WERAM Information

Tag Content
WERAM ID WERAM-Mum-0112
Ensembl Protein ID ENSMUSP00000033010.2
Uniprot Accession Q9CXT6; KDM8_MOUSE
Genbank Protein ID NP_084118.1
Protein Name Lysine-specific demethylase 8
Genbank Nucleotide ID NM_029842.5
Gene Name KDM8;JMJD5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030752.8 ENSMUST00000033010.8 ENSMUSP00000033010.2
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JmjC_only Jmjc H3K36me2 K 26711262; 22402282
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JmjC_only 6.00e-50 170.2 269 414
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1) (By similarity).
Domain Profile
  HDM JmjC_only
         JmjC_only.txt   4 dylvpktfsdqlwqlkeelsepfyclvgsn.........wfltGpassgfplHvddieaflvqveGrkrwrlyepsepaellk.....l 78 
                            yl++++++dq+++lk+++s+p+yc++g++         wf  Gp+++++plH+d++++flvqv Grk++rly+p+e+++ ++     l
  ENSMUSP00000033010.2 269 GYLAQHQLFDQIPELKRDISIPDYCCLGNGeeeeitinaWF--GPQGTISPLHQDPQQNFLVQVLGRKYIRLYSPQESEAVYPhethiL 355
                           6****************************************..********************************************** PP
         JmjC_only.txt  79 asdeqvkqedllltkftliaprplletvlepgellyiprgtwHqalsldvtlsvsqnfs 137
                           ++++qv++e+++l+kf++++++p+l+++l+pg++l+ip+++wH+++sld+++svs+++s
  ENSMUSP00000033010.2 356 HNTSQVDVENPDLEKFPKFTEAPFLSCILSPGDTLFIPAKYWHYVRSLDLSFSVSFWWS 414
                           **********************************************************8 PP
Protein Sequence
(Fasta)		MSEDTTEPLV GSSTLWKELR TLLPDKEEEL KLDLGEKVDR SVAALLRQAV GLFYAGHWQG 60
CLQASEAVLD YSWEKLNTGP WRDVDKEWRR VYSFGCLLKA LCLCQAPQKA TTVVEALRVC 120
DMGLLMGAAI LEDILLKVVA VLQTHQLPGK QPARGPHQDQ PATKKAKCDA SPAPDVMLER 180
MVPRLRCPPL QYFKQHFLVP GRPVILEGVA DHWPCMKKWS LQYIQEIAGC RTVPVEVGSR 240
YTDEDWSQTL MTVDEFIQKF ILSEAKDVGY LAQHQLFDQI PELKRDISIP DYCCLGNGEE 300
EEITINAWFG PQGTISPLHQ DPQQNFLVQV LGRKYIRLYS PQESEAVYPH ETHILHNTSQ 360
VDVENPDLEK FPKFTEAPFL SCILSPGDTL FIPAKYWHYV RSLDLSFSVS FWWS 414
Nucleotide Sequence
(Fasta)		AGAAGTGATC GATGCTCTCG GTGTAGTCGG TGATAAAGCC AGCCGAAGAA TCTTCGCCCG 60
GACGGAACCA GTCGTCGCCA GCAACGAGAG ACACAAACAA GTCCAAGCGC CAGAGAGGTG 120
CTGATCATGT CAGAGGACAC CACAGAGCCC CTGGTGGGGT CCAGCACCCT CTGGAAGGAG 180
CTCAGGACGC TCCTGCCTGA CAAAGAGGAG GAGCTGAAGC TGGACCTCGG TGAGAAGGTG 240
GACAGGAGCG TGGCTGCGCT TTTGCGGCAG GCTGTGGGTC TATTCTACGC GGGCCATTGG 300
CAGGGGTGCC TGCAGGCCAG TGAGGCCGTC CTAGACTACT CCTGGGAAAA GCTCAACACT 360
GGTCCCTGGA GAGATGTAGA CAAGGAGTGG CGCCGGGTAT ATTCCTTCGG CTGCCTCCTG 420
AAGGCCCTGT GCCTGTGCCA GGCACCACAG AAGGCCACTA CTGTGGTGGA AGCACTGCGG 480
