| Tag |
Content |
| WERAM ID |
WERAM-Hos-0033 |
| Ensembl Protein ID |
ENSP00000337332.1 |
| Uniprot Accession |
Q8N6T7; SIR6_HUMAN; B2RCD0; O75291; Q6IAF5; Q6PK99; Q8NCD2; Q9BSI5; Q9BWP3; Q9NRC7; Q9UQD1
|
| Genbank Protein ID |
NP_001180214.1; NP_057623.2
|
| Protein Name |
NAD-dependent protein deacetylase sirtuin-6 |
| Genbank Nucleotide ID |
NM_001193285.2; NM_016539.3
|
| Gene Name |
SIRT6;SIR2L6 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K9; H3K56 |
K |
19698979; 23995836
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
3.30e-67 |
228.9 |
36 |
273 |
|
| Organism |
Homo sapiens |
| NCBI Taxa ID |
9606 |
Functional Description
(View)Functional Description
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. |
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifd 53
+la+l+++s+++v++tGAGiSt++GIPDFR+++G++++ +++ +p+++++f+
ENSP00000337332.1 36 ELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFE 87
7899**************************************9999999997 PP
SIR2.txt 74 lgsakPtktHyflaelekkgkllrlytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCek........C 157
++sa+Pt+tH++l +le+ g+l++l++QN+DgL+ ++g+++dkl elHG++++++C kCk+++ r++++ ++ k++ + C+ C
ENSP00000337332.1 86 FESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVakarglraC 177
5799***********************************************************************9******999999999* PP
SIR2.txt 158 kgvlkpdivffgenlpeefleeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkll 249
+g l+++i+ ++++lp+++l ++e+ ++adl ++lGtSl+++p+ +l++++++++ + ++vnl+++k+d++adl+++g++dev+++l+k+l
ENSP00000337332.1 178 RGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHL 269
******************************************************************************************** PP
SIR2.txt 250 glee 253
gle+
ENSP00000337332.1 270 GLEI 273
9876 PP
|
Protein Sequence
(Fasta) | MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG 60
IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV 120
RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE 180
LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN 240
LQPTKHDRHA DLRIHGYVDE VMTRLMKHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK 300
EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS 355Protein Fasta Sequence
>ENSP00000337332.1|SIRT6;SIR2L6|Homo sapiens
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS |
Nucleotide Sequence
(Fasta) | GCCCCGCTTC CGGCGGAAGC GGCCTCAACA AGGGAAACTT TATTGTTCCC GTGGGGCAGT 60
CGAGGATGTC GGTGAATTAC GCGGCGGGGC TGTCGCCGTA CGCGGACAAG GGCAAGTGCG 120
GCCTCCCGGA GATCTTCGAC CCCCCGGAGG AGCTGGAGCG GAAGGTGTGG GAACTGGCGA 180
GGCTGGTCTG GCAGTCTTCC AGTGTGGTGT TCCACACGGG TGCCGGCATC AGCACTGCCT 240
CTGGCATCCC CGACTTCAGG GGTCCCCACG GAGTCTGGAC CATGGAGGAG CGAGGTCTGG 300
CCCCCAAGTT CGACACCACC TTTGAGAGCG CGCGGCCCAC GCAGACCCAC ATGGCGCTGG 360
TGCAGCTGGA GCGCGTGGGC CTCCTCCGCT TCCTGGTCAG CCAGAACGTG GACGGGCTCC 420
ATGTGCGCTC AGGCTTCCCC AGGGACAAAC TGGCAGAGCT CCACGGGAAC ATGTTTGTGG 480
AAGAATGTGC CAAGTGTAAG ACGCAGTACG TCCGAGACAC AGTCGTGGGC ACCATGGGCC 540
TGAAGGCCAC GGGCCGGCTC TGCACCGTGG CTAAGGCAAG GGGGCTGCGA GCCTGCAGGG 600
GAGAGCTGAG GGACACCATC CTAGACTGGG AGGACTCCCT GCCCGACCGG GACCTGGCAC 660
TCGCCGATGA GGCCAGCAGG AACGCCGACC TGTCCATCAC GCTGGGTACA TCGCTGCAGA 720
TCCGGCCCAG CGGGAACCTG CCGCTGGCTA CCAAGCGCCG GGGAGGCCGC CTGGTCATCG 780
TCAACCTGCA GCCCACCAAG CACGACCGCC ATGCTGACCT CCGCATCCAT GGCTACGTTG 840
ACGAGGTCAT GACCCGGCTC ATGAAGCACC TGGGGCTGGA GATCCCCGCC TGGGACGGCC 900
CCCGTGTGCT GGAGAGGGCG CTGCCACCCC TGCCCCGCCC GCCCACCCCC AAGCTGGAGC 960
CCAAGGAGGA ATCTCCCACC CGGATCAACG GCTCTATCCC CGCCGGCCCC AAGCAGGAGC 1020
CCTGCGCCCA GCACAACGGC TCAGAGCCCG CCAGCCCCAA ACGGGAGCGG CCCACCAGCC 1080
CTGCCCCCCA CAGACCCCCC AAAAGGGTGA AGGCCAAGGC GGTCCCCAGC TGACCAGGGT 1140
