| Tag |
Content |
| WERAM ID |
WERAM-Cae-0022 |
| Ensembl Protein ID |
R11A8.4a |
| Uniprot Accession |
Q21921; SIR2_CAEEL
|
| Genbank Protein ID |
NP_001255484.1
|
| Protein Name |
NAD-dependent protein deacetylase sir-2.1 |
| Genbank Nucleotide ID |
NM_001268555.1
|
| Gene Name |
SIR-2.1;SIR2;R11A8.4 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K9 |
K |
24835770
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
1.90e-89 |
300.1 |
138 |
381 |
|
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View)Functional Description
NAD-dependent deacetylase (By similarity). Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased life-span (PubMed:16777605, PubMed:16280150). May also regulate life-span independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticulum (ER) (PubMed:16256736, PubMed:16280150). Acts upstream of the nicotinic acid metabolism pathway, which may be linked to the regulation of longevity (PubMed:24077178). Plays a role in ascaroside-mediated longevity and stress resistance (PubMed:23509272). |
NAD-dependent deacetylase (By similarity). Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased life-span (PubMed:16777605, PubMed:16280150). May also regulate life-span independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticulum (ER) (PubMed:16256736, PubMed:16280150). Acts upstream of the nicotinic acid metabolism pathway, which may be linked to the regulation of longevity (PubMed:24077178). Plays a role in ascaroside-mediated longevity and stress resistance (PubMed:23509272).
|
| Domain Profile |
HDAC SIR2
SIR2.txt 3 lakllkkskkivvltGAGiStsaGIPDFRsseGlysklkke..elpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelekkgkllrlytQ 101
++l+k++k+i+vltGAG+S+s+GIPDFRs++G+y++l++e +lp+p+a+fd+++fr++p++fy++a+e++p g++ P++ H+f++ele++g+llr+ytQ
R11A8.4a 138 AVELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEfpDLPDPTAMFDIRYFRENPAPFYNFAREIFP-GQFVPSVSHRFIKELETSGRLLRNYTQ 237
57899************************************9*******************************.*************************** PP
SIR2.txt 102 NiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCekCkgvlkpdivffgenlpeefleeveedlkeadlllvlGtSlkvepv 202
NiD+Le+++g+k ++ve+HGs+++++Ct+C+++++++ei+e++ a +v +C++C+gv+kp+ivffge+l +ef+++v+ed++++dl++v+G+Slkv+pv
R11A8.4a 238 NIDTLEHQTGIK--RVVECHGSFSKCTCTRCGQKYDGNEIREEVLAM-RVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPV 335
***********9..*********************************.9**************************************************** PP
SIR2.txt 203 aslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkllg 250
a ++ ++v+k+vp++l+n+e ++ + +ad++llg+cd++++ ++ +lg
R11A8.4a 336 ALIP-HCVDKNVPQILINRESLP-HYNADIELLGNCDDIIRDICFSLG 381
*999.******************.9******************98877 PP
|
Protein Sequence
(Fasta) | MSRDSGNDSE VAVTHGEVQE ITEENPEIGS MHITQETDIS DAPETNTDSS RQRTESTTSV 60
SSESWQNNDE MMSNLRRAQR LLDDGATPLQ IIQQIFPDFN ASRIATMSEN AHFAILSDLL 120
ERAPVRQKLT NYNSLADAVE LFKTKKHILV LTGAGVSVSC GIPDFRSKDG IYARLRSEFP 180
