WERAM Information

Tag Content
WERAM ID WERAM-Hos-0258
Ensembl Protein ID ENSP00000397239.2
Uniprot Accession B2RXH2; KDM4E_HUMAN
Genbank Protein ID NP_001155102.1
Protein Name Lysine-specific demethylase 4E
Genbank Nucleotide ID NM_001161630.1
Gene Name KDM4E
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000235268.2 ENST00000450979.2 ENSP00000397239.2
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JHDM3_JMJD2 Jmjc H3K9 K 21914792
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JHDM3_JMJD2 2.60e-88 296.6 144 309
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
Domain Profile
  HDM JHDM3_JMJD2
          JHDM3.txt   2 edveeWnlnklktildsvekelkieieGvntpylyvgmlkttfaWhvedmdlysinylhfGapktWyavpseaakrlekllrkefsesakec 93 
                        e++++Wnl++l+tild +e+e+++ ieGvntpyly+gm+kttfaWh+edmdlysinylhfG+pktWy+vp+e++++le+l+r+ f++ +++c
  ENSP00000397239.2 144 ESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGC 235
                        6789**************************************************************************************** PP
          JHDM3.txt  94 eaflrhkttlisPellkkagipfnrivqeagefvitfPygyhaGfnhGfnlaestnfaterwievgkeaakcsc 167
                        eaflrhk++lisP++lk++gipfn ++qeagef++tfPygyhaGfnhGfn+ae++nfat+rwi++gk+a++csc
  ENSP00000397239.2 236 EAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSC 309
                        *************************************************************************9 PP
Protein Sequence
(Fasta)		MKSVHSSPQN TSHTIMTFYP TMEEFADFNT YVAYMESQGA HQAGLAKVIP PKEWKARQMY 60
DDIEDILIAT PLQQVTSGQG GVFTQYHKKK KAMRVGQYRR LANSKKYQTP PHQNFADLEQ 120
RYWKSHPGNP PIYGADISGS LFEESTKQWN LGHLGTILDL LEQECGVVIE GVNTPYLYFG 180
MWKTTFAWHT EDMDLYSINY LHFGEPKTWY VVPPEHGQHL ERLARELFPD ISRGCEAFLR 240
HKVALISPTV LKENGIPFNC MTQEAGEFMV TFPYGYHAGF NHGFNCAEAI NFATPRWIDY 300
GKMASQCSCG ESTVTFSMDP FVRIVQPESY ELWKHRQDLA IVEHTEPRVA ESQELSNWRD 360
DIVLRRAALG LRLLPNLTAQ CPTQPVSSGH CYNPKGCGTD AVPGSAFQSS AYHTQTQSLT 420
LGMSARVLLP STGSWGSGRG RGRGQGQGRG CSRGRGHGCC TRELGTEEPT VQPASKRRLL 480
MGTRSRAQGH RPQLPLANDL MTNLSL 506
Nucleotide Sequence
(Fasta)		CCAAGCCTGA GAATCAGGAG AAGCCTCACA GTGACACCCC CAACTGAGGA AACTCACAGA 60
GCTGGGACAT ACTCTACTTC TTCAGAAAAA AGTATACTGA CTAGAGTGGA GTCCCCCTGG 120
GGAGTCAGAA AGCCTGTGAA AGATCTCACT TGTTCAAAAG TCCAAGTGTG AATTACTGTC 180
TCACAGATAA ACCAAAGTAT TTTGAAAAAC AAAGGGGAGA AAAGAAATTA CTCCCCAGAA 240
CTCTCAGGCA TCTAGAGGAC ACCCAAGAAC GTGGGAGTCA GCTGCTTCTT GTGTGCAGCC 300
ATGAAGTCTG TGCACTCCAG TCCCCAGAAC ACGAGTCATA CCATCATGAC GTTTTACCCA 360
ACCATGGAAG AATTTGCAGA TTTCAACACA TATGTTGCTT ACATGGAGTC CCAAGGCGCA 420
CATCAAGCTG GCCTTGCCAA GGTAATTCCA CCCAAGGAAT GGAAAGCCAG ACAGATGTAT 480
GATGATATCG AAGACATCTT AATAGCCACT CCCCTCCAGC AGGTGACCTC TGGGCAGGGA 540
GGTGTGTTTA CTCAATACCA TAAAAAGAAG AAAGCCATGA GGGTGGGGCA GTATCGCCGC 600
