Tag |
Content |
WERAM ID |
WERAM-Mum-0131 |
Ensembl Protein ID |
ENSMUSP00000102011.1 |
Uniprot Accession |
Q8BW72; KDM4A_MOUSE; A2A8L8; Q3UKM5; Q3UM81; Q3UWV2; Q6ZQ72; Q8K137 |
Genbank Protein ID |
NP_001155295.1; NP_759014.2; XP_006503073.1 |
Protein Name |
Lysine-specific demethylase 4A |
Genbank Nucleotide ID |
NM_001161823.1; NM_172382.2; XM_006503010.2 |
Gene Name |
KDM4A;GPS2;JMJD2A |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDM |
JHDM3_JMJD2 |
Jmjc |
H3K9me3; H3K36me3 |
K |
26731476; 25193078; 24519938 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDM |
JHDM3_JMJD2 |
6.70e-90 |
300.9 |
143 |
308 |
Me_Reader |
TTD |
3.50e-43 |
148.6 |
397 |
1012 |
Me_Reader |
PHD |
5.40e-08 |
34.4 |
729 |
865 |
|
Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (By similarity). |
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (By similarity).
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Domain Profile |
HDM JHDM3_JMJD2
JHDM3.txt 2 edveeWnlnklktildsvekelkieieGvntpylyvgmlkttfaWhvedmdlysinylhfGapktWyavpseaakrlekllrkefsesa 90 ++v+eWn+++lktild veke++i+ieGvntpyly+gm+kt+faWh+edmdlysinylhfG+pk+Wy+vp+e++krle+l++ +f++sa ENSMUSP00000102011.1 143 QHVDEWNIGRLKTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSA 231 6899************************************************************************************* PP JHDM3.txt 91 keceaflrhkttlisPellkkagipfnrivqeagefvitfPygyhaGfnhGfnlaestnfaterwievgkeaakcsc 167 ++ceaflrhk+tlisP +lkk+gipf++++qeagef+itfPygyhaGfnhGfn+aestnfat+rwie+gk+a++csc ENSMUSP00000102011.1 232 QSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSC 308 ****************************************************************************9 PP
Me_Reader TTD
TTD.txt 53 ivpleklklrpegdpeaefqkgekVlaryp 82 ++ + +l + +e +++f+k+e+ +y ENSMUSP00000102011.1 397 KRHRVCLEIPQEVSQSELFPKEELSSGQYE 426 356778888888889999999998766665 PP TTD.txt 4 sievGakvaakdrdeewyqaevvkvsaettkyevdfeegkeredlskeyivpleklklrpegdpeaefqkgekVlarypdttfYpAk 90 si++G+kv++k++++++yq+evv++++et+ yev+f++g+++++l++e+iv++++l+l+p++ +ge+V++r++d+++Y+Ak ENSMUSP00000102011.1 898 SITAGQKVISKHKNGRFYQCEVVRLTTETF-YEVNFDDGSFSDNLYPEDIVSQDCLQLGPPA-------EGEVVQVRWTDGQVYGAK 976 89****************************.