WERAM Information

Tag Content
WERAM ID WERAM-Mum-0193
Ensembl Protein ID ENSMUSP00000061632.6
Uniprot Accession Q3U2K5; KDM4D_MOUSE; A2CGB5; B8JK34; Q2M1G7; Q8BI19
Genbank Protein ID NP_775609.2; XP_006510333.1; XP_006510334.1
Protein Name Lysine-specific demethylase 4D
Genbank Nucleotide ID NM_173433.2; XM_006510270.2; XM_006510271.2
Gene Name KDM4D
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000053914.9 ENSMUST00000058796.6 ENSMUSP00000061632.6
ENSMUSG00000053914.9 ENSMUST00000115647.2 ENSMUSP00000111311.2
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JHDM3_JMJD2 Jmjc H3K9me3 K 26526725
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JHDM3_JMJD2 3.90e-89 298.4 145 309
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).
Domain Profile
  HDM JHDM3_JMJD2
             JHDM3.txt   3 dveeWnlnklktildsvekelkieieGvntpylyvgmlkttfaWhvedmdlysinylhfGapktWyavpseaakrlekllrkefsesak 91 
                           ++++Wn+++l+ti+d +e+e++i ieGvntpyly+gm+kttfaWh+edmdlysinylhfG+pktWyavp+e+++rle+l+r+ f++s++
  ENSMUSP00000061632.6 145 KTQQWNVGHLGTIQDLLEQECGIVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGQPKTWYAVPPEHGRRLERLARELFPGSSQ 233
                           689************************************************************************************** PP
             JHDM3.txt  92 eceaflrhkttlisPellkkagipfnrivqeagefvitfPygyhaGfnhGfnlaestnfaterwievgkeaakcsc 167
                           +c+aflrhk++lisP++lk++gipf ri+qeagef++tfPygyhaGfnhGfn+ae++nfat+rwi++gk a++csc
  ENSMUSP00000061632.6 234 GCQAFLRHKVALISPTVLKENGIPFGRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSC 309
                           ***************************************************************************9 PP
Protein Sequence
(Fasta)		MKTKSTCAQN PNCSIMIFRP TKEEFNDFDK YIAYMESQGA HRAGLAKVIP PKEWRARQSY 60
DNISNILIAT PLQQVVSGQA GVFTQYHKKK KGMTVGEYRE LANSKKYQTP PHLDFEDLER 120
KYWKNRLYES PIYGADVSGS LFDGKTQQWN VGHLGTIQDL LEQECGIVIE GVNTPYLYFG 180
MWKTTFAWHT EDMDLYSINY LHFGQPKTWY AVPPEHGRRL ERLARELFPG SSQGCQAFLR 240
HKVALISPTV LKENGIPFGR ITQEAGEFMV TFPYGYHAGF NHGFNCAEAI NFATPRWIDY 300
GKVASQCSCG EARVSFSMDA FVRILQPERY ELWKRGQDQA VVDHTETMVS TSQELTTRRV 360
TKAPRKTWGL KRLRLRQVSR SLLPIATVSN VPCNMQVCHT SRQPSDVKGD DVQKSDSARA 420
SPHPLSLPSS GHMSTRRCSL GRRPCELGAQ ESSNGAPVKR QLPAGRDDTS PSPELQPQAV 480
SGDLIVDSGL VNPGPQHLMT ASEGGLTSDP
Nucleotide Sequence
(Fasta)		GACACGGGAA AAAGATGGAA TGACGTTGCC TAGGGGCGGA GCCAAGGCAG CTTAGGGGGC 60
GGGCGTTTGA AACCGGTGCT TCATAGTCGA CCCCAAATAT CATCTTTTTT CCTTTGCGAA 120