TTGGCAAACA GTAAAAAATA TCAGACTCCG CCACACCAGA ATTTTGCAGA TTTGGAGCAA 660
CGATACTGGA AGAGCCACCC CGGTAATCCA CCAATTTATG GTGCTGATAT CAGCGGCTCC 720
TTATTTGAAG AAAGCACTAA ACAATGGAAC CTAGGACACC TGGGAACAAT TCTGGACCTG 780
TTGGAGCAGG AATGTGGGGT TGTCATCGAG GGTGTCAACA CACCCTACCT GTACTTTGGC 840
ATGTGGAAGA CCACGTTTGC CTGGCACACA GAGGACATGG ACCTTTACAG CATCAACTAC 900
CTGCACTTTG GGGAGCCCAA AACTTGGTAC GTGGTGCCCC CAGAACATGG TCAGCACCTG 960
GAACGCCTGG CCAGGGAGCT CTTCCCAGAC ATTTCTCGGG GCTGTGAGGC CTTCCTGCGG 1020
CACAAAGTGG CCCTCATCTC GCCTACAGTT CTCAAGGAAA ATGGGATTCC CTTCAATTGC 1080
ATGACTCAGG AGGCTGGGGA GTTCATGGTG ACCTTTCCCT ATGGCTACCA TGCTGGCTTC 1140
AATCACGGCT TCAACTGCGC AGAAGCCATT AATTTTGCCA CTCCACGATG GATTGATTAT 1200
GGCAAAATGG CCTCTCAGTG TAGCTGTGGG GAGTCGACAG TGACCTTTTC CATGGACCCC 1260
TTTGTGCGCA TTGTGCAACC CGAGAGTTAT GAGCTCTGGA AACACAGGCA AGACTTGGCC 1320
ATTGTGGAAC ACACAGAGCC CAGGGTTGCA GAAAGCCAAG AGCTGAGCAA CTGGAGAGAT 1380
GATATAGTAC TTAGAAGAGC TGCTCTGGGC CTGAGGCTTC TCCCAAACCT CACAGCCCAG 1440
TGTCCCACAC AGCCTGTGTC CTCAGGGCAC TGTTACAACC CAAAAGGCTG TGGCACTGAT 1500
GCTGTGCCTG GATCCGCATT CCAAAGCTCT GCATATCATA CCCAGACCCA GTCACTTACC 1560
CTGGGGATGT CAGCCAGGGT TCTTCTCCCT TCCACTGGAA GCTGGGGTTC TGGTCGTGGT 1620
CGTGGTCGTG GTCAAGGTCA AGGTCGAGGT TGCAGTCGTG GTCGTGGTCA TGGTTGTTGT 1680
ACTCGAGAAC TGGGGACTGA GGAGCCAACT GTTCAGCCTG CATCCAAGAG GCGCCTTTTA 1740
ATGGGTACAA GGAGTAGAGC TCAAGGCCAC AGGCCTCAGC TCCCGCTTGC CAATGATTTG 1800
ATGACAAATC TGTCCCTTTG AGTGGTGGCC TTCAGCATCT TGCCAAGGCT TCTGGCTGCT 1860
GCTGTGTCCC TGATCTTCAA CTCCTGGGGC CCCCACTGGA TCGTGATGAA ACCATGCACC 1920
CTGGCCTGTG CCTGCTATCC CTCAACAGCA CTACTAGTAA TCTCCCTGAT GTTGTCTGCA 1980
TGACTCCTCC CAATGTCATT GTGCCTTTGA TTAAGTTTTC CAGGGACACT GGTGGGGACT 2040
GGAACTGATT AAGTTCACCA GGGACACTTG CCTGGTGAAC ATGGGCAAGG CTGTAGCAAT 2100
GGACCACTTT TACGGCTCTA GGGTTCTGAC TCCAACTAAG TTTTCCAGAA TCTCCTGGGC 2160
TCCTGACTCA TCTGCTGGGT CTAAAGACAC TGAGTTTAGG GATATTTTCC TCCAATACAT 2220
GATCAATCCT CTGGATCCAC GGCTATGGAA TATGGTGACA AATGTCAGTG TCTCTCTTAT 2280
TCCAACCCCA GGATCAGAGA AGATTCTTTA CCTGCAGTAA CTGACACATT TCCAAGGCC 2340
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
Interpro

IPR003347--JmjC_dom
IPR003349--JmjN
PROSITE

PS51184--JMJC
PS51183--JMJN
Pfam

PF02373--JmjC
PF02375--JmjN
Gene Ontology

GO:0005634--C:nucleus
GO:0051213--F:dioxygenase activity
GO:0046872--F:metal ion binding
GO:0016568--P:chromatin modification
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0215 ENSPTRP00000059926.1 Pan troglodytes 98 0.0 941
WERAM-Nol-0071 ENSNLEP00000008681.1 Nomascus leucogenys 93 0.0 900
WERAM-Paa-0097 ENSPANP00000014919.1 Papio anubis 88 0.0 853
WERAM-Chs-0036 ENSCSAP00000014755.1 Chlorocebus sabaeus 88 0.0 850
WERAM-Caj-0046 ENSCJAP00000007627.1 Callithrix jacchus 84 0.0 793
