WERAM Information


Tag Content
WERAM ID WERAM-Sac-0040
Ensembl Protein ID YOL068C
Uniprot Accession P53685; HST1_YEAST; D6W1Z9
Genbank Protein ID NP_014573.1
Protein Name NAD-dependent protein deacetylase HST1
Genbank Nucleotide ID NM_001183323.1
Gene Name HST1;YOL068C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YOL068C YOL068C YOL068C
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type H2A; H2B; H3; H4 K 25288982
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 3.40e-90 300.3 192 469
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)
NAD-dependent histone deacetylase involved in telomeric silencing. Histone deacetylase proteins act via the formation of large multiprotein complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Restores silencing at HMR in SIR2 mutants when overexpressed. Required to repress middle sporulation genes during vegetative growth. Acts as a sensor of NAD(+) levels and regulator of NAD(+) biosynthesis. Regulates the gene expression of de novo NAD(+) biosynthesis genes.
Domain Profile
  HDAC SIR2

  SIR2.txt   2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdldffrkdpkvfyalakelyp.lgsakPtktHyflaelekkgkllrlytQ 101
+++++l+++kki+vltGAG+Sts GIPDFRsseG+ysk+++ l++p+++f+ld+f +dp+vfy++a++++p ++ ++P H+f+++l++kgkllr+ytQ
YOL068C 192 HFTATLRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYNIAHMVLPpENMYSPL--HSFIKMLQDKGKLLRNYTQ 290
68999*******************************************************************999***99..******************* PP
SIR2.txt 102 NiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCekC..............................kgvlkpdivffgenl 172
NiD+Le+ ag++ dklv++HGs+atasC++C++++p+e+i e++++ ++p C+ C gvlkpd++ffge+l
YOL068C 291 NIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIPGEKIFENIRNL-ELPLCPYCyqkrkqyfpmsngnntvqtninfnspilksYGVLKPDMTFFGEAL 390
***********************************************.9************************************99************** PP
SIR2.txt 173 peefleeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkllglee 253
p++f++++++d+ e+dll+++GtSlkv+pv+++v ++v+++vp++l+n+++v+ ++++dl+llg cd+v++ ++k++++++
YOL068C 391 PSRFHKTIRKDILECDLLICIGTSLKVAPVSEIV-NMVPSHVPQILINRDMVT-HAEFDLNLLGFCDDVASLVAKKCHWDI 469
**********************************.******************.*************************86 PP

