WERAM Information

Tag Content
WERAM ID WERAM-Drm-0064
Ensembl Protein ID FBpp0293897
Uniprot Accession Q9VH08; SIR6_DROME; F3YD73
Genbank Protein ID NP_649990.2
Protein Name NAD-dependent protein deacetylase Sirt6
Genbank Nucleotide ID NM_141733.3
Gene Name SIRT6;CG6284
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0037802 FBtr0305358 FBpp0293897
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type K 12466527
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 3.10e-61 207.6 36 274
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span.
Domain Profile
  HDAC SIR2
     SIR2.txt   2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelekkgkllrly 99 
                  +la+l+kks ++v++tGAGiStsaGIPDFR+++G+++  +k+e p+++  fd                      +a+PtktH+++  l ++g +++++
  FBpp0293897  36 ELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEKPDFNVSFD----------------------EARPTKTHMAIIALIESGYVQYVI 111
                  799***********************************99997777666555......................569********************* PP
     SIR2.txt 100 tQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCek........Ck.gvlkpdivffgenlpeefleeveedlkead 188
                  +QNiDgL++k+gl+++ l+elHG+++ ++C+kC+++f     +e++ +k+  + C++        C+ g+l+++++ ++++lpe++le+   + + ad
  FBpp0293897 112 SQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSsmdskgrsCRsGILYDNVLDWEHDLPENDLEMGVMHSTVAD 209
                  *************************************************99999*9988888888866****************************** PP
     SIR2.txt 189 lllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkllglee 253
                  l + lGt+l++ p+ +l++k  k + + +++nl+++k+dk+a+l +++++d v+++++kllg+e+
  FBpp0293897 210 LNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYVDVVLSKVCKLLGVEI 274
                  *************************************************************9876 PP
Protein Sequence
(Fasta)		MSCNYADGLS AYDNKGILGA PESFDSDEVV AEKCQELAEL IKKSGHVVLH TGAGISTSAG 60
IPDFRGPKGV WTLEEKGEKP DFNVSFDEAR PTKTHMAIIA LIESGYVQYV ISQNIDGLHL 120
KSGLDRKYLS ELHGNIYIEQ CKKCRRQFVS PSAVETVGQK SLQRACKSSM DSKGRSCRSG 180
ILYDNVLDWE HDLPENDLEM GVMHSTVADL NIALGTTLQI VPSGDLPLKN LKCGGKFVIC 240
NLQPTKHDKK ANLIISSYVD VVLSKVCKLL GVEIPEYSEA SDPTKQSKPM EWTIPTSNVN 300
TFHRQYKKYV KDSKIESKAK KTKYT 325
Nucleotide Sequence
(Fasta)		ATAAACAATA AAATCTCGAT GGACTCATTT AGCCGTACAA AATATAAACA AATTAATACC 60
AAAAAGACAT AATAGTCGCT TTTGAAGTAG ATCAAACTTT TATCAAACCA TGAGCTGCAA 120
CTACGCGGAT GGATTGTCAG CCTACGACAA CAAGGGAATT TTGGGAGCAC CAGAGAGTTT 180
CGACAGCGAT GAGGTTGTGG CCGAAAAGTG CCAGGAATTG GCTGAATTGA TCAAGAAATC 240
GGGACACGTT GTCCTCCACA CGGGAGCTGG GATCAGTACG TCTGCAGGAA TTCCGGATTT 300
CCGCGGACCC AAGGGCGTTT GGACCCTGGA GGAGAAGGGC GAGAAGCCGG ACTTCAATGT 360
TTCCTTCGAT GAAGCCAGAC CAACTAAAAC CCACATGGCT ATCATAGCCC TGATTGAAAG 420
TGGCTATGTG CAGTACGTAA TCTCACAGAA TATTGATGGT CTCCACTTGA AATCCGGACT 480
GGATCGGAAG TATCTTTCCG AATTGCACGG CAACATTTAC ATCGAACAGT GTAAGAAATG 540
