WERAM Information

Tag Content
WERAM ID WERAM-Scp-0042
Ensembl Protein ID SPCC132.02.1:pep
Uniprot Accession Q9USN7; HST2_SCHPO
Genbank Protein ID NP_588147.1
Protein Name NAD-dependent protein deacetylase hst2
Genbank Nucleotide ID NM_001023136.2
Gene Name HST2;SPCC132.02
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPCC132.02 SPCC132.02.1 SPCC132.02.1:pep
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type H3K9 K 12466527
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 8.40e-93 308.5 17 270
Organism Schizosaccharomyces pombe
NCBI Taxa ID 284812
Functional Description
(View)		 NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
Domain Profile
  HDAC SIR2
          SIR2.txt   2 klakllk..kskkivvltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelek 91 
                       k+a+l+k  k+kki+v++GAGiSt+aGIPDFRs ++G+y++l++ +lp++ea+fdl++frk+p++fy+la+el+p ++++Pt+tHyf+++l++
  SPCC132.02.1:pep  17 KVASLIKegKVKKICVMVGAGISTAAGIPDFRSpETGIYNNLQRFNLPYAEAVFDLSYFRKNPRPFYELAHELMP-EKYRPTYTHYFIRLLHD 108
                       7889999889*****************************************************************.***************** PP
          SIR2.txt  92 kgkllrlytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCekCkgvlkpdivffgenlpeefleeveedl 184
                       k++l+++ytQNiD+Ler ag++++ l+e+HGs++ ++C++C +  ++e +++ +++k +vpkC++Ckg++kp ivf+ge lp++f+e++e+d+
  SPCC132.02.1:pep 109 KRLLQKCYTQNIDTLERLAGVPDKALIEAHGSFQYSRCIECYEMAETEYVRACIMQK-QVPKCNSCKGLIKPMIVFYGEGLPMRFFEHMEKDT 200
                       *******************************************************99.9********************************** PP
          SIR2.txt 185 keadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevk..adkladlkllgdcdevveellkllglee 253
                       k +d+ lv+GtSl v+p+a+l+ ++v++k++++l+n+e+ +   ++++d+ +lgdcd+ v++l+kllg+++
  SPCC132.02.1:pep 201 KVCDMALVIGTSLLVHPFADLP-EIVPNKCQRVLINREPAGdfGERKKDIMILGDCDSQVRALCKLLGWSD 270
                       **********************.******************9889************************86 PP
Protein Sequence
(Fasta)		MVKNTVKHVD SSKHLEKVAS LIKEGKVKKI CVMVGAGIST AAGIPDFRSP ETGIYNNLQR 60
FNLPYAEAVF DLSYFRKNPR PFYELAHELM PEKYRPTYTH YFIRLLHDKR LLQKCYTQNI 120
DTLERLAGVP DKALIEAHGS FQYSRCIECY EMAETEYVRA CIMQKQVPKC NSCKGLIKPM 180
IVFYGEGLPM RFFEHMEKDT KVCDMALVIG TSLLVHPFAD LPEIVPNKCQ RVLINREPAG 240
DFGERKKDIM ILGDCDSQVR ALCKLLGWSD ELEKLIDTSV ETLTEEISLL SVDSTIEKNA 300
SEQKKDDNSV NPFTKIEEKK KDEVTLLVSD DE 332
Nucleotide Sequence
(Fasta)		GTTCATATCT GAGAATTTTA AGTGATCCAA TTTTTGAAAG AGTTTGAGTT GGGATTTTTA 60
AGGTAAATCG ATTATTGGCT TGCTTTGGTT GTTCTCAGAA ATTCGACAAT GGTGAAAAAC 120
ACTGTTAAAC ACGTCGACTC TTCCAAGCAT TTAGAGAAAG TTGCATCCTT AATCAAAGAA 180
GGAAAAGTAA AGAAAATATG TGTTATGGTT GGTGCAGGGA TCAGCACTGC AGCAGGAATC 240
CCTGATTTTC GAAGCCCTGA GACTGGAATT TACAATAATT TACAAAGATT TAATCTTCCT 300
TACGCAGAAG CTGTTTTTGA TCTATCTTAT TTTCGAAAAA ATCCGCGTCC ATTCTACGAA 360
TTGGCTCACG AATTGATGCC TGAAAAGTAT AGACCAACTT ATACTCATTA TTTTATACGC 420
CTTTTACATG ATAAAAGGTT ACTACAAAAA TGTTATACCC AAAATATTGA TACCTTGGAG 480