CCAATTACTT AATCTCTCTT GCGTCTTTTC CTTTCCCGAC CCCCTCCCAG ACTCGTTCGC 180
TGCGGTTCTG CGAGGACGGA GGCGCCAGGA GCCGGTCCGC GTCTCGCAAG AGAGATGTGA 240
GGAGAGCTTG CCAACTGACC GACCCAACGG CTCCTGCTCC TCAGTAGACC CCGCAGCCTA 300
GGGACTAGAG TTGTCACTTA AGTGGATATG AAGAAGGCGC AAATAAGTAC GGGGGCAGCC 360
ACGAGCTTTC CAAAGATTGT GTCTTATTCA CATCCCTGAA GAGATTCTGC TGCACCCCAG 420
TCTGTGCACC CAGTAGCCTA CAAGAGGAAA GAACCAGGTT CCAACGGAAC ATATTAGACC 480
AAGGCTCCCT GACTGAGCTG CTGCCCTGAG TGCTGGCTCT GGGTTAGTCA GCAAGCCTAA 540
CAAAAGTTAG TCCCATCACA TGCACAGAGG CTGTCAGGAG ATTCGGCTCC ATCACAGCCA 600
CAGCAAGTCT TCTTTATTTA TTTTTTAAAT CCCCTTCCTC AATCCTGTGT GTATATTGGA 660
GTTTGGTGTA TACATTGAAG CTATGAAGAC GAAGTCCACA TGTGCTCAGA ATCCAAATTG 720
CAGCATAATG ATATTTCGTC CAACCAAAGA AGAGTTTAAT GATTTTGACA AATACATTGC 780
TTACATGGAG TCCCAAGGGG CACACCGAGC TGGACTGGCC AAGGTCATCC CACCAAAAGA 840
ATGGAGGGCC AGGCAGTCTT ATGACAATAT CAGCAACATC TTAATAGCAA CTCCCCTGCA 900
GCAAGTGGTC TCTGGGCAGG CAGGCGTGTT CACCCAATAC CATAAGAAGA AGAAAGGCAT 960
GACAGTGGGG GAGTACCGTG AGCTGGCCAA CAGCAAAAAG TACCAGACCC CGCCACACCT 1020
GGATTTTGAA GATTTGGAGC GAAAATACTG GAAGAATCGC CTGTATGAGT CACCGATTTA 1080
TGGTGCTGAC GTCAGCGGCT CCCTGTTTGA TGGGAAGACT CAACAGTGGA ATGTGGGTCA 1140
CCTGGGAACA ATTCAAGACC TATTGGAACA GGAATGTGGC ATAGTGATTG AGGGCGTCAA 1200
CACGCCCTAC CTGTACTTTG GCATGTGGAA GACCACCTTT GCGTGGCACA CGGAGGACAT 1260
GGACCTGTAC AGTATCAACT ACCTACACTT TGGGCAGCCC AAGACCTGGT ATGCTGTGCC 1320
CCCTGAGCAT GGCAGGCGCC TGGAGCGCCT GGCCAGGGAA CTCTTCCCTG GCAGCTCCCA 1380
GGGCTGCCAG GCCTTCCTGA GGCACAAGGT GGCGCTCATC TCGCCCACTG TGCTTAAGGA 1440
GAATGGCATC CCCTTTGGTC GCATCACCCA GGAGGCTGGG GAGTTCATGG TCACCTTTCC 1500
CTATGGCTAC CACGCGGGCT TCAACCATGG CTTCAACTGC GCAGAGGCCA TCAATTTTGC 1560
CACCCCAAGG TGGATTGACT ATGGCAAGGT GGCATCTCAG TGCAGCTGTG GGGAGGCCAG 1620
GGTGAGCTTC TCCATGGACG CCTTTGTGAG GATCTTGCAG CCTGAGCGAT ATGAACTGTG 1680
GAAACGTGGC CAAGATCAGG CAGTTGTGGA CCACACAGAG ACTATGGTGT CTACCAGTCA 1740
GGAGCTCACC ACCCGGCGGG TGACCAAAGC ACCAAGAAAA ACTTGGGGCT TGAAGCGTCT 1800
CCGGCTTCGC CAGGTCTCAC GATCTCTTCT GCCTATAGCC ACGGTAAGTA ACGTTCCTTG 1860
CAACATGCAG GTGTGCCACA CCTCCAGGCA ACCATCAGAT GTGAAAGGTG ATGATGTCCA 1920
GAAGTCTGAC TCAGCCAGAG CCTCACCACA TCCTCTGAGT CTGCCTTCTT CTGGTCACAT 1980
GTCAACTAGA AGATGTAGTC TTGGTCGTCG TCCTTGTGAA CTAGGAGCTC AGGAGTCCTC 2040
CAATGGAGCT CCAGTCAAGA GGCAACTTCC AGCAGGCAGA GATGACACAA GCCCCAGTCC 2100
AGAGCTTCAG CCCCAGGCTG TGAGTGGAGA CTTAATAGTC GACTCAGGAC TTGTGAACCC 2160
TGGCCCACAG CATCTTATGA CAGCTTCTGA AGGGGGATTG ACCTCCGACC CCTAAACCTA 2220
TGTCCTGGTT TATAGGGATG CTCCCTAAGT CCATTACCTC ATAGTTTTGA CTGAGTTTGC 2280
