WERAM Information


Tag Content
WERAM ID WERAM-Art-0143
Ensembl Protein ID AT5G55760.1
Uniprot Accession Q9FE17; SIR1_ARATH; Q7Y032
Genbank Protein ID NP_200387.1
Protein Name NAD-dependent protein deacetylase SRT1
Genbank Nucleotide ID NM_124958.2
Gene Name SRT1;At5g55760;MDF20.20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G55760 AT5G55760.1 AT5G55760.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type H3K9 K 26689639
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 6.80e-68 229.6 36 268
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)
NAD-dependent protein deacetylase. Has deacetylase activity towards H3K9Ac. May have a function in the safeguard against genome instabiliy and DNA damage to ensure plant cell growth (By similarity).
Domain Profile
  HDAC SIR2

     SIR2.txt   2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelekkgkllrly 99 
+lakl++ksk++vv+tGAGiSts+GIPDFR+++G+++ +++ +++ k+ +p+++a P++tH++l ele++g l++++
AT5G55760.1 36 ELAKLIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREG-----KDLP----------------KASLPFHRAMPSMTHMALVELERAGILKFVI 112
799**********************************96666.....3333................3346777899********************* PP
SIR2.txt 100 tQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCek..CkgvlkpdivffgenlpeefleeveedlkeadlllvlGt 195
+QN+DgL++++g++++kl+elHG+ ++++C +C++e+ r++ +e++ ke+ +kC+ C+++lk++++ ++++lp ++++ +e+++k+adl+l+lGt
AT5G55760.1 113 SQNVDGLHLRSGIPREKLSELHGDSFMEMCPSCGAEYLRDFEVETIGLKETSRKCSVekCGAKLKDTVLDWEDALPPKEIDPAEKHCKKADLVLCLGT 210
*******************************************************8666*************************************** PP
SIR2.txt 196 Slkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkllglee 253
Sl+++p+++l++k+ k + ++++vnl+++++dk+a+++++g +d+vv+ ++++l++++
AT5G55760.1 211 SLQITPACNLPLKCLKGGGKIVIVNLQKTPKDKKANVVIHGLVDKVVAGVMESLNMKI 268
*****************************************************99876 PP