GTGTGTGACA TGGGCCTGTT GATGGGGGCA GCCATCCTCG AGGACATTCT TCTCAAAGTT 540
GTCGCAGTCC TCCAGACACA CCAGCTCCCA GGAAAGCAGC CTGCCCGCGG CCCCCACCAG 600
GATCAGCCTG CCACCAAGAA GGCAAAGTGT GACGCCAGCC CAGCTCCTGA TGTCATGTTA 660
GAGCGGATGG TACCCAGGCT CCGCTGCCCA CCTCTGCAGT ACTTCAAGCA GCATTTTCTA 720
GTTCCTGGGA GGCCTGTGAT CTTGGAAGGT GTGGCCGACC ACTGGCCGTG CATGAAGAAG 780
TGGAGTCTGC AGTACATCCA GGAGATTGCT GGCTGCCGCA CCGTCCCCGT GGAAGTGGGC 840
TCAAGGTACA CAGATGAAGA CTGGTCCCAG ACTCTCATGA CAGTCGATGA GTTCATCCAG 900
AAGTTCATCC TGAGCGAGGC AAAGGATGTC GGGTACCTTG CTCAGCACCA GCTCTTCGAC 960
CAGATCCCAG AGTTGAAGCG GGACATCAGC ATCCCTGATT ACTGTTGCCT GGGCAATGGA 1020
GAAGAGGAAG AGATCACTAT CAATGCCTGG TTTGGTCCAC AAGGCACCAT CTCCCCACTG 1080
CATCAGGACC CCCAGCAGAA CTTCCTGGTC CAGGTGCTAG GAAGGAAGTA CATCCGATTG 1140
TATTCGCCGC AAGAGTCTGA GGCAGTGTAC CCTCACGAGA CGCACATTCT TCATAACACC 1200
AGCCAGGTTG ATGTGGAAAA CCCCGACCTT GAGAAGTTTC CCAAGTTCAC TGAGGCCCCA 1260
TTCCTGTCCT GCATTCTGTC CCCAGGAGAC ACCCTCTTTA TACCTGCTAA GTACTGGCAT 1320
TATGTGCGCT CCCTGGACCT GAGCTTCTCT GTCAGCTTCT GGTGGTCATA GCTAGGACCA 1380
GACTGGAAAG GACCTCTGGG CAGACACCTT ACCCAAAGGC AGTAAACCAA GTGTCAGTGT 1440
GGGCCCTGCA TGCCGCTAGA CTCCAGCAGC CCTGCCCCCA GCCAATGTCT GTTGTGTGAC 1500
AGAGCTGCTA TGTACCCACG TGTGGCCCAC CTGCTGTGTG TGCCCGCGTG TGTAGGGCAG 1560
AGCTGCTACA TGTACCTAAG CTATCCAGAT TATGGGTGCT TTTTTTCCTT TGTAACTGCT 1620
GGGCTGAGTA TCCCTTGCTG CTAGGTGCCC AAGGGCAGCT GGCAAGCTGC TCAGAGACAG 1680
AACACAACCT GTAATAGGGG TTTTCTTGGG TGGAATATAG CCGGGTCTGG GACAGCTGCT 1740
GTGGTCCCAG TCTTCTGTGT ACCCAGGCCT CACTGCCAGC TTACTACTAG GAGTTGGAAA 1800
CAGAGGTCCT TGGCTCCATA CTTCCCCTCG GGGCACTTAT GCACCAGGCT GGAAGAGGAG 1860
GGCAGCGGAA CTACTTTGTT GTGAATGTGG GGAATACAGA GAAGAGCGAG GTCTTCCCAG 1920
AATATATAGG AGCGGCCTTT TACAAGGAAG CCCCTGCCCC CAAGCCTCCT TGATGAAGAG 1980
ATGGTTCTTA CGTTCAAACT GTTTTAGTTG ATGGCGGATG TGCATGCACA CACCTTACTC 2040
AGGGTGAATC AAGGAGTAAA TACCTCTTGT GGGAAGGACT GCCCAGGAAG GGAAGCTCAT 2100
TGGCTGAACA CTCGGGGCCC ACTTAGATAC CACATTACCA TGGAGAACTC CAGGTTTTTA 2160
TGTTACAAGA CTGACTGTCA CCGTCCTCTC AGTGGGGTGT CATGTTCCAG ATCAGGTAGT 2220
TTGGCAGGGA GCTGGCTCTA CTCCAGCTGT TCTCAATTCT GAGATTTCCC CAGTCTGAGC 2280
CTGCTCAACC TTACCAGTTC TTCTGTCTGG TGGCCCGGTC CACTTGCCCC ATATGTAACT 2340
TAAATATTTT CAATAACAAT AAAATATATT TTATTAATTA AAAAACAAA
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR003347--JmjC_dom
PROSITE

PS51184--JMJC
Pfam
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0046872--F:metal ion binding
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0070544--P:histone H3-K36 demethylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0101 ENSRNOP00000020388.4 Rattus norvegicus 92 0.0 754
WERAM-Fec-0011 ENSFCAP00000000891.3 Felis catus 78 0.0 645
