WERAM Information


Tag Content
WERAM ID WERAM-Scp-0024
Ensembl Protein ID SPBC16D10.07c.1:pep
Uniprot Accession O94640; SIR2_SCHPO; Q6H8I3
Genbank Protein ID NP_001018840.1
Protein Name NAD-dependent histone deacetylase sir2
Genbank Nucleotide ID NM_001022423.2
Gene Name SIR2;SPBC16D10.07c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPBC16D10.07c SPBC16D10.07c.1 SPBC16D10.07c.1:pep
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type H4K16 K 12867036
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 2.30e-85 284.1 148 430
Organism Schizosaccharomyces pombe
NCBI Taxa ID 284812
Functional Description
(View)
Involved in silencing within the mating-type region, at the telomeres, and according to PubMed:12867036 also within centromeric DNA regions. Required for the localization of swi6 to the telomeres, silent mating type region, and according to PubMed:12867036 to the centromeric DNA regions. According to PubMed:15545655 not required for the localization of swi6 to centromeric foci. Deacetylates histone H3 on 'Lys-9' and 'Lys-16' of histone H4. This has a direct role in heterochromatin assembly.
Domain Profile
  HDAC SIR2

             SIR2.txt   2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdldffrkdpkvfyalakelyp.lgsakPtktHyflaele 90 
++++llkk+k++vvl+GAGiSts GI DFRs++G+y++l+++ l++p+++fd+++fr++p++fy++a++l+p +++++P+ H f+++le
SPBC16D10.07c.1:pep 148 DVVNLLKKAKNVVVLVGAGISTSLGILDFRSDNGFYARLARHGLSEPSEMFDIHTFRENPEIFYTFARDLLPeTNHYSPS--HAFIRLLE 235
7899****************************************************************************..******** PP
SIR2.txt 91 kkgkllrlytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCekC....................... 157
kk+kl++l+tQNiD+Le+k+gl+++k++++HGs+ata+C+kCk++++++e+ e+++++ +v+ C++C
SPBC16D10.07c.1:pep 236 KKNKLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSELYEDIRNQ-RVSYCNECgkpplklrrvgqnkkekhyfsdg 324
**********************************************************.9****************************** PP
SIR2.txt 158 ...........kgvlkpdivffgenlpeefleeveed.lkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkll 235
g++kpdi+ffge+lp++f+++v + l+e+dll+++GtSlkv+pv++l+ ++++ ++p++++++++v+ ++++d+++l
SPBC16D10.07c.1:pep 325 dsesseddlaqPGIMKPDITFFGEALPDSFFNKVGSGeLEETDLLICIGTSLKVAPVSELI-SVIPPTTPQIYISRTPVR-HTQFDVNFL 412
**********88*********************988659**********************.******************.99*****99 PP
SIR2.txt 236 gd.cdevveellkllgle 252
+ cd+v+ e++k++g+
SPBC16D10.07c.1:pep 413 SPyCDWVIVEICKRAGWL 430
866************996 PP