Protein Sequence
(Fasta)
MSLGYAEKLS FIEDVGQVGM AEFFDPSHLL QCKIEELAKL IQKSKHLVVF TGAGISTSCG 60
IPDFRGPKGI WTLQREGKDL PKASLPFHRA MPSMTHMALV ELERAGILKF VISQNVDGLH 120
LRSGIPREKL SELHGDSFME MCPSCGAEYL RDFEVETIGL KETSRKCSVE KCGAKLKDTV 180
LDWEDALPPK EIDPAEKHCK KADLVLCLGT SLQITPACNL PLKCLKGGGK IVIVNLQKTP 240
KDKKANVVIH GLVDKVVAGV MESLNMKIPP YVRIDLFQII LTQSISGDQR FINWTLRVAS 300
VHGLTSQLPF IKSIEVSFSD NHNYKDAVLD KQPFLMKRRT ARNETFDIFF KVNYSDGCDC 360
VSTQLSLPFE FKISTEEHVE IIDKEAVLQS LREKAVEESS CGQSGVVERR VVSEPRSEAV 420
VYATVTSLRT YHSQQSLLAN GDLKWKLEGS GTSRKRSRTG KRKSKALAEE TKA 473
Nucleotide Sequence
(Fasta)
ATACATCGAG AGGCAGAGAA GGTGTTCTTC TTCTTGTCCA AAAGAGAAGA CAAAACCTAA 60
ATGTCTTTAG GTTACGCAGA GAAATTATCC TTCATTGAAG ATGTTGGTCA AGTCGGCATG 120
GCTGAATTCT TCGACCCATC TCATCTTCTA CAATGCAAGA TTGAAGAACT TGCTAAGTTG 180
ATTCAAAAGA GTAAGCATCT AGTAGTCTTT ACTGGTGCAG GCATTTCAAC TTCTTGTGGT 240
ATTCCTGATT TCCGAGGCCC CAAAGGAATT TGGACGTTAC AGCGCGAGGG CAAAGATTTA 300
CCTAAAGCAT CTCTGCCATT TCACCGTGCA ATGCCGAGTA TGACCCATAT GGCTTTGGTT 360
GAATTAGAAA GAGCTGGCAT TTTAAAATTT GTTATCAGTC AGAATGTGGA TGGCTTACAT 420
CTTCGATCTG GAATACCAAG AGAGAAGCTT TCTGAACTGC ATGGAGACTC TTTTATGGAG 480
ATGTGCCCAT CATGTGGAGC AGAGTACCTG CGTGATTTCG AGGTGGAAAC TATTGGATTA 540
AAGGAGACAT CAAGAAAGTG TTCTGTTGAA AAGTGTGGAG CTAAACTTAA AGATACGGTC 600
TTGGATTGGG AGGATGCTTT GCCTCCAAAA GAAATTGATC CTGCGGAGAA GCACTGCAAA 660
AAGGCTGATC TTGTACTCTG TTTGGGTACC AGTTTGCAGA TAACCCCTGC TTGCAATTTG 720
CCTCTCAAGT GTCTCAAAGG TGGAGGCAAG ATCGTCATAG TTAATCTTCA GAAAACACCG 780
AAAGACAAGA AAGCAAATGT AGTGATTCAT GGTCTTGTTG ATAAGGTGGT TGCAGGGGTC 840
ATGGAATCGC TCAACATGAA GATTCCTCCA TATGTCAGAA TTGATCTTTT CCAGATAATC 900
CTAACTCAAT CTATAAGCGG AGATCAGAGG TTTATTAATT GGACCCTGCG TGTTGCGAGT 960
GTTCATGGAT TGACTTCTCA GTTACCATTC ATCAAGTCTA TTGAGGTTTC TTTCTCAGAT 1020
AACCATAATT ACAAAGACGC AGTTCTCGAT AAGCAGCCTT TTCTTATGAA AAGGAGAACA 1080
GCACGAAACG AAACTTTTGA TATATTCTTT AAAGTTAACT ACAGTGACGG TTGTGACTGT 1140
GTCTCCACTC AACTTAGCCT CCCATTTGAA TTCAAGATTT CAACAGAAGA GCATGTAGAG 1200
ATTATTGACA AGGAGGCTGT GCTACAAAGC CTGAGAGAGA AAGCGGTAGA AGAATCCAGT 1260
TGCGGGCAAA GCGGTGTGGT TGAGAGAAGA GTGGTTTCTG AACCGAGAAG TGAGGCTGTT 1320
GTGTATGCTA CGGTGACTAG TCTCAGGACT TACCATAGTC AACAATCTCT GCTTGCTAAT 1380
GGAGACCTGA AATGGAAGCT GGAAGGTTCT GGAACATCCC GTAAACGCTC TAGAACCGGG 1440
AAGCGAAAAT CGAAGGCTCT GGCAGAAGAA ACCAAGGCAT AGGAAGAAGA AAAGAAAGCT 1500
TTTGGTGTAT ATAAAGAAAC ACTAGTCTAA CCGGAATAGG TAATATGGAA GTTATTGGCG 1560
TTTTGAGAGC TGAGTGAATT TTGTTTTTGG TCCACATTCG GTTCTCTTGA AACAAAAGTT 1620
AACCAGGAAT TGAAAGAGAT AATCTTGGTT CGTTGTCGTT TAGTATCGGT TGATTTTTGT 1680
AGAAGCTAGT GCATTCGAAA TATTATTAAA AAAAATTTAC AAGATGATC
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
--

Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026590--Ssirtuin_cat_dom

PROSITE

PS50305--SIRTUIN

Pfam

PF02146--SIR2

Gene Ontology

GO:0005634--C:nucleus
GO:0016787--F:hydrolase activity
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0111 fgenesh2_kg.8__ 1477__ AT5G55760.1 Arabidopsis lyrata 97 0.0 869
WERAM-Brr-0144 Bra028961.1-P Brassica rapa 89 0.0 802
WERAM-Bro-0046 Bo3g021360.1 Brassica oleracea 89 0.0 802
WERAM-Glm-0232 GLYMA18G08450.1 Glycine max 71 0.0 663
WERAM-Pot-0016 POPTR_0001s37680.1 Populus trichocarpa 72 0.0 659
WERAM-Prp-0059 EMJ12601 Prunus persica 73 0.0 645
WERAM-Sol-0101 Solyc07g065550.2.1 Solanum lycopersicum 70 0.0 642
WERAM-Met-0085 KEH34091 Medicago truncatula 70 0.0 641
WERAM-Viv-0122 VIT_19s0015g00570.t01 Vitis vinifera 71 0.0 631
WERAM-Sot-0070 PGSC0003DMT400057382 Solanum tuberosum 69 1e-167 586
WERAM-Amt-0008 ERN05726 Amborella trichopoda 68 3e-165 578
WERAM-Mua-0125 GSMUA_Achr8P24470_001 Musa acuminata 68 8e-164 574
WERAM-Sob-0090 Sb06g020390.1 Sorghum bicolor 63 2e-155 546
WERAM-Orbr-0051 OB04G14570.1 Oryza brachyantha 63 1e-153 540
WERAM-Ors-0038 OS04T0271000-01 Oryza sativa 64 1e-149 527
WERAM-Tra-0045 Traes_2AS_69329D634.2 Triticum aestivum 60 6e-149 524
WERAM-Org-0043 ORGLA04G0042700.1 Oryza glaberrima 63 1e-148 523
WERAM-Ori-0050 BGIOSGA015454-PA Oryza indica 63 9e-148 520
WERAM-Brd-0122 BRADI5G02940.2 Brachypodium distachyon 60 2e-147 520
WERAM-Php-0065 PP1S272_33V6.1 Physcomitrella patens 57 1e-134 477
WERAM-Aet-0057 EMT21754 Aegilops tauschii 57 2e-130 463
WERAM-Sei-0037 Si010693m Setaria italica 74 4e-130 462
WERAM-Zem-0044 GRMZM2G058573_P01 Zea mays 76 8e-119 424
WERAM-Lep-0045 LPERR04G03890.1 Leersia perrieri 76 2e-117 419
WERAM-Orl-0053 KN539062.1_FGP005 Oryza longistaminata 55 4e-116 416
WERAM-Xet-0167 ENSXETP00000057383.2 Xenopus tropicalis 56 2e-82 303
WERAM-Mod-0008 ENSMODP00000000983.1 Monodelphis domestica 53 2e-81 300
WERAM-Ran-0038 ENSRNOP00000008758.3 Rattus norvegicus 52 3e-80 296
WERAM-Meg-0032 ENSMGAP00000002578.1 Meleagris gallopavo 49 4e-80 296
WERAM-Gaga-0011 ENSGALP00000001888.3 Gallus gallus 48 1e-79 294
WERAM-Sah-0106 ENSSHAP00000011597.1 Sarcophilus harrisii 53 2e-79 294
WERAM-Mam-0185 ENSMMUP00000026241.2 Macaca mulatta 51 3e-79 293
WERAM-Otg-0026 ENSOGAP00000001481.2 Otolemur garnettii 51 5e-79 292
WERAM-Lac-0065 ENSLACP00000008822.2 Latimeria chalumnae 52 7e-79 291
WERAM-Pof-0157 ENSPFOP00000012793.2 Poecilia formosa 53 7e-79 291
WERAM-Soa-0094 ENSSARP00000008710.1 Sorex araneus 51 1e-78 291
WERAM-Xim-0231 ENSXMAP00000019352.1 Xiphophorus maculatus 52 1e-78 291
