| Tag |
Content |
| WERAM ID |
WERAM-Drm-0023 |
| Ensembl Protein ID |
FBpp0080015 |
| Uniprot Accession |
Q9VK34; SIR2_DROME; D5SHQ6; O96505
|
| Genbank Protein ID |
NP_477351.1
|
| Protein Name |
NAD-dependent histone deacetylase Sir2 |
| Genbank Nucleotide ID |
NM_058003.4
|
| Gene Name |
SIR2;CG5216 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K56 |
K |
15520384
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
1.20e-91 |
307.2 |
213 |
483 |
|
| Organism |
Drosophila melanogaster |
| NCBI Taxa ID |
7227 |
Functional Description
(View)Functional Description
NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. |
NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkke..elpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelekkgkllr 97
++++l+kks+ki+vltGAG+S+s+GIPDFRs++G+y++l+++ +lp+p+a+fd+++f++dp++fy++a+e+yp g+++P+++H+f+++le+kgkllr
FBpp0080015 213 DVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDfpDLPDPQAMFDINYFKRDPRPFYKFAREIYP-GEFQPSPCHRFIKMLETKGKLLR 309
6899**********************************************************************.*********************** PP
SIR2.txt 98 lytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCekC........................kgvlkpdivffgen 171
+ytQNiD+Ler ag++ +++e+HGs++tasCtkC+ +++ + ++++++a+ ++p+C++C +g++kpdivffge
FBpp0080015 310 NYTQNIDTLERVAGIQ--RVIECHGSFSTASCTKCRFKCNADALRADIFAQ-RIPVCPQCqpnkeqsvdasvavteeelrqlveNGIMKPDIVFFGEG 404
***************9..*********************************.9******************************99************* PP
SIR2.txt 172 lpeefleeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkllgle 252
lp+e ++ +++d++ +dll+v+G+Slkv+pva+++ + ++++vp++l+n+e+++ + ++d++llgd d ++++++++l+++
FBpp0080015 405 LPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIP-SSIPATVPQILINREQLH-HLKFDVELLGDSDVIINQICHRLSDN 483
***********************************.*****************9.99*******************99875 PP
|
Protein Sequence
(Fasta) | MMENYEEIRL GHIRSKDLGN QVPDTTQFYP PTKFDFGAEI LASTSTEAEA EAEATATTTE 60
PATSELAGKA NGEIKTKTLA AREEQEIGAN LEHKTKNPTK SMGEDEDDEE EEEEDDEEEE 120
