WERAM Information

Tag Content
WERAM ID WERAM-Drm-0074
Ensembl Protein ID FBpp0084733
Uniprot Accession Q9VAQ1; SIR7_DROME
Genbank Protein ID NP_651664.2
Protein Name NAD-dependent protein deacetylase Sirt7
Genbank Nucleotide ID NM_143407.3
Gene Name SIRT7;CG11305
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0039631 FBtr0085364 FBpp0084733
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type K 12466527
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 7.00e-62 209.7 115 352
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 NAD-dependent protein deacetylase.
Domain Profile
  HDAC SIR2
     SIR2.txt   2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelekkgkllrly 99 
                  +la++++++k++v++tGAGiSt+a IPD+R+s+G+++ l+k+     ++i ++d                  l+sa+Pt+tH++l el+++++l++++
  FBpp0084733 115 QLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWTLLQKG-----QDIGEHD------------------LSSANPTYTHMALYELHRRRLLHHVV 189
                  7999**********************************9999.....8999999..................579*********************** PP
     SIR2.txt 100 tQNiDgLerkaglkedklvelHGslatasCtkCk..kefpreeikeklkak...ekvpkCekCkgvlkpdivffge....nlpeefleeveedlkead 188
                  +QN+DgL++++gl++++l+e+HG+++++ C++C+  + + r++ +++++a+   ++++ C++C++ l+++iv+fge    ++p +++ ++ +++++ad
  FBpp0084733 190 SQNCDGLHLRSGLPRNSLSEIHGNMYVEVCKNCRpnSVYWRQFDTTEMTARychKTHRLCHRCSEPLYDTIVHFGErgnvKWPLNWAGAT-ANAQRAD 286
                  **********************************9755556666666666677779********************66666777777776.5569*** PP
     SIR2.txt 189 lllvlGtSlkvepvaslvk...kavkkkvpvllvnleevkadkladlkllgdcdevveellkllgl 251
                  ++l+lG+Slkv + +++++   + +++++++++vnl+++++d++a++k++g+cd+v+++l++ll+ 
  FBpp0084733 287 VILCLGSSLKVLKKYTWLWqmdRPARQRAKICVVNLQWTPKDAIASIKINGKCDQVMAQLMHLLHI 352
                  ******************955556778888********************************9986 PP
Protein Sequence
(Fasta)		MEKDLGEEKD QDQEQNTEME PKQEMDVAQS YITRAKMNPA KKDNEKRRRK DAMRRVSMIL 60
RKCDSMRTTE DRQFLEKHPD MVKTTKKRKE RVEIYKERVV EREDAPHVIE AKVEQLANII 120
SQAKHLVCYT GAGISTAALI PDYRGSQGIW TLLQKGQDIG EHDLSSANPT YTHMALYELH 180
RRRLLHHVVS QNCDGLHLRS GLPRNSLSEI HGNMYVEVCK NCRPNSVYWR QFDTTEMTAR 240
YCHKTHRLCH RCSEPLYDTI VHFGERGNVK WPLNWAGATA NAQRADVILC LGSSLKVLKK 300