Protein Sequence
(Fasta)
MASNPLDNNM PTTPVEEKIP VASYSPSSSG SSSGASLLVD IMCGSKETED EEVDSDEWDK 60
PETENISDLD ERSEMVRYLR ASGYAKFLEK YLIEEELPVR SILKKLGINL PSALEEFEDI 120
DLLPLLKEVL KREVARRIKL PHFNTFEDVV NLLKKAKNVV VLVGAGISTS LGILDFRSDN 180
GFYARLARHG LSEPSEMFDI HTFRENPEIF YTFARDLLPE TNHYSPSHAF IRLLEKKNKL 240
STLFTQNIDN LEKKTGLSDN KIIQCHGSFA TATCIKCKHK VDGSELYEDI RNQRVSYCNE 300
CGKPPLKLRR VGQNKKEKHY FSDGDSESSE DDLAQPGIMK PDITFFGEAL PDSFFNKVGS 360
GELEETDLLI CIGTSLKVAP VSELISVIPP TTPQIYISRT PVRHTQFDVN FLSPYCDWVI 420
VEICKRAGWL NELQALCDLP ECHSGSKTRA FETDLDIKFE EPSTYHITST TNGSC 475
Nucleotide Sequence
(Fasta)
CATGGTTCAA AGCAACGTTT AAATTAACAA GTTGTATAGT TAAACTTATA CAGTGCTTTG 60
CTTCTAATAG CCATTATTAC CAGGAAATAA CGAGATCACA GTTGCCCGCA TACCATTAAG 120
CTAACGAAAC TTTACTGCAC TAAACAAGAG ACTAGCTTTT CGTAATTGTA ATAAGACTTA 180
TCGAAAAGTT GAACCAGAGA TCTTCAGTTC AGTAGATCAT TGCCTTTCTC AAACGAAGCT 240
TTAATTTATA CTTCCTTAAA AATAATTGAT TAGTCATATT TTCATGTTAT ACAAACTCTG 300
TCATGGCTTC CAATCCGCTA GATAATAATA TGCCGACGAC TCCCGTTGAG GAAAAAATTC 360
CAGTCGCTAG TTATTCTCCT AGCTCTTCTG GTAGTAGTTC CGGTGCTAGT TTACTAGTAG 420
ATATTATGTG CGGCAGTAAA GAAACTGAGG ATGAAGAGGT TGATTCTGAT GAATGGGATA 480
AACCAGAAAC AGAAAACATA AGTGATTTGG ATGAACGATC CGAAATGGTC AGATATTTAA 540
GGGCTTCAGG CTATGCGAAA TTCTTGGAGA AATATTTAAT AGAAGAAGAG TTGCCTGTAC 600
GATCGATTTT AAAAAAACTT GGAATCAATT TGCCTAGTGC ACTTGAAGAG TTTGAAGACA 660
TAGATTTACT TCCTTTGCTG AAGGAAGTTT TAAAACGTGA GGTTGCTAGG AGAATCAAAC 720
TTCCACATTT TAATACCTTT GAAGATGTTG TTAATTTATT GAAAAAAGCT AAAAATGTTG 780
TCGTCCTTGT TGGGGCAGGC ATAAGTACAA GTTTGGGAAT TTTAGATTTC CGTTCAGACA 840
ATGGTTTTTA TGCCCGTTTG GCACGCCATG GATTATCGGA ACCTTCTGAA ATGTTTGATA 900
TCCATACGTT TAGAGAAAAT CCAGAAATTT TTTATACTTT TGCTAGAGAT CTTTTGCCGG 960
AGACGAATCA TTATTCCCCC TCGCATGCCT TCATTAGATT GCTTGAAAAG AAGAATAAAT 1020
TATCAACATT GTTTACCCAA AATATAGACA ATTTGGAAAA AAAGACTGGA CTCTCCGATA 1080
ACAAAATTAT TCAATGTCAT GGGTCTTTTG CTACCGCAAC TTGTATCAAA TGCAAGCACA 1140
AGGTGGATGG ATCGGAGTTA TATGAAGACA TAAGAAATCA AAGAGTTTCT TACTGCAATG 1200
AATGCGGAAA ACCACCCTTA AAATTAAGAA GAGTCGGTCA AAATAAAAAA GAGAAACATT 1260
ATTTTTCAGA TGGTGATAGT GAATCTTCTG AAGATGATCT AGCTCAACCT GGGATTATGA 1320
AACCTGATAT CACATTTTTT GGGGAAGCCT TACCGGATTC TTTCTTTAAC AAAGTCGGGA 1380
GTGGTGAGCT TGAAGAGACT GATTTATTAA TTTGTATTGG AACTTCTTTA AAAGTGGCTC 1440
CTGTTTCAGA ACTCATCAGT GTTATTCCTC CTACTACTCC TCAGATTTAC ATTTCGAGGA 1500
CTCCTGTTCG TCATACCCAA TTCGATGTAA ATTTTCTAAG TCCTTATTGT GATTGGGTTA 1560
TTGTGGAGAT TTGTAAACGT GCTGGATGGC TGAATGAATT ACAAGCGCTT TGCGATTTAC 1620
CTGAGTGTCA TAGTGGTTCC AAAACGCGAG CTTTCGAAAC GGATTTGGAT ATAAAATTTG 1680
AGGAGCCCAG CACCTATCAT ATCACGAGCA CAACAAACGG TAGTTGTTAA TTTTAGGACT 1740
GATCGATCTA TCGAAGTTGA ATGTAGAAGC AAATATATTA TATACATATA TCGAGTATGA 1800
GAGCCAGATT ATTGGACATT AACTTATTAT CCGTTTGAGA CTTCTTAGTT TTGTAAGTGC 1860
CATTGTTAAA AACTGTTTTT TCTCTTCGCA CCTAATGTTT AAATCTGCTA AACTGGGTGA 1920
AAACACATTA AAACAAGTTA TAATACATTT TACAATACCA AGGACTGTGT AATTAGTAAA 1980
TGAACATTGA AGCAAATTAC ATTCATAGGC TATGCAAAAT TAGCTACTTT TTTAAGCATA 2040
GTAAATCAGT GAAAATGACA CAATTATTAT TTAAAATTGA AAGATTGATT GGTACATATC 2100
AATACAACCA ATGAAGCATC TAATTGTACG ATACTAAAGA GAAACAACTG AAAACGGAC 2160
Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0779--Telomere
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--

Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR007654--NAD-dep_histone_deAcase_SIR2_N
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026590--Ssirtuin_cat_dom

PROSITE

PS50305--SIRTUIN

Pfam

PF04574--DUF592
PF02146--SIR2

Gene Ontology

GO:0034507--C:chromosome, centromeric outer repeat region
GO:0000781--C:chromosome, telomeric region
GO:0031934--C:mating-type region heterochromatin
GO:0000790--C:nuclear chromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:1902377--C:nuclear rDNA heterochromatin
GO:1990707--C:nuclear subtelomeric heterochromatin
GO:0005634--C:nucleus
GO:0030869--C:RENT complex
GO:0004407--F:histone deacetylase activity
GO:0031078--F:histone deacetylase activity (H3-K14 specific)
GO:1990162--F:histone deacetylase activity (H3-K4 specific)
GO:0032129--F:histone deacetylase activity (H3-K9 specific)
GO:0034739--F:histone deacetylase activity (H4-K16 specific)
GO:0070403--F:NAD+ binding
GO:0046969--F:NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970--F:NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0008270--F:zinc ion binding
GO:0006342--P:chromatin silencing
GO:0030702--P:chromatin silencing at centromere
GO:1990141--P:chromatin silencing at centromere outer repeat region
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0006281--P:DNA repair
GO:0016575--P:histone deacetylation
GO:1990596--P:histone H3-K4 deacetylation
GO:1990619--P:histone H3-K9 deacetylation
GO:0061647--P:histone H3-K9 modification
GO:1990679--P:histone H4-K12 deacetylation
GO:1990678--P:histone H4-K16 deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0031453--P:positive regulation of heterochromatin assembly
GO:0070198--P:protein localization to chromosome, telomeric region
GO:0051570--P:regulation of histone H3-K9 methylation
GO:0006351--P:transcription, DNA-templated

Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Scj-0035 EEB09012 Schizosaccharomyces japonicus 56 9e-137 484
WERAM-Asf-0008 CADAFLAP00002195 Aspergillus flavus 49 8e-88 321
WERAM-Aso-0010 CADAORAP00001539 Aspergillus oryzae 49 1e-87 321
WERAM-Asc-0020 CADACLAP00004624 Aspergillus clavatus 48 9e-87 318
WERAM-Asni-0001 CADANGAP00000714 Aspergillus niger 48 1e-86 317
WERAM-Asn-0020 CADANIAP00005090 Aspergillus nidulans 48 3e-86 316
WERAM-Pyt-0034 EFQ87608 Pyrenophora teres 43 8e-85 311
WERAM-Pytr-0004 EDU40148 Pyrenophora triticirepentis 43 1e-84 311
WERAM-Asfu-0036 CADAFUAP00008087 Aspergillus fumigatus 49 4e-83 306
WERAM-Chg-0039 EAQ84978 Chaetomium globosum 47 2e-82 303
WERAM-Nec-0022 EFNCRP00000004459 Neurospora crassa 44 4e-82 302
WERAM-Ast-0032 CADATEAP00008928 Aspergillus terreus 45 5e-82 302
WERAM-Coi-0012 EAS36287 Coccidioides immitis 48 1e-81 301
WERAM-Lem-0019 CBX92855 Leptosphaeria maculans 42 9e-80 295
WERAM-Trr-0005 EGR51157 Trichoderma reesei 43 1e-79 294
WERAM-Trv-0037 EHK18208 Trichoderma virens 43 2e-79 294
WERAM-Fuo-0022 FOXG_06210P0 Fusarium oxysporum 44 6e-78 288
WERAM-Phn-0017 SNOT_06735 Phaeosphaeria nodorum 39 2e-76 283
WERAM-Zyt-0036 Mycgr3P98741 Zymoseptoria tritici 46 3e-72 270
WERAM-Gag-0001 GGTG_00614T0 Gaeumannomyces graminis 43 6e-70 262
WERAM-Kop-0003 CAY67751 Komagataella pastoris 42 2e-67 254
WERAM-Kll-0030 CAG98447 Kluyveromyces lactis 43 5e-66 249
WERAM-Mao-0007 MGG_02488T0 Magnaporthe oryzae 39 5e-66 249
WERAM-Cag-0008 CAG58313 Candida glabrata 38 7e-66 248
WERAM-Sac-0040 YOL068C Saccharomyces cerevisiae 42 1e-65 248
WERAM-Caa-0006 KGT71361 Candida albicans 39 3e-63 240
WERAM-Asg-0014 AAS52672 Ashbya gossypii 42 6e-63 239
WERAM-Spr-0016 CBQ70363 Sporisorium reilianum 41 5e-62 236
WERAM-Crn-0038 AAW46056 Cryptococcus neoformans 41 2e-61 234
WERAM-Usm-0005 UM00963P0 Ustilago maydis 40 5e-60 229
WERAM-Miv-0014 MVLG_02300T0 Microbotryum violaceum 37 2e-59 227
WERAM-Dar-0153 ENSDARP00000088981.3 Danio rerio 42 2e-56 217
WERAM-Drm-0023 FBpp0080015 Drosophila melanogaster 42 3e-56 217
WERAM-Asm-0030 ENSAMXP00000003809.1 Astyanax mexicanus 41 5e-56 216
WERAM-Orla-0143 ENSORLP00000017142.1 Oryzias latipes 42 3e-55 213
WERAM-Orn-0128 ENSONIP00000012918.1 Oreochromis niloticus 39 6e-55 212
WERAM-Mod-0155 ENSMODP00000021523.3 Monodelphis domestica 41 1e-54 211
WERAM-Pof-0119 ENSPFOP00000010381.2 Poecilia formosa 39 2e-54 211
WERAM-Leo-0106 ENSLOCP00000013852.1 Lepisosteus oculatus 41 2e-54 210
WERAM-Meg-0039 ENSMGAP00000003789.1 Meleagris gallopavo 41 2e-54 210
WERAM-Xim-0084 ENSXMAP00000007769.1 Xiphophorus maculatus 42 6e-54 209
WERAM-Fia-0160 ENSFALP00000013509.1 Ficedula albicollis 41 6e-54 209
WERAM-Anc-0109 ENSACAP00000010385.3 Anolis carolinensis 41 8e-54 208
WERAM-Gaga-0027 ENSGALP00000004350.5 Gallus gallus 40 9e-54 208
WERAM-Tag-0053 ENSTGUP00000003586.1 Taeniopygia guttata 41 1e-53 208
WERAM-Anp-0033 ENSAPLP00000003838.1 Anas platyrhynchos 41 1e-53 208
WERAM-Pes-0044 ENSPSIP00000006811.1 Pelodiscus sinensis 40 2e-53 207
WERAM-Tar-0218 ENSTRUP00000046065.1 Takifugu rubripes 40 3e-53 206
WERAM-Sah-0140 ENSSHAP00000014878.1 Sarcophilus harrisii 40 4e-53 206
WERAM-Cii-0062 ENSCINP00000027486.2 Ciona intestinalis 38 4e-53 206
WERAM-Cap-0003 ENSCPOP00000000777.2 Cavia porcellus 41 4e-53 206
WERAM-Ova-0039 ENSOARP00000005175.1 Ovis aries 40 4e-53 206
WERAM-Paa-0168 ENSPANP00000020463.1 Papio anubis 40 4e-53 206