EDDEEGITGT SNEDEDSSSN CSSSVEPDWK LRWLQREFYT GRVPRQVIAS IMPHFATGLA 180
GDTDDSVLWD YLAHLLNEPK RRNKLASVNT FDDVISLVKK SQKIIVLTGA GVSVSCGIPD 240
FRSTNGIYAR LAHDFPDLPD PQAMFDINYF KRDPRPFYKF AREIYPGEFQ PSPCHRFIKM 300
LETKGKLLRN YTQNIDTLER VAGIQRVIEC HGSFSTASCT KCRFKCNADA LRADIFAQRI 360
PVCPQCQPNK EQSVDASVAV TEEELRQLVE NGIMKPDIVF FGEGLPDEYH TVMATDKDVC 420
DLLIVIGSSL KVRPVAHIPS SIPATVPQIL INREQLHHLK FDVELLGDSD VIINQICHRL 480
SDNDDCWRQL CCDESVLTES KELMPPEHSN HHLHHHLLHH RHCSSESERQ SQLDTDTQSI 540
KSNSSADYIL GSAGTCSDSG FESSTFSCGK RSTAAEAAAI ERIKTDILVE LNETTALSCD 600
RLGLEGPQTT VESYRHLSID SSKDSGIEQC DNEATPSYVR PSNLVQETKT VAPSLTPIPQ 660
QRGKRQTAAE RLQPGTFYSH TNNYSYVFPG AQVFWDNDYS DDDDEEEERS HNRHSDLFGN 720
VGHNYKDDDE DACDLNAVPL SPLLPPSLEA HIVTDIVNGS NEPLPNSSPG QKRTACIIEQ 780
QPTPAIETEI PPLKKRRPSE ENKQQTQIER SEESPPPGQL AAV 823Protein Fasta Sequence
>FBpp0080015|SIR2;CG5216|Drosophila melanogaster
MMENYEEIRLGHIRSKDLGNQVPDTTQFYPPTKFDFGAEILASTSTEAEAEAEATATTTEPATSELAGKANGEIKTKTLAAREEQEIGANLEHKTKNPTKSMGEDEDDEEEEEEDDEEEEEDDEEGITGTSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGDSDVIINQICHRLSDNDDCWRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIKSNSSADYILGSAGTCSDSGFESSTFSCGKRSTAAEAAAIERIKTDILVELNETTALSCDRLGLEGPQTTVESYRHLSIDSSKDSGIEQCDNEATPSYVRPSNLVQETKTVAPSLTPIPQQRGKRQTAAERLQPGTFYSHTNNYSYVFPGAQVFWDNDYSDDDDEEEERSHNRHSDLFGNVGHNYKDDDEDACDLNAVPLSPLLPPSLEAHIVTDIVNGSNEPLPNSSPGQKRTACIIEQQPTPAIETEIPPLKKRRPSEENKQQTQIERSEESPPPGQLAAV |
Nucleotide Sequence
(Fasta) | TGCCAGCCCA CATACACACA CAGGCGCAGC TACGTGTGCC ATCTTGCTTT TTTCATCGGA 60
AAATTTTCCA GAAACTACGC TCGAAAATTA CGAAAAAATC GCAACCAAAT GGTGTCGAAA 120
TTTTTTTAAA ATTTAAGTTT CGTGCATATA CGTGAAATAA AGTCGGGTTG GTTGAAAAAA 180
TCGCGGCCAA ACGATCGCTG GAGAATTTTT TCAATCAAGC CAAATGGGTG CGAAGCTGAC 240
GACGTAAAAA TTTTTGTGTG TACCAACGAA AGAGCGGAGA AAACGGACGA GGCGAGAGCG 300
CAAAGCGGAG AGACCGAGGA AACACTCGCG CAAGAAGAAG AAGAGCCAGC AACAGCACCA 360
ACTACGAGAG TTTTCTCTCC GTGAGTCTGT GTGTGTGCGC GTGTGCGCGC GCTTGGGTTC 420
GGAAAAAATG ATGGAAAATT ACGAGGAAAT TCGCCTGGGC CACATTAGGT CTAAAGATCT 480
GGGCAACCAG GTGCCAGACA CTACGCAATT CTATCCGCCA ACTAAGTTTG ATTTTGGCGC 540
