WERAM Information

Tag Content
WERAM ID WERAM-Cae-0046
Ensembl Protein ID Y48B6A.11
Uniprot Accession Q9U297; KDM4_CAEEL
Genbank Protein ID NP_496969.2
Protein Name Lysine-specific demethylase 4
Genbank Nucleotide ID NM_064568.3
Gene Name KDM4;jmjd-2Y48B6A.11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00012982 Y48B6A.11 Y48B6A.11
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JHDM3_JMJD2 Jmjc H3K9; H3K36 K 16603238
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JHDM3_JMJD2 2.70e-77 259 224 388
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)		 Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate.
Domain Profile
  HDM JHDM3_JMJD2
  JHDM3.txt   2 edveeWnlnklktildsvekelkieieGvntpylyvgmlkttfaWhvedmdlysinylhfGapktWyavpseaakrlekllrkefs...esakeceaflr 98 
                ++veeWn+n+l+til+ ++ e    i+Gvnt+yly+gm+kttf+Wh+edmdlysin+lhfGapk+W+a++se+a+r+e++++++fs   e+a +c+aflr
  Y48B6A.11 224 AQVEEWNMNRLGTILEDTNYE----IKGVNTVYLYFGMYKTTFPWHAEDMDLYSINFLHFGAPKYWFAISSEHADRFERFMSQQFSyqnEYAPQCKAFLR 319
                6899**************999....************************************************************98878999******* PP
  JHDM3.txt  99 hkttlisPellkkagipfnrivqeagefvitfPygyhaGfnhGfnlaestnfaterwievgkeaakcsc 167
                hkt+l++Pell++agip++++vq+++ef+itfP+gyh+Gfn G+nlaestnfa++rwi++gk+a++c+c
  Y48B6A.11 320 HKTYLVTPELLRQAGIPYATMVQRPNEFIITFPRGYHMGFNLGYNLAESTNFASQRWIDYGKDAVLCDC 388
                *******************************************************************99 PP
Protein Sequence
(Fasta)		MASAATTTHF PSSRIPSEPC ASSGPLFPDD VLFTTEASSA SSSSCHVEND SRPLSPTMFT 60
DGRTPVNISA KHLKDHPLHE PTGTSEVLTF YPTMREFKNF SQYIKKIEQN GGHLKAGIAK 120
IVAPEGWTPR PTRKDFSDVD DYEITQPARE TIEATEKPGA YFKRNVTCRR KMPVREFRTL 180
ANSAQYRNPR PDLKGSEIEK HYFDNILHGE PIYGADTEGS FYDAQVEEWN MNRLGTILED 240
TNYEIKGVNT VYLYFGMYKT TFPWHAEDMD LYSINFLHFG APKYWFAISS EHADRFERFM 300
SQQFSYQNEY APQCKAFLRH KTYLVTPELL RQAGIPYATM VQRPNEFIIT FPRGYHMGFN 360
LGYNLAESTN FASQRWIDYG KDAVLCDCNK DSVKIDMTHF MAKYRPDEYT TWWTYWYGGG 420
RELWIPKKKK EVPKKRRQSL ADASKIAKRA RLGASSTATD SDGSSGSSGS EEATEGSSFM 480
RALPAGYTVH NWQLRPDYDE LLRKYKKETK LLRSDTRIDF YQEREFNHAR RAEWPHCAVC 540
QYFQPPHMNA INHTVPNSSR RLIPKWCFSK TDTKKHEDHH EPPPPLDRLL TCSNCHVTVH 600
SHCCSGGGGG GGDDDDVTSS GEPWRCPRCR NRTDVEIRTT SCQLCELRGG ALIPCQIGTD 660
STWAHVACAL FNRRAIFDCP NRPGACFVEP SPRQQSETPR MPPRRLSEEY RAELGDLYEN 720
SRWECVVCHR TDEGLAPCVL CIEEQATTSL PTLAHVTCAR RVGFVCEVRD YPRGVVMICH 780
KHEHSYLVNK TTQQQAYTNV KVGDFVFVED VVEPPQKLFT RGAIVRADKK ETVVVDFLDN 840
SCSRDNHVED IISCECLFCE NGDHQYGARV KVVWDDKQVY DAYFRGKGQM IEYTVRLEDG 900
