WERAM Information

Tag Content
WERAM ID WERAM-Sac-0014
Ensembl Protein ID YER169W
Uniprot Accession P39956; RPH1_YEAST; D3DM77
Genbank Protein ID NP_011096.1
Protein Name DNA damage-responsive transcriptional repressor RPH1
Genbank Nucleotide ID NM_001179059.1
Gene Name RPH1;YER169W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YER169W YER169W YER169W
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JHDM3_JMJD2 Jmjc H3K9; H3K36 K 25660547; 21296759; 17371840
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JHDM3_JMJD2 1.80e-78 260.7 195 355
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 Transcriptional repressor of photolyase PHR1. Recognizes and binds the sequence AG(4) in the upstream repressing sequence of PHR1. Derepresses PHR1 transcription when phosphorylated.
Domain Profile
  HDM JHDM3_JMJD2
  JHDM3.txt   3 dveeWnlnklktildsvekelkieieGvntpylyvgmlkttfaWhvedmdlysinylhfGapktWyavpseaakrlekllrkefsesakeceaflrhktt 102
                 ++ Wn++kl++ild++e++    ++Gvn++yly+g++k++f+Wh+ed+dlysiny+hfGapk+Wy++p+e++ +++k+++++f+e+ak+c++flrhk++
    YER169W 195 GLNVWNVAKLPNILDHMETK----VPGVNDSYLYAGLWKASFSWHLEDQDLYSINYIHFGAPKQWYSIPQEDRFKFYKFMQEQFPEEAKNCPEFLRHKMF 290
                6789*************999....**************************************************************************** PP
  JHDM3.txt 103 lisPellkkagipfnrivqeagefvitfPygyhaGfnhGfnlaestnfaterwievgkeaakcsc 167
                l sP+ll+++gi++n+iv+++gef+it+PygyhaGfn+G+nlaes+nfa+e+w+ +gk+a kc+c
    YER169W 291 LASPKLLQENGIRCNEIVHHEGEFMITYPYGYHAGFNYGYNLAESVNFALEEWLPIGKKAGKCHC 355
                ****************************************************************9 PP
Protein Sequence
(Fasta)		MTKLIAPSEI VGGVPVFKPT YEQFEDFYAY CKAINKYGMK SGVVKVIPPK EWKDKLDLPY 60
SAETLQKIKI KSPIQQHISG NKGLFMVQNV EKNKTYNIIQ WKDLSKDYVP PEDPKARRNS 120
RKGSVSKSTK LKLKNFESSF NIDDFEQFRT EYTIDLSDFQ NTERLKFLEE YYWKTLNFTT 180
PMYGADTPGS IFPEGLNVWN VAKLPNILDH METKVPGVND SYLYAGLWKA SFSWHLEDQD 240
LYSINYIHFG APKQWYSIPQ EDRFKFYKFM QEQFPEEAKN CPEFLRHKMF LASPKLLQEN 300
GIRCNEIVHH EGEFMITYPY GYHAGFNYGY NLAESVNFAL EEWLPIGKKA GKCHCISDSV 360
EIDVKKLAKS WRDNNKESKG TPPLNQLPNP AMPLLHRPTL KEMESSSLRS TSPDVGHFSN 420
FKSKSSGVSS PLLSRMKDYS NIVEPTLEDP TLKLKRISSF QEQPLNKLLK RETSQTAMLT 480
DHEDNIVAMS LTSMANSAAS SPRLPLSRLN SSNELSNAQP LLDMTNNTLA FPRPNGPSGL 540
NPLLYISNKN ISGISHSAPH SPVNPNISLI KRVKSPNIVT LNISRESSRS PIALNYEARQ 600
QHSQQHSFST PSTVSNLSTS VLGPLSDTND IKTPHPERPN HKTANRILKK ESPVETSKSN 660