AGGACATTGG CCATACCTGA GAGAGCTCCT GGTCAGTTCT AACTCCTAAA CACACCATGC 2340
ACTTCCAGAA CTTGGCAAGC CTCTGGATAA CTGCTAACTC CTGCTCTTCC AGCTGAGGTT 2400
GCATTGGTCA CTACTGTTGA GTTTCTGCAA GCTAAATTCA GCTGAGGCTG CTCAGCACTG 2460
ATCTCCCATG CTCAAGGCCA ACTCTAGAGG AAGCAGAACA CTCACACTCT CCTCCCCCTC 2520
TGCCATTTCT TGCAAAATAA ATGTCTGACT CTTGACCGCT AGATTACTCC TCACAAAGAA 2580
GTAGTCACAA AAAAGATTAA AGCCACTTGA GAGTCACAGA TGACCTCTCA AAGTTGATGT 2640
GTTACACAGT GTCTCACCCA GCTTTCACAA ATAAAGCAAA ACAGCCAAAA GGTTA 2696
Sequence Source Ensembl
Keyword

KW-0013--ADP-ribosylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
Interpro

IPR003347--JmjC_dom
IPR003349--JmjN
PROSITE

PS51184--JMJC
PS51183--JMJN
Pfam

PF02373--JmjC
PF02375--JmjN
Gene Ontology

GO:0072562--C:blood microparticle
GO:0005634--C:nucleus
GO:0005721--C:pericentric heterochromatin
GO:0035861--C:site of double-strand break
GO:0031490--F:chromatin DNA binding
GO:0003684--F:damaged DNA binding
GO:0051213--F:dioxygenase activity
GO:0032452--F:histone demethylase activity
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0046872--F:metal ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071479--P:cellular response to ionizing radiation
GO:0000724--P:double-strand break repair via homologous recombination
GO:0033169--P:histone H3-K9 demethylation
GO:1900113--P:negative regulation of histone H3-K9 trimethylation
GO:0035563--P:positive regulation of chromatin binding
GO:2001034--P:positive regulation of double-strand break repair via nonhomologous end joining
GO:0001932--P:regulation of protein phosphorylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0195 ENSRNOP00000067344.1 Rattus norvegicus 90 0.0 912
WERAM-Gog-0117 ENSGGOP00000009855.2 Gorilla gorilla 71 0.0 721
WERAM-Caj-0231 ENSCJAP00000041825.2 Callithrix jacchus 70 0.0 721
WERAM-Nol-0200 ENSNLEP00000023075.1 Nomascus leucogenys 71 0.0 719
WERAM-Hos-0223 ENSP00000482224.1 Homo sapiens 71 0.0 719
WERAM-Pat-0033 ENSPTRP00000007210.3 Pan troglodytes 70 0.0 717
WERAM-Paa-0001 ENSPANP00000006305.1 Papio anubis 71 0.0 712
WERAM-Mam-0214 ENSMMUP00000030770.2 Macaca mulatta 71 0.0 711
WERAM-Chs-0037 ENSCSAP00000014753.1 Chlorocebus sabaeus 71 0.0 710
WERAM-Ict-0157 ENSSTOP00000020411.1 Ictidomys tridecemlineatus 70 0.0 710
WERAM-Caf-0051 ENSCAFP00000006122.3 Canis familiaris 68 0.0 698
WERAM-Mup-0138 ENSMPUP00000012170.1 Mustela putorius furo 68 0.0 693
WERAM-Cap-0076 ENSCPOP00000005641.2 Cavia porcellus 81 0.0 683
WERAM-Myl-0213 ENSMLUP00000019471.1 Myotis lucifugus 85 0.0 678