REVRHPRNRL KTKRELNAYL KK 922
Nucleotide Sequence
(Fasta)		ATGGCATCAG CGGCTACTAC AACACACTTC CCATCATCCC GGATACCAAG CGAGCCGTGC 60
GCATCATCTG GCCCCTTATT TCCAGATGAT GTGCTCTTCA CCACCGAAGC TTCTTCGGCT 120
TCTTCCAGCT CATGCCACGT GGAGAACGAC AGTAGGCCCT TGTCGCCTAC CATGTTCACT 180
GATGGACGGA CGCCAGTTAA TATTTCGGCA AAACATCTAA AAGATCATCC ACTCCACGAG 240
CCAACCGGCA CTTCAGAAGT GCTAACATTC TACCCAACAA TGCGGGAATT CAAGAATTTT 300
AGCCAATATA TCAAGAAAAT CGAGCAAAAC GGAGGTCATC TGAAAGCCGG AATCGCAAAA 360
ATTGTGGCGC CCGAAGGTTG GACGCCACGG CCGACAAGGA AGGATTTTTC AGATGTTGAT 420
GACTATGAAA TTACACAGCC GGCCCGCGAA ACAATCGAAG CCACCGAAAA GCCCGGAGCC 480
TACTTCAAAC GAAACGTCAC GTGTCGACGA AAAATGCCAG TCCGCGAGTT CCGCACGCTA 540
GCCAACTCTG CCCAATACCG TAACCCGCGG CCCGATCTAA AAGGCTCGGA AATCGAAAAG 600
CACTACTTTG ACAACATTCT CCACGGAGAA CCGATCTACG GAGCCGACAC CGAGGGAAGC 660
TTCTACGATG CTCAAGTGGA AGAGTGGAAT ATGAATCGGC TGGGCACAAT TTTAGAGGAC 720
ACGAATTACG AGATTAAGGG TGTTAATACA GTATATCTAT ATTTTGGAAT GTATAAAACC 780
ACTTTTCCCT GGCACGCCGA GGACATGGAT TTATATTCCA TTAATTTCCT TCATTTTGGA 840
GCCCCGAAAT ATTGGTTTGC AATCAGCTCG GAGCATGCTG ATCGATTCGA GCGGTTTATG 900
AGCCAACAGT TTTCATATCA GAATGAGTAT GCACCACAAT GTAAGGCATT CCTAAGGCAT 960
AAGACCTACC TGGTGACGCC TGAGCTGTTG AGGCAGGCCG GGATACCGTA TGCAACGATG 1020
GTTCAGAGGC CGAATGAGTT TATTATTACA TTTCCTCGTG GCTATCATAT GGGCTTTAAT 1080
CTCGGCTATA ACCTCGCAGA ATCCACCAAC TTCGCCTCTC AGAGATGGAT TGACTATGGA 1140
AAGGATGCGG TGTTGTGTGA TTGTAACAAG GATTCGGTGA AAATCGATAT GACCCATTTT 1200
ATGGCAAAAT ATCGGCCGGA TGAGTACACG ACTTGGTGGA CATACTGGTA CGGTGGCGGT 1260
CGGGAGCTCT GGATTCCGAA GAAGAAGAAG GAGGTGCCGA AGAAGCGGCG GCAGAGCCTT 1320
GCCGATGCAT CGAAGATCGC AAAAAGAGCA CGACTCGGAG CATCATCGAC GGCGACGGAT 1380
TCTGATGGAT CGTCGGGATC ATCGGGATCC GAGGAAGCGA CGGAAGGATC GAGCTTCATG 1440
AGGGCTCTGC CTGCTGGATA TACTGTACAC AATTGGCAGC TGAGACCGGA TTATGATGAG 1500
CTTTTGCGGA AGTATAAGAA GGAGACGAAA CTTCTTCGCT CGGACACACG AATCGATTTC 1560
TACCAGGAAC GAGAATTCAA TCATGCTCGG CGAGCCGAAT GGCCGCATTG CGCCGTCTGC 1620
CAGTACTTTC AGCCGCCTCA CATGAACGCT ATCAATCATA CGGTGCCTAA CTCATCTCGC 1680
CGGCTCATCC CAAAATGGTG CTTCTCGAAA ACCGACACCA AAAAGCACGA GGATCACCAC 1740
GAGCCGCCAC CACCGCTGGA CCGTCTGCTC ACTTGCTCCA ACTGCCACGT CACCGTCCAT 1800
TCTCATTGCT GCTCTGGCGG CGGCGGCGGC GGCGGCGACG ACGATGACGT CACAAGCTCC 1860
GGAGAGCCCT GGCGCTGCCC ACGATGCCGA AACCGAACCG ACGTCGAGAT CCGAACAACG 1920
TCCTGCCAGC TCTGCGAACT CCGCGGCGGA GCACTAATCC CGTGCCAAAT CGGCACAGAC 1980
TCGACGTGGG CTCACGTGGC GTGTGCTCTT TTCAATCGAA GAGCCATTTT TGATTGCCCA 2040
AACCGGCCTG GAGCATGCTT CGTCGAGCCA TCGCCCCGAC AGCAATCGGA GACCCCACGG 2100