CGTTTGGCAG GTGTGCCTGA CAAAGCTCTG ATTGAAGCAC ATGGCTCTTT CCAATACAGC 540
CGCTGTATTG AATGTTACGA AATGGCGGAA ACGGAGTATG TTAGAGCATG TATTATGCAA 600
AAACAGGTCC CTAAATGCAA CAGTTGCAAA GGTCTCATCA AACCAATGAT TGTGTTTTAT 660
GGCGAGGGAT TACCAATGCG TTTCTTCGAG CACATGGAAA AGGACACAAA AGTCTGTGAT 720
ATGGCACTGG TAATTGGAAC AAGTTTACTT GTTCATCCAT TCGCGGATTT GCCTGAAATA 780
GTGCCAAATA AATGTCAACG AGTTTTGATT AATCGAGAAC CAGCTGGCGA CTTTGGGGAG 840
AGAAAAAAGG ATATCATGAT ATTGGGGGAT TGTGATTCCC AAGTACGTGC GTTATGTAAA 900
CTATTAGGAT GGTCTGATGA ATTGGAAAAG TTGATTGATA CGAGTGTTGA AACGCTGACA 960
GAAGAAATAT CTTTACTTTC TGTTGACTCT ACAATAGAAA AGAATGCCTC TGAACAAAAG 1020
AAAGACGATA ACTCGGTCAA TCCTTTCACT AAAATAGAGG AGAAGAAAAA AGACGAGGTG 1080
ACGCTGTTAG TTTCTGATGA TGAATAGTTC AGTTATTCGG GAAATTTTCT ATATTGTCAT 1140
GATTAAAACT AGGAGATCCC TATATTTATT ATACTAAGAA AACGGAAATT CACGATTCGG 1200
TTTGATGAAT ATTTGAATCT ACACATACGA TTCGTTTTCT TTTAAACAAG TTTAAATACT 1260
TTTTTTTATT TCAGCAATTT TATAATATTT CCTTCCAGGC GTCCTTTTGA TTGCCTCTTA 1320
ACCATGAATC ATATTGCTCT CTTTATGAGT TGTATGCTGG GTTAAACTAA TGCGAAAAGG 1380
ATAACAAAAA GGGGGTTCTG TATACGATCT CGATCAAACT CATGAAGATG CCCTCGCATT 1440
TTCGTGAAAA TAACTTGCAT TTTTTTTAAA ATTGGCGTCC ATCTATATAC GCAATTTGGG 1500
TTATGAGAAA GTTGCGCTAG AATAATTGAT AATGGTTTCA AATTTACTGC ACTGTAATCT 1560
AATACAATCT TTGTCGAAAC CTTTTTTCTG TTCAGTTTGG AACATATAGT TCTGAAATGG 1620
GAGATTATTC ATTTTCATTT AATAAAACTT TGAATTATCC AAGAATTGGA AATAGGA 1678
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR017328--Sirtuin_class_I
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0034507--C:chromosome, centromeric outer repeat region
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031934--C:mating-type region heterochromatin
GO:0000790--C:nuclear chromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:1902377--C:nuclear rDNA heterochromatin
GO:1990707--C:nuclear subtelomeric heterochromatin
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0033558--F:protein deacetylase activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0030702--P:chromatin silencing at centromere
GO:1990141--P:chromatin silencing at centromere outer repeat region
GO:0000183--P:chromatin silencing at rDNA
GO:1990619--P:histone H3-K9 deacetylation
GO:0006476--P:protein deacetylation
GO:0060303--P:regulation of nucleosome density
GO:1900392--P:regulation of transport by negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Scj-0005 EEB06048 Schizosaccharomyces japonicus 62 1e-113 406
WERAM-Asn-0005 CADANIAP00000554 Aspergillus nidulans 48 3e-85 312
WERAM-Zyt-0001 Mycgr3P100618 Zymoseptoria tritici 57 6e-85 311
WERAM-Trr-0018 EGR46788 Trichoderma reesei 57 8e-85 311
WERAM-Trv-0012 EHK19002 Trichoderma virens 55 2e-83 306
WERAM-Pyt-0039 EFQ86136 Pyrenophora teres 49 2e-83 306
WERAM-Fuo-0021 FOXG_06023P0 Fusarium oxysporum 46 3e-83 305
WERAM-Asc-0030 CADACLAP00006830 Aspergillus clavatus 52 9e-83 304
WERAM-Mao-0040 MGG_17827T0 Magnaporthe oryzae 55 2e-82 303
WERAM-Ast-0036 CADATEAP00009630 Aspergillus terreus 52 6e-82 301
WERAM-Lab-0008 EDR12994 Laccaria bicolor 47 3e-80 296