WERAM-Pat-0085 ENSPTRP00000017501.2 Pan troglodytes 51 2e-78 290
WERAM-Gog-0100 ENSGGOP00000008641.2 Gorilla gorilla 51 2e-78 290
WERAM-Paa-0028 ENSPANP00000011086.1 Papio anubis 51 2e-78 290
WERAM-Ict-0164 ENSSTOP00000015068.1 Ictidomys tridecemlineatus 51 2e-78 290
WERAM-Mup-0054 ENSMPUP00000004703.1 Mustela putorius furo 51 3e-78 289
WERAM-Hos-0033 ENSP00000337332.1 Homo sapiens 51 4e-78 289
WERAM-Caj-0156 ENSCJAP00000027893.2 Callithrix jacchus 51 5e-78 289
WERAM-Mum-0135 ENSMUSP00000048971.8 Mus musculus 52 5e-78 289
WERAM-Chs-0131 ENSCSAP00000006979.1 Chlorocebus sabaeus 51 5e-78 289
WERAM-Poa-0078 ENSPPYP00000010537.2 Pongo abelii 51 6e-78 288
WERAM-Caf-0197 ENSCAFP00000028217.2 Canis familiaris 51 1e-77 288
WERAM-Aim-0033 ENSAMEP00000002298.1 Ailuropoda melanoleuca 51 3e-77 286
WERAM-Tar-0090 ENSTRUP00000017073.1 Takifugu rubripes 52 4e-77 286
WERAM-Gaa-0163 ENSGACP00000020196.1 Gasterosteus aculeatus 53 6e-77 285
WERAM-Mae-0123 ENSMEUP00000012391.1 Macropus eugenii 51 6e-77 285
WERAM-Loa-0191 ENSLAFP00000023357.1 Loxodonta africana 51 7e-77 285
WERAM-Orn-0127 ENSONIP00000012860.1 Oreochromis niloticus 52 1e-76 284
WERAM-Bot-0171 ENSBTAP00000026521.5 Bos taurus 51 2e-76 283
WERAM-Fia-0011 ENSFALP00000000954.1 Ficedula albicollis 54 2e-75 280
WERAM-Cis-0072 ENSCSAVP00000015450.1 Ciona savignyi 48 3e-75 280
WERAM-Ova-0116 ENSOARP00000011370.1 Ovis aries 49 8e-74 275
WERAM-Pes-0079 ENSPSIP00000009554.1 Pelodiscus sinensis 53 1e-73 274
WERAM-Sus-0098 ENSSSCP00000014344.2 Sus scrofa 49 7e-73 271
WERAM-Gam-0126 ENSGMOP00000013105.1 Gadus morhua 51 3e-72 270
WERAM-Myl-0098 ENSMLUP00000007946.2 Myotis lucifugus 51 9e-71 265
WERAM-Drm-0064 FBpp0293897 Drosophila melanogaster 48 3e-67 253
WERAM-Eqc-0160 ENSECAP00000016959.1 Equus caballus 42 9e-50 195
WERAM-Anp-0140 ENSAPLP00000015159.1 Anas platyrhynchos 42 1e-48 191
WERAM-Asfu-0001 CADAFUAP00000229 Aspergillus fumigatus 35 2e-25 114
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 34 3e-23 107
WERAM-Chr-0008 EDP00705 Chlamydomonas reinhardtii 29 6e-23 106
WERAM-Thc-0008 EOX92647 Theobroma cacao 27 2e-22 104
WERAM-Asc-0026 CADACLAP00005809 Aspergillus clavatus 34 3e-22 103
WERAM-Ast-0001 CADATEAP00000292 Aspergillus terreus 31 6e-22 102
WERAM-Chh-0046 ENSCHOP00000005172.1 Choloepus hoffmanni 31 1e-21 102
WERAM-Sem-0060 EFJ23112 Selaginella moellendorffii 30 2e-21 101
WERAM-Fec-0171 ENSFCAP00000020847.1 Felis catus 32 3e-21 100
WERAM-Aso-0017 CADAORAP00002263 Aspergillus oryzae 28 5e-21 99.8
WERAM-Fuo-0021 FOXG_06023P0 Fusarium oxysporum 30 9e-21 99.0
WERAM-Trr-0018 EGR46788 Trichoderma reesei 29 1e-20 98.2