*******************************.......****************** PP TTD.txt 91 viaskkdgtysvkFeDgssevvkraqvyalskeenk 126 ++as++ ++y+v+FeDgs+ vvkr++vy+l++e++k ENSMUSP00000102011.1 977 FVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPK 1012 **********************************95 PP
Me_Reader PHD
PHD.txt 11 degekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 ++g++++v C++C+ +H++C+++p +++++++w+C +C ENSMUSP00000102011.1 729 EDGTSMLVSCKKCSVRVHASCYGVP--PAKASEEWMCSRCS 767 45556699*****************..6666657******7 PP PHD.txt 4 ClvCgkddegekemvqCdeCddwfHlkCv 32 Cl C g ++q + d+w+H++C ENSMUSP00000102011.1 776 CL-C-SLRGG---ALQRANDDRWVHVSCA 799 44.6.33333...456666689******7 PP PHD.txt 4 ClvC.gkddegekemvqCde..CddwfHlkCvklpl 36 C++C ++++ ++ ++vqC++ C+++fH++C + + ENSMUSP00000102011.1 830 CVFCkKRRKRNAGCCVQCSHgrCPTAFHVSCAQAAG 865 ****5467777889*****************99874 PP
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Protein Sequence (Fasta) | MASESETLNP SARIMTFYPT MEEFRNFSRY IAYIESQGAH RAGLAKVVPP KEWKPRTSYD 60 DIDDLVIPAP IQQLVTGQSG LFTQYNIQKK AMTVREFRKI ANSDKYCTPR YSEFEELERK 120 YWKNLTFNPP IYGADVNGTL YEQHVDEWNI GRLKTILDLV EKESGITIEG VNTPYLYFGM 180 WKTSFAWHTE DMDLYSINYL HFGEPKSWYS VPPEHGKRLE RLAKGFFPGS AQSCEAFLRH 240 KMTLISPLML KKYGIPFDKV TQEAGEFMIT FPYGYHAGFN HGFNCAESTN FATRRWIEYG 300 KQAVLCSCRK DMVKISMDVF VRRFQPERYK LWKAGKDSMV IDHTLPTPEA AEFLKDSGGL 360 TPRAGSEECP EEDVEAADQG EEGDVKRSLA KHRIGTKRHR VCLEIPQEVS QSELFPKEEL 420 SSGQYEMTEC PATLAPVRPT HSSVRQVEDS LPFPDYSDPT EVKFEELKNV KLEEEDEEDE 480 PEAAALDLSV NPASVGGRLV FSGSKKKSSS SLGSTSSQDS VSSDSETAES VSCQGQEKTG 540 VLTVHSYARG DGKAATGEPS VKKKRSAPRS ISEQELAEVA DEYMLSLEEN KKTKGRRQPL 600 SKLPRHHPLV LQECGSDDET SEQLTPEEEA EETEAWAKPL SQLWQNRPPN FEAEKEFNEI 660 MAQQAPHCAV CMIFQTYHQV EFGAFSQSCG DASEPAAQTQ RTKPLIPEMC FTTTGCSTDI 720 NLSTPYLEED GTSMLVSCKK CSVRVHASCY GVPPAKASEE WMCSRCSANA LEEDCCLCSL 780 RGGALQRAND DRWVHVSCAV AILEARFVNI AERSPVDVSK IPLPRFKLKC VFCKKRRKRN 840 AGCCVQCSHG RCPTAFHVSC AQAAGVMMQP DDWPFVVFIT CFRHKIPNLE RAKGALLSIT 900 AGQKVISKHK NGRFYQCEVV RLTTETFYEV NFDDGSFSDN LYPEDIVSQD CLQLGPPAEG 960 EVVQVRWTDG QVYGAKFVAS HPIQMYQVEF EDGSQLVVKR DDVYTLDEEL PKRVKSRLSV 1020 ASDMRFNEIF TEKEVKQEKK RQRVINSRYR EDYIEPALYR AIME 1064Protein Fasta Sequence