GCTTGGGGAG GGTGGGGCTT TTTGTAGAAA CTGTGGATTC TTTTTCTCTC GTGGTCTCAC 1200
TTTGTTACTT GTTTCTGTCC CCGGGAGCCT CAGGGCTCTG AGAGCTGTGC TCCAGGCCAG 1260
GGGTTACACC TGCCCTCCGT GGTCCCTCCC TGGGCTCCAG GGGCCTCTGG TGCGGTTCCG 1320
GGAAGAAGCC ACACCCCAGA GGTGACAGGT GAGCCCCTGC CACACCCCAG CCTCTGACTT 1380
GCTGTGTTGT CCAGAGGTGA GGCTGGGCCC TCCCTGGTCT CCAGCTTAAA CAGGAGTGAA 1440
CTCCCTCTGT CCCCAGGGCC TCCCTTCTGG GCCCCCTACA GCCCACCCTA CCCCTCCTCC 1500
ATGGGCCCTG CAGGAGGGGA GACCCACCTT GAAGTGGGGG ATCAGTAGAG GCTTGCACTG 1560
CCTTTGGGGC TGGAGGGAGA CGTGGGTCCA CCAGGCTTCT GGAAAAGTCC TCAATGCAAT 1620
AAAAACAATT TCTTTCTTGC A
1642Nucleotide Fasta Sequence
>ENSP00000337332.1|SIR2|Homo sapiens
GCCCCGCTTCCGGCGGAAGCGGCCTCAACAAGGGAAACTTTATTGTTCCCGTGGGGCAGTCGAGGATGTCGGTGAATTACGCGGCGGGGCTGTCGCCGTACGCGGACAAGGGCAAGTGCGGCCTCCCGGAGATCTTCGACCCCCCGGAGGAGCTGGAGCGGAAGGTGTGGGAACTGGCGAGGCTGGTCTGGCAGTCTTCCAGTGTGGTGTTCCACACGGGTGCCGGCATCAGCACTGCCTCTGGCATCCCCGACTTCAGGGGTCCCCACGGAGTCTGGACCATGGAGGAGCGAGGTCTGGCCCCCAAGTTCGACACCACCTTTGAGAGCGCGCGGCCCACGCAGACCCACATGGCGCTGGTGCAGCTGGAGCGCGTGGGCCTCCTCCGCTTCCTGGTCAGCCAGAACGTGGACGGGCTCCATGTGCGCTCAGGCTTCCCCAGGGACAAACTGGCAGAGCTCCACGGGAACATGTTTGTGGAAGAATGTGCCAAGTGTAAGACGCAGTACGTCCGAGACACAGTCGTGGGCACCATGGGCCTGAAGGCCACGGGCCGGCTCTGCACCGTGGCTAAGGCAAGGGGGCTGCGAGCCTGCAGGGGAGAGCTGAGGGACACCATCCTAGACTGGGAGGACTCCCTGCCCGACCGGGACCTGGCACTCGCCGATGAGGCCAGCAGGAACGCCGACCTGTCCATCACGCTGGGTACATCGCTGCAGATCCGGCCCAGCGGGAACCTGCCGCTGGCTACCAAGCGCCGGGGAGGCCGCCTGGTCATCGTCAACCTGCAGCCCACCAAGCACGACCGCCATGCTGACCTCCGCATCCATGGCTACGTTGACGAGGTCATGACCCGGCTCATGAAGCACCTGGGGCTGGAGATCCCCGCCTGGGACGGCCCCCGTGTGCTGGAGAGGGCGCTGCCACCCCTGCCCCGCCCGCCCACCCCCAAGCTGGAGCCCAAGGAGGAATCTCCCACCCGGATCAACGGCTCTATCCCCGCCGGCCCCAAGCAGGAGCCCTGCGCCCAGCACAACGGCTCAGAGCCCGCCAGCCCCAAACGGGAGCGGCCCACCAGCCCTGCCCCCCACAGACCCCCCAAAAGGGTGAAGGCCAAGGCGGTCCCCAGCTGACCAGGGTGCTTGGGGAGGGTGGGGCTTTTTGTAGAAACTGTGGATTCTTTTTCTCTCGTGGTCTCACTTTGTTACTTGTTTCTGTCCCCGGGAGCCTCAGGGCTCTGAGAGCTGTGCTCCAGGCCAGGGGTTACACCTGCCCTCCGTGGTCCCTCCCTGGGCTCCAGGGGCCTCTGGTGCGGTTCCGGGAAGAAGCCACACCCCAGAGGTGACAGGTGAGCCCCTGCCACACCCCAGCCTCTGACTTGCTGTGTTGTCCAGAGGTGAGGCTGGGCCCTCCCTGGTCTCCAGCTTAAACAGGAGTGAACTCCCTCTGTCCCCAGGGCCTCCCTTCTGGGCCCCCTACAGCCCACCCTACCCCTCCTCCATGGGCCCTGCAGGAGGGGAGACCCACCTTGAAGTGGGGGATCAGTAGAGGCTTGCACTGCCTTTGGGGCTGGAGGGAGACGTGGGTCCACCAGGCTTCTGGAAAAGTCCTCAATGCAATAAAAACAATTTCTTTCTTGCA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005724--C:nuclear telomeric heterochromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003956--F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0003950--F:NAD+ ADP-ribosyltransferase activity
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0046969--F:NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0034979--F:NAD-dependent protein deacetylase activity
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006284--P:base-excision repair
GO:0042593--P:glucose homeostasis
GO:0016575--P:histone deacetylation
GO:1990619--P:histone H3-K9 deacetylation
GO:0061647--P:histone H3-K9 modification
GO:0008285--P:negative regulation of cell proliferation
GO:0046325--P:negative regulation of glucose import
GO:0045820--P:negative regulation of glycolytic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0048146--P:positive regulation of fibroblast proliferation
GO:2000648--P:positive regulation of stem cell proliferation
GO:0003247--P:post-embryonic cardiac muscle cell growth involved in heart morphogenesis
GO:0006471--P:protein ADP-ribosylation
GO:0006476--P:protein deacetylation
GO:0031648--P:protein destabilization
GO:0010569--P:regulation of double-strand break repair via homologous recombination
GO:0031667--P:response to nutrient levels
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