WERAM-Asn-0013 CADANIAP00002934 Aspergillus nidulans 31 1e-20 98.2
WERAM-Ect-0086 ENSETEP00000009903.1 Echinops telfairi 28 1e-19 95.1
WERAM-Cap-0138 ENSCPOP00000011117.2 Cavia porcellus 30 1e-19 95.1
WERAM-Tut-0072 ENSTTRP00000005343.1 Tursiops truncatus 32 1e-19 95.1
WERAM-Pyt-0039 EFQ86136 Pyrenophora teres 31 2e-19 94.7
WERAM-Tas-0026 ENSTSYP00000002962.1 Tarsius syrichta 29 2e-19 94.7
WERAM-Cae-0022 R11A8.4a Caenorhabditis elegans 27 5e-19 93.2
WERAM-Trv-0012 EHK19002 Trichoderma virens 28 1e-18 92.4
WERAM-Ten-0147 ENSTNIP00000015282.1 Tetraodon nigroviridis 29 1e-18 92.0
WERAM-Orc-0113 ENSOCUP00000009744.3 Oryctolagus cuniculus 29 1e-18 91.7
WERAM-Lem-0007 CBY02082 Leptosphaeria maculans 31 3e-18 90.9
WERAM-Orm-0102 OMERI12G03010.1 Oryza meridionalis 24 3e-18 90.9
WERAM-Asf-0024 CADAFLAP00010064 Aspergillus flavus 31 3e-18 90.9
WERAM-Asni-0009 CADANGAP00002892 Aspergillus niger 32 3e-18 90.5
WERAM-Scj-0005 EEB06048 Schizosaccharomyces japonicus 32 3e-18 90.5
WERAM-Ocp-0148 ENSOPRP00000015399.1 Ochotona princeps 28 4e-18 90.5
WERAM-Ptv-0014 ENSPVAP00000002101.1 Pteropus vampyrus 28 4e-18 90.1
WERAM-Orp-0109 OPUNC12G04720.1 Oryza punctata 24 5e-18 90.1
WERAM-Orr-0119 ORUFI12G05460.1 Oryza rufipogon 24 6e-18 89.7
WERAM-Orla-0002 ENSORLP00000000105.1 Oryzias latipes 32 6e-18 89.7
WERAM-Ora-0041 ENSOANP00000006568.2 Ornithorhynchus anatinus 28 6e-18 89.4
WERAM-Leo-0156 ENSLOCP00000018785.1 Lepisosteus oculatus 31 8e-18 89.4
WERAM-Asg-0028 AAS54472 Ashbya gossypii 30 1e-17 88.6
WERAM-Dar-0026 ENSDARP00000027611.6 Danio rerio 26 1e-17 88.6
WERAM-Mao-0029 MGG_10267T0 Magnaporthe oryzae 29 1e-17 88.2
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 31 2e-17 88.2
WERAM-Dan-0168 ENSDNOP00000020521.1 Dasypus novemcinctus 27 2e-17 88.2
WERAM-Pytr-0009 EDU41553 Pyrenophora triticirepentis 31 2e-17 87.8
WERAM-Asm-0153 ENSAMXP00000015326.1 Astyanax mexicanus 31 2e-17 87.8
WERAM-Zyt-0001 Mycgr3P100618 Zymoseptoria tritici 30 2e-17 87.4
WERAM-Yal-0031 CAG78100 Yarrowia lipolytica 30 3e-17 87.0
WERAM-Scp-0042 SPCC132.02.1:pep Schizosaccharomyces pombe 29 1e-16 85.5
WERAM-Tag-0120 ENSTGUP00000009802.1 Taeniopygia guttata 27 2e-16 84.7
WERAM-Kop-0003 CAY67751 Komagataella pastoris 28 2e-16 84.3
WERAM-Cii-0061 ENSCINP00000027422.2 Ciona intestinalis 27 2e-16 84.3
WERAM-Anc-0100 ENSACAP00000009519.3 Anolis carolinensis 30 5e-16 83.2
WERAM-Osl-0012 ABO98065 Ostreococcus lucimarinus 30 6e-16 82.8
WERAM-Nol-0008 ENSNLEP00000001018.1 Nomascus leucogenys 26 7e-16 82.8
WERAM-Ere-0059 ENSEEUP00000005136.1 Erinaceus europaeus 26 7e-16 82.8
Created Date 25-Jun-2016