WERAM Information

Tag Content
WERAM ID WERAM-Art-0126
Ensembl Protein ID AT5G22650.1
Uniprot Accession Q56WH4; HDT2_ARATH; O49209; Q9FNJ6
Genbank Protein ID NP_197657.3; NP_851056.1
Protein Name Histone deacetylase HDT2
Genbank Nucleotide ID NM_122171.3; NM_180725.2
Gene Name HDT2;HD2;HD2B;HDA4;At5g22650;MDJ22.7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G22650 AT5G22650.1 AT5G22650.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC HD2 H2A; H2B; H3; H4 K 26689639
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC HD2 3.00e-83 305
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)		 Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Domain Profile
  HDAC HD2
Query: 1   MEFWGVAVTPKNATKVTPEEDSLVHISQASLDCTVKSGESVVLSVTVGGAKLVIGTLSQD 60
           MEFWGVAVTPKNATKVTPEEDSLVHISQASLDCTVKSGESVVLSVTVGGAKLVIGTLSQD
Sbjct: 1   MEFWGVAVTPKNATKVTPEEDSLVHISQASLDCTVKSGESVVLSVTVGGAKLVIGTLSQD 60
Query: 61  KFPQISFDLVFDKEFELSHSGTKANVHFIGYKSPNIEQDDFTSSDXXXXXXXXXXXXXXX 120
           KFPQISFDLVFDKEFELSHSGTKANVHFIGYKSPNIEQDDFTSSD               
Sbjct: 61  KFPQISFDLVFDKEFELSHSGTKANVHFIGYKSPNIEQDDFTSSDDEDVPEAVPAPAPTA 120
Query: 121 XXXXXXXXXXXXKADTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKGMDVXX 180
                       KADT                                     KGMDV  
Sbjct: 121 VTANGNAGAAVVKADTKPKAKPAEVKPAEEKPESDEEDESDDEDESEEDDDSEKGMDVDE 180
Query: 181 XXXXXXXXXXXXXXXXXXTPKKPEPINKKRPNESVSKTPVSGXXXXXXXXXXSTPQKTEE 240
                             TPKKPEPINKKRPNESVSKTPVSG          STPQKTEE
Sbjct: 181 DDSDDDEEEDSEDEEEEETPKKPEPINKKRPNESVSKTPVSGKKAKPAAAPASTPQKTEE 240
Query: 241 KKKGGHTATPHPAKKGGKSPVNA 263
           KKKGGHTATPHPAKKGGKSPVNA
Sbjct: 241 KKKGGHTATPHPAKKGGKSPVNA 263
Protein Sequence
(Fasta)		MEFWGVAVTP KNATKVTPEE DSLVHISQAS LDCTVKSGES VVLSVTVGGA KLVIGTLSQD 60
KFPQISFDLV FDKEFELSHS GTKANVHFIG YKSPNIEQDD FTSSDDEDVP EAVPAPAPTA 120
VTANGNAGAA VVKADTKPKA KPAEVKPAEE KPESDEEDES DDEDESEEDD DSEKGMDVDE 180
DDSDDDEEED SEDEEEEETP KKPEPINKKR PNESVSKTPV SGKKAKPAAA PASTPQKTEE 240
KKKGGHTATP HPAKKGGKSP VNANQSPKSG GQSSGGNNNK KPFNSGKQFG GSNNKGSNKG 300
KGKGRA 306
Nucleotide Sequence
(Fasta)		ATAAAATAGC CCCAAACCCA CTGCCTCTTT CACTGCAATT TCTCTCTTTC GCTTCTAAAA 60
AAAAACCTAA CAACCTCTCT TCTCTCTTCC TCGTTCAACA ACAATGGAGT TCTGGGGAGT 120
TGCGGTGACA CCAAAAAACG CTACTAAGGT GACTCCTGAA GAAGACAGCC TTGTCCACAT 180
TTCTCAGGCT TCACTTGACT GCACAGTGAA ATCTGGAGAA TCTGTGGTTT TGAGTGTGAC 240
TGTTGGTGGG GCTAAACTTG TTATTGGAAC ACTTTCACAA GACAAGTTCC CTCAGATTAG 300
CTTTGATTTG GTTTTTGATA AAGAGTTTGA GCTTTCACAC AGCGGTACCA AAGCAAATGT 360
TCATTTCATT GGCTACAAAT CCCCCAACAT CGAGCAGGAT GACTTCACTA GTTCGGATGA 420
TGAGGATGTT CCTGAAGCTG TTCCTGCTCC TGCCCCTACT GCTGTTACTG CCAACGGAAA 480
TGCTGGAGCA GCTGTTGTCA AGGCTGACAC AAAGCCAAAG GCCAAACCTG CCGAAGTGAA 540
GCCTGCAGAA GAGAAGCCTG AATCAGACGA GGAAGATGAG TCTGATGATG AAGATGAGTC 600
TGAAGAGGAT GATGACTCTG AGAAAGGAAT GGATGTTGAT GAAGATGACT CAGATGATGA 660
CGAGGAGGAG GATTCTGAGG ATGAAGAAGA GGAGGAGACT CCTAAGAAGC CTGAGCCAAT 720
CAACAAGAAG AGGCCAAATG AATCTGTATC CAAAACACCC GTCTCTGGAA AGAAGGCAAA 780
ACCAGCAGCA GCACCAGCTT CTACTCCTCA GAAGACAGAA GAGAAGAAGA AAGGAGGACA 840
