| Tag |
Content |
| WERAM ID |
WERAM-Mum-0135 |
| Ensembl Protein ID |
ENSMUSP00000048971.8 |
| Uniprot Accession |
P59941; SIR6_MOUSE
|
| Genbank Protein ID |
NP_853617.1
|
| Protein Name |
NAD-dependent protein deacetylase sirtuin-6 |
| Genbank Nucleotide ID |
NM_181586.3
|
| Gene Name |
SIRT6;Sir2l6 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K9 |
K |
26639398
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
1.00e-66 |
226.5 |
36 |
273 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (By similarity). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein. Has a role in the regulation of life span in male mice, but not in female mice. |
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (By similarity). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein. Has a role in the regulation of life span in male mice, but not in female mice.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaele 90
+la+l+++s+++v++tGAGiSt++GIPDFR+++G++++ +++ +p+++++f+ +a+P+ktH++l +le
ENSMUSP00000048971.8 36 ELARLMWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFE----------------------NARPSKTHMALVQLE 102
789*************************************997777666554......................569************ PP
SIR2.txt 91 kkgkllrlytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCek........Ckgvlkpdivffgen 171
+ g l++l++QN+DgL+ ++g+++dkl elHG++++++C kCk+++ r++++ ++ k++ + C+ C+g l+++i+ ++++
ENSMUSP00000048971.8 103 RMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKTQYVRDTVVGTMGLKATGRLCTVaktrglraCRGELRDTILDWEDS 191
**********************************************************9*****9999999999*************** PP
SIR2.txt 172 lpeefleeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkllglee 253
lp+++l ++e+ ++adl ++lGtSl+++p+ +l++++++++ + ++vnl+++k+d++adl+++g++dev+ +l+k+lgle+
ENSMUSP00000048971.8 192 LPDRDLMLADEASRTADLSVTLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLRIHGYVDEVMCRLMKHLGLEI 273
******************************************************************************9876 PP
|
Protein Sequence
(Fasta) | MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL MWQSSSVVFH TGAGISTASG 60
IPDFRGPHGV WTMEERGLAP KFDTTFENAR PSKTHMALVQ LERMGFLSFL VSQNVDGLHV 120
RSGFPRDKLA ELHGNMFVEE CPKCKTQYVR DTVVGTMGLK ATGRLCTVAK TRGLRACRGE 180
LRDTILDWED SLPDRDLMLA DEASRTADLS VTLGTSLQIR PSGNLPLATK RRGGRLVIVN 240
LQPTKHDRQA DLRIHGYVDE VMCRLMKHLG LEIPAWDGPC VLDKALPPLP RPVALKAEPP 300
VHLNGAVHVS YKSKPNSPIL HRPPKRVKTE AAPS 334Protein Fasta Sequence
>ENSMUSP00000048971.8|SIRT6;Sir2l6|Mus musculus
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLMWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFENARPSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKTQYVRDTVVGTMGLKATGRLCTVAKTRGLRACRGELRDTILDWEDSLPDRDLMLADEASRTADLSVTLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLRIHGYVDEVMCRLMKHLGLEIPAWDGPCVLDKALPPLPRPVALKAEPPVHLNGAVHVSYKSKPNSPILHRPPKRVKTEAAPS |