WERAM-Mam-0214 ENSMMUP00000030770.2 Macaca mulatta 67 0.0 633
WERAM-Gog-0117 ENSGGOP00000009855.2 Gorilla gorilla 82 0.0 632
WERAM-Ict-0001 ENSSTOP00000000027.2 Ictidomys tridecemlineatus 81 3e-179 625
WERAM-Mup-0138 ENSMPUP00000012170.1 Mustela putorius furo 81 2e-178 622
WERAM-Caf-0051 ENSCAFP00000006122.3 Canis familiaris 80 7e-177 617
WERAM-Cap-0076 ENSCPOP00000005641.2 Cavia porcellus 78 5e-175 611
WERAM-Myl-0213 ENSMLUP00000019471.1 Myotis lucifugus 78 1e-174 610
WERAM-Mum-0193 ENSMUSP00000061632.6 Mus musculus 78 1e-174 610
WERAM-Loa-0052 ENSLAFP00000018671.1 Loxodonta africana 77 3e-174 608
WERAM-Ran-0195 ENSRNOP00000067344.1 Rattus norvegicus 78 2e-173 606
WERAM-Aim-0132 ENSAMEP00000011999.1 Ailuropoda melanoleuca 79 2e-173 605
WERAM-Otg-0216 ENSOGAP00000018016.1 Otolemur garnettii 63 7e-173 604
WERAM-Tub-0114 ENSTBEP00000012601.1 Tupaia belangeri 79 3e-171 598
WERAM-Orc-0012 ENSOCUP00000023109.2 Oryctolagus cuniculus 60 5e-168 588
WERAM-Bot-0018 ENSBTAP00000002234.5 Bos taurus 76 5e-168 588
WERAM-Sus-0114 ENSSSCP00000015888.2 Sus scrofa 75 3e-164 575
WERAM-Ocp-0126 ENSOPRP00000013322.1 Ochotona princeps 70 6e-158 554
WERAM-Mim-0121 ENSMICP00000012586.1 Microcebus murinus 69 3e-157 552
WERAM-Fec-0081 ENSFCAP00000006707.3 Felis catus 69 8e-157 551
WERAM-Poa-0081 ENSPPYP00000010565.2 Pongo abelii 69 1e-156 550
WERAM-Eqc-0110 ENSECAP00000012427.1 Equus caballus 69 2e-156 550
WERAM-Meg-0063 ENSMGAP00000006048.2 Meleagris gallopavo 67 1e-155 547
WERAM-Pes-0166 ENSPSIP00000019770.1 Pelodiscus sinensis 67 2e-155 546
WERAM-Lac-0142 ENSLACP00000016270.1 Latimeria chalumnae 67 3e-155 546
WERAM-Gaga-0045 ENSGALP00000006501.4 Gallus gallus 67 3e-155 546
WERAM-Sah-0042 ENSSHAP00000004870.1 Sarcophilus harrisii 67 4e-155 545
WERAM-Tag-0013 ENSTGUP00000000796.1 Taeniopygia guttata 66 1e-154 544
WERAM-Mod-0013 ENSMODP00000032606.2 Monodelphis domestica 67 2e-154 543
WERAM-Dan-0145 ENSDNOP00000027472.1 Dasypus novemcinctus 68 4e-154 542
WERAM-Anc-0086 ENSACAP00000008291.3 Anolis carolinensis 67 2e-153 540
WERAM-Ova-0094 ENSOARP00000009861.1 Ovis aries 73 6e-153 538
WERAM-Fia-0015 ENSFALP00000001261.1 Ficedula albicollis 66 5e-152 535
WERAM-Asm-0230 ENSAMXP00000022237.1 Astyanax mexicanus 66 3e-151 532
WERAM-Leo-0002 ENSLOCP00000000123.1 Lepisosteus oculatus 65 7e-150 528
WERAM-Ten-0118 ENSTNIP00000012969.1 Tetraodon nigroviridis 66 7e-150 528
WERAM-Orn-0150 ENSONIP00000015836.1 Oreochromis niloticus 66 1e-149 527
WERAM-Tar-0036 ENSTRUP00000008201.1 Takifugu rubripes 66 3e-149 525
WERAM-Dar-0206 ENSDARP00000133766.1 Danio rerio 66 4e-149 525
WERAM-Pof-0260 ENSPFOP00000023871.1 Poecilia formosa 66 1e-148 523
WERAM-Orla-0066 ENSORLP00000008475.1 Oryzias latipes 65 2e-148 523
WERAM-Gaa-0088 ENSGACP00000011572.1 Gasterosteus aculeatus 63 8e-148 521
