaWhvedmdlysinylhfGapktWyavpseaakrlekllrkefsesake 92 de++++Wnl++l+ti+d +eke+++ ieGvntpyly+gm+kttfaWh+edmdlysinylh+G+pktWy+vp+e+++rle+l+r+ f++s+++ ENSP00000482224.1 146 DENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRG 237 67899*************************************************************************************** PP JHDM3.txt 93 ceaflrhkttlisPellkkagipfnrivqeagefvitfPygyhaGfnhGfnlaestnfaterwievgkeaakcsc 167 c aflrhk++lisP++lk++gipfnri+qeagef++tfPygyhaGfnhGfn+ae++nfat+rwi++gk+a++csc ENSP00000482224.1 238 CGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSC 312 **************************************************************************9 PP
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Protein Sequence (Fasta) | METMKSKANC AQNPNCNIMI FHPTKEEFND FDKYIAYMES QGAHRAGLAK IIPPKEWKAR 60 ETYDNISEIL IATPLQQVAS GRAGVFTQYH KKKKAMTVGE YRHLANSKKY QTPPHQNFED 120 LERKYWKNRI YNSPIYGADI SGSLFDENTK QWNLGHLGTI QDLLEKECGV VIEGVNTPYL 180 YFGMWKTTFA WHTEDMDLYS INYLHLGEPK TWYVVPPEHG QRLERLAREL FPGSSRGCGA 240 FLRHKVALIS PTVLKENGIP FNRITQEAGE FMVTFPYGYH AGFNHGFNCA EAINFATPRW 300 IDYGKMASQC SCGEARVTFS MDAFVRILQP ERYDLWKRGQ DRAVVDHMEP RVPASQELST 360 QKEVQLPRRA ALGLRQLPSH WARHSPWPMA ARSGTRCHTL VCSSLPRRSA VSGTATQPRA 420 AAVHSSKKPS STPSSTPGPS AQIIHPSNGR RGRGRPPQKL RAQELTLQTP AKRPLLAGTT 480 CTASGPEPEP LPEDGALMDK PVPLSPGLQH PVKASGCSWA PVP 523Protein Fasta Sequence
>ENSP00000482224.1|KDM4D;JMJD2D|Homo sapiens METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
|
Nucleotide Sequence (Fasta) | GCTGCTGCCC AGAGTGGAAT CTCACTAGTG AATAAACAAG CCCAAGAAAG ATTATCATCT 60 CATTTGCAAA AAAAAAAGTA CGCTGGTAGA TCCTGCTACC TCATAGATAA CACCAGTCAA 120 ATTTTTTTTT AAAGTAGCAT TTTCCTACAT TGTCAACTAT CTAGAACATA CCTAAAAACT 180 AAGAGTTTAC TGCTTATTAA ATGGAAACTA TGAAGTCTAA GGCCAACTGT GCCCAGAATC 240 CAAATTGTAA CATAATGATA TTTCATCCAA CCAAAGAAGA GTTTAATGAT TTTGATAAAT 300 ATATTGCTTA CATGGAATCC CAAGGTGCAC ACAGAGCTGG CTTGGCTAAG ATAATTCCAC 360 CCAAAGAATG GAAAGCCAGA GAGACCTATG ATAATATCAG TGAAATCTTA ATAGCCACTC 420 CCCTCCAGCA GGTGGCCTCT GGGCGGGCAG GGGTGTTTAC TCAATACCAT AAAAAAAAGA 480 AAGCCATGAC TGTGGGGGAG TATCGCCATT TGGCAAACAG TAAAAAATAT CAGACTCCAC 540 CACACCAGAA TTTCGAAGAT TTGGAGCGAA AATACTGGAA GAACCGCATC TATAATTCAC 600 CGATTTATGG TGCTGACATC AGTGGCTCCT TGTTTGATGA AAACACTAAA CAATGGAATC 660 TTGGGCACCT GGGAACAATT CAGGACCTGC TGGAAAAGGA ATGTGGGGTT GTCATAGAAG 720 GCGTCAATAC ACCCTACTTG TACTTTGGCA TGTGGAAAAC CACGTTTGCT TGGCATACAG 780 AGGACATGGA CCTTTACAGC ATCAACTACC TGCACCTTGG GGAGCCCAAA ACTTGGTATG 840 TGGTGCCCCC AGAACATGGC CAGCGCCTGG AACGCCTGGC CAGGGAGCTC TTCCCAGGCA 900 GTTCCCGGGG TTGTGGGGCC