CACCGCCACA CCACACCCAG CTAAGAAGGG TGGAAAGTCT CCTGTGAATG CTAACCAGAG 900
CCCCAAGTCT GGAGGTCAAT CATCCGGTGG TAACAACAAC AAGAAGCCAT TCAACTCAGG 960
CAAACAATTT GGTGGTTCCA ACAACAAGGG TTCTAACAAG GGCAAGGGAA AGGGTAGAGC 1020
TTAAGGACGT GGATCAAGGA GAGGTTTTGG GTTTTCGAGT AGATGATGAA AACACTTGGA 1080
AGTGTGGTTT TGGATTTTTA TCTTATTTTA TTAGTATAAC TTGTTATCGG ATGAGCTATT 1140
TTGAGTATTT GCAATTTCTA CTTTCCTATG TAATTCAGTA TATGAATATT TGCTGAAATG 1200
AGAAAGAAGA CTCGAATTGC AAACACAAAT TGAGTTTATT ACT 1244
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro
PROSITE
Pfam
Gene Ontology

GO:0005618--C:cell wall
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005730--C:nucleolus
GO:0005774--C:vacuolar membrane
GO:0004407--F:histone deacetylase activity
GO:0009294--P:DNA mediated transformation
GO:0016575--P:histone deacetylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0009944--P:polarity specification of adaxial/abaxial axis
GO:0010162--P:seed dormancy process
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0013 Al_scaffold_0006_2135 Arabidopsis lyrata 75 6e-42 168
WERAM-Brr-0103 Bra020209.1-P Brassica rapa 67 1e-31 134
WERAM-Bro-0028 Bo2g024240.1 Brassica oleracea 69 1e-31 134
WERAM-Mua-0006 GSMUA_Achr10P04780_001 Musa acuminata 50 4e-25 112
WERAM-Ors-0052 OS05T0597100-01 Oryza sativa 54 1e-24 110
WERAM-Ori-0055 BGIOSGA017430-PA Oryza indica 54 1e-24 110
WERAM-Orbr-0066 OB05G35770.1 Oryza brachyantha 52 1e-24 110
WERAM-Viv-0052 VIT_08s0007g03940.t01 Vitis vinifera 57 2e-24 110
WERAM-Tru-0046 TRIUR3_21067-P1 Triticum urartu 51 8e-24 108
WERAM-Hov-0097 MLOC_70585.1 Hordeum vulgare 54 2e-23 106
WERAM-Thc-0115 EOY33573 Theobroma cacao 50 6e-23 105
WERAM-Aet-0097 EMT09079 Aegilops tauschii 52 2e-22 103
WERAM-Sot-0024 PGSC0003DMT400021644 Solanum tuberosum 52 2e-22 103
WERAM-Sol-0131 Solyc10g085560.1.1 Solanum lycopersicum 53 2e-22 103
WERAM-Orp-0054 OPUNC05G25830.1 Oryza punctata 55 4e-22 102
WERAM-Orb-0056 OBART05G28290.1 Oryza barthii 55 4e-22 102
WERAM-Sei-0085 Si022778m Setaria italica 53 4e-22 102
WERAM-Lep-0059 LPERR05G23920.1 Leersia perrieri 54 2e-21 100
WERAM-Sob-0059 Sb03g043350.1 Sorghum bicolor 48 2e-21 100
WERAM-Orl-0054 KN539082.1_FGP007 Oryza longistaminata 49 3e-21 100
WERAM-Pot-0109 POPTR_0009s15160.1 Populus trichocarpa 50 3e-21 99.8
WERAM-Prp-0078 EMJ06874 Prunus persica 48 3e-21 99.8
WERAM-Met-0051 KEH38943 Medicago truncatula 49 1e-20 97.8
WERAM-Zem-0062 GRMZM2G100146_P01 Zea mays 52 2e-20 97.1
WERAM-Glm-0023 GLYMA03G34850.3 Glycine max 53 2e-20 97.1
WERAM-Brd-0043 BRADI2G14120.1 Brachypodium distachyon 51 2e-17 87.0
WERAM-Tra-0342 TRAES3BF048700110CFD_t1 Triticum aestivum 46 2e-17 86.7
WERAM-Org-0014 ORGLA01G0351500.1 Oryza glaberrima 41 1e-15 80.9
WERAM-Php-0037 PP1S183_93V6.3 Physcomitrella patens 39 1e-14 78.2
WERAM-Sem-0061 EFJ07202 Selaginella moellendorffii 40 3e-14 76.6
WERAM-Orr-0013 ORUFI01G44570.1 Oryza rufipogon 43 4e-14 76.3
WERAM-Orni-0013 ONIVA01G46280.1 Oryza nivara 43 4e-14 76.3
WERAM-Orgl-0013 OGLUM01G45450.3 Oryza glumaepatula 37 1e-11 68.2
WERAM-Amt-0052 ERN12770 Amborella trichopoda 51 1e-09 61.2
WERAM-Orm-0015 OMERI01G38270.1 Oryza meridionalis 34 9e-09 58.2
Created Date 25-Jun-2016