CAGACGGCAA TTTGTGAGCC CATCTGCCGT GGAAACAGTG GGTCAAAAAT CCCTGCAACG 600
TGCCTGCAAG TCTTCAATGG ATAGCAAAGG TCGTAGCTGT AGATCGGGAA TCCTATACGA 660
TAACGTTCTG GACTGGGAGC ACGATCTTCC CGAAAACGAC CTCGAAATGG GTGTGATGCA 720
CTCCACCGTC GCTGACCTAA ATATTGCGCT TGGAACCACT TTGCAGATCG TTCCCAGCGG 780
AGACCTTCCT TTAAAGAATC TAAAATGCGG TGGAAAATTT GTCATTTGTA ATCTGCAGCC 840
CACAAAACAT GACAAAAAGG CTAACTTAAT CATATCCAGT TATGTGGATG TGGTTTTGTC 900
CAAAGTTTGT AAACTATTGG GTGTTGAGAT ACCCGAATAT TCGGAGGCTT CCGATCCTAC 960
AAAGCAGTCC AAGCCAATGG AGTGGACAAT ACCCACAAGC AATGTAAATA CCTTTCACAG 1020
ACAATATAAA AAGTATGTAA AAGACTCAAA AATTGAATCT AAAGCTAAGA AAACAAAGTA 1080
CACGTAAGTC AAATGTTTAA AGTTACTAAT ATCT 1115
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-1185--Reference proteome
KW-0862--Zinc
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0005634--C:nucleus
GO:0004407--F:histone deacetylase activity
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
GO:0008340--P:determination of adult lifespan
GO:0016575--P:histone deacetylation
GO:0031937--P:positive regulation of chromatin silencing
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Xim-0231 ENSXMAP00000019352.1 Xiphophorus maculatus 55 2e-87 320
WERAM-Pof-0157 ENSPFOP00000012793.2 Poecilia formosa 55 2e-87 319
WERAM-Ict-0164 ENSSTOP00000015068.1 Ictidomys tridecemlineatus 53 2e-86 316
WERAM-Gaa-0163 ENSGACP00000020196.1 Gasterosteus aculeatus 55 2e-86 316
WERAM-Lac-0065 ENSLACP00000008822.2 Latimeria chalumnae 55 2e-86 316
WERAM-Orn-0127 ENSONIP00000012860.1 Oreochromis niloticus 55 2e-86 316
WERAM-Tar-0090 ENSTRUP00000017073.1 Takifugu rubripes 54 3e-85 312
WERAM-Mam-0185 ENSMMUP00000026241.2 Macaca mulatta 53 4e-85 311
WERAM-Paa-0028 ENSPANP00000011086.1 Papio anubis 52 3e-84 309
WERAM-Pat-0085 ENSPTRP00000017501.2 Pan troglodytes 52 3e-84 309
WERAM-Gog-0100 ENSGGOP00000008641.2 Gorilla gorilla 52 3e-84 309
WERAM-Chs-0131 ENSCSAP00000006979.1 Chlorocebus sabaeus 52 4e-84 308
WERAM-Poa-0078 ENSPPYP00000010537.2 Pongo abelii 52 4e-84 308
WERAM-Mum-0135 ENSMUSP00000048971.8 Mus musculus 46 5e-84 308
WERAM-Soa-0094 ENSSARP00000008710.1 Sorex araneus 53 5e-84 308
WERAM-Hos-0033 ENSP00000337332.1 Homo sapiens 52 5e-84 308
WERAM-Caj-0156 ENSCJAP00000027893.2 Callithrix jacchus 52 7e-84 307
WERAM-Ran-0038 ENSRNOP00000008758.3 Rattus norvegicus 52 8e-84 307
WERAM-Bot-0171 ENSBTAP00000026521.5 Bos taurus 53 1e-83 307
WERAM-Otg-0026 ENSOGAP00000001481.2 Otolemur garnettii 53 2e-83 306
WERAM-Mup-0054 ENSMPUP00000004703.1 Mustela putorius furo 52 2e-83 306
WERAM-Caf-0197 ENSCAFP00000028217.2 Canis familiaris 52 3e-83 305
WERAM-Gaga-0011 ENSGALP00000001888.3 Gallus gallus 52 3e-83 305
WERAM-Loa-0191 ENSLAFP00000023357.1 Loxodonta africana 52 7e-83 304
WERAM-Meg-0032 ENSMGAP00000002578.1 Meleagris gallopavo 52 1e-82 303
WERAM-Mod-0008 ENSMODP00000000983.1 Monodelphis domestica 52 2e-82 302
WERAM-Aim-0033 ENSAMEP00000002298.1 Ailuropoda melanoleuca 51 3e-82 302
WERAM-Sah-0106 ENSSHAP00000011597.1 Sarcophilus harrisii 52 5e-82 301
