| Tag |
Content |
| WERAM ID |
WERAM-Art-0143 |
| Ensembl Protein ID |
AT5G55760.1 |
| Uniprot Accession |
Q9FE17; SIR1_ARATH; Q7Y032
|
| Genbank Protein ID |
NP_200387.1
|
| Protein Name |
NAD-dependent protein deacetylase SRT1 |
| Genbank Nucleotide ID |
NM_124958.2
|
| Gene Name |
SRT1;At5g55760;MDF20.20 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K9 |
K |
26689639
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
6.80e-68 |
229.6 |
36 |
268 |
|
| Organism |
Arabidopsis thaliana |
| NCBI Taxa ID |
3702 |
Functional Description
(View)Functional Description
NAD-dependent protein deacetylase. Has deacetylase activity towards H3K9Ac. May have a function in the safeguard against genome instabiliy and DNA damage to ensure plant cell growth (By similarity). |
NAD-dependent protein deacetylase. Has deacetylase activity towards H3K9Ac. May have a function in the safeguard against genome instabiliy and DNA damage to ensure plant cell growth (By similarity).
|
| Domain Profile |
HDAC SIR2
SIR2.txt 2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelekkgkllrly 99
+lakl++ksk++vv+tGAGiSts+GIPDFR+++G+++ +++ +++ k+ +p+++a P++tH++l ele++g l++++
AT5G55760.1 36 ELAKLIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREG-----KDLP----------------KASLPFHRAMPSMTHMALVELERAGILKFVI 112
799**********************************96666.....3333................3346777899********************* PP
SIR2.txt 100 tQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCek..CkgvlkpdivffgenlpeefleeveedlkeadlllvlGt 195
+QN+DgL++++g++++kl+elHG+ ++++C +C++e+ r++ +e++ ke+ +kC+ C+++lk++++ ++++lp ++++ +e+++k+adl+l+lGt
AT5G55760.1 113 SQNVDGLHLRSGIPREKLSELHGDSFMEMCPSCGAEYLRDFEVETIGLKETSRKCSVekCGAKLKDTVLDWEDALPPKEIDPAEKHCKKADLVLCLGT 210
*******************************************************8666*************************************** PP
SIR2.txt 196 Slkvepvaslvkkavkkkvpvllvnleevkadkladlkllgdcdevveellkllglee 253
Sl+++p+++l++k+ k + ++++vnl+++++dk+a+++++g +d+vv+ ++++l++++
AT5G55760.1 211 SLQITPACNLPLKCLKGGGKIVIVNLQKTPKDKKANVVIHGLVDKVVAGVMESLNMKI 268
*****************************************************99876 PP
|
Protein Sequence
(Fasta) | MSLGYAEKLS FIEDVGQVGM AEFFDPSHLL QCKIEELAKL IQKSKHLVVF TGAGISTSCG 60
IPDFRGPKGI WTLQREGKDL PKASLPFHRA MPSMTHMALV ELERAGILKF VISQNVDGLH 120
LRSGIPREKL SELHGDSFME MCPSCGAEYL RDFEVETIGL KETSRKCSVE KCGAKLKDTV 180
LDWEDALPPK EIDPAEKHCK KADLVLCLGT SLQITPACNL PLKCLKGGGK IVIVNLQKTP 240
KDKKANVVIH GLVDKVVAGV MESLNMKIPP YVRIDLFQII LTQSISGDQR FINWTLRVAS 300
VHGLTSQLPF IKSIEVSFSD NHNYKDAVLD KQPFLMKRRT ARNETFDIFF KVNYSDGCDC 360
VSTQLSLPFE FKISTEEHVE IIDKEAVLQS LREKAVEESS CGQSGVVERR VVSEPRSEAV 420
VYATVTSLRT YHSQQSLLAN GDLKWKLEGS GTSRKRSRTG KRKSKALAEE TKA 473Protein Fasta Sequence
>AT5G55760.1|SRT1;At5g55760;MDF20.20|Arabidopsis thaliana
MSLGYAEKLSFIEDVGQVGMAEFFDPSHLLQCKIEELAKLIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGKDLPKASLPFHRAMPSMTHMALVELERAGILKFVISQNVDGLHLRSGIPREKLSELHGDSFMEMCPSCGAEYLRDFEVETIGLKETSRKCSVEKCGAKLKDTVLDWEDALPPKEIDPAEKHCKKADLVLCLGTSLQITPACNLPLKCLKGGGKIVIVNLQKTPKDKKANVVIHGLVDKVVAGVMESLNMKIPPYVRIDLFQIILTQSISGDQRFINWTLRVASVHGLTSQLPFIKSIEVSFSDNHNYKDAVLDKQPFLMKRRTARNETFDIFFKVNYSDGCDCVSTQLSLPFEFKISTEEHVEIIDKEAVLQSLREKAVEESSCGQSGVVERRVVSEPRSEAVVYATVTSLRTYHSQQSLLANGDLKWKLEGSGTSRKRSRTGKRKSKALAEETKA |
Nucleotide Sequence
(Fasta) | ATACATCGAG AGGCAGAGAA GGTGTTCTTC TTCTTGTCCA AAAGAGAAGA CAAAACCTAA 60
ATGTCTTTAG GTTACGCAGA GAAATTATCC TTCATTGAAG ATGTTGGTCA AGTCGGCATG 120
GCTGAATTCT TCGACCCATC TCATCTTCTA CAATGCAAGA TTGAAGAACT TGCTAAGTTG 180
ATTCAAAAGA GTAAGCATCT AGTAGTCTTT ACTGGTGCAG GCATTTCAAC TTCTTGTGGT 240
ATTCCTGATT TCCGAGGCCC CAAAGGAATT TGGACGTTAC AGCGCGAGGG CAAAGATTTA 300
CCTAAAGCAT CTCTGCCATT TCACCGTGCA ATGCCGAGTA TGACCCATAT GGCTTTGGTT 360
GAATTAGAAA GAGCTGGCAT TTTAAAATTT GTTATCAGTC AGAATGTGGA TGGCTTACAT 420
CTTCGATCTG GAATACCAAG AGAGAAGCTT TCTGAACTGC ATGGAGACTC TTTTATGGAG 480
ATGTGCCCAT CATGTGGAGC AGAGTACCTG CGTGATTTCG AGGTGGAAAC TATTGGATTA 540
AAGGAGACAT CAAGAAAGTG TTCTGTTGAA AAGTGTGGAG CTAAACTTAA AGATACGGTC 600
TTGGATTGGG AGGATGCTTT GCCTCCAAAA GAAATTGATC CTGCGGAGAA GCACTGCAAA 660
AAGGCTGATC TTGTACTCTG TTTGGGTACC AGTTTGCAGA TAACCCCTGC TTGCAATTTG 720
CCTCTCAAGT GTCTCAAAGG TGGAGGCAAG ATCGTCATAG TTAATCTTCA GAAAACACCG 780
AAAGACAAGA AAGCAAATGT AGTGATTCAT GGTCTTGTTG ATAAGGTGGT TGCAGGGGTC 840
ATGGAATCGC TCAACATGAA GATTCCTCCA TATGTCAGAA TTGATCTTTT CCAGATAATC 900
CTAACTCAAT CTATAAGCGG AGATCAGAGG TTTATTAATT GGACCCTGCG TGTTGCGAGT 960
GTTCATGGAT TGACTTCTCA GTTACCATTC ATCAAGTCTA TTGAGGTTTC TTTCTCAGAT 1020
AACCATAATT ACAAAGACGC AGTTCTCGAT AAGCAGCCTT TTCTTATGAA AAGGAGAACA 1080
GCACGAAACG AAACTTTTGA TATATTCTTT AAAGTTAACT ACAGTGACGG TTGTGACTGT 1140
GTCTCCACTC AACTTAGCCT CCCATTTGAA TTCAAGATTT CAACAGAAGA GCATGTAGAG 1200
ATTATTGACA AGGAGGCTGT GCTACAAAGC CTGAGAGAGA AAGCGGTAGA AGAATCCAGT 1260
TGCGGGCAAA GCGGTGTGGT TGAGAGAAGA GTGGTTTCTG AACCGAGAAG TGAGGCTGTT 1320
GTGTATGCTA CGGTGACTAG TCTCAGGACT TACCATAGTC AACAATCTCT GCTTGCTAAT 1380
GGAGACCTGA AATGGAAGCT GGAAGGTTCT GGAACATCCC GTAAACGCTC TAGAACCGGG 1440
AAGCGAAAAT CGAAGGCTCT GGCAGAAGAA ACCAAGGCAT AGGAAGAAGA AAAGAAAGCT 1500
TTTGGTGTAT ATAAAGAAAC ACTAGTCTAA CCGGAATAGG TAATATGGAA GTTATTGGCG 1560
TTTTGAGAGC TGAGTGAATT TTGTTTTTGG TCCACATTCG GTTCTCTTGA AACAAAAGTT 1620
AACCAGGAAT TGAAAGAGAT AATCTTGGTT CGTTGTCGTT TAGTATCGGT TGATTTTTGT 1680
AGAAGCTAGT GCATTCGAAA TATTATTAAA AAAAATTTAC AAGATGATC
Nucleotide Fasta Sequence
>AT5G55760.1|SIR2|Arabidopsis thaliana
ATACATCGAGAGGCAGAGAAGGTGTTCTTCTTCTTGTCCAAAAGAGAAGACAAAACCTAAATGTCTTTAGGTTACGCAGAGAAATTATCCTTCATTGAAGATGTTGGTCAAGTCGGCATGGCTGAATTCTTCGACCCATCTCATCTTCTACAATGCAAGATTGAAGAACTTGCTAAGTTGATTCAAAAGAGTAAGCATCTAGTAGTCTTTACTGGTGCAGGCATTTCAACTTCTTGTGGTATTCCTGATTTCCGAGGCCCCAAAGGAATTTGGACGTTACAGCGCGAGGGCAAAGATTTACCTAAAGCATCTCTGCCATTTCACCGTGCAATGCCGAGTATGACCCATATGGCTTTGGTTGAATTAGAAAGAGCTGGCATTTTAAAATTTGTTATCAGTCAGAATGTGGATGGCTTACATCTTCGATCTGGAATACCAAGAGAGAAGCTTTCTGAACTGCATGGAGACTCTTTTATGGAGATGTGCCCATCATGTGGAGCAGAGTACCTGCGTGATTTCGAGGTGGAAACTATTGGATTAAAGGAGACATCAAGAAAGTGTTCTGTTGAAAAGTGTGGAGCTAAACTTAAAGATACGGTCTTGGATTGGGAGGATGCTTTGCCTCCAAAAGAAATTGATCCTGCGGAGAAGCACTGCAAAAAGGCTGATCTTGTACTCTGTTTGGGTACCAGTTTGCAGATAACCCCTGCTTGCAATTTGCCTCTCAAGTGTCTCAAAGGTGGAGGCAAGATCGTCATAGTTAATCTTCAGAAAACACCGAAAGACAAGAAAGCAAATGTAGTGATTCATGGTCTTGTTGATAAGGTGGTTGCAGGGGTCATGGAATCGCTCAACATGAAGATTCCTCCATATGTCAGAATTGATCTTTTCCAGATAATCCTAACTCAATCTATAAGCGGAGATCAGAGGTTTATTAATTGGACCCTGCGTGTTGCGAGTGTTCATGGATTGACTTCTCAGTTACCATTCATCAAGTCTATTGAGGTTTCTTTCTCAGATAACCATAATTACAAAGACGCAGTTCTCGATAAGCAGCCTTTTCTTATGAAAAGGAGAACAGCACGAAACGAAACTTTTGATATATTCTTTAAAGTTAACTACAGTGACGGTTGTGACTGTGTCTCCACTCAACTTAGCCTCCCATTTGAATTCAAGATTTCAACAGAAGAGCATGTAGAGATTATTGACAAGGAGGCTGTGCTACAAAGCCTGAGAGAGAAAGCGGTAGAAGAATCCAGTTGCGGGCAAAGCGGTGTGGTTGAGAGAAGAGTGGTTTCTGAACCGAGAAGTGAGGCTGTTGTGTATGCTACGGTGACTAGTCTCAGGACTTACCATAGTCAACAATCTCTGCTTGCTAATGGAGACCTGAAATGGAAGCTGGAAGGTTCTGGAACATCCCGTAAACGCTCTAGAACCGGGAAGCGAAAATCGAAGGCTCTGGCAGAAGAAACCAAGGCATAGGAAGAAGAAAAGAAAGCTTTTGGTGTATATAAAGAAACACTAGTCTAACCGGAATAGGTAATATGGAAGTTATTGGCGTTTTGAGAGCTGAGTGAATTTTGTTTTTGGTCCACATTCGGTTCTCTTGAAACAAAAGTTAACCAGGAATTGAAAGAGATAATCTTGGTTCGTTGTCGTTTAGTATCGGTTGATTTTTGTAGAAGCTAGTGCATTCGAAATATTATTAAAAAAAATTTACAAGATGATC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0016787--F:hydrolase activity
GO:0046872--F:metal ion binding
GO:0070403--F:NAD+ binding
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