Nucleotide Sequence
(Fasta) | TGGTCGCGGA TCCCAGGACT GGGGAATCCA CTAAGTCAGA GAGGTAGTCT CGGCCAGCAC 60
TGAAGACTAA GCTTGCTGCA TCAGGAGGGC GCATGCGCTC TGGAAAGAAT GCTGTTTTTC 120
ACCTCCACGT ACCCACCCCA CCCTCAGGCA CGTATCTAGG GAAGGCGGCT ACTCTTTCCC 180
GACCGTCCCT TCACCACTTC CGGCGGAAGC GGCCTCAACA AGGGAAACTT TATTGTTCCC 240
GTGCGGCAGC GCCGGCGACG ATGTCGGTGA ATTATGCAGC AGGGTTGTCG CCTTACGCGG 300
ATAAGGGCAA GTGCGGGCTG CCCGAGATCT TCGACCCACC AGAGGAGCTG GAACGCAAGG 360
TGTGGGAGCT GGCCCGGCTA ATGTGGCAGT CCTCCAGCGT GGTTTTCCAC ACGGGCGCCG 420
GCATCAGCAC CGCCTCTGGC ATCCCCGACT TCAGAGGCCC CCATGGCGTG TGGACCATGG 480
AGGAACGCGG CCTGGCCCCC AAGTTTGACA CCACCTTCGA GAATGCTCGG CCCTCGAAGA 540
CCCACATGGC CCTGGTTCAG CTAGAACGCA TGGGCTTCCT CAGCTTCCTG GTCAGCCAGA 600
ACGTAGACGG GCTGCACGTG CGCTCGGGCT TCCCCAGGGA CAAGCTGGCA GAGCTGCACG 660
GAAACATGTT TGTAGAGGAA TGTCCCAAGT GTAAGACGCA GTACGTCAGA GACACGGTTG 720
TGGGCACCAT GGGCCTCAAG GCCACAGGCC GGCTCTGCAC CGTGGCCAAG ACCAGGGGAC 780
TTCGGGCCTG TAGAGGGGAG CTGAGAGACA CCATTCTGGA CTGGGAGGAC TCGTTGCCTG 840
ACCGGGACCT GATGCTCGCT GATGAGGCCA GCAGGACCGC AGACCTGTCT GTCACCCTGG 900
GTACCTCGCT GCAGATCCGC CCCAGTGGGA ACCTGCCCCT TGCCACTAAG CGCCGAGGAG 960
GCCGTCTGGT CATTGTCAAC CTGCAACCCA CAAAACATGA CCGCCAGGCT GACCTGCGCA 1020
TCCACGGCTA CGTGGATGAG GTGATGTGCA GACTCATGAA GCATCTGGGG CTGGAGATTC 1080
CAGCCTGGGA TGGACCCTGC GTGCTAGACA AAGCCCTGCC ACCTCTGCCT CGCCCAGTAG 1140
CACTCAAGGC TGAGCCCCCC GTGCATCTCA ATGGTGCAGT GCATGTTTCG TATAAGTCCA 1200
AGCCCAACAG CCCTATACTC CACAGGCCCC CCAAAAGAGT GAAGACCGAG GCTGCCCCCA 1260
GCTGACCCGG GTATGTGGGG CGGGAGGGGA ACTTGAAGGA ACCACACATG TTGAGGTTTT 1320
TGTTTGTTTG TTTGTTTGTT TGTTTTTTAT ATTCTGGGGA CTGAGCCCAG GTTTGCATAT 1380
CTCACCCTGG TGTCTTTTCA GATTTTTTTT TTTTTTTTTT TTTTTTTGAG ACCAGGACTC 1440
CCTAGATCGC TCAGGCTGGT CTGGAACTCA CTGCTATAGC CCAGGCTGGC CTGGAACTAG 1500
CCTGCCTGCC TCAGCCTCTA CTGTAGTAGG GACAGCGGGC AGGTACACCA TGTCCAACAC 1560
AGCTCCTTTC TTCAAAGTCT CACTGTGTCC CTTGTCCAGG TCCTTCCAGG GAATCTCAGG 1620
GCATGGGGAA TCCCACACAT GTGGAAGAGG CCGTGTCCCA GGGATCCACG TGCCTCTCTA 1680
CCAATCACAC CCGCTCGTGA CTCAGGATGT GCCCGGAGCA GCAGTCTCAC ACACTCCACA 1740
CACCATTGCT GCCCCCTGCA CGCATCTCCC CCCCATCCCC TGGCCCTGAC ACAGAGCCAC 1800
CAAGGGCCCA CCAGGCACCC ATCTGTGCTA AGGGCCCCAG GCTCCCAGAA GCTCCCAATG 1860
CAATAAATAC AAAATCCCTT CCATTCTTTT A
1892Nucleotide Fasta Sequence
>ENSMUSP00000048971.8|SIR2|Mus musculus