LILSKVASTR QEDSFTSRND DLDKEQGSSP LNSKFAPEEI VLSGKNKIYI CKECQRKFSS 720
GHHLTRHKKS VHSGEKPHSC PKCGKRFKRR DHVLQHLNKK IPCISNETTV DAPIMNPTVQ 780
PQDGKAAINQ QSTPLN 796
Nucleotide Sequence
(Fasta)		ATGACGAAAC TAATCGCTCC TTCAGAAATC GTGGGCGGAG TGCCCGTCTT CAAACCCACA 60
TACGAGCAAT TCGAAGATTT CTATGCATAC TGCAAGGCCA TAAACAAATA TGGCATGAAA 120
AGTGGTGTTG TGAAAGTAAT CCCACCTAAA GAATGGAAAG ACAAATTAGA TCTGCCTTAT 180
TCTGCGGAAA CGCTCCAAAA GATCAAGATT AAATCACCTA TTCAGCAGCA TATTTCTGGT 240
AATAAAGGTC TTTTTATGGT GCAGAACGTG GAGAAAAACA AGACCTATAA CATTATACAG 300
TGGAAAGATC TTTCTAAGGA CTATGTGCCT CCGGAGGATC CTAAAGCAAG ACGTAATTCT 360
AGGAAAGGCT CCGTTTCCAA ATCCACGAAG TTGAAACTGA AAAATTTTGA ATCGTCTTTT 420
AATATTGATG ATTTTGAACA GTTCAGGACG GAGTATACAA TAGATTTATC TGACTTCCAA 480
AATACGGAGA GATTAAAGTT CTTGGAAGAG TATTATTGGA AAACGCTAAA TTTTACTACG 540
CCTATGTACG GCGCAGATAC ACCAGGATCA ATCTTTCCTG AAGGGCTGAA CGTTTGGAAT 600
GTTGCCAAAC TACCGAACAT CTTGGACCAT ATGGAAACAA AGGTTCCTGG GGTGAATGAC 660
TCCTATCTAT ACGCTGGTCT ATGGAAGGCT TCTTTTTCTT GGCACTTGGA AGATCAGGAC 720
CTGTATTCCA TAAATTATAT TCATTTCGGT GCCCCAAAAC AGTGGTATTC GATACCGCAA 780
GAGGATAGGT TCAAATTCTA CAAATTCATG CAGGAGCAAT TTCCCGAAGA AGCCAAAAAT 840
TGTCCTGAAT TTTTAAGACA TAAAATGTTT TTGGCTTCGC CCAAACTGCT GCAGGAAAAT 900
GGCATACGAT GCAATGAAAT TGTCCACCAT GAAGGCGAAT TCATGATCAC TTATCCCTAT 960
GGTTACCATG CAGGGTTCAA TTATGGATAT AACTTGGCAG AATCCGTCAA CTTTGCTTTG 1020
GAGGAGTGGC TACCGATTGG GAAGAAAGCT GGAAAATGCC ACTGCATTTC AGACTCAGTG 1080
GAAATAGATG TTAAGAAACT CGCTAAATCT TGGAGGGACA ATAATAAAGA GTCGAAAGGA 1140
ACGCCACCCC TCAATCAATT ACCCAATCCT GCCATGCCCT TACTTCACAG GCCAACTTTA 1200
AAAGAAATGG AAAGCAGCTC GCTTAGATCT ACAAGCCCAG ATGTGGGTCA TTTTTCAAAC 1260
TTTAAATCCA AGAGCTCTGG TGTTTCTTCT CCCTTATTAT CACGTATGAA AGATTATTCC 1320
AACATTGTCG AGCCCACACT AGAAGATCCA ACTTTGAAAT TAAAAAGAAT CTCTTCTTTT 1380
CAAGAACAGC CCTTAAACAA ACTTTTGAAA AGAGAAACTT CGCAAACGGC GATGCTCACA 1440
GATCACGAAG ACAACATAGT GGCCATGAGC CTTACTTCAA TGGCAAACAG TGCGGCGTCT 1500
TCTCCGAGGT TGCCACTGTC AAGATTGAAT TCATCTAATG AACTCTCAAA TGCCCAACCA 1560
TTGCTTGACA TGACAAACAA TACTCTTGCC TTCCCGCGAC CTAATGGACC ATCTGGATTG 1620
AACCCTTTAT TATATATCTC TAACAAGAAT ATTAGCGGGA TATCTCACTC GGCTCCACAT 1680
TCTCCAGTGA ATCCAAATAT ATCGCTGATA AAACGAGTTA AGTCTCCCAA CATTGTAACA 1740
TTAAATATAT CCAGGGAATC GTCAAGAAGC CCTATAGCTC TGAATTACGA GGCAAGACAA 1800
CAACATTCGC AACAACATTC ATTCTCCACA CCATCAACCG TGTCAAATCT CTCTACTTCT 1860
GTGCTCGGGC CACTGAGTGA CACAAACGAC ATAAAAACAC CGCACCCTGA AAGACCAAAT 1920
CACAAGACAG CAAATAGAAT ACTCAAAAAG GAATCTCCTG TCGAGACATC AAAATCAAAT 1980