YTWLWQMDRP ARQRAKICVV NLQWTPKDAI ASIKINGKCD QVMAQLMHLL HIPVPVYTKE 360
KDPIFAHASL LMPEELHTLT QPLLKNADEE EAFTTTTEET QDSTISSESC SFNYSDLPIG 420
KGPRIRTPIK NGRRVKTNLE LRQKFKTLNG QDEEIKVEHV KTNGEVKTEK DLITLESSIK 480
IETEVKLEKL ECSDTNFQQE LKLLELLPKL EPLSLKEETE ETPSNGFPEL PKLVAIQKTH 540
AECLSAVPTE SRLKPLQLPP LVPIGAPLST PFVEPKLVLP PASQSSSIQI KSEGDGDSST 600
ENDNEEEEES ELAQMDLLRQ NNDEELLRQL PTWYDAKYAY SGLHSILIPP PADLNIWNSQ 660
VVPNFAMNRS AASCFFCFDR YAELECQFYR RWNLSQRKHK KRARSGRFVV CECCPTSDDD 720
DDYDENISLA HIAAAETAKR RQQLSTSFPR KLARTQAGWY GKGYKKGRKR R 771
Nucleotide Sequence
(Fasta)		TAGTTGTTTA CCTTTTTTTC CCAAAAAAAA GAAACATTTA CAAAACAAAA GTCGTCGCTG 60
GATTTGGATT GTAAATTACC AATGACCAGA GGTCTGAAGC CGCATGGCGA ATACGATGTA 120
AGCGGACATC CTGCGCAGGA TTCCACATCA CAATTTCCCC TTCCTGGCTG CGGCGCATTT 180
TATTTTGTCC CCGCATAATT GCCAATTGTG CCGGATCATG GAGAAGGATC TGGGTGAGGA 240
AAAGGACCAG GATCAGGAGC AGAACACTGA GATGGAGCCC AAGCAGGAGA TGGACGTGGC 300
GCAGTCTTAC ATAACGCGGG CCAAGATGAA TCCTGCCAAG AAGGATAACG AGAAGCGACG 360
ACGCAAGGAT GCCATGCGAA GGGTCTCGAT GATACTGCGA AAATGCGACT CCATGCGCAC 420
GACGGAAGAT CGACAGTTTT TGGAGAAACA CCCGGACATG GTGAAGACGA CCAAGAAGCG 480
CAAGGAGCGG GTAGAGATAT ACAAGGAGCG GGTTGTGGAA CGCGAGGATG CGCCGCACGT 540
GATCGAGGCG AAGGTGGAGC AGTTGGCCAA CATCATTTCG CAGGCTAAGC ATCTAGTTTG 600
CTACACGGGA GCCGGTATAA GCACGGCAGC CCTGATTCCG GACTATCGCG GTAGCCAGGG 660
AATATGGACA CTGCTCCAAA AGGGTCAGGA CATCGGCGAG CATGATCTAT CCAGCGCGAA 720
TCCCACCTAC ACGCACATGG CACTTTATGA GCTGCATCGC CGCAGATTGC TGCATCATGT 780
GGTCTCCCAG AATTGTGATG GCCTGCACTT GCGATCCGGA TTACCGAGAA ATTCGTTGTC 840
CGAAATCCAT GGAAACATGT ACGTGGAGGT GTGCAAGAAC TGTCGACCGA ACAGCGTTTA 900
CTGGCGCCAG TTCGACACCA CGGAGATGAC TGCCCGCTAT TGCCACAAGA CCCACCGCCT 960
ATGCCATCGC TGCTCGGAGC CTTTGTACGA CACCATTGTG CACTTCGGAG AGCGGGGGAA 1020
CGTCAAGTGG CCATTGAACT GGGCGGGAGC CACTGCCAAT GCGCAGCGAG CGGATGTGAT 1080
TCTCTGCTTG GGCTCCAGTC TCAAGGTACT CAAGAAGTAC ACTTGGCTTT GGCAGATGGA 1140
CCGGCCTGCC CGCCAGCGAG CAAAGATCTG TGTGGTCAAC TTGCAGTGGA CGCCCAAGGA 1200
TGCGATTGCT AGCATAAAGA TCAATGGGAA ATGCGATCAG GTGATGGCCC AATTGATGCA 1260
TCTACTCCAC ATTCCAGTTC CCGTTTACAC GAAAGAGAAG GATCCGATTT TCGCACATGC 1320
TTCGCTTCTG ATGCCCGAGG AACTGCACAC GCTTACACAA CCATTGCTGA AGAATGCCGA 1380
CGAGGAGGAG GCCTTCACCA CTACCACTGA GGAAACGCAA GACTCGACTA TCTCCAGCGA 1440