GGAAATTCTG GCCTCAACGT CAACAGAGGC AGAGGCAGAG GCAGAAGCAA CAGCAACAAC 600
CACAGAACCA GCAACAAGCG AACTTGCTGG CAAAGCAAAT GGTGAAATCA AAACAAAAAC 660
ATTGGCTGCC AGGGAAGAAC AAGAGATTGG CGCCAATTTG GAGCATAAAA CCAAAAATCC 720
CACAAAGTCA ATGGGCGAGG ATGAAGATGA CGAGGAGGAG GAGGAAGAGG ACGATGAGGA 780
GGAGGAGGAG GACGACGAGG AGGGAATCAC CGGAACGAGC AACGAGGATG AGGACTCCAG 840
CTCAAATTGC TCCTCATCCG TGGAACCCGA CTGGAAGCTG CGCTGGTTGC AACGAGAATT 900
TTACACAGGT CGTGTGCCGC GCCAGGTTAT TGCCAGCATT ATGCCGCATT TCGCCACCGG 960
CCTGGCGGGC GACACCGACG ACTCCGTGCT GTGGGACTAT TTGGCCCACC TGTTGAACGA 1020
GCCGAAGCGG CGCAACAAGC TGGCCTCAGT GAACACCTTC GACGATGTCA TCAGTTTGGT 1080
CAAGAAATCA CAGAAGATCA TTGTGCTAAC GGGAGCCGGA GTATCCGTCT CCTGCGGCAT 1140
TCCGGACTTC CGGTCCACCA ATGGCATATA TGCGCGATTG GCCCATGATT TTCCCGATCT 1200
GCCCGATCCG CAGGCCATGT TTGATATCAA CTACTTCAAG AGGGATCCAC GACCGTTCTA 1260
CAAGTTTGCC CGCGAGATAT ATCCCGGCGA GTTTCAGCCC TCACCCTGCC ATCGTTTCAT 1320
CAAAATGCTG GAGACCAAGG GCAAACTGTT GCGCAACTAC ACACAGAACA TCGACACCCT 1380
CGAGCGGGTG GCAGGCATTC AGCGAGTAAT CGAGTGTCAC GGCTCCTTTT CAACGGCCTC 1440
GTGCACCAAG TGTCGTTTCA AGTGCAACGC TGACGCCCTG CGGGCGGACA TATTTGCCCA 1500
GCGAATTCCG GTGTGCCCGC AGTGCCAGCC CAATAAGGAG CAGAGCGTGG ATGCCTCGGT 1560
GGCCGTTACT GAGGAGGAGC TGCGCCAACT GGTCGAGAAC GGCATCATGA AGCCGGATAT 1620
CGTCTTTTTC GGCGAGGGAC TGCCGGATGA GTACCACACG GTCATGGCCA CCGACAAGGA 1680
CGTGTGCGAT CTACTGATCG TGATCGGCTC CTCGCTGAAG GTCCGACCTG TGGCCCACAT 1740
TCCCAGCAGC ATACCGGCCA CGGTGCCGCA GATTCTTATC AATCGCGAGC AGCTGCATCA 1800
CCTTAAGTTC GATGTGGAGC TGCTGGGCGA CTCCGATGTG ATCATCAACC AGATTTGCCA 1860
CCGGTTGTCG GACAACGATG ATTGCTGGCG GCAGCTGTGC TGCGATGAGT CAGTGCTTAC 1920
CGAAAGCAAG GAGCTAATGC CTCCGGAGCA CTCTAATCAC CACCTCCATC ATCATCTACT 1980
TCACCACCGC CACTGCAGTT CAGAGAGCGA GCGACAGTCG CAACTGGACA CGGATACGCA 2040
GTCTATTAAA TCAAATAGTT CGGCGGACTA CATACTAGGA TCAGCTGGCA CCTGCTCGGA 2100
TAGTGGATTT GAGTCATCTA CTTTTAGCTG TGGAAAGCGT TCCACTGCCG CCGAAGCGGC 2160
AGCCATCGAA CGTATTAAAA CAGACATACT GGTTGAGCTG AACGAGACCA CAGCCCTAAG 2220
TTGCGATCGT CTGGGCCTGG AAGGCCCTCA GACAACGGTG GAGAGCTATC GCCATCTTTC 2280
CATTGATTCC TCCAAGGATA GCGGCATCGA GCAGTGCGAC AACGAAGCCA CGCCTAGCTA 2340