TGGTCGCGGATCCCAGGACTGGGGAATCCACTAAGTCAGAGAGGTAGTCTCGGCCAGCACTGAAGACTAAGCTTGCTGCATCAGGAGGGCGCATGCGCTCTGGAAAGAATGCTGTTTTTCACCTCCACGTACCCACCCCACCCTCAGGCACGTATCTAGGGAAGGCGGCTACTCTTTCCCGACCGTCCCTTCACCACTTCCGGCGGAAGCGGCCTCAACAAGGGAAACTTTATTGTTCCCGTGCGGCAGCGCCGGCGACGATGTCGGTGAATTATGCAGCAGGGTTGTCGCCTTACGCGGATAAGGGCAAGTGCGGGCTGCCCGAGATCTTCGACCCACCAGAGGAGCTGGAACGCAAGGTGTGGGAGCTGGCCCGGCTAATGTGGCAGTCCTCCAGCGTGGTTTTCCACACGGGCGCCGGCATCAGCACCGCCTCTGGCATCCCCGACTTCAGAGGCCCCCATGGCGTGTGGACCATGGAGGAACGCGGCCTGGCCCCCAAGTTTGACACCACCTTCGAGAATGCTCGGCCCTCGAAGACCCACATGGCCCTGGTTCAGCTAGAACGCATGGGCTTCCTCAGCTTCCTGGTCAGCCAGAACGTAGACGGGCTGCACGTGCGCTCGGGCTTCCCCAGGGACAAGCTGGCAGAGCTGCACGGAAACATGTTTGTAGAGGAATGTCCCAAGTGTAAGACGCAGTACGTCAGAGACACGGTTGTGGGCACCATGGGCCTCAAGGCCACAGGCCGGCTCTGCACCGTGGCCAAGACCAGGGGACTTCGGGCCTGTAGAGGGGAGCTGAGAGACACCATTCTGGACTGGGAGGACTCGTTGCCTGACCGGGACCTGATGCTCGCTGATGAGGCCAGCAGGACCGCAGACCTGTCTGTCACCCTGGGTACCTCGCTGCAGATCCGCCCCAGTGGGAACCTGCCCCTTGCCACTAAGCGCCGAGGAGGCCGTCTGGTCATTGTCAACCTGCAACCCACAAAACATGACCGCCAGGCTGACCTGCGCATCCACGGCTACGTGGATGAGGTGATGTGCAGACTCATGAAGCATCTGGGGCTGGAGATTCCAGCCTGGGATGGACCCTGCGTGCTAGACAAAGCCCTGCCACCTCTGCCTCGCCCAGTAGCACTCAAGGCTGAGCCCCCCGTGCATCTCAATGGTGCAGTGCATGTTTCGTATAAGTCCAAGCCCAACAGCCCTATACTCCACAGGCCCCCCAAAAGAGTGAAGACCGAGGCTGCCCCCAGCTGACCCGGGTATGTGGGGCGGGAGGGGAACTTGAAGGAACCACACATGTTGAGGTTTTTGTTTGTTTGTTTGTTTGTTTGTTTTTTATATTCTGGGGACTGAGCCCAGGTTTGCATATCTCACCCTGGTGTCTTTTCAGATTTTTTTTTTTTTTTTTTTTTTTTTGAGACCAGGACTCCCTAGATCGCTCAGGCTGGTCTGGAACTCACTGCTATAGCCCAGGCTGGCCTGGAACTAGCCTGCCTGCCTCAGCCTCTACTGTAGTAGGGACAGCGGGCAGGTACACCATGTCCAACACAGCTCCTTTCTTCAAAGTCTCACTGTGTCCCTTGTCCAGGTCCTTCCAGGGAATCTCAGGGCATGGGGAATCCCACACATGTGGAAGAGGCCGTGTCCCAGGGATCCACGTGCCTCTCTACCAATCACACCCGCTCGTGACTCAGGATGTGCCCGGAGCAGCAGTCTCACACACTCCACACACCATTGCTGCCCCCTGCACGCATCTCCCCCCCATCCCCTGGCCCTGACACAGAGCCACCAAGGGCCCACCAGGCACCCATCTGTGCTAAGGGCCCCAGGCTCCCAGAAGCTCCCAATGCAATAAATACAAAATCCCTTCCATTCTTTTA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005724--C:nuclear telomeric heterochromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003956--F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0046969--F:NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006284--P:base-excision repair
GO:0042593--P:glucose homeostasis
GO:1990619--P:histone H3-K9 deacetylation
GO:0061647--P:histone H3-K9 modification
GO:0008285--P:negative regulation of cell proliferation
GO:0046325--P:negative regulation of glucose import
GO:0045820--P:negative regulation of glycolytic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048146--P:positive regulation of fibroblast proliferation
GO:2000648--P:positive regulation of stem cell proliferation
GO:0003247--P:post-embryonic cardiac muscle cell growth involved in heart morphogenesis
GO:0006471--P:protein ADP-ribosylation
GO:0031648--P:protein destabilization
GO:0010569--P:regulation of double-strand break repair via homologous recombination
GO:0031667--P:response to nutrient levels
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