ATGCCCCCCC GGCGGCTCAG CGAAGAGTAT CGCGCGGAGC TCGGCGATCT CTACGAGAAT 2160
TCCCGTTGGG AATGTGTCGT CTGCCATCGA ACAGACGAGG GTCTGGCTCC GTGTGTGCTC 2220
TGTATTGAGG AGCAGGCGAC CACATCGCTT CCAACACTGG CTCATGTCAC GTGTGCTCGC 2280
CGTGTTGGAT TTGTGTGTGA AGTTCGTGAC TATCCACGTG GCGTTGTGAT GATCTGTCAT 2340
AAGCACGAGC ACTCGTATCT CGTGAATAAG ACGACGCAGC AGCAGGCCTA TACTAACGTG 2400
AAAGTCGGCG ATTTTGTATT TGTGGAGGAC GTGGTGGAGC CGCCGCAGAA ATTGTTCACG 2460
AGAGGAGCCA TCGTACGAGC TGATAAGAAG GAGACCGTTG TCGTTGACTT CCTTGATAAT 2520
AGCTGTAGTC GTGATAATCA CGTGGAGGAT ATCATCTCGT GTGAATGCCT GTTCTGTGAG 2580
AACGGAGATC ATCAGTATGG GGCGAGAGTA AAAGTAGTGT GGGACGACAA GCAAGTCTAC 2640
GACGCGTACT TCCGTGGAAA AGGACAGATG ATCGAGTACA CGGTCCGACT GGAAGATGGC 2700
CGAGAAGTCC GCCATCCACG GAACAGGCTG AAAACGAAGC GAGAACTGAA CGCGTATCTC 2760
AAAAAATAGC TTTAATAAAT AAATAAATAT TCGATTTTTT AAAATTTACT ATTAAATAGT 2820
CCCTGACAAA AAATTCTTGT CAAAATGTAA TATATTCTCT CTTTCCCGCC CGTCTACCCT 2880
CAAATATGTG ATCTCTGCGC CTCTTTTCCC CCCAGTTTTT TTTTGTACGA AAAGTCGAAG 2940
AATCTCTAAT TATCCCTGTT TTTCTGTTTT TTTTCTGTAT TTTTTTGTCA TTTAAATATT 3000
TTTCGCTATT TTTCCCTATT ATTTTGCAGA AACTTTTAAA TGTTTTCCCC GAAATTGATC 3060
AATTTATCTA ATAAACCTTT TTTTTTCCAA 3091
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
Interpro

IPR003347--JmjC_dom
IPR003349--JmjN
PROSITE

PS51184--JMJC
PS51183--JMJN
Pfam

PF02373--JmjC
PF02375--JmjN
Gene Ontology

GO:0005634--C:nucleus
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0046872--F:metal ion binding
GO:0016577--P:histone demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Orla-0089 ENSORLP00000010913.1 Oryzias latipes 51 1e-93 342
WERAM-Xim-0041 ENSXMAP00000003894.1 Xiphophorus maculatus 50 3e-93 340
WERAM-Pof-0014 ENSPFOP00000001533.1 Poecilia formosa 50 2e-92 338
WERAM-Gam-0188 ENSGMOP00000018250.1 Gadus morhua 50 3e-92 337
WERAM-Mam-0104 ENSMMUP00000016387.2 Macaca mulatta 49 7e-91 332
WERAM-Bot-0023 ENSBTAP00000002687.4 Bos taurus 49 7e-91 332
WERAM-Orc-0034 ENSOCUP00000003513.2 Oryctolagus cuniculus 49 7e-91 332
WERAM-Mim-0069 ENSMICP00000006516.1 Microcebus murinus 49 9e-91 332
WERAM-Tub-0094 ENSTBEP00000011062.1 Tupaia belangeri 49 9e-91 332
WERAM-Paa-0091 ENSPANP00000000299.1 Papio anubis 49 9e-91 332
WERAM-Otg-0022 ENSOGAP00000001046.2 Otolemur garnettii 49 9e-91 332
WERAM-Eqc-0144 ENSECAP00000016194.1 Equus caballus 49 1e-90 332
WERAM-Loa-0025 ENSLAFP00000001404.3 Loxodonta africana 49 1e-90 332
WERAM-Poa-0011 ENSPPYP00000001670.2 Pongo abelii 49 1e-90 332
WERAM-Ict-0091 ENSSTOP00000009626.2 Ictidomys tridecemlineatus 49 1e-90 332
WERAM-Ptv-0162 ENSPVAP00000013602.1 Pteropus vampyrus 49 1e-90 332