CGTGCGACCC AGCAATCTTG TTCAGGAGAC CAAGACAGTG GCGCCCAGCC TGACGCCCAT 2400
TCCACAACAG AGGGGAAAGC GACAGACAGC AGCCGAGCGT CTGCAGCCTG GAACATTCTA 2460
TTCGCACACC AACAACTATT CGTATGTGTT TCCAGGAGCC CAGGTATTCT GGGACAACGA 2520
TTACAGCGAT GATGATGACG AAGAAGAGGA AAGATCACAC AATAGACACA GTGATCTCTT 2580
TGGCAATGTG GGGCACAATT ATAAGGATGA TGATGAGGAT GCATGTGATC TGAACGCCGT 2640
TCCATTGTCA CCATTGCTAC CGCCTTCACT GGAGGCTCAC ATAGTCACCG ATATAGTGAA 2700
TGGATCCAAC GAACCGCTGC CCAACAGCAG TCCCGGCCAG AAAAGAACCG CCTGCATTAT 2760
AGAACAGCAG CCAACGCCCG CTATTGAAAC GGAAATTCCC CCACTAAAGA AGCGGCGACC 2820
AAGTGAGGAA AATAAGCAGC AGACCCAAAT AGAAAGATCT GAGGAGAGTC CGCCTCCAGG 2880
ACAGTTAGCA GCAGTGTAAA CGTAATCTTA GCCCCTGCTA GTAGTGTAGT ATTTATTTTA 2940
AATGCAATTC AAGCCAACTT GTAAACAGAG AAGCTGCGAA ATCGTAGCCG AGGGCCATGT 3000
TACCAATTTC ATTCCCCGGA AAGGTACTGG AATCGGAAAC GGTAAACCGT TTACTTGTTA 3060
TTTATTTAGA ATATGAGAAC ACTTCAATTC CCGGTATCAC GAAGTTTTCA AGAAATGAAA 3120
CCGGATCCAC TAGTTTACTC AATTCGAGGC TTTAGAGATC TGACCCTCGT TGCTTTACCA 3180
CCAACCCCTT ATGCCCAATC CCGTTTTGAT ATTTTTGAAA AACTCTTAGT TTATTTATTA 3240
TCTCTCTTTT TCAAAACGAA ACGCTGTAAA TGTTAGTATT TTATTATATT AAGTTGTTAT 3300
TGAGGCCTTT TTAGACAAAC TAAAGAGATA AGCGGAAAGT TGAAAATCCT TTAGAAAGCA 3360
GGATTTCTTT GTATTCAAAG AGAAGCAGCG CCTCAACTTT AAATCTAGTT CTAAGCGTAA 3420
CATATTCAAA ACTATGCAAA TGCAAACGGA AAAATACGTT AGTTTTAGTT AAAAACTAGA 3480
CACAAACACT CTGTATATAA GCACTCGCCC CTAATTTGTA TTGTACATGA TTCTTTTTCT 3540
ACTTTTTTGT GTTATCTCCT TACCATTTTA TATTTCTATC GGTTATGGCA ACTATTTTTT 3600
AACATTTATA CACTCGCACC CACATCAAAA TGTAACAGCG CATGGATTTC AAAATATTCA 3660
TAAGAGTTGG AAATTTGGTG TGCGTGTTTG AAATGTTTAT TCGAAACCTA GCATAAATAT 3720
ATAGCCACCA AACGCAGTGT AAACATAGCA GTAAGAATTT AGTCTATATG TCTTAAAAGT 3780
GTATTAATAT CCAGAATATA AACCAATCT
Nucleotide Fasta Sequence
>FBpp0080015|SIR2|Drosophila melanogaster