GAGCTGTAGC TTTAACTACA GTGATCTTCC CATCGGCAAA GGACCCCGCA TTCGCACACC 1500
CATCAAAAAT GGTCGAAGAG TTAAGACTAA CCTGGAGCTC CGACAGAAAT TCAAGACGCT 1560
CAATGGCCAG GACGAGGAAA TTAAGGTGGA GCATGTGAAA ACAAATGGGG AGGTTAAAAC 1620
AGAGAAGGAC TTAATCACGC TGGAGTCGTC CATTAAAATA GAGACTGAAG TTAAGCTGGA 1680
GAAATTAGAG TGCTCGGACA CCAATTTTCA GCAGGAGTTG AAACTTTTGG AGCTGCTACC 1740
AAAGCTAGAA CCACTTTCGC TCAAAGAAGA GACGGAGGAA ACGCCGAGCA ATGGTTTTCC 1800
AGAGCTGCCA AAACTAGTCG CCATACAAAA AACTCATGCG GAATGTTTGT CCGCGGTCCC 1860
AACTGAATCA AGACTAAAGC CGCTTCAGCT GCCACCGCTG GTGCCCATTG GAGCACCACT 1920
GTCCACACCC TTTGTTGAGC CCAAATTGGT CCTGCCACCT GCCTCTCAGT CGTCCAGCAT 1980
ACAGATAAAG AGCGAGGGCG ATGGTGATTC CAGCACAGAG AACGATAACG AAGAGGAGGA 2040
GGAAAGCGAG CTGGCCCAGA TGGATTTGTT GAGGCAAAAC AACGATGAGG AGCTGCTTCG 2100
CCAATTACCC ACGTGGTACG ATGCCAAGTA CGCGTATTCT GGTCTGCATA GCATCCTGAT 2160
CCCACCACCA GCGGATCTCA ATATTTGGAA CTCGCAGGTG GTGCCGAACT TTGCGATGAA 2220
CAGATCCGCT GCCAGTTGTT TCTTCTGCTT TGATCGGTAT GCGGAGCTGG AGTGCCAGTT 2280
TTACCGGCGT TGGAACCTCA GTCAGCGCAA ACACAAGAAA CGGGCCAGAA GCGGTCGGTT 2340
CGTGGTCTGC GAGTGCTGTC CAACTTCCGA CGACGACGAT GACTACGATG AGAATATATC 2400
CTTGGCACAC ATAGCAGCGG CGGAAACGGC AAAGCGAAGA CAGCAGCTGA GCACGAGTTT 2460
TCCACGGAAG TTGGCGCGAA CCCAGGCAGG ATGGTATGGC AAGGGCTATA AGAAAGGTCG 2520
GAAGAGACGG TAGATTCCCA TTTATGTACG GCCGTGATTC CTCCCTAAGA TAAGAAGGTG 2580
AAATGATTAC CCTTGAGTCA ATGGCTTTTT GGAAACGTTT GATCTTATAC TTGATATGAA 2640
GGAGCTAGCT GTTTCTTTTC TACGGAAAAG ATCGACCTGC CCTCACCGAG ACATATGCTC 2700
GCTTCAATAG TATTTTAGCT ATAGGTTTAT AAGTCATAGA TGATAGTGGC AGCTAGAATA 2760
GAATAGGGTT CCTTTTATTT AGACGTGTTT TTTAAAATGC TCTATTTGTC AGTCTTTGAT 2820
TATATTAATA GGTCAGCCCG TTTTTGTCTA TTTTCGATAT TTAGTTTAAT TTTAATGGGT 2880
TTGATTGTAT GTCACAATTG TGTAACTCTT GTCCTGGTAT TTTGGTGCAC TTGCTGCAGA 2940
AATCATTTGA CCTTGTTTTT AATTATTAAT ATAGGTTTTT ACTTTTAGAA CGCTAACCTA 3000
ACATCCGCCC CTCTACACAC GTAAGTTAAA TAAAGAAAAT AAGCATTATG GTATAATG 3059
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0005634--C:nucleus
GO:0016787--F:hydrolase activity
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Mod-0025 ENSMODP00000003748.3 Monodelphis domestica 53 9e-100 362
WERAM-Pat-0205 ENSPTRP00000016642.5 Pan troglodytes 52 2e-98 358
WERAM-Bot-0001 ENSBTAP00000000043.4 Bos taurus 52 2e-97 354