>ENSMUSP00000102011.1|KDM4A;GPS2;JMJD2A|Mus musculus MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRTSYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEQHVDEWNIGRLKTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRRFQPERYKLWKAGKDSMVIDHTLPTPEAAEFLKDSGGLTPRAGSEECPEEDVEAADQGEEGDVKRSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEELSSGQYEMTECPATLAPVRPTHSSVRQVEDSLPFPDYSDPTEVKFEELKNVKLEEEDEEDEPEAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSTSSQDSVSSDSETAESVSCQGQEKTGVLTVHSYARGDGKAATGEPSVKKKRSAPRSISEQELAEVADEYMLSLEENKKTKGRRQPLSKLPRHHPLVLQECGSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNEIMAQQAPHCAVCMIFQTYHQVEFGAFSQSCGDASEPAAQTQRTKPLIPEMCFTTTGCSTDINLSTPYLEEDGTSMLVSCKKCSVRVHASCYGVPPAKASEEWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCVFCKKRRKRNAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALLSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQLGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
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Nucleotide Sequence (Fasta) | TCTTTCGCCC TCAAGAAAGA CAGTGGGATC GGCGAGTGGC GACAACAGCA ATCGGGCCTG 60 AGCCCTGCTA GGGCTTTAGG CTCCAGCAAA ATCGGCCTCA AAAACAGAGA AGACAAGATG 120 GCTTCTGAAT CAGAAACTTT GAACCCCAGT GCTCGGATCA TGACCTTTTA CCCCACCATG 180 GAAGAGTTCC GGAACTTCAG CCGCTACATT GCCTACATTG AATCCCAAGG AGCTCATCGG 240 GCTGGGCTAG CCAAGGTCGT TCCTCCCAAA GAGTGGAAGC CTCGAACATC CTACGACGAT 300 ATTGATGATC TAGTCATCCC TGCGCCCATC CAGCAGCTGG TGACTGGCCA GTCTGGCCTC 360 TTCACTCAGT ACAACATACA GAAGAAAGCC ATGACCGTTC GTGAGTTCCG CAAGATCGCC 420 AATAGCGACA AGTACTGCAC CCCGCGATAC AGTGAATTTG AAGAACTTGA GCGTAAATAC 480 TGGAAAAACC TCACATTCAA TCCTCCCATC TATGGAGCAG ACGTGAATGG TACTCTCTAT 540 GAACAGCACG TTGATGAGTG GAATATCGGC CGGCTGAAGA CCATCCTGGA CCTGGTGGAG 600 AAGGAGAGCG GGATCACCAT TGAGGGGGTG AACACCCCCT ACCTTTACTT CGGCATGTGG 660 AAGACGTCCT TCGCCTGGCA CACGGAAGAC ATGGATCTAT ACAGCATCAA CTATCTGCAC 720 TTCGGAGAGC CAAAGTCTTG GTACTCTGTT CCACCTGAGC