TGCCAGCCCACATACACACACAGGCGCAGCTACGTGTGCCATCTTGCTTTTTTCATCGGAAAATTTTCCAGAAACTACGCTCGAAAATTACGAAAAAATCGCAACCAAATGGTGTCGAAATTTTTTTAAAATTTAAGTTTCGTGCATATACGTGAAATAAAGTCGGGTTGGTTGAAAAAATCGCGGCCAAACGATCGCTGGAGAATTTTTTCAATCAAGCCAAATGGGTGCGAAGCTGACGACGTAAAAATTTTTGTGTGTACCAACGAAAGAGCGGAGAAAACGGACGAGGCGAGAGCGCAAAGCGGAGAGACCGAGGAAACACTCGCGCAAGAAGAAGAAGAGCCAGCAACAGCACCAACTACGAGAGTTTTCTCTCCGTGAGTCTGTGTGTGTGCGCGTGTGCGCGCGCTTGGGTTCGGAAAAAATGATGGAAAATTACGAGGAAATTCGCCTGGGCCACATTAGGTCTAAAGATCTGGGCAACCAGGTGCCAGACACTACGCAATTCTATCCGCCAACTAAGTTTGATTTTGGCGCGGAAATTCTGGCCTCAACGTCAACAGAGGCAGAGGCAGAGGCAGAAGCAACAGCAACAACCACAGAACCAGCAACAAGCGAACTTGCTGGCAAAGCAAATGGTGAAATCAAAACAAAAACATTGGCTGCCAGGGAAGAACAAGAGATTGGCGCCAATTTGGAGCATAAAACCAAAAATCCCACAAAGTCAATGGGCGAGGATGAAGATGACGAGGAGGAGGAGGAAGAGGACGATGAGGAGGAGGAGGAGGACGACGAGGAGGGAATCACCGGAACGAGCAACGAGGATGAGGACTCCAGCTCAAATTGCTCCTCATCCGTGGAACCCGACTGGAAGCTGCGCTGGTTGCAACGAGAATTTTACACAGGTCGTGTGCCGCGCCAGGTTATTGCCAGCATTATGCCGCATTTCGCCACCGGCCTGGCGGGCGACACCGACGACTCCGTGCTGTGGGACTATTTGGCCCACCTGTTGAACGAGCCGAAGCGGCGCAACAAGCTGGCCTCAGTGAACACCTTCGACGATGTCATCAGTTTGGTCAAGAAATCACAGAAGATCATTGTGCTAACGGGAGCCGGAGTATCCGTCTCCTGCGGCATTCCGGACTTCCGGTCCACCAATGGCATATATGCGCGATTGGCCCATGATTTTCCCGATCTGCCCGATCCGCAGGCCATGTTTGATATCAACTACTTCAAGAGGGATCCACGACCGTTCTACAAGTTTGCCCGCGAGATATATCCCGGCGAGTTTCAGCCCTCACCCTGCCATCGTTTCATCAAAATGCTGGAGACCAAGGGCAAACTGTTGCGCAACTACACACAGAACATCGACACCCTCGAGCGGGTGGCAGGCATTCAGCGAGTAATCGAGTGTCACGGCTCCTTTTCAACGGCCTCGTGCACCAAGTGTCGTTTCAAGTGCAACGCTGACGCCCTGCGGGCGGACATATTTGCCCAGCGAATTCCGGTGTGCCCGCAGTGCCAGCCCAATAAGGAGCAGAGCGTGGATGCCTCGGTGGCCGTTACTGAGGAGGAGCTGCGCCAACTGGTCGAGAACGGCATCATGAAGCCGGATATCGTCTTTTTCGGCGAGGGACTGCCGGATGAGTACCACACGGTCATGGCCACCGACAAGGACGTGTGCGATCTACTGATCGTGATCGGCTCCTCGCTGAAGGTCCGACCTGTGGCCCACATTCCCAGCAGCATACCGGCCACGGTGCCGCAGATTCTTATCAATCGCGAGCAGCTGCATCACCTTAAGTTCGATGTGGAGCTGCTGGGCGACTCCGATGTGATCATCAACCAGATTTGCCACCGGTTGTCGGACAACGATGATTGCTGGCGGCAGCTGTGCTGCGATGAGTCAGTGCTTACCGAAAGCAAGGAGCTAATGCCTCCGGAGCACTCTAATCACCACCTCCATCATCATCTACTTCACCACCGCCACTGCAGTTCAGAGAGCGAGCGACAGTCGCAACTGGACACGGATACGCAGTCTATTAAATCAAATAGTTCGGCGGACTACATACTAGGATCAGCTGGCACCTGCTCGGATAGTGGATTTGAGTCATCTACTTTTAGCTGTGGAAAGCGTTCCACTGCCGCCGAAGCGGCAGCCATCGAACGTATTAAAACAGACATACTGGTTGAGCTGAACGAGACCACAGCCCTAAGTTGCGATCGTCTGGGCCTGGAAGGCCCTCAGACAACGGTGGAGAGCTATCGCCATCTTTCCATTGATTCCTCCAAGGATAGCGGCATCGAGCAGTGCGACAACGAAGCCACGCCTAGCTACGTGCGACCCAGCAATCTTGTTCAGGAGACCAAGACAGTGGCGCCCAGCCTGACGCCCATTCCACAACAGAGGGGAAAGCGACAGACAGCAGCCGAGCGTCTGCAGCCTGGAACATTCTATTCGCACACCAACAACTATTCGTATGTGTTTCCAGGAGCCCAGGTATTCTGGGACAACGATTACAGCGATGATGATGACGAAGAAGAGGAAAGATCACACAATAGACACAGTGATCTCTTTGGCAATGTGGGGCACAATTATAAGGATGATGATGAGGATGCATGTGATCTGAACGCCGTTCCATTGTCACCATTGCTACCGCCTTCACTGGAGGCTCACATAGTCACCGATATAGTGAATGGATCCAACGAACCGCTGCCCAACAGCAGTCCCGGCCAGAAAAGAACCGCCTGCATTATAGAACAGCAGCCAACGCCCGCTATTGAAACGGAAATTCCCCCACTAAAGAAGCGGCGACCAAGTGAGGAAAATAAGCAGCAGACCCAAATAGAAAGATCTGAGGAGAGTCCGCCTCCAGGACAGTTAGCAGCAGTGTAAACGTAATCTTAGCCCCTGCTAGTAGTGTAGTATTTATTTTAAATGCAATTCAAGCCAACTTGTAAACAGAGAAGCTGCGAAATCGTAGCCGAGGGCCATGTTACCAATTTCATTCCCCGGAAAGGTACTGGAATCGGAAACGGTAAACCGTTTACTTGTTATTTATTTAGAATATGAGAACACTTCAATTCCCGGTATCACGAAGTTTTCAAGAAATGAAACCGGATCCACTAGTTTACTCAATTCGAGGCTTTAGAGATCTGACCCTCGTTGCTTTACCACCAACCCCTTATGCCCAATCCCGTTTTGATATTTTTGAAAAACTCTTAGTTTATTTATTATCTCTCTTTTTCAAAACGAAACGCTGTAAATGTTAGTATTTTATTATATTAAGTTGTTATTGAGGCCTTTTTAGACAAACTAAAGAGATAAGCGGAAAGTTGAAAATCCTTTAGAAAGCAGGATTTCTTTGTATTCAAAGAGAAGCAGCGCCTCAACTTTAAATCTAGTTCTAAGCGTAACATATTCAAAACTATGCAAATGCAAACGGAAAAATACGTTAGTTTTAGTTAAAAACTAGACACAAACACTCTGTATATAAGCACTCGCCCCTAATTTGTATTGTACATGATTCTTTTTCTACTTTTTTGTGTTATCTCCTTACCATTTTATATTTCTATCGGTTATGGCAACTATTTTTTAACATTTATACACTCGCACCCACATCAAAATGTAACAGCGCATGGATTTCAAAATATTCATAAGAGTTGGAAATTTGGTGTGCGTGTTTGAAATGTTTATTCGAAACCTAGCATAAATATATAGCCACCAAACGCAGTGTAAACATAGCAGTAAGAATTTAGTCTATATGTCTTAAAAGTGTATTAATATCCAGAATATAAACCAATCT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004407--F:histone deacetylase activity
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0008134--F:transcription factor binding
GO:0048149--P:behavioral response to ethanol
GO:0006342--P:chromatin silencing
GO:0008340--P:determination of adult lifespan
GO:0016575--P:histone deacetylation
GO:2000253--P:positive regulation of feeding behavior
GO:0042981--P:regulation of apoptotic process
GO:0035065--P:regulation of histone acetylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007584--P:response to nutrient
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