WERAM-Hos-0166 ENSP00000286096.4 Homo sapiens 78 0.0 642
WERAM-Eqc-0005 ENSECAP00000000474.1 Equus caballus 79 0.0 642
WERAM-Gog-0074 ENSGGOP00000006358.2 Gorilla gorilla 77 0.0 641
WERAM-Otg-0122 ENSOGAP00000010606.2 Otolemur garnettii 77 0.0 640
WERAM-Pat-0060 ENSPTRP00000013519.3 Pan troglodytes 77 0.0 640
WERAM-Nol-0122 ENSNLEP00000014249.2 Nomascus leucogenys 77 0.0 638
WERAM-Poa-0063 ENSPPYP00000008151.1 Pongo abelii 77 0.0 638
WERAM-Paa-0062 ENSPANP00000012432.1 Papio anubis 78 0.0 637
WERAM-Mam-0145 ENSMMUP00000020806.2 Macaca mulatta 78 0.0 635
WERAM-Chs-0075 ENSCSAP00000002744.1 Chlorocebus sabaeus 77 0.0 634
WERAM-Prc-0093 ENSPCAP00000008339.1 Procavia capensis 74 0.0 634
WERAM-Caf-0187 ENSCAFP00000025742.3 Canis familiaris 75 0.0 634
WERAM-Aim-0052 ENSAMEP00000004259.1 Ailuropoda melanoleuca 76 0.0 634
WERAM-Ptv-0038 ENSPVAP00000004151.1 Pteropus vampyrus 74 0.0 633
WERAM-Ova-0201 ENSOARP00000020136.1 Ovis aries 77 0.0 632
WERAM-Mup-0147 ENSMPUP00000012892.1 Mustela putorius furo 75 0.0 630
WERAM-Loa-0169 ENSLAFP00000015542.3 Loxodonta africana 78 9e-179 623
WERAM-Bot-0170 ENSBTAP00000026023.5 Bos taurus 77 1e-178 623
WERAM-Myl-0091 ENSMLUP00000007518.2 Myotis lucifugus 74 3e-178 622
WERAM-Cap-0027 ENSCPOP00000002073.2 Cavia porcellus 76 5e-178 621
WERAM-Chh-0005 ENSCHOP00000000442.1 Choloepus hoffmanni 72 3e-174 608
WERAM-Tut-0101 ENSTTRP00000008521.1 Tursiops truncatus 76 8e-174 607
WERAM-Sus-0055 ENSSSCP00000008347.2 Sus scrofa 74 8e-172 600
WERAM-Ict-0169 ENSSTOP00000022768.1 Ictidomys tridecemlineatus 71 9e-171 597
WERAM-Dan-0154 ENSDNOP00000024517.1 Dasypus novemcinctus 76 3e-169 591
WERAM-Tub-0083 ENSTBEP00000009713.1 Tupaia belangeri 81 4e-169 591
WERAM-Dio-0095 ENSDORP00000009624.1 Dipodomys ordii 70 5e-163 571
WERAM-Sah-0112 ENSSHAP00000012011.1 Sarcophilus harrisii 71 2e-162 569
WERAM-Mim-0094 ENSMICP00000008672.1 Microcebus murinus 71 3e-162 568
WERAM-Ere-0039 ENSEEUP00000002911.1 Erinaceus europaeus 70 3e-161 565
WERAM-Mod-0137 ENSMODP00000019296.2 Monodelphis domestica 67 2e-160 562
WERAM-Lac-0048 ENSLACP00000007034.1 Latimeria chalumnae 64 1e-147 520
WERAM-Pes-0097 ENSPSIP00000011968.1 Pelodiscus sinensis 62 2e-146 516
WERAM-Caj-0217 ENSCJAP00000038116.2 Callithrix jacchus 66 2e-145 513
WERAM-Leo-0023 ENSLOCP00000004737.1 Lepisosteus oculatus 58 2e-137 486
WERAM-Pof-0141 ENSPFOP00000011752.1 Poecilia formosa 58 7e-136 481
WERAM-Gaga-0066 ENSGALP00000010168.4 Gallus gallus 62 3e-135 479
WERAM-Orn-0019 ENSONIP00000001749.1 Oreochromis niloticus 58 9e-135 477
WERAM-Tag-0119 ENSTGUP00000009777.1 Taeniopygia guttata 64 1e-134 476