CTTATACTTT CAAAGGTTGC ATCCACTCGC CAAGAGGATT CTTTTACAAG CCGAAATGAC 2040
GATCTGGACA AAGAACAAGG CTCTTCTCCA TTAAACTCTA AGTTTGCGCC CGAAGAAATC 2100
GTGTTATCAG GTAAGAACAA GATTTATATT TGTAAGGAAT GCCAAAGAAA GTTCTCTTCT 2160
GGTCACCATC TTACAAGACA CAAAAAATCC GTCCACTCTG GTGAGAAACC TCATTCTTGT 2220
CCCAAATGTG GCAAAAGATT TAAAAGGAGA GATCACGTTC TGCAGCACTT GAATAAGAAA 2280
ATACCGTGTA TTTCAAACGA AACAACAGTA GATGCTCCAA TAATGAACCC TACAGTGCAA 2340
CCGCAGGACG GGAAAGCGGC CATTAATCAA CAGAGTACAC CTTTAAACTG A 2392
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR003347--JmjC_dom
IPR003349--JmjN
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
PROSITE

PS51184--JMJC
PS51183--JMJN
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF02373--JmjC
PF02375--JmjN
Gene Ontology

GO:0005634--C:nucleus
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0016577--P:histone demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0010507--P:negative regulation of autophagy
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Asg-0030 AAS54607 Ashbya gossypii 49 0.0 691
WERAM-Cag-0029 CAG62258 Candida glabrata 64 3e-151 533
WERAM-Kll-0015 CAH01842 Kluyveromyces lactis 65 4e-148 522
WERAM-Yal-0032 CAG78224 Yarrowia lipolytica 57 2e-118 424
WERAM-Kop-0009 CAY68663 Komagataella pastoris 54 2e-116 417
WERAM-Caa-0021 KGT68489 Candida albicans 54 3e-110 397
WERAM-Tum-0008 CAZ80461 Tuber melanosporum 47 1e-104 378
WERAM-Aso-0001 CADAORAP00000267 Aspergillus oryzae 48 1e-104 378
WERAM-Asni-0024 CADANGAP00006693 Aspergillus niger 50 2e-103 374
WERAM-Ast-0031 CADATEAP00008693 Aspergillus terreus 46 2e-93 341
WERAM-Zyt-0023 Mycgr3P48794 Zymoseptoria tritici 56 1e-81 302
WERAM-Lem-0022 CBX90465 Leptosphaeria maculans 55 1e-80 298
WERAM-Asc-0010 CADACLAP00002196 Aspergillus clavatus 56 1e-79 295
WERAM-Asn-0010 CADANIAP00001580 Aspergillus nidulans 54 2e-79 295
WERAM-Asf-0016 CADAFLAP00008126 Aspergillus flavus 56 2e-79 294
WERAM-Asfu-0032 CADAFUAP00007532 Aspergillus fumigatus 55 2e-79 294
WERAM-Phn-0009 SNOT_01206 Phaeosphaeria nodorum 55 5e-79 293
WERAM-Pyt-0032 EFQ88003 Pyrenophora teres 59 7e-79 292
WERAM-Pytr-0014 EDU46512 Pyrenophora triticirepentis 59 8e-79 292
WERAM-Nec-0015 EFNCRP00000002609 Neurospora crassa 49 9e-78 289
WERAM-Gag-0034 GGTG_10896T0 Gaeumannomyces graminis 53 2e-77 288
WERAM-Ved-0030 EGY16315 Verticillium dahliae 51 5e-77 286
WERAM-Map-0001 MAPG_00110T0 Magnaporthe poae 53 6e-77 286
WERAM-Mao-0026 MGG_09186T0 Magnaporthe oryzae 53 2e-76 284