WERAM-Caf-0071 ENSCAFP00000008821.3 Canis familiaris 55 2e-96 350
WERAM-Pof-0036 ENSPFOP00000003160.2 Poecilia formosa 52 5e-95 346
WERAM-Gaga-0079 ENSGALP00000030803.4 Gallus gallus 55 5e-95 346
WERAM-Xim-0159 ENSXMAP00000012987.1 Xiphophorus maculatus 52 3e-94 343
WERAM-Mam-0111 ENSMMUP00000033896.1 Macaca mulatta 55 1e-93 342
WERAM-Lac-0078 ENSLACP00000010190.1 Latimeria chalumnae 55 3e-93 340
WERAM-Loa-0218 ENSLAFP00000028885.1 Loxodonta africana 55 4e-89 327
WERAM-Aim-0202 ENSAMEP00000018412.1 Ailuropoda melanoleuca 59 3e-88 323
WERAM-Ova-0187 ENSOARP00000019088.1 Ovis aries 59 4e-88 323
WERAM-Eqc-0160 ENSECAP00000016959.1 Equus caballus 59 7e-88 322
WERAM-Meg-0056 ENSMGAP00000005219.1 Meleagris gallopavo 61 2e-85 314
WERAM-Anp-0140 ENSAPLP00000015159.1 Anas platyrhynchos 61 3e-85 313
WERAM-Php-0065 PP1S272_33V6.1 Physcomitrella patens 37 4e-47 187
WERAM-Pot-0016 POPTR_0001s37680.1 Populus trichocarpa 41 5e-47 187
WERAM-Arl-0111 fgenesh2_kg.8__ 1477__ AT5G55760.1 Arabidopsis lyrata 41 1e-46 185
WERAM-Brr-0144 Bra028961.1-P Brassica rapa 40 1e-46 185
WERAM-Art-0143 AT5G55760.1 Arabidopsis thaliana 40 4e-46 184
WERAM-Bro-0046 Bo3g021360.1 Brassica oleracea 40 4e-46 184
WERAM-Met-0085 KEH34091 Medicago truncatula 40 5e-46 183
WERAM-Amt-0008 ERN05726 Amborella trichopoda 40 9e-46 182
WERAM-Brd-0122 BRADI5G02940.2 Brachypodium distachyon 38 3e-45 181
WERAM-Glm-0232 GLYMA18G08450.1 Glycine max 40 4e-45 181
WERAM-Ors-0038 OS04T0271000-01 Oryza sativa 39 4e-45 180
WERAM-Prp-0059 EMJ12601 Prunus persica 40 4e-45 180
WERAM-Tra-0088 Traes_2DS_071650798.1 Triticum aestivum 40 8e-45 179
WERAM-Org-0043 ORGLA04G0042700.1 Oryza glaberrima 39 9e-45 179
WERAM-Sol-0101 Solyc07g065550.2.1 Solanum lycopersicum 39 2e-44 178
WERAM-Orbr-0051 OB04G14570.1 Oryza brachyantha 39 3e-44 177
WERAM-Mua-0125 GSMUA_Achr8P24470_001 Musa acuminata 38 5e-44 177
WERAM-Ori-0050 BGIOSGA015454-PA Oryza indica 39 8e-44 176
WERAM-Sei-0037 Si010693m Setaria italica 38 3e-43 174
WERAM-Sob-0090 Sb06g020390.1 Sorghum bicolor 37 9e-43 172
WERAM-Aet-0057 EMT21754 Aegilops tauschii 40 1e-41 169
WERAM-Viv-0122 VIT_19s0015g00570.t01 Vitis vinifera 38 5e-41 167
WERAM-Zem-0044 GRMZM2G058573_P01 Zea mays 38 7e-41 166
WERAM-Orn-0127 ENSONIP00000012860.1 Oreochromis niloticus 41 9e-41 166