Protein Sequence
(Fasta)
MNILLMQRIV SFILVVSQGR YFHVGELTMT MLKRPQEEES DNNATKKLKT RLTYPCILGK 60
DKVTGKFIFP AITKDDVMNA RLFLKDNDLK TFLEYFLPVE VNSIYIYFMI KLLGFDVKDK 120
ELFMALNSNI TSNKERSSAE LSSIHAKAED EDELTDPLEK KHAVKLIKDL QKAINKVLST 180
RLRLPNFNTI DHFTATLRNA KKILVLTGAG VSTSLGIPDF RSSEGFYSKI RHLGLEDPQD 240
VFNLDIFLQD PSVFYNIAHM VLPPENMYSP LHSFIKMLQD KGKLLRNYTQ NIDNLESYAG 300
IDPDKLVQCH GSFATASCVT CHWQIPGEKI FENIRNLELP LCPYCYQKRK QYFPMSNGNN 360
TVQTNINFNS PILKSYGVLK PDMTFFGEAL PSRFHKTIRK DILECDLLIC IGTSLKVAPV 420
SEIVNMVPSH VPQILINRDM VTHAEFDLNL LGFCDDVASL VAKKCHWDIP HKKWQDLKKI 480
DYNCTEIDKG TYKIKKQPRK KQQ 503
Nucleotide Sequence
(Fasta)
ATGAACATAT TGCTAATGCA ACGGATAGTT AGTTTTATTT TGGTGGTTAG TCAAGGGCGA 60
TACTTTCATG TTGGAGAGCT GACCATGACA ATGTTGAAAA GACCTCAAGA AGAAGAGTCA 120
GATAATAATG CTACGAAGAA GCTGAAAACG AGATTAACGT ACCCTTGTAT CCTCGGGAAG 180
GATAAGGTGA CGGGCAAATT CATCTTTCCT GCAATCACTA AAGATGATGT TATGAATGCA 240
AGACTGTTTT TGAAGGACAA CGATTTGAAA ACTTTTTTAG AATATTTTTT GCCAGTGGAA 300
GTCAACTCGA TCTACATTTA TTTCATGATA AAATTGCTGG GATTCGACGT CAAAGATAAA 360
GAACTATTTA TGGCGTTAAA CTCTAATATC ACTTCTAATA AAGAACGTTC TAGTGCGGAA 420
CTATCGTCTA TACATGCAAA AGCTGAAGAT GAGGACGAGT TGACCGATCC CTTAGAGAAA 480
AAGCATGCAG TAAAATTAAT CAAAGATTTA CAAAAAGCCA TAAATAAAGT CCTTAGTACA 540
AGGCTTCGAT TACCCAACTT CAATACGATT GATCATTTCA CCGCCACTTT GCGTAACGCC 600
AAAAAAATTT TGGTTCTGAC GGGCGCTGGA GTTTCCACTT CTTTAGGTAT TCCCGATTTT 660
AGATCATCTG AGGGGTTTTA TTCTAAGATC CGACACCTTG GATTGGAAGA CCCTCAGGAT 720
GTTTTCAACT TGGATATATT CTTACAGGAC CCTTCTGTTT TTTACAATAT TGCCCATATG 780
GTTTTACCAC CAGAGAACAT GTATTCTCCG TTGCACAGCT TCATTAAAAT GCTACAAGAC 840
AAGGGCAAAC TATTAAGAAA CTACACACAG AATATAGATA ACTTAGAATC GTATGCAGGG 900
ATAGATCCTG ATAAATTAGT GCAATGTCAC GGTTCATTCG CCACTGCATC TTGTGTGACT 960
TGCCATTGGC AAATACCTGG TGAGAAAATA TTCGAAAATA TTAGAAACCT TGAACTACCA 1020
TTATGTCCCT ACTGTTATCA AAAAAGAAAA CAATATTTTC CTATGAGTAA TGGCAATAAT 1080
ACGGTGCAAA CAAACATAAA TTTCAACTCA CCCATTTTAA AGTCGTATGG TGTTTTGAAA 1140
CCAGACATGA CATTTTTTGG CGAGGCCCTG CCATCGCGAT TTCATAAGAC CATCCGCAAA 1200
GATATACTGG AATGCGATCT ATTGATTTGT ATAGGAACAA GTTTGAAAGT GGCTCCTGTG 1260
TCTGAAATTG TCAATATGGT ACCTTCACAT GTTCCGCAGA TTTTGATCAA TAGGGATATG 1320
GTTACACATG CAGAGTTTGA CTTAAACCTG TTGGGATTCT GTGATGACGT GGCCAGTCTC 1380
GTAGCTAAAA AATGCCATTG GGATATACCG CATAAAAAAT GGCAAGATCT AAAGAAGATA 1440
GATTACAACT GTACGGAAAT AGATAAAGGT ACGTATAAGA TTAAGAAACA GCCACGAAAG 1500
AAACAACAGT AA 1513
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0749--Sporulation
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--

Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR007654--NAD-dep_histone_deAcase_SIR2_N
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026590--Ssirtuin_cat_dom

PROSITE

PS50305--SIRTUIN

Pfam

PF04574--DUF592
PF02146--SIR2

Gene Ontology

GO:0034967--C:Set3 complex
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0045129--F:NAD-independent histone deacetylase activity
GO:0008270--F:zinc ion binding
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0016575--P:histone deacetylation
GO:0045950--P:negative regulation of mitotic recombination
GO:0070623--P:regulation of thiamine biosynthetic process
GO:0030435--P:sporulation resulting in formation of a cellular spore
GO:0006351--P:transcription, DNA-templated