WERAM-Bot-0128 ENSBTAP00000018630.5 Bos taurus 40 5e-53 206
WERAM-Gog-0119 ENSGGOP00000009943.2 Gorilla gorilla 40 5e-53 206
WERAM-Chs-0089 ENSCSAP00000003766.1 Chlorocebus sabaeus 40 5e-53 206
WERAM-Myl-0044 ENSMLUP00000003901.2 Myotis lucifugus 41 5e-53 206
WERAM-Pat-0020 ENSPTRP00000004394.5 Pan troglodytes 40 6e-53 206
WERAM-Hos-0051 ENSP00000212015.6 Homo sapiens 40 6e-53 205
WERAM-Tut-0187 ENSTTRP00000015416.1 Tursiops truncatus 40 6e-53 205
WERAM-Poa-0024 ENSPPYP00000002788.1 Pongo abelii 40 6e-53 205
WERAM-Sus-0073 ENSSSCP00000010911.2 Sus scrofa 40 7e-53 205
WERAM-Ict-0145 ENSSTOP00000015219.1 Ictidomys tridecemlineatus 40 8e-53 205
WERAM-Eqc-0101 ENSECAP00000011762.1 Equus caballus 40 8e-53 205
WERAM-Tas-0108 ENSTSYP00000011158.1 Tarsius syrichta 40 1e-52 205
WERAM-Otg-0131 ENSOGAP00000011294.2 Otolemur garnettii 40 1e-52 205
WERAM-Orc-0096 ENSOCUP00000022814.1 Oryctolagus cuniculus 40 1e-52 205
WERAM-Aim-0210 ENSAMEP00000019150.1 Ailuropoda melanoleuca 40 1e-52 204
WERAM-Caf-0143 ENSCAFP00000019617.3 Canis familiaris 40 1e-52 204
WERAM-Ten-0160 ENSTNIP00000016076.1 Tetraodon nigroviridis 40 2e-52 203
WERAM-Ran-0227 ENSRNOP00000070943.1 Rattus norvegicus 40 3e-52 203
WERAM-Fec-0125 ENSFCAP00000011479.3 Felis catus 40 3e-52 203
WERAM-Xet-0156 ENSXETP00000050907.3 Xenopus tropicalis 42 3e-52 203
WERAM-Nol-0129 ENSNLEP00000014593.1 Nomascus leucogenys 40 4e-52 202
WERAM-Ere-0116 ENSEEUP00000012184.1 Erinaceus europaeus 40 5e-52 202
WERAM-Mum-0030 ENSMUSP00000020257.6 Mus musculus 40 5e-52 202
WERAM-Mae-0013 ENSMEUP00000001070.1 Macropus eugenii 40 1e-51 201
WERAM-Mup-0133 ENSMPUP00000011868.1 Mustela putorius furo 42 1e-51 201
WERAM-Loa-0094 ENSLAFP00000007775.3 Loxodonta africana 40 9e-51 198
WERAM-Ocp-0033 ENSOPRP00000002702.1 Ochotona princeps 43 1e-48 191
WERAM-Dan-0059 ENSDNOP00000005573.3 Dasypus novemcinctus 39 1e-48 191
WERAM-Vip-0121 ENSVPAP00000010985.1 Vicugna pacos 43 9e-48 188
WERAM-Cae-0022 R11A8.4a Caenorhabditis elegans 38 6e-45 179
WERAM-Yal-0031 CAG78100 Yarrowia lipolytica 38 1e-44 178
WERAM-Ptv-0071 ENSPVAP00000006727.1 Pteropus vampyrus 39 1e-43 174
WERAM-Lab-0008 EDR12994 Laccaria bicolor 36 2e-42 171
WERAM-Mam-0220 ENSMMUP00000035809.1 Macaca mulatta 36 3e-42 170
WERAM-Cym-0033 CMT600CT Cyanidioschyzon merolae 38 1e-41 168
WERAM-Caj-0204 ENSCJAP00000035895.2 Callithrix jacchus 42 8e-41 165
WERAM-Ect-0113 ENSETEP00000012577.1 Echinops telfairi 35 7e-40 162
WERAM-Lac-0067 ENSLACP00000009079.1 Latimeria chalumnae 39 4e-39 160
WERAM-Pem-0066 ENSPMAP00000007192.1 Petromyzon marinus 35 6e-39 159
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 36 1e-36 151
WERAM-Gam-0078 ENSGMOP00000008397.1 Gadus morhua 33 2e-36 150
WERAM-Osl-0012 ABO98065 Ostreococcus lucimarinus 34 2e-36 150
WERAM-Gaa-0170 ENSGACP00000020749.1 Gasterosteus aculeatus 33 3e-36 150
WERAM-Soa-0118 ENSSARP00000011447.1 Sorex araneus 35 5e-36 149
WERAM-Cis-0075 ENSCSAVP00000016120.1 Ciona savignyi 36 5e-36 149
WERAM-Mel-0010 EGG12163 Melampsora laricipopulina 33 7e-35 145
WERAM-Tub-0067 ENSTBEP00000008310.1 Tupaia belangeri 33 1e-34 145
WERAM-Pug-0030 EFP89251 Puccinia graminis 40 2e-33 141
WERAM-Prc-0140 ENSPCAP00000012593.1 Procavia capensis 36 4e-33 140
WERAM-Dio-0047 ENSDORP00000004875.1 Dipodomys ordii 35 4e-33 140
WERAM-Mim-0072 ENSMICP00000006861.1 Microcebus murinus 35 5e-33 139
WERAM-Ved-0011 EGY21147 Verticillium dahliae 35 6e-29 126
Created Date 25-Jun-2016