ATGGGAAACG CCTGGAGCGT 780 CTTGCCAAAG GCTTTTTCCC AGGAAGTGCT CAAAGCTGTG AGGCTTTTCT CCGCCACAAG 840 ATGACCCTGA TCTCCCCATT AATGCTGAAG AAGTATGGCA TTCCCTTTGA CAAGGTGACC 900 CAAGAAGCTG GCGAGTTTAT GATCACTTTT CCGTATGGTT ACCATGCTGG CTTCAACCAT 960 GGCTTCAACT GTGCAGAGTC AACCAATTTT GCTACCCGTC GGTGGATTGA GTATGGCAAG 1020 CAGGCTGTGC TGTGCTCCTG CAGAAAAGAT ATGGTGAAGA TCTCCATGGA CGTGTTCGTG 1080 AGGAGGTTCC AGCCGGAACG CTACAAACTT TGGAAAGCTG GGAAGGACAG CATGGTTATT 1140 GACCACACTC TGCCCACACC GGAAGCAGCC GAGTTCCTGA AGGACAGCGG CGGACTAACC 1200 CCGAGAGCAG GGAGTGAGGA GTGCCCAGAG GAGGACGTGG AAGCAGCGGA TCAGGGAGAG 1260 GAGGGGGATG TGAAGAGAAG CCTGGCCAAG CATCGGATCG GGACAAAGAG ACACAGAGTC 1320 TGTCTGGAAA TACCCCAGGA GGTCAGTCAG AGCGAGCTCT TCCCCAAGGA AGAGCTAAGT 1380 TCTGGACAGT ATGAGATGAC AGAGTGCCCG GCCACCCTCG CCCCAGTGAG GCCCACCCAC 1440 AGCTCCGTGC GGCAAGTTGA GGACAGTCTT CCCTTCCCAG ATTACTCTGA CCCCACTGAA 1500 GTCAAATTTG AAGAGCTGAA GAATGTCAAA CTAGAAGAGG AAGATGAGGA GGATGAGCCC 1560 GAAGCAGCCG CACTGGACCT TTCTGTGAAT CCTGCGTCTG TAGGAGGACG CCTCGTCTTC 1620 TCGGGTTCCA AAAAGAAATC ATCTTCCAGC CTGGGCTCCA CTTCATCTCA GGATTCAGTT 1680 TCTTCAGATT CTGAAACCGC CGAGTCTGTC TCTTGCCAGG GCCAAGAGAA AACGGGAGTT 1740 CTCACCGTGC ACAGCTATGC CAGAGGGGAC GGCAAGGCTG CCACAGGAGA GCCGAGTGTG 1800 AAGAAGAAGC GCAGTGCTCC CCGCAGCATC AGCGAGCAGG AGCTGGCAGA GGTTGCAGAT 1860 GAGTACATGC TTTCCCTGGA GGAGAATAAG AAGACCAAGG GTCGCCGCCA GCCCTTGAGC 1920 AAGCTCCCAC GCCACCACCC ACTCGTGCTG CAGGAGTGCG GCAGCGATGA CGAGACTTCT 1980 GAGCAGCTGA CCCCCGAGGA GGAGGCTGAG GAGACAGAGG CTTGGGCCAA GCCTCTGAGC 2040 CAGCTGTGGC AGAACCGACC CCCGAACTTT GAGGCTGAAA AGGAATTCAA TGAGATCATG 2100 GCCCAACAGG CCCCTCACTG TGCTGTGTGT ATGATCTTCC AGACCTACCA TCAGGTGGAA 2160 TTTGGAGCCT TCAGTCAGAG CTGTGGGGAT GCTTCAGAGC CGGCTGCCCA GACTCAGAGG 2220 ACCAAGCCAC TGATCCCCGA AATGTGCTTT ACCACCACTG GCTGCAGCAC AGACATCAAT 2280 CTGTCCACCC CGTACCTAGA GGAGGATGGC ACCAGCATGC TAGTGTCCTG CAAGAAGTGC 2340 AGTGTCCGGG TCCACGCCAG TTGCTATGGC GTCCCTCCTG CCAAGGCTTC TGAAGAATGG 2400 ATGTGCTCTC GATGTTCAGC CAATGCCCTG GAGGAAGACT GCTGCTTATG CTCGTTGCGT 2460 GGAGGGGCCC TGCAGAGAGC CAATGACGAC AGATGGGTTC ATGTTTCATG TGCAGTGGCA 2520 ATTCTAGAAG CAAGGTTTGT CAACATTGCT