WERAM-Tut-0165 ENSTTRP00000014088.1 Tursiops truncatus 65 1e-146 517
WERAM-Xim-0047 ENSXMAP00000004480.1 Xiphophorus maculatus 63 7e-146 514
WERAM-Vip-0025 ENSVPAP00000002379.1 Vicugna pacos 64 7e-146 514
WERAM-Xet-0001 ENSXETP00000001154.3 Xenopus tropicalis 62 2e-143 506
WERAM-Ora-0068 ENSOANP00000010212.2 Ornithorhynchus anatinus 65 6e-143 504
WERAM-Ptv-0162 ENSPVAP00000013602.1 Pteropus vampyrus 66 7e-143 504
WERAM-Gam-0058 ENSGMOP00000005645.1 Gadus morhua 63 1e-142 504
WERAM-Chh-0006 ENSCHOP00000000484.1 Choloepus hoffmanni 69 1e-132 471
WERAM-Ect-0076 ENSETEP00000008389.1 Echinops telfairi 68 1e-127 454
WERAM-Mae-0017 ENSMEUP00000001333.1 Macropus eugenii 59 1e-122 437
WERAM-Soa-0057 ENSSARP00000005556.1 Sorex araneus 66 5e-119 425
WERAM-Anp-0103 ENSAPLP00000012119.1 Anas platyrhynchos 68 9e-118 421
WERAM-Ere-0016 ENSEEUP00000000943.1 Erinaceus europaeus 54 3e-115 412
WERAM-Drm-0085 FBpp0291264 Drosophila melanogaster 56 6e-114 408
WERAM-Dio-0074 ENSDORP00000007460.1 Dipodomys ordii 56 5e-108 389
WERAM-Cii-0012 ENSCINP00000004028.3 Ciona intestinalis 60 4e-97 352
WERAM-Cis-0058 ENSCSAVP00000013108.1 Ciona savignyi 60 2e-80 297
WERAM-Cae-0046 Y48B6A.11 Caenorhabditis elegans 43 2e-79 294
WERAM-Yal-0032 CAG78224 Yarrowia lipolytica 39 2e-71 267
WERAM-Tum-0008 CAZ80461 Tuber melanosporum 37 2e-68 257
WERAM-Kll-0015 CAH01842 Kluyveromyces lactis 38 2e-67 254
WERAM-Asni-0024 CADANGAP00006693 Aspergillus niger 37 3e-67 253
WERAM-Sac-0014 YER169W Saccharomyces cerevisiae 37 3e-66 249
WERAM-Asg-0030 AAS54607 Ashbya gossypii 37 1e-65 248
WERAM-Caa-0021 KGT68489 Candida albicans 37 1e-64 244
WERAM-Cag-0029 CAG62258 Candida glabrata 37 2e-64 244
WERAM-Asfu-0032 CADAFUAP00007532 Aspergillus fumigatus 47 4e-64 243
WERAM-Asc-0010 CADACLAP00002196 Aspergillus clavatus 48 9e-64 241
WERAM-Asf-0016 CADAFLAP00008126 Aspergillus flavus 49 2e-61 233
WERAM-Aso-0001 CADAORAP00000267 Aspergillus oryzae 46 3e-61 233
WERAM-Asn-0010 CADANIAP00001580 Aspergillus nidulans 48 4e-61 233
WERAM-Scs-0007 EDN97054 Sclerotinia sclerotiorum 53 4e-61 233
WERAM-Ast-0031 CADATEAP00008693 Aspergillus terreus 48 7e-61 232
WERAM-Fuo-0032 FOXG_11150P0 Fusarium oxysporum 53 2e-60 231
WERAM-Zyt-0023 Mycgr3P48794 Zymoseptoria tritici 48 4e-60 229
WERAM-Nec-0015 EFNCRP00000002609 Neurospora crassa 50 1e-59 228
WERAM-Coi-0033 EAS31415 Coccidioides immitis 50 1e-59 228
WERAM-Ved-0030 EGY16315 Verticillium dahliae 50 1e-59 228
WERAM-Miv-0023 MVLG_03426T0 Microbotryum violaceum 51 3e-59 227
WERAM-Lab-0019 EDR09176 Laccaria bicolor 47 9e-59 225
WERAM-Spr-0038 CBQ69859 Sporisorium reilianum 50 1e-58 224
WERAM-Phn-0009 SNOT_01206 Phaeosphaeria nodorum 47 2e-58 224
WERAM-Trv-0008 EHK16031 Trichoderma virens 50 2e-58 223
WERAM-Trr-0030 EGR47972 Trichoderma reesei 50 2e-58 223
Created Date 25-Jun-2016