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Cag-0008 CAG58313 Candida glabrata 69 0.0 642
WERAM-Kll-0030 CAG98447 Kluyveromyces lactis 63 2e-174 609
WERAM-Asg-0014 AAS52672 Ashbya gossypii 59 7e-165 577
WERAM-Kop-0003 CAY67751 Komagataella pastoris 49 1e-111 400
WERAM-Caa-0006 KGT71361 Candida albicans 46 2e-104 376
WERAM-Asf-0008 CADAFLAP00002195 Aspergillus flavus 49 7e-88 322
WERAM-Aso-0010 CADAORAP00001539 Aspergillus oryzae 48 6e-87 318
WERAM-Chg-0039 EAQ84978 Chaetomium globosum 49 9e-87 318
WERAM-Asc-0020 CADACLAP00004624 Aspergillus clavatus 50 1e-85 314
WERAM-Coi-0012 EAS36287 Coccidioides immitis 49 3e-85 313
WERAM-Asni-0001 CADANGAP00000714 Aspergillus niger 46 3e-84 310
WERAM-Asfu-0036 CADAFUAP00008087 Aspergillus fumigatus 48 4e-84 309
WERAM-Ast-0032 CADATEAP00008928 Aspergillus terreus 46 4e-84 309
WERAM-Trv-0037 EHK18208 Trichoderma virens 48 4e-84 309
WERAM-Nec-0022 EFNCRP00000004459 Neurospora crassa 46 1e-83 308
WERAM-Asn-0020 CADANIAP00005090 Aspergillus nidulans 45 5e-83 306
WERAM-Fuo-0022 FOXG_06210P0 Fusarium oxysporum 45 6e-83 305
WERAM-Trr-0005 EGR51157 Trichoderma reesei 46 8e-83 305
WERAM-Pytr-0004 EDU40148 Pyrenophora triticirepentis 46 7e-82 301
WERAM-Scj-0035 EEB09012 Schizosaccharomyces japonicus 47 5e-81 299
WERAM-Pyt-0034 EFQ87608 Pyrenophora teres 45 1e-80 297
WERAM-Gag-0001 GGTG_00614T0 Gaeumannomyces graminis 44 5e-80 295
WERAM-Mao-0007 MGG_02488T0 Magnaporthe oryzae 41 4e-78 289
WERAM-Lem-0019 CBX92855 Leptosphaeria maculans 46 1e-76 285
WERAM-Scp-0024 SPBC16D10.07c.1:pep Schizosaccharomyces pombe 42 3e-73 273
WERAM-Phn-0017 SNOT_06735 Phaeosphaeria nodorum 46 2e-71 266
WERAM-Zyt-0036 Mycgr3P98741 Zymoseptoria tritici 43 3e-69 259
WERAM-Miv-0014 MVLG_02300T0 Microbotryum violaceum 43 4e-69 259
WERAM-Usm-0005 UM00963P0 Ustilago maydis 41 2e-68 257
WERAM-Spr-0016 CBQ70363 Sporisorium reilianum 41 8e-67 252
WERAM-Drm-0023 FBpp0080015 Drosophila melanogaster 44 1e-65 248
WERAM-Dar-0153 ENSDARP00000088981.3 Danio rerio 43 2e-64 244
WERAM-Crn-0038 AAW46056 Cryptococcus neoformans 41 1e-63 241
WERAM-Leo-0106 ENSLOCP00000013852.1 Lepisosteus oculatus 42 1e-63 241
WERAM-Xim-0084 ENSXMAP00000007769.1 Xiphophorus maculatus 43 1e-63 241
WERAM-Pof-0119 ENSPFOP00000010381.2 Poecilia formosa 43 2e-63 241
WERAM-Yal-0031 CAG78100 Yarrowia lipolytica 41 3e-63 240
WERAM-Orla-0143 ENSORLP00000017142.1 Oryzias latipes 41 1e-62 238
WERAM-Orn-0128 ENSONIP00000012918.1 Oreochromis niloticus 41 1e-62 238
WERAM-Cii-0062 ENSCINP00000027486.2 Ciona intestinalis 44 4e-62 236
WERAM-Ten-0160 ENSTNIP00000016076.1 Tetraodon nigroviridis 44 4e-61 233
WERAM-Meg-0039 ENSMGAP00000003789.1 Meleagris gallopavo 44 6e-61 232
WERAM-Tar-0218 ENSTRUP00000046065.1 Takifugu rubripes 43 7e-61 232
WERAM-Xet-0156 ENSXETP00000050907.3 Xenopus tropicalis 44 1e-60 231
WERAM-Anp-0033 ENSAPLP00000003838.1 Anas platyrhynchos 44 1e-60 231
WERAM-Tag-0053 ENSTGUP00000003586.1 Taeniopygia guttata 44 2e-60 231
WERAM-Asm-0030 ENSAMXP00000003809.1 Astyanax mexicanus 42 2e-60 231
WERAM-Mod-0155 ENSMODP00000021523.3 Monodelphis domestica 44 3e-60 229
WERAM-Gaga-0027 ENSGALP00000004350.5 Gallus gallus 44 4e-60 229
WERAM-Ova-0039 ENSOARP00000005175.1 Ovis aries 43 4e-60 229
WERAM-Fia-0160 ENSFALP00000013509.1 Ficedula albicollis 44 5e-60 229
WERAM-Bot-0128 ENSBTAP00000018630.5 Bos taurus 43 5e-60 229
WERAM-Mup-0133 ENSMPUP00000011868.1 Mustela putorius furo 43 6e-60 229