WERAM-Caa-0033 KGT64755 Candida albicans 47 4e-79 291
WERAM-Gag-0013 GGTG_03219T0 Gaeumannomyces graminis 52 9e-79 291
WERAM-Asm-0153 ENSAMXP00000015326.1 Astyanax mexicanus 51 1e-78 290
WERAM-Pytr-0009 EDU41553 Pyrenophora triticirepentis 49 1e-78 290
WERAM-Lem-0007 CBY02082 Leptosphaeria maculans 54 2e-78 290
WERAM-Gaa-0170 ENSGACP00000020749.1 Gasterosteus aculeatus 51 2e-78 289
WERAM-Aso-0005 CADAORAP00000633 Aspergillus oryzae 52 1e-77 287
WERAM-Asf-0024 CADAFLAP00010064 Aspergillus flavus 52 1e-77 287
WERAM-Asni-0009 CADANGAP00002892 Aspergillus niger 52 1e-77 287
WERAM-Dar-0078 ENSDARP00000051972.5 Danio rerio 52 1e-77 286
WERAM-Asfu-0013 CADAFUAP00003392 Aspergillus fumigatus 52 3e-77 286
WERAM-Cis-0075 ENSCSAVP00000016120.1 Ciona savignyi 49 4e-77 285
WERAM-Gaga-0047 ENSGALP00000006674.4 Gallus gallus 51 9e-77 284
WERAM-Pem-0066 ENSPMAP00000007192.1 Petromyzon marinus 49 1e-76 283
WERAM-Anc-0100 ENSACAP00000009519.3 Anolis carolinensis 46 1e-76 283
WERAM-Leo-0013 ENSLOCP00000002849.1 Lepisosteus oculatus 51 2e-76 283
WERAM-Drm-0067 FBpp0310647 Drosophila melanogaster 46 2e-76 283
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 51 3e-76 282
WERAM-Pof-0038 ENSPFOP00000003166.2 Poecilia formosa 50 3e-76 282
WERAM-Xim-0026 ENSXMAP00000002581.1 Xiphophorus maculatus 49 4e-76 282
WERAM-Otg-0196 ENSOGAP00000020777.1 Otolemur garnettii 48 6e-76 281
WERAM-Ran-0088 ENSRNOP00000018861.5 Rattus norvegicus 50 7e-76 281
WERAM-Orc-0194 ENSOCUP00000019306.2 Oryctolagus cuniculus 49 8e-76 281
WERAM-Gam-0078 ENSGMOP00000008397.1 Gadus morhua 50 1e-75 280
WERAM-Dan-0202 ENSDNOP00000027446.1 Dasypus novemcinctus 50 1e-75 280
WERAM-Meg-0026 ENSMGAP00000002050.2 Meleagris gallopavo 50 2e-75 280
WERAM-Soa-0118 ENSSARP00000011447.1 Sorex araneus 50 2e-75 279
WERAM-Tar-0064 ENSTRUP00000012981.1 Takifugu rubripes 49 2e-75 279
WERAM-Kop-0007 CAY68156 Komagataella pastoris 48 3e-75 279
WERAM-Orn-0188 ENSONIP00000019610.1 Oreochromis niloticus 49 3e-75 279
WERAM-Pes-0119 ENSPSIP00000014160.1 Pelodiscus sinensis 49 4e-75 278
WERAM-Miv-0009 MVLG_01362T0 Microbotryum violaceum 50 6e-75 278
WERAM-Tub-0067 ENSTBEP00000008310.1 Tupaia belangeri 50 6e-75 278
WERAM-Anp-0145 ENSAPLP00000015403.1 Anas platyrhynchos 50 6e-75 278
WERAM-Fec-0035 ENSFCAP00000002455.2 Felis catus 50 7e-75 278
WERAM-Coi-0005 EAS35645 Coccidioides immitis 49 8e-75 277
WERAM-Chs-0045 ENSCSAP00000000306.1 Chlorocebus sabaeus 48 1e-74 277
WERAM-Mod-0192 ENSMODP00000026476.2 Monodelphis domestica 51 1e-74 276
WERAM-Paa-0135 ENSPANP00000006205.1 Papio anubis 48 1e-74 276
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 50 2e-74 276
WERAM-Caf-0076 ENSCAFP00000009649.3 Canis familiaris 49 2e-74 276
WERAM-Poa-0087 ENSPPYP00000011137.1 Pongo abelii 48 2e-74 276
WERAM-Pat-0091 ENSPTRP00000018763.5 Pan troglodytes 48 4e-74 275
WERAM-Hos-0274 ENSP00000489602.1 Homo sapiens 48 4e-74 275
WERAM-Gog-0026 ENSGGOP00000002451.2 Gorilla gorilla 48 4e-74 275
WERAM-Orla-0002 ENSORLP00000000105.1 Oryzias latipes 46 4e-74 275
WERAM-Pug-0030 EFP89251 Puccinia graminis 49 4e-74 275
WERAM-Cii-0054 ENSCINP00000012226.3 Ciona intestinalis 48 5e-74 275
WERAM-Xet-0018 ENSXETP00000005130.2 Xenopus tropicalis 48 6e-74 275
WERAM-Mup-0089 ENSMPUP00000008357.1 Mustela putorius furo 48 9e-74 274
WERAM-Ptv-0186 ENSPVAP00000016701.1 Pteropus vampyrus 48 2e-73 273
WERAM-Ict-0131 ENSSTOP00000013488.2 Ictidomys tridecemlineatus 50 2e-73 273
WERAM-Eqc-0017 ENSECAP00000002534.1 Equus caballus 50 3e-73 273
WERAM-Nol-0162 ENSNLEP00000017842.2 Nomascus leucogenys 48 3e-73 272
WERAM-Aim-0043 ENSAMEP00000003493.1 Ailuropoda melanoleuca 48 4e-73 272
WERAM-Sus-0110 ENSSSCP00000015488.2 Sus scrofa 50 4e-73 272
WERAM-Ten-0144 ENSTNIP00000015099.1 Tetraodon nigroviridis 48 4e-73 272
WERAM-Cap-0128 ENSCPOP00000010177.2 Cavia porcellus 46 5e-73 271
WERAM-Bot-0020 ENSBTAP00000002327.5 Bos taurus 43 6e-73 271
WERAM-Mum-0022 ENSMUSP00000072732.4 Mus musculus 46 2e-72 270
WERAM-Myl-0011 ENSMLUP00000000900.2 Myotis lucifugus 45 2e-72 269
WERAM-Caj-0143 ENSCJAP00000025706.2 Callithrix jacchus 46 4e-72 268
WERAM-Lac-0044 ENSLACP00000006675.2 Latimeria chalumnae 46 2e-71 266
WERAM-Ova-0058 ENSOARP00000006315.1 Ovis aries 43 3e-71 266
WERAM-Sah-0089 ENSSHAP00000010517.1 Sarcophilus harrisii 51 6e-71 265
WERAM-Fia-0142 ENSFALP00000011956.1 Ficedula albicollis 51 1e-70 264
WERAM-Tag-0102 ENSTGUP00000007081.1 Taeniopygia guttata 52 1e-70 264
WERAM-Crn-0031 AAW44797 Cryptococcus neoformans 41 1e-70 263
WERAM-Loa-0172 ENSLAFP00000017245.2 Loxodonta africana 46 2e-70 263
WERAM-Mel-0010 EGG12163 Melampsora laricipopulina 50 2e-70 263
WERAM-Asg-0028 AAS54472 Ashbya gossypii 46 2e-70 263
WERAM-Chg-0025 EAQ89546 Chaetomium globosum 51 1e-68 257
WERAM-Kll-0027 CAG98291 Kluyveromyces lactis 47 4e-68 255
WERAM-Cag-0026 CAG62123 Candida glabrata 41 4e-67 252
WERAM-Osl-0012 ABO98065 Ostreococcus lucimarinus 46 1e-66 250
WERAM-Sac-0046 YPL015C Saccharomyces cerevisiae 41 5e-66 248
WERAM-Mam-0216 ENSMMUP00000031121.2 Macaca mulatta 44 4e-64 242
WERAM-Ocp-0048 ENSOPRP00000004238.2 Ochotona princeps 49 8e-64 241
WERAM-Mim-0058 ENSMICP00000005750.1 Microcebus murinus 45 1e-63 240
WERAM-Usm-0036 UM05892P0 Ustilago maydis 39 7e-63 238
WERAM-Dio-0012 ENSDORP00000001437.1 Dipodomys ordii 43 2e-61 233
WERAM-Cym-0017 CML119CT Cyanidioschyzon merolae 41 7e-59 224
WERAM-Spr-0042 CBQ70931 Sporisorium reilianum 45 3e-58 223
WERAM-Tut-0151 ENSTTRP00000012839.1 Tursiops truncatus 43 8e-58 221
WERAM-Ved-0011 EGY21147 Verticillium dahliae 43 1e-54 210
WERAM-Mae-0115 ENSMEUP00000010974.1 Macropus eugenii 55 1e-54 210
WERAM-Ect-0047 ENSETEP00000005080.1 Echinops telfairi 41 2e-53 206
WERAM-Tas-0108 ENSTSYP00000011158.1 Tarsius syrichta 42 1e-51 200
WERAM-Ere-0116 ENSEEUP00000012184.1 Erinaceus europaeus 42 2e-51 200
WERAM-Cae-0022 R11A8.4a Caenorhabditis elegans 41 2e-50 196
WERAM-Yal-0031 CAG78100 Yarrowia lipolytica 39 7e-47 184
WERAM-Vip-0121 ENSVPAP00000010985.1 Vicugna pacos 42 1e-46 184
WERAM-Phn-0017 SNOT_06735 Phaeosphaeria nodorum 34 2e-43 174
Created Date 25-Jun-2016