GAAAGAAGTC CAGTGGATGT GAGCAAAATC 2580 CCTCTGCCCC GCTTCAAACT GAAGTGTGTT TTTTGTAAGA AGCGGAGAAA ACGGAATGCT 2640 GGCTGCTGTG TGCAGTGCTC CCATGGCCGC TGCCCCACTG CCTTCCATGT GAGCTGTGCC 2700 CAGGCTGCTG GGGTGATGAT GCAACCCGAC GACTGGCCCT TTGTTGTCTT CATCACGTGC 2760 TTCCGTCACA AGATTCCCAA TCTGGAGCGT GCTAAGGGAG CCTTGCTGAG CATCACGGCG 2820 GGCCAGAAGG TTATCAGCAA ACACAAGAAC GGGCGCTTCT ACCAGTGTGA GGTGGTCAGA 2880 CTCACCACCG AGACCTTCTA CGAAGTCAAC TTTGACGACG GCTCCTTCAG TGACAACCTT 2940 TATCCTGAGG ACATAGTGAG TCAGGACTGT CTCCAACTGG GGCCTCCTGC TGAAGGTGAA 3000 GTGGTTCAAG TCAGATGGAC AGATGGCCAA GTCTATGGGG CTAAGTTTGT GGCCTCCCAC 3060 CCCATCCAGA TGTACCAGGT GGAGTTTGAG GATGGCTCGC AGCTGGTGGT TAAGAGAGAT 3120 GATGTATACA CACTCGATGA AGAGCTTCCC AAGAGAGTCA AGTCTAGACT GTCGGTGGCT 3180 TCAGACATGC GCTTCAATGA GATTTTCACA GAGAAGGAAG TGAAGCAAGA AAAGAAGAGG 3240 CAACGGGTCA TCAACTCGCG GTACCGGGAG GATTACATCG AGCCAGCGCT GTACCGGGCC 3300 ATCATGGAGT AGATGCTTCC AGGATCTGAG AGGTTCCCAG CCATCAAGGC GAGAGCACTC 3360 TAGGGTTCCA CAGCACAGCA GACACTTGGA ACTCGAACTT GGAACTTCAC TTCGAAAGTG 3420 AAGCTGTACA CAGAAAAGGA ATGACGTGTC CGACCTTTCA CCTTCTCACT CCACCCTCGA 3480 TGCATTCTGC CGGGAAAAGA CAAGCCTATT GTGGGTGCTT GGCAGCAGCT GTCCGTCCTC 3540 AGCTGACGGG CCGACACTGG GATGCTGTGA TTGCATCAGC CCCCAGTCCA ATCGGGTCAG 3600 CTGTTCCTGC TGGGCGGATT GTTCTTTCTT AGTGGCTTGC TTCCTACCCG CCCACCGGCA 3660 CCAGCAAGGC AGAGAGGTGC TGGTGCTGAC CCAATCCCCT TTTGTATTTA TGTATGCGTG 3720 TGTGAGCGTG CACACGTGCA AGTGTGTACC TGTGTGTAAG CGTGAGAACG TGTGAGTGTA 3780 CACCTGTGTG TGTGTGTGTG TGTGTGCTTG AGAATGTGTG TGTGGGTGTG CAAGTACGTA 3840 TGTGGTTGCA CTCGTGTACG TGAGTGCGTG TGTGTGCTTG GTCAGGACTA GCTTCTGCCA 3900 GCCCCTGGGC TTCACTTTCT TCTTTGCCTC TGCAGGGCAA ACAAAATGTG AAATTCTGCC 3960 CTCAGCCAAG CTGAGTAAGG GCCCCGGGGG ATGGGTAGAG GTGGGGTGCC ATCTGTCCCT 4020 TCCTGGACCG ATCTCAAGAG AGCGCCGGCA AAGCTGCAGT ATTGGGATGC TAAGGAGCTG 4080 GCTGCCACCT CTGTCCACCC TTGAAGTAGA ACTCAGAGGT TATATACTAT GAGCCCACAA 4140 ATGTCAGGCA CGGAAGCCCC TGCCTGCGGC CACAGTGTTA GAGGGTGTGG GTGGGGACCA 4200 CCTTGAAGGG ATAATTTTAA TGATGGAAAC AGGCAGAGCC TGGTGGGTGA TTTTTGTGCA 4260 GTTATGCAGG GGCTAACTAT GGGTTAGGAT GAACTGGGGC CACTGGAGGC CAAGGGCTGG 4320 TATAGCTACG CCCTTGGTCA GGGGTGGGGT GGGGCTGGTT GAGGGTGGGG GTGGGATGGG 4380 ACTAGAGGGC AACATTGAAG GGGTTAAACA GGTTCCTGAA TTTGTTTGCC TGGGCCCAAT 4440 ATGGAGGGCT TCATACCTTG CTCTGTATAC AGGAGTCAGA TTTATAATAC TTCCCCTTTT 4500 TTGTTACGTA TGAACTCTAT AAACCAAATT ATTTTG