WERAM-Nol-0153 ENSNLEP00000016645.1 Nomascus leucogenys 49 1e-90 332
WERAM-Mup-0157 ENSMPUP00000013554.1 Mustela putorius furo 49 1e-90 332
WERAM-Gaa-0172 ENSGACP00000021016.1 Gasterosteus aculeatus 50 1e-90 332
WERAM-Sah-0098 ENSSHAP00000011151.1 Sarcophilus harrisii 49 1e-90 332
WERAM-Chs-0013 ENSCSAP00000016827.1 Chlorocebus sabaeus 49 1e-90 332
WERAM-Mum-0131 ENSMUSP00000102011.1 Mus musculus 49 1e-90 332
WERAM-Hos-0022 ENSP00000361473.3 Homo sapiens 49 1e-90 332
WERAM-Fec-0150 ENSFCAP00000014024.3 Felis catus 49 2e-90 331
WERAM-Caf-0058 ENSCAFP00000007322.4 Canis familiaris 49 2e-90 331
WERAM-Ora-0068 ENSOANP00000010212.2 Ornithorhynchus anatinus 49 2e-90 331
WERAM-Dar-0049 ENSDARP00000009763.7 Danio rerio 50 2e-90 331
WERAM-Orn-0131 ENSONIP00000013230.1 Oreochromis niloticus 51 2e-90 331
WERAM-Leo-0029 ENSLOCP00000005114.1 Lepisosteus oculatus 50 4e-90 330
WERAM-Tar-0098 ENSTRUP00000020050.1 Takifugu rubripes 50 5e-90 330
WERAM-Xet-0028 ENSXETP00000007538.3 Xenopus tropicalis 49 6e-90 330
WERAM-Ten-0130 ENSTNIP00000013987.1 Tetraodon nigroviridis 50 7e-90 329
WERAM-Asm-0208 ENSAMXP00000019809.1 Astyanax mexicanus 49 1e-89 328
WERAM-Anc-0149 ENSACAP00000013998.3 Anolis carolinensis 49 1e-89 328
WERAM-Vip-0006 ENSVPAP00000000498.1 Vicugna pacos 48 1e-88 325
WERAM-Mod-0135 ENSMODP00000019003.3 Monodelphis domestica 47 3e-88 323
WERAM-Cii-0012 ENSCINP00000004028.3 Ciona intestinalis 33 4e-88 323
WERAM-Fia-0137 ENSFALP00000011104.1 Ficedula albicollis 48 5e-88 323
WERAM-Cap-0049 ENSCPOP00000004232.2 Cavia porcellus 49 1e-87 322
WERAM-Ova-0145 ENSOARP00000014697.1 Ovis aries 49 1e-87 322
WERAM-Gaga-0161 ENSGALP00000032199.3 Gallus gallus 48 1e-87 322
WERAM-Aim-0007 ENSAMEP00000000397.1 Ailuropoda melanoleuca 48 2e-87 322
WERAM-Pat-0194 ENSPTRP00000042061.3 Pan troglodytes 48 2e-87 321
WERAM-Gog-0004 ENSGGOP00000000499.2 Gorilla gorilla 48 2e-87 321
WERAM-Pes-0136 ENSPSIP00000016220.1 Pelodiscus sinensis 47 5e-87 320
WERAM-Tut-0165 ENSTTRP00000014088.1 Tursiops truncatus 48 2e-86 318
WERAM-Lac-0147 ENSLACP00000016939.1 Latimeria chalumnae 47 2e-86 318
WERAM-Meg-0063 ENSMGAP00000006048.2 Meleagris gallopavo 48 1e-85 315
WERAM-Caj-0184 ENSCJAP00000031985.2 Callithrix jacchus 48 2e-85 315
WERAM-Myl-0095 ENSMLUP00000007906.2 Myotis lucifugus 48 2e-85 315
WERAM-Ocp-0126 ENSOPRP00000013322.1 Ochotona princeps 48 4e-85 313
WERAM-Ran-0213 ENSRNOP00000066803.1 Rattus norvegicus 47 1e-84 312
WERAM-Tag-0013 ENSTGUP00000000796.1 Taeniopygia guttata 47 3e-84 311
WERAM-Dan-0145 ENSDNOP00000027472.1 Dasypus novemcinctus 47 2e-83 308