WERAM-Coi-0033 EAS31415 Coccidioides immitis 52 2e-76 284
WERAM-Trr-0030 EGR47972 Trichoderma reesei 53 4e-76 283
WERAM-Trv-0008 EHK16031 Trichoderma virens 53 3e-75 280
WERAM-Scs-0007 EDN97054 Sclerotinia sclerotiorum 51 5e-74 276
WERAM-Asm-0230 ENSAMXP00000022237.1 Astyanax mexicanus 39 2e-73 275
WERAM-Fuo-0032 FOXG_11150P0 Fusarium oxysporum 51 5e-73 273
WERAM-Ten-0118 ENSTNIP00000012969.1 Tetraodon nigroviridis 39 3e-72 271
WERAM-Pof-0260 ENSPFOP00000023871.1 Poecilia formosa 39 4e-72 270
WERAM-Anc-0086 ENSACAP00000008291.3 Anolis carolinensis 38 2e-71 268
WERAM-Orn-0150 ENSONIP00000015836.1 Oreochromis niloticus 38 2e-71 268
WERAM-Leo-0132 ENSLOCP00000016408.1 Lepisosteus oculatus 38 2e-71 268
WERAM-Tar-0036 ENSTRUP00000008201.1 Takifugu rubripes 38 4e-71 267
WERAM-Dar-0206 ENSDARP00000133766.1 Danio rerio 38 5e-71 266
WERAM-Otg-0094 ENSOGAP00000008322.2 Otolemur garnettii 40 5e-71 266
WERAM-Xim-0047 ENSXMAP00000004480.1 Xiphophorus maculatus 38 5e-71 266
WERAM-Ova-0145 ENSOARP00000014697.1 Ovis aries 39 1e-70 265
WERAM-Mum-0090 ENSMUSP00000030102.5 Mus musculus 39 1e-70 265
WERAM-Usm-0031 UM05449P0 Ustilago maydis 58 2e-70 265
WERAM-Lac-0147 ENSLACP00000016939.1 Latimeria chalumnae 38 2e-70 265
WERAM-Nol-0191 ENSNLEP00000021460.1 Nomascus leucogenys 38 2e-70 265
WERAM-Chs-0109 ENSCSAP00000005249.1 Chlorocebus sabaeus 38 2e-70 264
WERAM-Paa-0206 ENSPANP00000019220.1 Papio anubis 38 2e-70 264
WERAM-Cap-0049 ENSCPOP00000004232.2 Cavia porcellus 38 2e-70 264
WERAM-Hos-0273 ENSP00000442382.1 Homo sapiens 39 2e-70 264
WERAM-Orc-0061 ENSOCUP00000005900.3 Oryctolagus cuniculus 38 2e-70 264
WERAM-Poa-0180 ENSPPYP00000021530.1 Pongo abelii 38 3e-70 264
WERAM-Gog-0004 ENSGGOP00000000499.2 Gorilla gorilla 38 3e-70 264
WERAM-Fia-0137 ENSFALP00000011104.1 Ficedula albicollis 38 3e-70 264
WERAM-Ocp-0126 ENSOPRP00000013322.1 Ochotona princeps 38 3e-70 264
WERAM-Fec-0092 ENSFCAP00000007646.3 Felis catus 38 3e-70 264
WERAM-Mup-0012 ENSMPUP00000001247.1 Mustela putorius furo 38 4e-70 263
WERAM-Chg-0034 EAQ86808 Chaetomium globosum 52 4e-70 263
WERAM-Vip-0025 ENSVPAP00000002379.1 Vicugna pacos 39 5e-70 263
WERAM-Loa-0124 ENSLAFP00000011582.3 Loxodonta africana 39 5e-70 263
WERAM-Orla-0066 ENSORLP00000008475.1 Oryzias latipes 39 8e-70 262
WERAM-Aim-0007 ENSAMEP00000000397.1 Ailuropoda melanoleuca 38 9e-70 262
WERAM-Gam-0058 ENSGMOP00000005645.1 Gadus morhua 37 9e-70 262
WERAM-Tut-0165 ENSTTRP00000014088.1 Tursiops truncatus 38 1e-69 262