WERAM-Tut-0187 ENSTTRP00000015416.1 Tursiops truncatus 42 7e-60 229
WERAM-Aim-0210 ENSAMEP00000019150.1 Ailuropoda melanoleuca 43 7e-60 229
WERAM-Fec-0125 ENSFCAP00000011479.3 Felis catus 43 8e-60 228
WERAM-Eqc-0101 ENSECAP00000011762.1 Equus caballus 42 9e-60 228
WERAM-Myl-0044 ENSMLUP00000003901.2 Myotis lucifugus 42 9e-60 228
WERAM-Tas-0108 ENSTSYP00000011158.1 Tarsius syrichta 42 1e-59 228
WERAM-Ict-0145 ENSSTOP00000015219.1 Ictidomys tridecemlineatus 42 1e-59 228
WERAM-Caf-0143 ENSCAFP00000019617.3 Canis familiaris 43 1e-59 228
WERAM-Sus-0073 ENSSSCP00000010911.2 Sus scrofa 42 1e-59 228
WERAM-Pes-0044 ENSPSIP00000006811.1 Pelodiscus sinensis 42 1e-59 228
WERAM-Gog-0119 ENSGGOP00000009943.2 Gorilla gorilla 42 2e-59 227
WERAM-Poa-0024 ENSPPYP00000002788.1 Pongo abelii 42 2e-59 227
WERAM-Hos-0051 ENSP00000212015.6 Homo sapiens 42 2e-59 227
WERAM-Pat-0020 ENSPTRP00000004394.5 Pan troglodytes 42 2e-59 227
WERAM-Paa-0168 ENSPANP00000020463.1 Papio anubis 42 2e-59 227
WERAM-Chs-0089 ENSCSAP00000003766.1 Chlorocebus sabaeus 42 2e-59 227
WERAM-Otg-0131 ENSOGAP00000011294.2 Otolemur garnettii 42 2e-59 227
WERAM-Mum-0030 ENSMUSP00000020257.6 Mus musculus 42 2e-59 227
WERAM-Orc-0096 ENSOCUP00000022814.1 Oryctolagus cuniculus 42 2e-59 227
WERAM-Cap-0003 ENSCPOP00000000777.2 Cavia porcellus 42 4e-59 226
WERAM-Ere-0116 ENSEEUP00000012184.1 Erinaceus europaeus 42 4e-59 226
WERAM-Ran-0227 ENSRNOP00000070943.1 Rattus norvegicus 42 4e-59 226
WERAM-Sah-0140 ENSSHAP00000014878.1 Sarcophilus harrisii 43 2e-58 223
WERAM-Nol-0129 ENSNLEP00000014593.1 Nomascus leucogenys 42 3e-58 223
WERAM-Mae-0013 ENSMEUP00000001070.1 Macropus eugenii 43 7e-58 222
WERAM-Loa-0094 ENSLAFP00000007775.3 Loxodonta africana 42 7e-58 222
WERAM-Anc-0109 ENSACAP00000010385.3 Anolis carolinensis 42 8e-58 222
WERAM-Cym-0033 CMT600CT Cyanidioschyzon merolae 42 9e-56 215
WERAM-Dan-0059 ENSDNOP00000005573.3 Dasypus novemcinctus 41 2e-55 214
WERAM-Cae-0022 R11A8.4a Caenorhabditis elegans 40 1e-53 208
WERAM-Ocp-0033 ENSOPRP00000002702.1 Ochotona princeps 42 7e-52 202
WERAM-Vip-0121 ENSVPAP00000010985.1 Vicugna pacos 42 3e-51 200
WERAM-Ptv-0071 ENSPVAP00000006727.1 Pteropus vampyrus 38 7e-50 195
WERAM-Mam-0220 ENSMMUP00000035809.1 Macaca mulatta 41 5e-49 192
WERAM-Ect-0113 ENSETEP00000012577.1 Echinops telfairi 38 2e-48 191
WERAM-Lac-0044 ENSLACP00000006675.2 Latimeria chalumnae 42 2e-48 190
WERAM-Soa-0118 ENSSARP00000011447.1 Sorex araneus 39 1e-44 178
WERAM-Cis-0075 ENSCSAVP00000016120.1 Ciona savignyi 35 2e-44 177
WERAM-Caj-0204 ENSCJAP00000035895.2 Callithrix jacchus 40 2e-43 174
WERAM-Gam-0078 ENSGMOP00000008397.1 Gadus morhua 37 3e-43 174
WERAM-Gaa-0122 ENSGACP00000015659.1 Gasterosteus aculeatus 37 5e-43 172
WERAM-Tub-0067 ENSTBEP00000008310.1 Tupaia belangeri 37 3e-41 167
WERAM-Osl-0012 ABO98065 Ostreococcus lucimarinus 34 8e-41 165
WERAM-Lab-0008 EDR12994 Laccaria bicolor 35 3e-40 163
WERAM-Pem-0066 ENSPMAP00000007192.1 Petromyzon marinus 36 1e-39 162
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 34 2e-38 157
WERAM-Mel-0010 EGG12163 Melampsora laricipopulina 35 2e-37 154
WERAM-Pug-0030 EFP89251 Puccinia graminis 36 1e-36 151
WERAM-Mim-0058 ENSMICP00000005750.1 Microcebus murinus 32 2e-33 140
WERAM-Dio-0012 ENSDORP00000001437.1 Dipodomys ordii 29 2e-32 138
WERAM-Ved-0011 EGY21147 Verticillium dahliae 33 3e-29 127
Created Date 25-Jun-2016