WERAM-Drm-0085 FBpp0291264 Drosophila melanogaster 46 2e-82 305
WERAM-Sus-0033 ENSSSCP00000005588.2 Sus scrofa 47 2e-81 301
WERAM-Chh-0006 ENSCHOP00000000484.1 Choloepus hoffmanni 48 9e-80 296
WERAM-Ect-0041 ENSETEP00000004107.1 Echinops telfairi 50 1e-78 292
WERAM-Soa-0057 ENSSARP00000005556.1 Sorex araneus 48 1e-76 285
WERAM-Mae-0017 ENSMEUP00000001333.1 Macropus eugenii 45 5e-76 283
WERAM-Anp-0103 ENSAPLP00000012119.1 Anas platyrhynchos 48 9e-71 266
WERAM-Ere-0016 ENSEEUP00000000943.1 Erinaceus europaeus 55 3e-67 254
WERAM-Dio-0105 ENSDORP00000010572.1 Dipodomys ordii 53 1e-66 252
WERAM-Tum-0008 CAZ80461 Tuber melanosporum 34 2e-62 238
WERAM-Asni-0024 CADANGAP00006693 Aspergillus niger 37 6e-62 236
WERAM-Yal-0032 CAG78224 Yarrowia lipolytica 36 2e-60 232
WERAM-Asc-0010 CADACLAP00002196 Aspergillus clavatus 41 2e-59 228
WERAM-Asn-0010 CADANIAP00001580 Aspergillus nidulans 50 3e-59 228
WERAM-Cis-0058 ENSCSAVP00000013108.1 Ciona savignyi 55 3e-59 228
WERAM-Asfu-0032 CADAFUAP00007532 Aspergillus fumigatus 50 7e-59 226
WERAM-Caa-0021 KGT68489 Candida albicans 37 9e-59 226
WERAM-Scs-0007 EDN97054 Sclerotinia sclerotiorum 45 4e-58 224
WERAM-Asg-0030 AAS54607 Ashbya gossypii 34 2e-57 221
WERAM-Ast-0031 CADATEAP00008693 Aspergillus terreus 49 2e-57 221
WERAM-Kll-0015 CAH01842 Kluyveromyces lactis 33 2e-57 221
WERAM-Asf-0016 CADAFLAP00008126 Aspergillus flavus 49 4e-57 220
WERAM-Aso-0001 CADAORAP00000267 Aspergillus oryzae 49 7e-57 220
WERAM-Coi-0033 EAS31415 Coccidioides immitis 43 7e-57 219
WERAM-Sac-0014 YER169W Saccharomyces cerevisiae 34 2e-56 218
WERAM-Zyt-0023 Mycgr3P48794 Zymoseptoria tritici 46 3e-56 218
WERAM-Lem-0022 CBX90465 Leptosphaeria maculans 48 4e-56 217
WERAM-Pug-0013 EFP80553 Puccinia graminis 47 6e-56 216
WERAM-Phn-0009 SNOT_01206 Phaeosphaeria nodorum 47 8e-56 216
WERAM-Pytr-0014 EDU46512 Pyrenophora triticirepentis 48 1e-55 216
WERAM-Pyt-0032 EFQ88003 Pyrenophora teres 48 1e-55 216
WERAM-Trr-0030 EGR47972 Trichoderma reesei 39 7e-55 213
WERAM-Cag-0029 CAG62258 Candida glabrata 47 1e-54 212
WERAM-Miv-0023 MVLG_03426T0 Microbotryum violaceum 47 2e-54 212
WERAM-Trv-0008 EHK16031 Trichoderma virens 39 2e-54 211
WERAM-Kop-0009 CAY68663 Komagataella pastoris 33 3e-54 211
WERAM-Ved-0030 EGY16315 Verticillium dahliae 46 1e-53 209
WERAM-Lab-0019 EDR09176 Laccaria bicolor 47 2e-53 208
WERAM-Nec-0015 EFNCRP00000002609 Neurospora crassa 42 3e-53 207
WERAM-Fuo-0032 FOXG_11150P0 Fusarium oxysporum 42 4e-53 207
WERAM-Mel-0011 EGG02391 Melampsora laricipopulina 51 7e-53 206
Created Date 25-Jun-2016