WERAM-Sot-0070 PGSC0003DMT400057382 Solanum tuberosum 39 1e-40 165
WERAM-Lep-0045 LPERR04G03890.1 Leersia perrieri 40 2e-40 165
WERAM-Ict-0164 ENSSTOP00000015068.1 Ictidomys tridecemlineatus 40 4e-40 164
WERAM-Gam-0126 ENSGMOP00000013105.1 Gadus morhua 39 5e-40 164
WERAM-Orl-0053 KN539062.1_FGP005 Oryza longistaminata 39 6e-40 163
WERAM-Gaa-0163 ENSGACP00000020196.1 Gasterosteus aculeatus 40 2e-39 161
WERAM-Pes-0079 ENSPSIP00000009554.1 Pelodiscus sinensis 38 7e-38 156
WERAM-Tar-0090 ENSTRUP00000017073.1 Takifugu rubripes 39 9e-38 156
WERAM-Xet-0167 ENSXETP00000057383.2 Xenopus tropicalis 39 2e-37 155
WERAM-Paa-0028 ENSPANP00000011086.1 Papio anubis 38 2e-37 155
WERAM-Gog-0100 ENSGGOP00000008641.2 Gorilla gorilla 38 2e-37 154
WERAM-Chs-0131 ENSCSAP00000006979.1 Chlorocebus sabaeus 38 2e-37 154
WERAM-Otg-0026 ENSOGAP00000001481.2 Otolemur garnettii 38 3e-37 154
WERAM-Caj-0156 ENSCJAP00000027893.2 Callithrix jacchus 38 3e-37 154
WERAM-Poa-0078 ENSPPYP00000010537.2 Pongo abelii 38 3e-37 154
WERAM-Hos-0033 ENSP00000337332.1 Homo sapiens 38 3e-37 154
WERAM-Fia-0011 ENSFALP00000000954.1 Ficedula albicollis 39 4e-37 154
WERAM-Soa-0094 ENSSARP00000008710.1 Sorex araneus 36 3e-36 151
WERAM-Mup-0054 ENSMPUP00000004703.1 Mustela putorius furo 37 3e-36 150
WERAM-Sah-0106 ENSSHAP00000011597.1 Sarcophilus harrisii 38 7e-36 150
WERAM-Mae-0123 ENSMEUP00000012391.1 Macropus eugenii 38 4e-35 147
WERAM-Mum-0135 ENSMUSP00000048971.8 Mus musculus 36 6e-35 146
WERAM-Ran-0038 ENSRNOP00000008758.3 Rattus norvegicus 36 2e-34 145
WERAM-Myl-0098 ENSMLUP00000007946.2 Myotis lucifugus 37 7e-34 143
WERAM-Cis-0072 ENSCSAVP00000015450.1 Ciona savignyi 34 2e-33 141
WERAM-Sus-0098 ENSSSCP00000014344.2 Sus scrofa 34 9e-31 132
WERAM-Ocp-0148 ENSOPRP00000015399.1 Ochotona princeps 28 4e-17 87.8
WERAM-Orc-0113 ENSOCUP00000009744.3 Oryctolagus cuniculus 27 4e-16 84.3
WERAM-Fec-0171 ENSFCAP00000020847.1 Felis catus 28 1e-15 83.2
WERAM-Sem-0060 EFJ23112 Selaginella moellendorffii 28 4e-15 80.9
WERAM-Chh-0046 ENSCHOP00000005172.1 Choloepus hoffmanni 26 8e-15 80.1
WERAM-Tas-0026 ENSTSYP00000002962.1 Tarsius syrichta 27 9e-15 79.7
WERAM-Dar-0026 ENSDARP00000027611.6 Danio rerio 27 2e-14 79.0
WERAM-Ora-0041 ENSOANP00000006568.2 Ornithorhynchus anatinus 26 3e-14 78.2