DLPDPTAMFD IRYFRENPAP FYNFAREIFP GQFVPSVSHR FIKELETSGR LLRNYTQNID 240
TLEHQTGIKR VVECHGSFSK CTCTRCGQKY DGNEIREEVL AMRVAHCKRC EGVIKPNIVF 300
FGEDLGREFH QHVTEDKHKV DLIVVIGSSL KVRPVALIPH CVDKNVPQIL INRESLPHYN 360
ADIELLGNCD DIIRDICFSL GGSFTELITS YDSIMEQQGK TKSQKPSQNK RQLISQEDFL 420
NICMKEKRND DSSDEPTLKK PRMSVADDSM DSEKNNFQEI QKHKSEDDDD TRNSDDILKK 480
IKHPRLLSIT EMLHDNKCVA ISAHQTVFPG AECSFDLETL KLVRDVHHET HCESSCGSSC 540
SSNADSEANQ LSRAQSLDDF VLSDEDRKNT IHLDLQRADS CDGDFQYELS ETIDPETFSH 600
LCEEMRI 607Protein Fasta Sequence
>R11A8.4a|SIR-2.1;SIR2;R11A8.4|Caenorhabditis elegans
MSRDSGNDSEVAVTHGEVQEITEENPEIGSMHITQETDISDAPETNTDSSRQRTESTTSVSSESWQNNDEMMSNLRRAQRLLDDGATPLQIIQQIFPDFNASRIATMSENAHFAILSDLLERAPVRQKLTNYNSLADAVELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIKRVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRESLPHYNADIELLGNCDDIIRDICFSLGGSFTELITSYDSIMEQQGKTKSQKPSQNKRQLISQEDFLNICMKEKRNDDSSDEPTLKKPRMSVADDSMDSEKNNFQEIQKHKSEDDDDTRNSDDILKKIKHPRLLSITEMLHDNKCVAISAHQTVFPGAECSFDLETLKLVRDVHHETHCESSCGSSCSSNADSEANQLSRAQSLDDFVLSDEDRKNTIHLDLQRADSCDGDFQYELSETIDPETFSHLCEEMRI |
Nucleotide Sequence
(Fasta) | TTCTGGTCTA CTTTTAATAA AATTAATCAT ATCGATAAAC GATGTCACGT GATAGTGGCA 60
ACGATTCAGA AGTTGCGGTC ACACACGGGG AAGTGCAAGA AATAACGGAG GAAAATCCAG 120
AAATCGGTTC TATGCACATT ACACAAGAAA CAGATATTTC CGATGCACCC GAAACAAACA 180
CAGATTCGAG TAGACAAAGA ACAGAAAGTA CAACCAGTGT CAGTTCAGAG TCTTGGCAAA 240
ATAATGACGA AATGATGTCG AATCTTCGTC GTGCTCAAAG ACTTCTTGAT GATGGTGCCA 300
CTCCATTACA AATTATTCAA CAAATTTTTC CTGATTTTAA TGCATCACGA ATTGCAACAA 360
TGTCAGAGAA CGCGCATTTC GCCATATTAA GCGATCTTCT AGAACGTGCT CCTGTAAGGC 420
AGAAACTCAC AAACTACAAC TCACTAGCAG ATGCAGTCGA ACTATTTAAA ACAAAGAAAC 480
ATATTCTTGT GTTGACTGGC GCTGGAGTGT CAGTATCCTG TGGAATTCCA GATTTTCGAA 540
GTAAAGATGG TATTTATGCA CGACTTCGGA GCGAGTTTCC CGATCTTCCT GATCCGACAG 600
CAATGTTCGA TATTCGTTAC TTCCGAGAAA ATCCTGCTCC GTTCTACAAT TTTGCGAGAG 660
AAATCTTCCC AGGACAGTTC GTACCATCTG TATCACATCG ATTTATCAAA GAGCTTGAAA 720
CTTCTGGTCG TCTTCTTCGA AATTACACTC AAAATATCGA TACATTAGAG CATCAGACTG 780
GAATTAAAAG AGTTGTGGAA TGTCATGGAT CCTTTTCGAA ATGTACATGT ACACGTTGTG 840
GACAAAAATA TGATGGGAAT GAGATTCGTG AGGAAGTTCT TGCTATGCGT GTTGCCCATT 900
GCAAACGTTG CGAAGGAGTG ATCAAACCGA ATATTGTATT CTTTGGAGAG GATCTCGGAA 960
GAGAATTTCA TCAACATGTT ACAGAAGACA AGCATAAAGT AGATCTCATT GTAGTTATTG 1020
GATCTTCTCT CAAAGTTCGA CCAGTTGCAT TAATTCCACA TTGTGTTGAT AAGAATGTTC 1080
CACAAATTCT AATCAACAGA GAATCCCTCC CACATTATAA TGCAGATATT GAATTGCTCG 1140
GAAATTGTGA TGACATCATC AGAGATATCT GTTTCAGTCT TGGAGGCTCC TTCACTGAAC 1200
TGATTACATC TTATGATTCG ATTATGGAAC AACAAGGAAA AACGAAATCA CAAAAGCCTT 1260
CACAAAACAA ACGACAGTTG ATTTCACAGG AAGACTTTTT GAATATTTGT ATGAAAGAGA 1320
AAAGAAATGA TGATTCGAGT GATGAGCCAA CATTGAAGAA ACCAAGAATG TCGGTGGCTG 1380
ACGATTCGAT GGATTCCGAG AAGAATAATT TCCAAGAAAT ACAAAAACAT AAGTCAGAAG 1440
ATGACGATGA TACACGGAAT TCGGACGATA TTCTCAAGAA AATAAAGCAT CCAAGGCTGC 1500
TGAGCATTAC TGAGATGCTC CATGACAATA AGTGTGTCGC GATTTCTGCT CATCAAACCG 1560
TCTTTCCTGG AGCCGAATGC TCATTTGATC TAGAAACATT GAAACTGGTT CGTGATGTTC 1620