WERAM-Xet-0167 ENSXETP00000057383.2 Xenopus tropicalis 52 6e-82 301
WERAM-Gam-0126 ENSGMOP00000013105.1 Gadus morhua 52 2e-80 296
WERAM-Ova-0116 ENSOARP00000011370.1 Ovis aries 51 3e-80 295
WERAM-Sus-0098 ENSSSCP00000014344.2 Sus scrofa 51 4e-80 295
WERAM-Mae-0123 ENSMEUP00000012391.1 Macropus eugenii 51 2e-79 293
WERAM-Myl-0098 ENSMLUP00000007946.2 Myotis lucifugus 52 5e-77 285
WERAM-Fia-0011 ENSFALP00000000954.1 Ficedula albicollis 53 8e-77 284
WERAM-Cis-0072 ENSCSAVP00000015450.1 Ciona savignyi 49 4e-76 282
WERAM-Pes-0079 ENSPSIP00000009554.1 Pelodiscus sinensis 52 1e-75 280
WERAM-Prp-0059 EMJ12601 Prunus persica 47 4e-70 262
WERAM-Brr-0144 Bra028961.1-P Brassica rapa 43 4e-69 258
WERAM-Amt-0008 ERN05726 Amborella trichopoda 45 4e-69 258
WERAM-Bro-0046 Bo3g021360.1 Brassica oleracea 43 1e-68 257
WERAM-Brd-0122 BRADI5G02940.2 Brachypodium distachyon 44 2e-68 256
WERAM-Arl-0111 fgenesh2_kg.8__ 1477__ AT5G55760.1 Arabidopsis lyrata 48 3e-68 256
WERAM-Org-0043 ORGLA04G0042700.1 Oryza glaberrima 46 5e-68 255
WERAM-Pot-0016 POPTR_0001s37680.1 Populus trichocarpa 47 6e-68 254
WERAM-Art-0143 AT5G55760.1 Arabidopsis thaliana 48 1e-67 254
WERAM-Tra-0045 Traes_2AS_69329D634.2 Triticum aestivum 43 2e-67 253
WERAM-Sol-0101 Solyc07g065550.2.1 Solanum lycopersicum 46 2e-67 253
WERAM-Ors-0038 OS04T0271000-01 Oryza sativa 46 4e-67 252
WERAM-Ori-0050 BGIOSGA015454-PA Oryza indica 46 5e-67 251
WERAM-Orbr-0051 OB04G14570.1 Oryza brachyantha 45 1e-66 250
WERAM-Mua-0125 GSMUA_Achr8P24470_001 Musa acuminata 44 1e-66 250
WERAM-Met-0085 KEH34091 Medicago truncatula 47 1e-66 250
WERAM-Glm-0232 GLYMA18G08450.1 Glycine max 46 2e-66 249
WERAM-Sei-0037 Si010693m Setaria italica 46 3e-66 249
WERAM-Sob-0090 Sb06g020390.1 Sorghum bicolor 45 1e-65 247
WERAM-Orl-0053 KN539062.1_FGP005 Oryza longistaminata 47 7e-65 244
WERAM-Lep-0045 LPERR04G03890.1 Leersia perrieri 46 1e-64 243
WERAM-Aet-0057 EMT21754 Aegilops tauschii 43 4e-64 242
WERAM-Zem-0044 GRMZM2G058573_P01 Zea mays 45 6e-64 241
WERAM-Php-0065 PP1S272_33V6.1 Physcomitrella patens 45 2e-63 240
WERAM-Viv-0122 VIT_19s0015g00570.t01 Vitis vinifera 45 3e-62 236
WERAM-Sot-0070 PGSC0003DMT400057382 Solanum tuberosum 48 1e-60 230
WERAM-Eqc-0160 ENSECAP00000016959.1 Equus caballus 38 2e-37 153
WERAM-Anp-0140 ENSAPLP00000015159.1 Anas platyrhynchos 36 4e-35 145
WERAM-Sem-0060 EFJ23112 Selaginella moellendorffii 27 2e-19 94.0
WERAM-Scp-0042 SPCC132.02.1:pep Schizosaccharomyces pombe 28 1e-17 87.8
WERAM-Chr-0008 EDP00705 Chlamydomonas reinhardtii 26 6e-17 85.5
WERAM-Zyt-0036 Mycgr3P98741 Zymoseptoria tritici 27 3e-16 83.2
WERAM-Trr-0018 EGR46788 Trichoderma reesei 30 5e-16 82.4
WERAM-Ast-0036 CADATEAP00009630 Aspergillus terreus 25 5e-16 82.4
WERAM-Caa-0033 KGT64755 Candida albicans 28 7e-16 82.0
WERAM-Dan-0202 ENSDNOP00000027446.1 Dasypus novemcinctus 31 8e-16 82.0
WERAM-Pyt-0039 EFQ86136 Pyrenophora teres 29 1e-15 81.3
WERAM-Crn-0031 AAW44797 Cryptococcus neoformans 30 3e-15 80.1