TTCCTGCGGC ACAAGGTGGC CCTCATCTCG CCTACAGTTC 960 TCAAGGAAAA TGGGATTCCC TTCAATCGCA TAACTCAGGA GGCTGGAGAG TTCATGGTGA 1020 CCTTTCCCTA TGGCTACCAT GCTGGCTTCA ACCATGGTTT CAACTGCGCA GAGGCCATCA 1080 ATTTTGCCAC TCCGCGATGG ATTGATTATG GCAAAATGGC CTCCCAGTGT AGCTGTGGGG 1140 AGGCAAGGGT GACCTTTTCC ATGGATGCCT TCGTGCGCAT CCTGCAACCT GAACGCTATG 1200 ACCTGTGGAA ACGTGGGCAA GACCGGGCAG TTGTGGACCA CATGGAGCCC AGGGTACCAG 1260 CCAGCCAAGA GCTGAGCACC CAGAAGGAAG TCCAGTTACC CAGGAGAGCA GCGCTGGGCC 1320 TGAGACAACT CCCTTCCCAC TGGGCCCGGC ATTCCCCTTG GCCTATGGCT GCCCGCAGTG 1380 GGACACGGTG CCACACCCTT GTGTGCTCTT CACTCCCACG CCGATCTGCA GTTAGTGGCA 1440 CTGCTACGCA GCCCCGGGCT GCTGCTGTCC ACAGCTCTAA GAAGCCCAGC TCAACTCCAT 1500 CATCCACCCC TGGTCCATCT GCACAGATTA TCCACCCGTC AAATGGCAGA CGTGGTCGTG 1560 GTCGCCCTCC TCAGAAACTG AGAGCTCAGG AGCTGACCCT CCAGACTCCA GCCAAGAGGC 1620 CCCTCTTGGC GGGCACAACA TGCACAGCTT CGGGCCCAGA ACCTGAGCCC CTACCTGAGG 1680 ATGGGGCTTT GATGGACAAG CCTGTACCAC TGAGCCCAGG GCTCCAGCAT CCTGTCAAGG 1740 CTTCTGGGTG CAGCTGGGCC CCTGTGCCCT AAGTCCACGG GCTGTCTTTA TATCCCACTG 1800 CCCTGCTGTG TGACAGTTTG ATGAAACTGG TTACATTTAC ATCCCAAAAC TTTGGTTGAG 1860 TTTGCAGGAC TCTAGGCATG CATGAAAGAG CCCCCCTGGT GATGCCCTTG GATGCTGCCA 1920 AGTCCATGGT AGTTTTCAAT TTTGCCATAC TTTTGTTCTT CCTACCGGAC CCTGGAATGT 1980 CTTTGGATAT TGCTAAAATC TATTTCTGCA GCTGAGGTTT TATCCACTGG ACACATTTGT 2040 GTGTGAGAAC TAGGTCTTGT TGAGGTTAGC GTAACCTGGT ATATGCAACT ACCATCCTCT 2100 GGGCCAACTG TGGAAGCTGC TGCACTTGTG AAGAATCCTG AGCTTTGATT CCTCTTCAGT 2160 CTACGCATTT CTCTCTTCCC CTCCCTCACC C
2192Nucleotide Fasta Sequence
>ENSP00000482224.1|JHDM3_JMJD2|Homo sapiens GCTGCTGCCCAGAGTGGAATCTCACTAGTGAATAAACAAGCCCAAGAAAGATTATCATCTCATTTGCAAAAAAAAAAGTACGCTGGTAGATCCTGCTACCTCATAGATAACACCAGTCAAATTTTTTTTTAAAGTAGCATTTTCCTACATTGTCAACTATCTAGAACATACCTAAAAACTAAGAGTTTACTGCTTATTAAATGGAAACTATGAAGTCTAAGGCCAACTGTGCCCAGAATCCAAATTGTAACATAATGATATTTCATCCAACCAAAGAAGAGTTTAATGATTTTGATAAATATATTGCTTACATGGAATCCCAAGGTGCACACAGAGCTGGCTTGGCTAAGATAATTCCACCCAAAGAATGGAAAGCCAGAGAGACCTATGATAATATCAGTGAAATCTTAATAGCCACTCCCCTCCAGCAGGTGGCCTCTGGGCGGGCAGGGGTGTTTACTCAATACCATAAAAAAAAGAAAGCCATGACTGTGGGGGAGTATCGCCATTTGGCAAACAGTAAAAAATATCAGACTCCACCACACCAGAATTTCGAAGATTTGGAGCGAAAATACTGGAAGAACCGCATCTATAATTCACCGATTTATGGTGCTGACATCAGTGGCTCCTTGTTTGATGAAAACACTAAACAATGGAATCTTGGGCACCTGGGAACAATTCAGGACCTGCTGGAAAAGGAATGTGGGGTTGTCATAGAAGGCGTCAATACACCCTACTTGTACTTTGGCATGTGGAAAACCACGTTTGCTTGGCATACAGAGGACATGGACCTTTACAGCATCAACTACCTGCACCTTGGGGAGCCCAAAACTTGGTATGTGGTGCCCCCAGAACATGGCCAGCGCCTGGAACGCCTGGCCAGGGAGCTCTTCCCAGGCAGTTCCCGGGGTTGTGGGGCCTTCCTGCGGCACAAGGTGGCCCTCATCTCGCCTACAGTTCTCAAGGAAAATGGGATTCCCTTCAATCGCATAACTCAGGAGGCTGGAGAGTTCATGGTGACCTTTCCCTATGGCTACCATGCTGGCTTCAACCATGGTTTCAACTGCGCAGAGGCCATCAATTTTGCCACTCCGCGATGGATTGATTATGGCAAAATGGCCTCCCAGTGTAGCTGTGGGGAGGCAAGGGTGACCTTTTCCATGGATGCCTTCGTGCGCATCCTGCAACCTGAACGCTATGACCTGTGGAAACGTGGGCAAGACCGGGCAGTTGTGGACCACATGGAGCCCAGGGTACCAGCCAGCCAAGAGCTGAGCACCCAGAAGGAAGTCCAGTTACCCAGGAGAGCAGCGCTGGGCCTGAGACAACTCCCTTCCCACTGGGCCCGGCATTCCCCTTGGCCTATGGCTGCCCGCAGTGGGACACGGTGCCACACCCTTGTGTGCTCTTCACTCCCACGCCGATCTGCAGTTAGTGGCACTGCTACGCAGCCCCGGGCTGCTGCTGTCCACAGCTCTAAGAAGCCCAGCTCAACTCCATCATCCACCCCTGGTCCATCTGCACAGATTATCCACCCGTCAAATGGCAGACGTGGTCGTGGTCGCCCTCCTCAGAAACTGAGAGCTCAGGAGCTGACCCTCCAGACTCCAGCCAAGAGGCCCCTCTTGGCGGGCACAACATGCACAGCTTCGGGCCCAGAACCTGAGCCCCTACCTGAGGATGGGGCTTTGATGGACAAGCCTGTACCACTGAGCCCAGGGCTCCAGCATCCTGTCAAGGCTTCTGGGTGCAGCTGGGCCCCTGTGCCCTAAGTCCACGGGCTGTCTTTATATCCCACTGCCCTGCTGTGTGACAGTTTGATGAAACTGGTTACATTTACATCCCAAAACTTTGGTTGAGTTTGCAGGACTCTAGGCATGCATGAAAGAGCCCCCCTGGTGATGCCCTTGGATGCTGCCAAGTCCATGGTAGTTTTCAATTTTGCCATACTTTTGTTCTTCCTACCGGACCCTGGAATGTCTTTGGATATTGCTAAAATCTATTTCTGCAGCTGAGGTTTTATCCACTGGACACATTTGTGTGTGAGAACTAGGTCTTGTTGAGGTTAGCGTAACCTGGTATATGCAACTACCATCCTCTGGGCCAACTGTGGAAGCTGCTGCACTTGTGAAGAATCCTGAGCTTTGATTCCTCTTCAGTCTACGCATTTCTCTCTTCCCCTCCCTCACCC
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Sequence Source |
Ensembl |
Keyword |
KW-0002--3D-structure KW-0013--ADP-ribosylation KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0223--Dioxygenase KW-0408--Iron KW-0479--Metal-binding KW-0539--Nucleus KW-0560--Oxidoreductase KW-0621--Polymorphism KW-1185--Reference proteome KW-0804--Transcription KW-0805--Transcription regulation KW-0862--Zinc --
|
Interpro |
IPR003347--JmjC_dom IPR003349--JmjN
|
PROSITE |
PS51184--JMJC PS51183--JMJN
|
Pfam |
PF02373--JmjC PF02375--JmjN
|
Gene Ontology |
GO:0072562--C:blood microparticle GO:0005654--C:nucleoplasm GO:0035861--C:site of double-strand break GO:0051213--F:dioxygenase activity GO:0032452--F:histone demethylase activity GO:0032454--F:histone demethylase activity (H3-K9 specific) GO:0046872--F:metal ion binding GO:0071479--P:cellular response to ionizing radiation GO:0000724--P:double-strand break repair via homologous recombination GO:0033169--P:histone H3-K9 demethylation GO:0035563--P:positive regulation of chromatin binding GO:2001034--P:positive regulation of double-strand break repair via nonhomologous end joining GO:0001932--P:regulation of protein phosphorylation GO:0006355--P:regulation of transcription, DNA-templated GO:0006351--P:transcription, DNA-templated
|
Orthology |
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Created Date |
25-Jun-2016 |