WERAM-Otg-0216 ENSOGAP00000018016.1 Otolemur garnettii 66 0.0 677
WERAM-Aim-0132 ENSAMEP00000011999.1 Ailuropoda melanoleuca 84 0.0 670
WERAM-Bot-0018 ENSBTAP00000002234.5 Bos taurus 66 0.0 654
WERAM-Orc-0012 ENSOCUP00000023109.2 Oryctolagus cuniculus 66 0.0 649
WERAM-Tub-0114 ENSTBEP00000012601.1 Tupaia belangeri 82 0.0 646
WERAM-Sus-0179 ENSSSCP00000015886.1 Sus scrofa 81 0.0 641
WERAM-Ocp-0126 ENSOPRP00000013322.1 Ochotona princeps 71 3e-166 582
WERAM-Mim-0121 ENSMICP00000012586.1 Microcebus murinus 71 4e-166 582
WERAM-Fec-0081 ENSFCAP00000006707.3 Felis catus 71 1e-165 580
WERAM-Eqc-0110 ENSECAP00000012427.1 Equus caballus 70 2e-165 579
WERAM-Poa-0081 ENSPPYP00000010565.2 Pongo abelii 71 2e-165 579
WERAM-Pes-0166 ENSPSIP00000019770.1 Pelodiscus sinensis 70 2e-165 579
WERAM-Meg-0063 ENSMGAP00000006048.2 Meleagris gallopavo 70 4e-165 578
WERAM-Gaga-0045 ENSGALP00000006501.4 Gallus gallus 70 1e-164 577
WERAM-Sah-0042 ENSSHAP00000004870.1 Sarcophilus harrisii 70 2e-164 576
WERAM-Lac-0142 ENSLACP00000016270.1 Latimeria chalumnae 70 5e-164 575
WERAM-Tag-0013 ENSTGUP00000000796.1 Taeniopygia guttata 70 1e-163 573
WERAM-Mod-0013 ENSMODP00000032606.2 Monodelphis domestica 70 1e-163 573
WERAM-Dan-0145 ENSDNOP00000027472.1 Dasypus novemcinctus 70 4e-163 572
WERAM-Fia-0015 ENSFALP00000001261.1 Ficedula albicollis 70 2e-162 569
WERAM-Leo-0002 ENSLOCP00000000123.1 Lepisosteus oculatus 72 6e-162 568
WERAM-Ten-0118 ENSTNIP00000012969.1 Tetraodon nigroviridis 72 6e-162 568
WERAM-Ova-0095 ENSOARP00000009920.1 Ovis aries 82 8e-162 567
WERAM-Tar-0036 ENSTRUP00000008201.1 Takifugu rubripes 71 1e-161 567
WERAM-Anc-0086 ENSACAP00000008291.3 Anolis carolinensis 70 1e-161 566
WERAM-Orn-0150 ENSONIP00000015836.1 Oreochromis niloticus 72 6e-161 564
WERAM-Pof-0260 ENSPFOP00000023871.1 Poecilia formosa 72 3e-160 562
WERAM-Gaa-0088 ENSGACP00000011572.1 Gasterosteus aculeatus 70 9e-160 560
WERAM-Asm-0230 ENSAMXP00000022237.1 Astyanax mexicanus 73 1e-159 560
WERAM-Orla-0066 ENSORLP00000008475.1 Oryzias latipes 71 7e-159 557
WERAM-Loa-0160 ENSLAFP00000014109.3 Loxodonta africana 70 1e-157 554
WERAM-Dar-0206 ENSDARP00000133766.1 Danio rerio 72 2e-157 553
WERAM-Tut-0165 ENSTTRP00000014088.1 Tursiops truncatus 68 1e-156 550
WERAM-Vip-0025 ENSVPAP00000002379.1 Vicugna pacos 67 1e-155 547
WERAM-Xim-0047 ENSXMAP00000004480.1 Xiphophorus maculatus 66 7e-152 534
WERAM-Xet-0001 ENSXETP00000001154.3 Xenopus tropicalis 64 2e-151 533
WERAM-Ptv-0183 ENSPVAP00000016320.1 Pteropus vampyrus 65 1e-150 530