4537Nucleotide Fasta Sequence
>ENSMUSP00000102011.1|PHD|Mus musculus TCTTTCGCCCTCAAGAAAGACAGTGGGATCGGCGAGTGGCGACAACAGCAATCGGGCCTGAGCCCTGCTAGGGCTTTAGGCTCCAGCAAAATCGGCCTCAAAAACAGAGAAGACAAGATGGCTTCTGAATCAGAAACTTTGAACCCCAGTGCTCGGATCATGACCTTTTACCCCACCATGGAAGAGTTCCGGAACTTCAGCCGCTACATTGCCTACATTGAATCCCAAGGAGCTCATCGGGCTGGGCTAGCCAAGGTCGTTCCTCCCAAAGAGTGGAAGCCTCGAACATCCTACGACGATATTGATGATCTAGTCATCCCTGCGCCCATCCAGCAGCTGGTGACTGGCCAGTCTGGCCTCTTCACTCAGTACAACATACAGAAGAAAGCCATGACCGTTCGTGAGTTCCGCAAGATCGCCAATAGCGACAAGTACTGCACCCCGCGATACAGTGAATTTGAAGAACTTGAGCGTAAATACTGGAAAAACCTCACATTCAATCCTCCCATCTATGGAGCAGACGTGAATGGTACTCTCTATGAACAGCACGTTGATGAGTGGAATATCGGCCGGCTGAAGACCATCCTGGACCTGGTGGAGAAGGAGAGCGGGATCACCATTGAGGGGGTGAACACCCCCTACCTTTACTTCGGCATGTGGAAGACGTCCTTCGCCTGGCACACGGAAGACATGGATCTATACAGCATCAACTATCTGCACTTCGGAGAGCCAAAGTCTTGGTACTCTGTTCCACCTGAGCATGGGAAACGCCTGGAGCGTCTTGCCAAAGGCTTTTTCCCAGGAAGTGCTCAAAGCTGTGAGGCTTTTCTCCGCCACAAGATGACCCTGATCTCCCCATTAATGCTGAAGAAGTATGGCATTCCCTTTGACAAGGTGACCCAAGAAGCTGGCGAGTTTATGATCACTTTTCCGTATGGTTACCATGCTGGCTTCAACCATGGCTTCAACTGTGCAGAGTCAACCAATTTTGCTACCCGTCGGTGGATTGAGTATGGCAAGCAGGCTGTGCTGTGCTCCTGCAGAAAAGATATGGTGAAGATCTCCATGGACGTGTTCGTGAGGAGGTTCCAGCCGGAACGCTACAAACTTTGGAAAGCTGGGAAGGACAGCATGGTTATTGACCACACTCTGCCCACACCGGAAGCAGCCGAGTTCCTGAAGGACAGCGGCGGACTAACCCCGAGAGCAGGGAGTGAGGAGTGCCCAGAGGAGGACGTGGAAGCAGCGGATCAGGGAGAGGAGGGGGATGTGAAGAGAAGCCTGGCCAAGCATCGGATCGGGACAAAGAGACACAGAGTCTGTCTGGAAATACCCCAGGAGGTCAGTCAGAGCGAGCTCTTCCCCAAGGAAGAGCTAAGTTCTGGACAGTATGAGATGACAGAGTGCCCGGCCACCCTCGCCCCAGTGAGGCCCACCCACAGCTCCGTGCGGCAAGTTGAGGACAGTCTTCCCTTCCCAGATTACTCTGACCCCACTGAAGTCAAATTTGAAGAGCTGAAGAATGTCAAACTAGAAGAGGAAGATGAGGAGGATGAGCCCGAAGCAGCCGCACTGGACCTTTCTGTGAATCCTGCGTCTGTAGGAGGACGCCTCGTCTTCTCGGGTTCCAAAAAGAAATCATCTTCCAGCCTGGGCTCCACTTCATCTCAGGATTCAGTTTCTTCAGATTCTGAAACCGCCGAGTCTGTCTCTTGCCAGGGCCAAGAGAAAACGGGAGTTCTCACCGTGCACAGCTATGCCAGAGGGGACGGCAAGGCTGCCACAGGAGAGCCGAGTGTGAAGAAGAAGCGCAGTGCTCCCCGCAGCATCAGCGAGCAGGAGCTGGCAGAGGTTGCAGATGAGTACATGCTTTCCCTGGAGGAGAATAAGAAGACCAAGGGTCGCCGCCAGCCCTTGAGCAAGCTCCCACGCCACCACCCACTCGTGCTGCAGGAGTGCGGCAGCGATGACGAGACTTCTGAGCAGCTGACCCCCGAGGAGGAGGCTGAGGAGACAGAGGCTTGGGCCAAGCCTCTGAGCCAGCTGTGGCAGAACCGACCCCCGAACTTTGAGGCTGAAAAGGAATTCAATGAGATCATGGCCCAACAGGCCCCTCACTGTGCTGTGTGTATGATCTTCCAGACCTACCATCAGGTGGAATTTGGAGCCTTCAGTCAGAGCTGTGGGGATGCTTCAGAGCCGGCTGCCCAGACTCAGAGGACCAAGCCACTGATCCCCGAAATGTGCTTTACCACCACTGGCTGCAGCACAGACATCAATCTGTCCACCCCGTACCTAGAGGAGGATGGCACCAGCATGCTAGTGTCCTGCAAGAAGTGCAGTGTCCGGGTCCACGCCAGTTGCTATGGCGTCCCTCCTGCCAAGGCTTCTGAAGAATGGATGTGCTCTCGATGTTCAGCCAATGCCCTGGAGGAAGACTGCTGCTTATGCTCGTTGCGTGGAGGGGCCCTGCAGAGAGCCAATGACGACAGATGGGTTCATGTTTCATGTGCAGTGGCAATTCTAGAAGCAAGGTTTGTCAACATTGCTGAAAGAAGTCCAGTGGATGTGAGCAAAATCCCTCTGCCCCGCTTCAAACTGAAGTGTGTTTTTTGTAAGAAGCGGAGAAAACGGAATGCTGGCTGCTGTGTGCAGTGCTCCCATGGCCGCTGCCCCACTGCCTTCCATGTGAGCTGTGCCCAGGCTGCTGGGGTGATGATGCAACCCGACGACTGGCCCTTTGTTGTCTTCATCACGTGCTTCCGTCACAAGATTCCCAATCTGGAGCGTGCTAAGGGAGCCTTGCTGAGCATCACGGCGGGCCAGAAGGTTATCAGCAAACACAAGAACGGGCGCTTCTACCAGTGTGAGGTGGTCAGACTCACCACCGAGACCTTCTACGAAGTCAACTTTGACGACGGCTCCTTCAGTGACAACCTTTATCCTGAGGACATAGTGAGTCAGGACTGTCTCCAACTGGGGCCTCCTGCTGAAGGTGAAGTGGTTCAAGTCAGATGGACAGATGGCCAAGTCTATGGGGCTAAGTTTGTGGCCTCCCACCCCATCCAGATGTACCAGGTGGAGTTTGAGGATGGCTCGCAGCTGGTGGTTAAGAGAGATGATGTATACACACTCGATGAAGAGCTTCCCAAGAGAGTCAAGTCTAGACTGTCGGTGGCTTCAGACATGCGCTTCAATGAGATTTTCACAGAGAAGGAAGTGAAGCAAGAAAAGAAGAGGCAACGGGTCATCAACTCGCGGTACCGGGAGGATTACATCGAGCCAGCGCTGTACCGGGCCATCATGGAGTAGATGCTTCCAGGATCTGAGAGGTTCCCAGCCATCAAGGCGAGAGCACTCTAGGGTTCCACAGCACAGCAGACACTTGGAACTCGAACTTGGAACTTCACTTCGAAAGTGAAGCTGTACACAGAAAAGGAATGACGTGTCCGACCTTTCACCTTCTCACTCCACCCTCGATGCATTCTGCCGGGAAAAGACAAGCCTATTGTGGGTGCTTGGCAGCAGCTGTCCGTCCTCAGCTGACGGGCCGACACTGGGATGCTGTGATTGCATCAGCCCCCAGTCCAATCGGGTCAGCTGTTCCTGCTGGGCGGATTGTTCTTTCTTAGTGGCTTGCTTCCTACCCGCCCACCGGCACCAGCAAGGCAGAGAGGTGCTGGTGCTGACCCAATCCCCTTTTGTATTTATGTATGCGTGTGTGAGCGTGCACACGTGCAAGTGTGTACCTGTGTGTAAGCGTGAGAACGTGTGAGTGTACACCTGTGTGTGTGTGTGTGTGTGTGCTTGAGAATGTGTGTGTGGGTGTGCAAGTACGTATGTGGTTGCACTCGTGTACGTGAGTGCGTGTGTGTGCTTGGTCAGGACTAGCTTCTGCCAGCCCCTGGGCTTCACTTTCTTCTTTGCCTCTGCAGGGCAAACAAAATGTGAAATTCTGCCCTCAGCCAAGCTGAGTAAGGGCCCCGGGGGATGGGTAGAGGTGGGGTGCCATCTGTCCCTTCCTGGACCGATCTCAAGAGAGCGCCGGCAAAGCTGCAGTATTGGGATGCTAAGGAGCTGGCTGCCACCTCTGTCCACCCTTGAAGTAGAACTCAGAGGTTATATACTATGAGCCCACAAATGTCAGGCACGGAAGCCCCTGCCTGCGGCCACAGTGTTAGAGGGTGTGGGTGGGGACCACCTTGAAGGGATAATTTTAATGATGGAAACAGGCAGAGCCTGGTGGGTGATTTTTGTGCAGTTATGCAGGGGCTAACTATGGGTTAGGATGAACTGGGGCCACTGGAGGCCAAGGGCTGGTATAGCTACGCCCTTGGTCAGGGGTGGGGTGGGGCTGGTTGAGGGTGGGGGTGGGATGGGACTAGAGGGCAACATTGAAGGGGTTAAACAGGTTCCTGAATTTGTTTGCCTGGGCCCAATATGGAGGGCTTCATACCTTGCTCTGTATACAGGAGTCAGATTTATAATACTTCCCCTTTTTTGTTACGTATGAACTCTATAAACCAAATTATTTTG
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Sequence Source |
Ensembl |
Keyword |
KW-0007--Acetylation KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0223--Dioxygenase KW-0903--Direct protein sequencing KW-0408--Iron KW-0479--Metal-binding KW-0539--Nucleus KW-0560--Oxidoreductase KW-1185--Reference proteome KW-0677--Repeat KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR003347--JmjC_dom IPR003349--JmjN IPR002999--Tudor IPR011011--Znf_FYVE_PHD IPR001965--Znf_PHD IPR013083--Znf_RING/FYVE/PHD
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PROSITE |
PS51184--JMJC PS51183--JMJN
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Pfam |
PF02373--JmjC PF02375--JmjN
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0005730--C:nucleolus GO:0005634--C:nucleus GO:0005721--C:pericentric heterochromatin GO:0032452--F:histone demethylase activity GO:0051864--F:histone demethylase activity (H3-K36 specific) GO:0035064--F:methylated histone binding GO:0031625--F:ubiquitin protein ligase binding GO:0008270--F:zinc ion binding GO:0014898--P:cardiac muscle hypertrophy in response to stress GO:0016577--P:histone demethylation GO:0070544--P:histone H3-K36 demethylation GO:0010507--P:negative regulation of autophagy GO:0010629--P:negative regulation of gene expression GO:1900113--P:negative regulation of histone H3-K9 trimethylation GO:0045892--P:negative regulation of transcription, DNA-templated GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |