WERAM Information

Tag Content
WERAM ID WERAM-Hos-0166
Ensembl Protein ID ENSP00000286096.4
Uniprot Accession Q8N371; KDM8_HUMAN; B4DLU9; Q6VAK5; Q9H8B1
Genbank Protein ID NP_001138820.1; NP_079049.2
Protein Name Lysine-specific demethylase 8
Genbank Nucleotide ID NM_001145348.1; NM_024773.2
Gene Name KDM8;JMJD5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000155666.11 ENST00000286096.8 ENSP00000286096.4
ENSG00000155666.11 ENST00000441782.6 ENSP00000398410.2
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JmjC_only Jmjc H3K36me2 K 20457893
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JmjC_only 1.40e-48 166.6 271 416
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
Domain Profile
  HDM JmjC_only
      JmjC_only.txt   4 dylvpktfsdqlwqlkeelsepfyclvgsn.........wfltGpassgfplHvddieaflvqveGrkrwrlyepsepaellk.....lasd 81 
                         yl++++++dq+++lk+++s+p+yc +g++         wf  Gp+++++plH+d++++flvqv+Grk++rly+p+e+ +l++     l+++
  ENSP00000286096.4 271 GYLAQHQLFDQIPELKQDISIPDYCSLGDGeeeeitinaWF--GPQGTISPLHQDPQQNFLVQVMGRKYIRLYSPQESGALYPhdthlLHNT 360
                        6****************************************..************************************************* PP
      JmjC_only.txt  82 eqvkqedllltkftliaprplletvlepgellyiprgtwHqalsldvtlsvsqnfs 137
                        +qv++e+++l+kf+++a++p+l+++l+pge+l+ip ++wH++++ld+++svs+++s
  ENSP00000286096.4 361 SQVDVENPDLEKFPKFAKAPFLSCILSPGEILFIPVKYWHYVRALDLSFSVSFWWS 416
                        *******************************************************8 PP
Protein Sequence
(Fasta)		MAGDTHCPAE PLAREGTLWE ALRALLPHSK EDLKLDLGEK VERSVVTLLQ RATELFYEGR 60
RDECLQSSEV ILDYSWEKLN TGTWQDVDKD WRRVYAIGCL LKALCLCQAP EDANTVAAAL 120
RVCDMGLLMG AAILGDILLK VAAILQTHLP GKRPARGSLP EQPCTKKARA DHGLIPDVKL 180
EKTVPRLHRP SLQHFREQFL VPGRPVILKG VADHWPCMQK WSLEYIQEIA GCRTVPVEVG 240
SRYTDEEWSQ TLMTVNEFIS KYIVNEPRDV GYLAQHQLFD QIPELKQDIS IPDYCSLGDG 300
EEEEITINAW FGPQGTISPL HQDPQQNFLV QVMGRKYIRL YSPQESGALY PHDTHLLHNT 360
SQVDVENPDL EKFPKFAKAP FLSCILSPGE ILFIPVKYWH YVRALDLSFS VSFWWS 416
Nucleotide Sequence
(Fasta)		GTCGTGATCA GACGAGCGGT GAGCGATCGA TACTCCTATG CTAGCCTCTG GCTCCTCAGG 60
GGACACAGCC GAGTGGTCGG ACCAAACGCA ACGAGTCTTC GCCAGCCCAA AGGCGACTCG 120
ACACCGTCCC AGCTGAAGAG AGGCACGGGA CTGAACCAGC TGGTGGTGGC CCGATGGCTG 180
GAGACACCCA CTGCCCCGCA GAGCCCCTGG CCAGAGAAGG CACTTTATGG GAGGCCCTCA 240
GGGCGCTCCT GCCGCACAGT AAAGAAGACC TGAAGTTGGA CCTCGGGGAG AAAGTGGAGA 300
GGAGCGTGGT GACATTGTTG CAGCGAGCCA CTGAGCTCTT CTACGAGGGC AGGAGGGACG 360
AGTGTCTGCA GAGCAGCGAG GTGATCCTGG ACTACTCCTG GGAGAAGCTC AACACGGGCA 420
CATGGCAGGA CGTAGACAAA GACTGGCGCC GGGTCTACGC CATCGGCTGC CTCCTGAAAG 480
CCCTGTGTCT GTGCCAGGCA CCTGAGGATG CCAACACTGT GGCCGCAGCC CTGCGGGTCT 540
GTGACATGGG CCTGCTGATG GGGGCAGCCA TCCTGGGGGA CATCCTTCTT AAAGTCGCTG 600
CCATCCTCCA GACACACCTC CCTGGAAAGA GGCCTGCCCG TGGCTCCCTC CCAGAGCAAC 660
CCTGCACAAA GAAAGCAAGG GCGGACCATG GTTTGATTCC AGATGTGAAG TTAGAAAAAA 720
CAGTCCCCCG GCTGCACCGT CCGTCCCTCC AGCATTTCAG GGAGCAGTTT TTGGTTCCAG 780
GGAGGCCCGT GATCCTGAAA GGCGTGGCTG ACCACTGGCC GTGCATGCAG AAGTGGAGTT 840
TGGAGTATAT CCAGGAGATC GCTGGCTGCC GAACTGTCCC AGTGGAAGTT GGTTCGAGGT 900
ACACAGATGA GGAATGGTCC CAGACCCTCA TGACGGTCAA CGAGTTCATC AGCAAATACA 960
TCGTGAATGA GCCAAGGGAC GTCGGGTACC TTGCTCAGCA CCAGCTCTTT GACCAGATCC 1020
CGGAGTTGAA GCAGGACATC AGCATCCCCG ACTACTGCAG CCTGGGCGAT GGGGAGGAGG 1080
AGGAAATCAC CATCAATGCC TGGTTTGGTC CCCAGGGAAC CATCTCCCCA CTACATCAGG 1140
ATCCCCAGCA AAACTTCCTA GTGCAGGTGA TGGGGAGGAA GTACATCCGG CTGTATTCCC 1200
CGCAGGAGTC AGGGGCTCTG TACCCTCATG ACACGCACCT TCTCCATAAC ACGAGCCAGG 1260
TTGACGTGGA GAATCCCGAC CTGGAAAAGT TCCCCAAGTT TGCCAAGGCC CCATTCCTGT 1320
CCTGCATCCT GTCTCCTGGA GAGATCCTGT TCATCCCGGT GAAATACTGG CATTACGTGC 1380
GGGCTCTGGA TTTGAGCTTC TCGGTCAGCT TCTGGTGGTC GTAGCCAGGA TAGGAGCTGA 1440
AAGGGCCTGA CATGCAGACA GCATTCATCT GTTCACTAAT TTCCTGGGTC CTGGAATCTA 1500
TAGAGACAAG CAGGACTGAA CCTGTGTCCT GAAGAGCCTT CACTGCCCAG TGGCAGCCCT 1560
GGGGGGCTGA GCTCCAGCAC TGGACAGGCA CAGAGCAGGG GCTGCCCAGG AAGGAGCACA 1620
CTCCAGGCCA GGGGTGCATG GCAGAGGAAG GTGGGGAGAG CCCAGAAGGA CATTGCAGAC 1680
AGACAGCCTG CATGGGGACT CTGGCATCAG AAAGCCGAAT GTTTTTGGGA AACGGGTGGG 1740
TCACACAGGC AGGGGTGAAA CATGGGCTCT GAGGTTGGCT ACCTGATTCA AACCCGGCCG 1800
CGCTGTGCAC CTGCTGGGTG ACTTGGCCAG GATCCCCCAC TTCGCTGTGC CCATATGGAA 1860
AAGAGGGCAA GGCCAGTCCT CACTGCCGAG GGCCGAGAAG GCGGTGCCGA GCCCCTGCTG 1920
CTGCATGAAC CTTAGCCGCT GTCACTGATC CCAATTACTC TGATCCTTTT GCCCTTCCTT 1980
CCCATAACGG CCTGCTGGAC GCCACAGCCT GAATACTGGA GAGAGCTGGG CATTGCCCAG 2040
GTCACAGGAG AGAGTCCGTA GAGACCTGCG CAGGAGCCGG GACCCCTGCT GAGCAGTGGG 2100
AGCTTTCTGT CATCCCCATG GCTCAAGGAT AACCTACCTG CCTGCAGAGA AGTGCGAAGG 2160
TCTTGCTGGA TGACTTTTCA CCCGCACTCA CCCAGGAGCA GGCTCCCAAG TGAAGAAACC 2220
ACCGAACCAT CACCAGCTCC TAGAAGCCTC CCTCCTACCA CCTTCTAGTC ACCATCCCCC 2280
AGAAGTAATG ACTCTCAAAC CTGGGGGATT TGAGGCCAGG GGGAGAGCCA GGCTCTATGC 2340
TTTCTGTAAT TGTGTCTCGT TTGTGTGCAC GCAGGTTTGT TTTATGTTTT GGCCATTAAG 2400
ATTTTCCCCA GCCCTCTGTT TTTTGTTTTT TAAACTAAAT AGAGATGGGA TCTTGCTATG 2460
TT 2463
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR003347--JmjC_dom
PROSITE

PS51184--JMJC
Pfam
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0046872--F:metal ion binding
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0070544--P:histone H3-K36 demethylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Pat-0060 ENSPTRP00000013519.3 Pan troglodytes 99 0.0 857
WERAM-Poa-0063 ENSPPYP00000008151.1 Pongo abelii 98 0.0 852
WERAM-Gog-0074 ENSGGOP00000006358.2 Gorilla gorilla 98 0.0 851
WERAM-Nol-0122 ENSNLEP00000014249.2 Nomascus leucogenys 97 0.0 842
WERAM-Chs-0075 ENSCSAP00000002744.1 Chlorocebus sabaeus 95 0.0 828
WERAM-Mam-0145 ENSMMUP00000020806.2 Macaca mulatta 95 0.0 827
WERAM-Paa-0062 ENSPANP00000012432.1 Papio anubis 95 0.0 822
WERAM-Otg-0122 ENSOGAP00000010606.2 Otolemur garnettii 85 0.0 735
WERAM-Prc-0093 ENSPCAP00000008339.1 Procavia capensis 81 0.0 704
WERAM-Eqc-0005 ENSECAP00000000474.1 Equus caballus 85 0.0 704
WERAM-Fec-0011 ENSFCAP00000000891.3 Felis catus 84 0.0 698
WERAM-Myl-0091 ENSMLUP00000007518.2 Myotis lucifugus 82 0.0 698
WERAM-Loa-0169 ENSLAFP00000015542.3 Loxodonta africana 85 0.0 695
WERAM-Ptv-0038 ENSPVAP00000004151.1 Pteropus vampyrus 81 0.0 691
WERAM-Aim-0052 ENSAMEP00000004259.1 Ailuropoda melanoleuca 82 0.0 686
WERAM-Caf-0187 ENSCAFP00000025742.3 Canis familiaris 80 0.0 685
WERAM-Ova-0201 ENSOARP00000020136.1 Ovis aries 82 0.0 682
WERAM-Chh-0005 ENSCHOP00000000442.1 Choloepus hoffmanni 79 0.0 681
WERAM-Bot-0170 ENSBTAP00000026023.5 Bos taurus 83 0.0 681
WERAM-Sus-0055 ENSSSCP00000008347.2 Sus scrofa 82 0.0 680
WERAM-Ran-0101 ENSRNOP00000020388.4 Rattus norvegicus 78 0.0 676
WERAM-Mum-0112 ENSMUSP00000033010.2 Mus musculus 78 0.0 674
WERAM-Mim-0094 ENSMICP00000008672.1 Microcebus murinus 80 0.0 669
WERAM-Tut-0101 ENSTTRP00000008521.1 Tursiops truncatus 82 0.0 664
WERAM-Cap-0027 ENSCPOP00000002073.2 Cavia porcellus 80 0.0 663
WERAM-Dan-0154 ENSDNOP00000024517.1 Dasypus novemcinctus 83 0.0 660
WERAM-Caj-0217 ENSCJAP00000038116.2 Callithrix jacchus 79 0.0 659
WERAM-Mup-0147 ENSMPUP00000012892.1 Mustela putorius furo 77 0.0 654
WERAM-Ict-0169 ENSSTOP00000022768.1 Ictidomys tridecemlineatus 74 0.0 646
WERAM-Sah-0112 ENSSHAP00000012011.1 Sarcophilus harrisii 73 1e-177 620
WERAM-Mod-0137 ENSMODP00000019296.2 Monodelphis domestica 72 4e-177 618
WERAM-Tub-0083 ENSTBEP00000009713.1 Tupaia belangeri 87 2e-176 615
WERAM-Dio-0095 ENSDORP00000009624.1 Dipodomys ordii 71 2e-176 615
WERAM-Ere-0039 ENSEEUP00000002911.1 Erinaceus europaeus 73 1e-171 600
WERAM-Pes-0097 ENSPSIP00000011968.1 Pelodiscus sinensis 64 2e-163 572
WERAM-Lac-0048 ENSLACP00000007034.1 Latimeria chalumnae 62 6e-151 531
WERAM-Tas-0011 ENSTSYP00000001358.1 Tarsius syrichta 88 6e-147 518
WERAM-Leo-0023 ENSLOCP00000004737.1 Lepisosteus oculatus 58 7e-144 507
WERAM-Mae-0065 ENSMEUP00000005887.1 Macropus eugenii 61 8e-143 504
WERAM-Gaga-0066 ENSGALP00000010168.4 Gallus gallus 61 4e-142 501
WERAM-Tar-0148 ENSTRUP00000031961.1 Takifugu rubripes 58 6e-142 501
WERAM-Dar-0218 ENSDARP00000133489.1 Danio rerio 57 1e-141 499
WERAM-Orn-0019 ENSONIP00000001749.1 Oreochromis niloticus 57 2e-141 499
WERAM-Tag-0119 ENSTGUP00000009777.1 Taeniopygia guttata 61 2e-140 496
WERAM-Ten-0217 ENSTNIP00000021769.1 Tetraodon nigroviridis 57 5e-139 491
WERAM-Pof-0141 ENSPFOP00000011752.1 Poecilia formosa 57 5e-139 491
WERAM-Xim-0107 ENSXMAP00000009477.1 Xiphophorus maculatus 57 5e-138 488
WERAM-Gaa-0145 ENSGACP00000018511.1 Gasterosteus aculeatus 56 9e-137 484
WERAM-Xet-0135 ENSXETP00000047024.2 Xenopus tropicalis 52 4e-133 471
WERAM-Orla-0050 ENSORLP00000006206.1 Oryzias latipes 55 3e-130 462
WERAM-Gam-0047 ENSGMOP00000004939.1 Gadus morhua 57 2e-129 459
WERAM-Anc-0031 ENSACAP00000003528.2 Anolis carolinensis 56 2e-123 440
WERAM-Fia-0169 ENSFALP00000014680.1 Ficedula albicollis 75 6e-110 395
WERAM-Anp-0138 ENSAPLP00000014931.1 Anas platyrhynchos 72 8e-107 384
WERAM-Sem-0129 EFJ37386 Selaginella moellendorffii 42 3e-78 289
WERAM-Mua-0142 GSMUA_Achr9P20180_001 Musa acuminata 44 9e-77 284
WERAM-Php-0008 PP1S105_124V6.1 Physcomitrella patens 42 1e-76 284
WERAM-Zem-0040 GRMZM2G052908_P01 Zea mays 43 3e-75 279
WERAM-Lep-0101 LPERR09G10850.1 Leersia perrieri 44 3e-75 279
WERAM-Sob-0030 Sb02g028370.1 Sorghum bicolor 42 6e-75 278
WERAM-Pot-0003 POPTR_0001s05390.1 Populus trichocarpa 43 6e-75 278
WERAM-Prp-0114 EMJ09022 Prunus persica 44 3e-74 276
WERAM-Ors-0093 OS09T0489200-00 Oryza sativa 45 4e-74 275
WERAM-Sei-0115 Si029989m Setaria italica 42 1e-73 274
WERAM-Thc-0109 EOY32544 Theobroma cacao 42 1e-73 274
WERAM-Brr-0177 Bra035742.1-P Brassica rapa 41 1e-73 274
WERAM-Orgl-0101 OGLUM09G15350.1 Oryza glumaepatula 44 2e-73 273
WERAM-Sot-0067 PGSC0003DMT400055008 Solanum tuberosum 41 2e-73 273
WERAM-Art-0076 AT3G20810.2 Arabidopsis thaliana 41 5e-73 272
WERAM-Arl-0063 fgenesh2_kg.3__ 2308__ AT3G20810.2 Arabidopsis lyrata 40 5e-73 272
WERAM-Viv-0032 VIT_06s0004g01630.t01 Vitis vinifera 41 3e-72 270
WERAM-Bro-0097 Bo5g106210.1 Brassica oleracea 40 3e-72 269
WERAM-Glm-0128 GLYMA11G13911.1 Glycine max 42 6e-72 268
WERAM-Ori-0103 BGIOSGA029547-PA Oryza indica 43 6e-71 265
WERAM-Met-0103 KEH30262 Medicago truncatula 40 6e-71 265
WERAM-Brd-0110 BRADI4G33727.1 Brachypodium distachyon 44 3e-67 253
WERAM-Orr-0098 ORUFI08G22350.2 Oryza rufipogon 40 2e-63 240
WERAM-Orbr-0102 OB08G26850.1 Oryza brachyantha 49 2e-63 240
WERAM-Tru-0087 TRIUR3_31518-P1 Triticum urartu 49 1e-62 238
WERAM-Tra-0293 Traes_7AS_08AEBE00A.2 Triticum aestivum 49 1e-62 237
WERAM-Orni-0094 ONIVA08G22510.3 Oryza nivara 39 4e-57 219
WERAM-Hov-0087 MLOC_65982.1 Hordeum vulgare 51 3e-52 203
Created Date 25-Jun-2016