WERAM-Ict-0165 ENSSTOP00000017819.1 Ictidomys tridecemlineatus 39 1e-69 262
WERAM-Pat-0194 ENSPTRP00000042061.3 Pan troglodytes 38 1e-69 262
WERAM-Ran-0213 ENSRNOP00000066803.1 Rattus norvegicus 38 1e-69 262
WERAM-Caj-0184 ENSCJAP00000031985.2 Callithrix jacchus 38 1e-69 262
WERAM-Eqc-0110 ENSECAP00000012427.1 Equus caballus 38 1e-69 262
WERAM-Mod-0135 ENSMODP00000019003.3 Monodelphis domestica 37 1e-69 261
WERAM-Mim-0121 ENSMICP00000012586.1 Microcebus murinus 38 1e-69 261
WERAM-Mam-0106 ENSMMUP00000016650.2 Macaca mulatta 38 2e-69 261
WERAM-Ora-0068 ENSOANP00000010212.2 Ornithorhynchus anatinus 36 2e-69 261
WERAM-Gaga-0161 ENSGALP00000032199.3 Gallus gallus 38 2e-69 261
WERAM-Bot-0143 ENSBTAP00000020586.4 Bos taurus 38 2e-69 261
WERAM-Caf-0195 ENSCAFP00000027917.3 Canis familiaris 38 2e-69 261
WERAM-Myl-0095 ENSMLUP00000007906.2 Myotis lucifugus 38 2e-69 261
WERAM-Gaa-0172 ENSGACP00000021016.1 Gasterosteus aculeatus 38 2e-69 261
WERAM-Pes-0136 ENSPSIP00000016220.1 Pelodiscus sinensis 38 3e-69 261
WERAM-Ptv-0162 ENSPVAP00000013602.1 Pteropus vampyrus 37 3e-69 260
WERAM-Tub-0094 ENSTBEP00000011062.1 Tupaia belangeri 37 4e-69 260
WERAM-Sah-0098 ENSSHAP00000011151.1 Sarcophilus harrisii 36 1e-68 259
WERAM-Drm-0085 FBpp0291264 Drosophila melanogaster 36 1e-68 259
WERAM-Meg-0063 ENSMGAP00000006048.2 Meleagris gallopavo 38 1e-68 259
WERAM-Xet-0028 ENSXETP00000007538.3 Xenopus tropicalis 38 1e-68 258
WERAM-Sus-0033 ENSSSCP00000005588.2 Sus scrofa 38 3e-68 257
WERAM-Chh-0006 ENSCHOP00000000484.1 Choloepus hoffmanni 39 3e-68 257
WERAM-Dan-0145 ENSDNOP00000027472.1 Dasypus novemcinctus 37 6e-68 256
WERAM-Tag-0013 ENSTGUP00000000796.1 Taeniopygia guttata 37 1e-67 255
WERAM-Miv-0023 MVLG_03426T0 Microbotryum violaceum 48 3e-67 254
WERAM-Spr-0038 CBQ69859 Sporisorium reilianum 57 4e-67 253
WERAM-Crn-0034 AAW45261 Cryptococcus neoformans 54 4e-67 253
WERAM-Pug-0013 EFP80553 Puccinia graminis 58 6e-66 249
WERAM-Lab-0019 EDR09176 Laccaria bicolor 50 1e-65 248
WERAM-Mel-0011 EGG02391 Melampsora laricipopulina 58 1e-63 241
WERAM-Ect-0041 ENSETEP00000004107.1 Echinops telfairi 38 3e-63 241
WERAM-Soa-0057 ENSSARP00000005556.1 Sorex araneus 38 8e-63 239
WERAM-Cii-0012 ENSCINP00000004028.3 Ciona intestinalis 49 8e-63 239
WERAM-Ere-0016 ENSEEUP00000000943.1 Erinaceus europaeus 49 2e-60 231
WERAM-Anp-0103 ENSAPLP00000012119.1 Anas platyrhynchos 40 8e-59 226
WERAM-Dio-0105 ENSDORP00000010572.1 Dipodomys ordii 47 2e-58 225
Created Date 25-Jun-2016