WERAM-Miv-0009 MVLG_01362T0 Microbotryum violaceum 29 6e-15 79.0
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 29 9e-15 78.6
WERAM-Cag-0026 CAG62123 Candida glabrata 27 9e-15 78.2
WERAM-Mao-0040 MGG_17827T0 Magnaporthe oryzae 29 1e-14 78.2
WERAM-Anc-0100 ENSACAP00000009519.3 Anolis carolinensis 28 1e-14 77.8
WERAM-Cap-0199 ENSCPOP00000018954.1 Cavia porcellus 31 1e-14 77.8
WERAM-Tub-0067 ENSTBEP00000008310.1 Tupaia belangeri 30 2e-14 77.4
WERAM-Fec-0035 ENSFCAP00000002455.2 Felis catus 29 2e-14 77.4
WERAM-Thc-0008 EOX92647 Theobroma cacao 24 3e-14 76.6
WERAM-Scj-0005 EEB06048 Schizosaccharomyces japonicus 25 4e-14 76.3
WERAM-Trv-0012 EHK19002 Trichoderma virens 29 4e-14 76.3
WERAM-Ptv-0186 ENSPVAP00000016701.1 Pteropus vampyrus 28 5e-14 75.9
WERAM-Nol-0170 ENSNLEP00000018956.1 Nomascus leucogenys 29 6e-14 75.5
WERAM-Coi-0012 EAS36287 Coccidioides immitis 24 9e-14 75.1
WERAM-Lem-0007 CBY02082 Leptosphaeria maculans 29 1e-13 74.7
WERAM-Orla-0002 ENSORLP00000000105.1 Oryzias latipes 27 1e-13 74.7
WERAM-Asfu-0001 CADAFUAP00000229 Aspergillus fumigatus 28 1e-13 74.7
WERAM-Orc-0194 ENSOCUP00000019306.2 Oryctolagus cuniculus 29 2e-13 74.3
WERAM-Ocp-0048 ENSOPRP00000004238.2 Ochotona princeps 29 2e-13 73.9
WERAM-Leo-0156 ENSLOCP00000018785.1 Lepisosteus oculatus 26 2e-13 73.9
WERAM-Asg-0028 AAS54472 Ashbya gossypii 26 2e-13 73.9
WERAM-Aso-0005 CADAORAP00000633 Aspergillus oryzae 22 2e-13 73.9
WERAM-Asf-0024 CADAFLAP00010064 Aspergillus flavus 22 2e-13 73.9
WERAM-Kop-0007 CAY68156 Komagataella pastoris 30 2e-13 73.6
WERAM-Fuo-0021 FOXG_06023P0 Fusarium oxysporum 27 2e-13 73.6
WERAM-Asni-0009 CADANGAP00002892 Aspergillus niger 28 3e-13 73.6
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 27 3e-13 73.2
WERAM-Dar-0078 ENSDARP00000051972.5 Danio rerio 27 3e-13 73.2
WERAM-Cii-0054 ENSCINP00000012226.3 Ciona intestinalis 27 3e-13 73.2
WERAM-Asn-0005 CADANIAP00000554 Aspergillus nidulans 25 5e-13 72.8
WERAM-Asm-0215 ENSAMXP00000020722.1 Astyanax mexicanus 31 7e-13 72.0
WERAM-Pytr-0009 EDU41553 Pyrenophora triticirepentis 28 1e-12 71.2
WERAM-Ora-0041 ENSOANP00000006568.2 Ornithorhynchus anatinus 26 3e-12 70.1
WERAM-Osl-0012 ABO98065 Ostreococcus lucimarinus 29 3e-12 70.1
WERAM-Orp-0109 OPUNC12G04720.1 Oryza punctata 33 4e-12 69.7
WERAM-Asc-0026 CADACLAP00005809 Aspergillus clavatus 25 5e-12 69.3
WERAM-Tut-0151 ENSTTRP00000012839.1 Tursiops truncatus 35 5e-12 68.9
WERAM-Orm-0102 OMERI12G03010.1 Oryza meridionalis 33 6e-12 68.9
WERAM-Lab-0008 EDR12994 Laccaria bicolor 25 8e-12 68.6
WERAM-Orr-0119 ORUFI12G05460.1 Oryza rufipogon 33 8e-12 68.6
WERAM-Cae-0024 F46G10.3 Caenorhabditis elegans 24 9e-12 68.2
WERAM-Kll-0017 CAH00978 Kluyveromyces lactis 28 9e-12 68.2
WERAM-Mel-0010 EGG12163 Melampsora laricipopulina 29 1e-11 68.2
WERAM-Pem-0044 ENSPMAP00000005386.1 Petromyzon marinus 28 1e-11 67.8
WERAM-Pug-0030 EFP89251 Puccinia graminis 28 2e-11 67.4
WERAM-Ten-0144 ENSTNIP00000015099.1 Tetraodon nigroviridis 30 2e-11 67.0
Created Date 25-Jun-2016