WERAM-Gam-0058 ENSGMOP00000005645.1 Gadus morhua 66 8e-150 527
WERAM-Ora-0068 ENSOANP00000010212.2 Ornithorhynchus anatinus 68 4e-149 525
WERAM-Chh-0006 ENSCHOP00000000484.1 Choloepus hoffmanni 74 2e-141 499
WERAM-Ect-0076 ENSETEP00000008389.1 Echinops telfairi 70 6e-135 478
WERAM-Drm-0085 FBpp0291264 Drosophila melanogaster 61 5e-126 448
WERAM-Mae-0017 ENSMEUP00000001333.1 Macropus eugenii 60 7e-126 448
WERAM-Ere-0016 ENSEEUP00000000943.1 Erinaceus europaeus 57 3e-124 442
WERAM-Anp-0103 ENSAPLP00000012119.1 Anas platyrhynchos 70 8e-124 441
WERAM-Soa-0057 ENSSARP00000005556.1 Sorex araneus 68 2e-122 436
WERAM-Dio-0074 ENSDORP00000007460.1 Dipodomys ordii 57 2e-113 407
WERAM-Cii-0012 ENSCINP00000004028.3 Ciona intestinalis 61 5e-99 358
WERAM-Cis-0058 ENSCSAVP00000013108.1 Ciona savignyi 64 1e-82 304
WERAM-Cae-0046 Y48B6A.11 Caenorhabditis elegans 43 1e-79 294
WERAM-Yal-0032 CAG78224 Yarrowia lipolytica 42 7e-76 282
WERAM-Asni-0024 CADANGAP00006693 Aspergillus niger 37 6e-69 259
WERAM-Asg-0030 AAS54607 Ashbya gossypii 37 1e-68 258
WERAM-Tum-0008 CAZ80461 Tuber melanosporum 35 2e-68 257
WERAM-Sac-0014 YER169W Saccharomyces cerevisiae 37 3e-68 256
WERAM-Kll-0015 CAH01842 Kluyveromyces lactis 37 1e-67 254
WERAM-Cag-0029 CAG62258 Candida glabrata 34 2e-66 250
WERAM-Asfu-0032 CADAFUAP00007532 Aspergillus fumigatus 43 6e-66 249
WERAM-Asc-0010 CADACLAP00002196 Aspergillus clavatus 49 2e-65 247
WERAM-Scs-0007 EDN97054 Sclerotinia sclerotiorum 53 9e-65 245
WERAM-Asn-0010 CADANIAP00001580 Aspergillus nidulans 44 8e-64 242
WERAM-Ast-0031 CADATEAP00008693 Aspergillus terreus 47 1e-63 241
WERAM-Aso-0001 CADAORAP00000267 Aspergillus oryzae 47 3e-63 239
WERAM-Asf-0016 CADAFLAP00008126 Aspergillus flavus 47 4e-63 239
WERAM-Trr-0030 EGR47972 Trichoderma reesei 50 4e-63 239
WERAM-Trv-0008 EHK16031 Trichoderma virens 50 5e-63 239
WERAM-Caa-0021 KGT68489 Candida albicans 38 6e-63 239
WERAM-Fuo-0032 FOXG_11150P0 Fusarium oxysporum 51 9e-63 238
WERAM-Nec-0015 EFNCRP00000002609 Neurospora crassa 50 4e-62 236
WERAM-Lem-0022 CBX90465 Leptosphaeria maculans 49 7e-62 235
WERAM-Ved-0030 EGY16315 Verticillium dahliae 50 9e-62 235
WERAM-Phn-0009 SNOT_01206 Phaeosphaeria nodorum 49 3e-61 233
WERAM-Coi-0033 EAS31415 Coccidioides immitis 48 3e-61 233
WERAM-Miv-0023 MVLG_03426T0 Microbotryum violaceum 48 7e-61 232
WERAM-Mao-0026 MGG_09186T0 Magnaporthe oryzae 49 1e-60 231
WERAM-Pyt-0032 EFQ88003 Pyrenophora teres 48 1e-60 231
WERAM-Pytr-0014 EDU46512 Pyrenophora triticirepentis 48 2e-60 231
Created Date 25-Jun-2016