WERAM-Orp-0109 OPUNC12G04720.1 Oryza punctata 26 5e-14 77.4
WERAM-Orr-0119 ORUFI12G05460.1 Oryza rufipogon 26 2e-13 75.9
WERAM-Orm-0103 OMERI12G03020.1 Oryza meridionalis 26 2e-13 75.9
WERAM-Tut-0072 ENSTTRP00000005343.1 Tursiops truncatus 29 2e-13 75.1
WERAM-Ptv-0014 ENSPVAP00000002101.1 Pteropus vampyrus 27 5e-13 73.9
WERAM-Thc-0008 EOX92647 Theobroma cacao 25 2e-12 72.4
WERAM-Ect-0086 ENSETEP00000009903.1 Echinops telfairi 25 2e-12 72.0
WERAM-Tub-0044 ENSTBEP00000005291.1 Tupaia belangeri 26 2e-12 72.0
WERAM-Chr-0008 EDP00705 Chlamydomonas reinhardtii 27 3e-12 71.6
WERAM-Asm-0019 ENSAMXP00000002317.1 Astyanax mexicanus 27 5e-12 70.9
WERAM-Dan-0155 ENSDNOP00000033669.1 Dasypus novemcinctus 28 6e-12 70.5
WERAM-Nol-0169 ENSNLEP00000018942.2 Nomascus leucogenys 27 9e-12 70.1
WERAM-Pyt-0039 EFQ86136 Pyrenophora teres 30 1e-11 69.7
WERAM-Leo-0156 ENSLOCP00000018785.1 Lepisosteus oculatus 28 2e-11 68.9
WERAM-Pytr-0009 EDU41553 Pyrenophora triticirepentis 29 2e-11 68.6
WERAM-Pem-0012 ENSPMAP00000001780.1 Petromyzon marinus 24 3e-11 68.2
WERAM-Lab-0008 EDR12994 Laccaria bicolor 26 6e-11 67.4
WERAM-Orla-0208 ENSORLP00000024753.1 Oryzias latipes 24 1e-10 66.2
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 27 1e-10 66.2
WERAM-Tag-0120 ENSTGUP00000009802.1 Taeniopygia guttata 25 1e-10 66.2
WERAM-Kop-0015 CAY69145 Komagataella pastoris 24 6e-10 63.9
WERAM-Pug-0030 EFP89251 Puccinia graminis 27 2e-09 62.4
WERAM-Anc-0024 ENSACAP00000002561.3 Anolis carolinensis 24 2e-09 62.0
WERAM-Scp-0042 SPCC132.02.1:pep Schizosaccharomyces pombe 29 5e-09 60.8
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 25 8e-09 60.1
WERAM-Ten-0144 ENSTNIP00000015099.1 Tetraodon nigroviridis 27 1e-08 59.3
WERAM-Scj-0005 EEB06048 Schizosaccharomyces japonicus 28 2e-08 59.3
WERAM-Cap-0175 ENSCPOP00000019359.1 Cavia porcellus 23 2e-08 58.9
WERAM-Cag-0008 CAG58313 Candida glabrata 23 3e-08 58.2
WERAM-Zyt-0001 Mycgr3P100618 Zymoseptoria tritici 27 4e-08 57.8
WERAM-Ere-0059 ENSEEUP00000005136.1 Erinaceus europaeus 28 4e-07 54.3
WERAM-Kll-0017 CAH00978 Kluyveromyces lactis 27 8e-07 53.5
WERAM-Trr-0005 EGR51157 Trichoderma reesei 30 9e-07 53.5
WERAM-Caa-0006 KGT71361 Candida albicans 29 2e-06 52.4
WERAM-Dio-0050 ENSDORP00000004937.1 Dipodomys ordii 28 2e-06 52.0
Created Date 25-Jun-2016