ATCACGAGAC ACATTGCGAA AGTTCGTGTG GTTCGTCTTG CTCATCAAAT GCCGATTCAG 1680
AAGCAAATCA ATTATCTAGA GCACAATCGC TAGATGACTT TGTACTATCT GACGAGGATC 1740
GAAAAAACAC GATACATCTG GACTTGCAAC GAGCCGATTC ATGTGATGGA GATTTTCAGT 1800
ATGAACTATC TGAAACGATT GATCCTGAAA CATTCTCGCA TTTGTGTGAA GAAATGCGTA 1860
TCTGAATCTC ATGTTAAAAA ATTTCAATTT TCCTTCTCTT GTGTTCTCAA TTTTACACCA 1920
AATCCCATTG AAAAACGCGT TTTCATCTGT TATTGTGTGT TTAAACTTTT AAAACTTTAA 1980
ATTGTTTTTC AATTCTTTGC AAACATCAAA ATAAAATTAA AAAATTTCAT
2031Nucleotide Fasta Sequence
>R11A8.4a|SIR2|Caenorhabditis elegans
TTCTGGTCTACTTTTAATAAAATTAATCATATCGATAAACGATGTCACGTGATAGTGGCAACGATTCAGAAGTTGCGGTCACACACGGGGAAGTGCAAGAAATAACGGAGGAAAATCCAGAAATCGGTTCTATGCACATTACACAAGAAACAGATATTTCCGATGCACCCGAAACAAACACAGATTCGAGTAGACAAAGAACAGAAAGTACAACCAGTGTCAGTTCAGAGTCTTGGCAAAATAATGACGAAATGATGTCGAATCTTCGTCGTGCTCAAAGACTTCTTGATGATGGTGCCACTCCATTACAAATTATTCAACAAATTTTTCCTGATTTTAATGCATCACGAATTGCAACAATGTCAGAGAACGCGCATTTCGCCATATTAAGCGATCTTCTAGAACGTGCTCCTGTAAGGCAGAAACTCACAAACTACAACTCACTAGCAGATGCAGTCGAACTATTTAAAACAAAGAAACATATTCTTGTGTTGACTGGCGCTGGAGTGTCAGTATCCTGTGGAATTCCAGATTTTCGAAGTAAAGATGGTATTTATGCACGACTTCGGAGCGAGTTTCCCGATCTTCCTGATCCGACAGCAATGTTCGATATTCGTTACTTCCGAGAAAATCCTGCTCCGTTCTACAATTTTGCGAGAGAAATCTTCCCAGGACAGTTCGTACCATCTGTATCACATCGATTTATCAAAGAGCTTGAAACTTCTGGTCGTCTTCTTCGAAATTACACTCAAAATATCGATACATTAGAGCATCAGACTGGAATTAAAAGAGTTGTGGAATGTCATGGATCCTTTTCGAAATGTACATGTACACGTTGTGGACAAAAATATGATGGGAATGAGATTCGTGAGGAAGTTCTTGCTATGCGTGTTGCCCATTGCAAACGTTGCGAAGGAGTGATCAAACCGAATATTGTATTCTTTGGAGAGGATCTCGGAAGAGAATTTCATCAACATGTTACAGAAGACAAGCATAAAGTAGATCTCATTGTAGTTATTGGATCTTCTCTCAAAGTTCGACCAGTTGCATTAATTCCACATTGTGTTGATAAGAATGTTCCACAAATTCTAATCAACAGAGAATCCCTCCCACATTATAATGCAGATATTGAATTGCTCGGAAATTGTGATGACATCATCAGAGATATCTGTTTCAGTCTTGGAGGCTCCTTCACTGAACTGATTACATCTTATGATTCGATTATGGAACAACAAGGAAAAACGAAATCACAAAAGCCTTCACAAAACAAACGACAGTTGATTTCACAGGAAGACTTTTTGAATATTTGTATGAAAGAGAAAAGAAATGATGATTCGAGTGATGAGCCAACATTGAAGAAACCAAGAATGTCGGTGGCTGACGATTCGATGGATTCCGAGAAGAATAATTTCCAAGAAATACAAAAACATAAGTCAGAAGATGACGATGATACACGGAATTCGGACGATATTCTCAAGAAAATAAAGCATCCAAGGCTGCTGAGCATTACTGAGATGCTCCATGACAATAAGTGTGTCGCGATTTCTGCTCATCAAACCGTCTTTCCTGGAGCCGAATGCTCATTTGATCTAGAAACATTGAAACTGGTTCGTGATGTTCATCACGAGACACATTGCGAAAGTTCGTGTGGTTCGTCTTGCTCATCAAATGCCGATTCAGAAGCAAATCAATTATCTAGAGCACAATCGCTAGATGACTTTGTACTATCTGACGAGGATCGAAAAAACACGATACATCTGGACTTGCAACGAGCCGATTCATGTGATGGAGATTTTCAGTATGAACTATCTGAAACGATTGATCCTGAAACATTCTCGCATTTGTGTGAAGAAATGCGTATCTGAATCTCATGTTAAAAAATTTCAATTTTCCTTCTCTTGTGTTCTCAATTTTACACCAAATCCCATTGAAAAACGCGTTTTCATCTGTTATTGTGTGTTTAAACTTTTAAAACTTTAAATTGTTTTTCAATTCTTTGCAAACATCAAAATAAAATTAAAAAATTTCAT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019213--F:deacetylase activity
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
GO:0040024--P:dauer larval development
GO:0008340--P:determination of adult lifespan
GO:0070932--P:histone H3 deacetylation
GO:0043970--P:histone H3-K9 acetylation
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0006476--P:protein deacetylation
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