WERAM-Xim-0107 ENSXMAP00000009477.1 Xiphophorus maculatus 58 3e-134 475
WERAM-Ten-0217 ENSTNIP00000021769.1 Tetraodon nigroviridis 56 8e-134 474
WERAM-Tas-0011 ENSTSYP00000001358.1 Tarsius syrichta 80 3e-133 472
WERAM-Mae-0065 ENSMEUP00000005887.1 Macropus eugenii 61 9e-133 470
WERAM-Dar-0218 ENSDARP00000133489.1 Danio rerio 59 6e-132 468
WERAM-Tar-0148 ENSTRUP00000031961.1 Takifugu rubripes 56 3e-131 465
WERAM-Gaa-0145 ENSGACP00000018511.1 Gasterosteus aculeatus 57 1e-130 463
WERAM-Orla-0050 ENSORLP00000006206.1 Oryzias latipes 58 2e-130 463
WERAM-Gam-0047 ENSGMOP00000004939.1 Gadus morhua 60 3e-128 455
WERAM-Xet-0135 ENSXETP00000047024.2 Xenopus tropicalis 53 8e-128 454
WERAM-Anc-0031 ENSACAP00000003528.2 Anolis carolinensis 57 3e-119 426
WERAM-Fia-0169 ENSFALP00000014680.1 Ficedula albicollis 72 3e-110 395
WERAM-Anp-0138 ENSAPLP00000014931.1 Anas platyrhynchos 72 7e-106 381
WERAM-Php-0008 PP1S105_124V6.1 Physcomitrella patens 45 4e-83 305
WERAM-Sem-0027 EFJ27560 Selaginella moellendorffii 44 5e-78 288
WERAM-Pot-0003 POPTR_0001s05390.1 Populus trichocarpa 42 1e-77 287
WERAM-Viv-0032 VIT_06s0004g01630.t01 Vitis vinifera 42 2e-77 286
WERAM-Sob-0030 Sb02g028370.1 Sorghum bicolor 42 5e-77 285
WERAM-Met-0103 KEH30262 Medicago truncatula 43 1e-76 284
WERAM-Brr-0177 Bra035742.1-P Brassica rapa 42 2e-76 283
WERAM-Sot-0067 PGSC0003DMT400055008 Solanum tuberosum 41 4e-76 282
WERAM-Zem-0040 GRMZM2G052908_P01 Zea mays 41 5e-76 282
WERAM-Thc-0109 EOY32544 Theobroma cacao 42 8e-76 281
WERAM-Bro-0097 Bo5g106210.1 Brassica oleracea 41 2e-75 280
WERAM-Lep-0101 LPERR09G10850.1 Leersia perrieri 43 4e-75 279
WERAM-Art-0076 AT3G20810.2 Arabidopsis thaliana 40 5e-75 278
WERAM-Mua-0127 GSMUA_Achr8P25590_001 Musa acuminata 41 6e-75 278
WERAM-Arl-0063 fgenesh2_kg.3__ 2308__ AT3G20810.2 Arabidopsis lyrata 41 7e-75 278
WERAM-Prp-0114 EMJ09022 Prunus persica 42 1e-74 277
WERAM-Ors-0093 OS09T0489200-00 Oryza sativa 44 2e-74 276
WERAM-Glm-0128 GLYMA11G13911.1 Glycine max 42 3e-74 276
WERAM-Orgl-0101 OGLUM09G15350.1 Oryza glumaepatula 44 8e-74 275
WERAM-Sei-0115 Si029989m Setaria italica 40 3e-73 273
WERAM-Ori-0103 BGIOSGA029547-PA Oryza indica 41 7e-71 265
WERAM-Brd-0110 BRADI4G33727.1 Brachypodium distachyon 43 1e-69 260
WERAM-Orr-0098 ORUFI08G22350.2 Oryza rufipogon 40 1e-65 248
WERAM-Tru-0087 TRIUR3_31518-P1 Triticum urartu 49 3e-65 246
WERAM-Tra-0293 Traes_7AS_08AEBE00A.2 Triticum aestivum 49 4e-65 246
WERAM-Orbr-0102 OB08G26850.1 Oryza brachyantha 50 7e-65 245
WERAM-Orni-0094 ONIVA08G22510.3 Oryza nivara 38 1e-58 224
WERAM-Hov-0087 MLOC_65982.1 Hordeum vulgare 53 4e-53 206
Created Date 25-Jun-2016