WERAM Information


Tag Content
WERAM ID WERAM-Ova-0117
Ensembl Protein ID ENSOARP00000011454.1
Gene Name PRDM2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOARG00000010675.1 ENSOART00000011614.1 ENSOARP00000011454.1
Status Unreviewed
Classification
Type Family E-value Score Start End
HMT RIZ 8.60e-38 129.2 28 176
Organism Ovis aries
Domain Profile
  HMT RIZ

               RIZ.txt   2 evelaessipkeglgvyakkkiekgekfGPfvGekkileeveenanekliweisedkgevkyivDasdeeksnWlryvnvArskeeqNL 90 
ev+l++s+++k+++gv+a+k i kg+kfGPfvG+kk++++v++n ++we++ + + ++++Da+d+ek+nWlryvn+A+s eeqNL
ENSOARP00000011454.1 28 EVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNV---YMWEVY-YPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNL 112
89*************************************999988...******.********************************** PP
RIZ.txt 91 aalqineqifYktikdIepd 110
++l+in++i+Ykt+k+ +d
ENSOARP00000011454.1 113 FPLEINRAIYYKTLKPDVED 132
**************975555 PP
RIZ.txt 54 isedkgevkyivDasdeeks 73
++++k+ ky+v ++++++
ENSOARP00000011454.1 157 KQTSKQINKYCVSGKKKSQE 176
45688999999999998876 PP

Protein Sequence
(Fasta)
LQNAAEPVAT TETLAEVPEH VLRGLPEEVR LFPSAVDKTR IGVWATKPIL KGKKFGPFVG 60
DKKKRSQVKN NVYMWEVYYP NLGWMCIDAT DPEKGNWLRY VNWACSGEEQ NLFPLEINRA 120
IYYKTLKPDV EDRQLTETLN SPRDPEIRII VSDQMNKQTS KQINKYCVSG KKKSQESKNK 180
ANKTEDVQLK TSEPDPSPAN MRDSAEGPKD EDEKPSASAT EQPAVPQEIV NQDVPPEFAL 240
PPPAHEPQTG PDAEQEAVLC EANEVVEEEE EEEEEELEED GDEAADVPNE SSLREPEIRC 300
DEKPEDLLEE PKTVSKETLE DSAEAAPVVK TPRAREEANG DVFETFLFPC QHCERKFTTK 360
QGLERHTHIH MSTASHAFKC KYCGPAGSKA PSDDAPPQDD TQPPGLGQDG LTLSSEKVSQ 420
DSVTPSVVEE NGEAKELHPC KYCKKVFGTH TNMRRHQRRV HERHLIPKGV RRKGGLLEEP 480
QPPAEQAPPA PSVYVPSTDP EEEGEADDVY IMDISSNISE NLNYYIDGKI QTSSSTSNCD 540
VIEMESNSAD LYGINCLLTP VTVEITQNIK TTQVPITDDL PKEPSSSTNS ESKKRRTASP 600
PVLPKIKAET ESDPATPSCS LSLPLSISTT EAVSFHKEKS VYLSSKLKQL LQTQDKLTPP 660
AGISATEIPK LGPVCVSAPA SMLPVTSSRF KRRTSSPPSS PQHSPALRDF GKPGDGKAVW 720
TEAVLSSKKP KLESHSNSPA WSLSGRDERE TGSPPGFDEY KVSNEWAASS AFSSVCNQQP 780
LDLSSGVKQK AEGPGRAPVQ WEAVLDLSVH KKPCGDSEGK EFKENHVLQP SCSAVKKRKP 840
TTCMLQKVLL NEYNGVDLPV ENAPEASGSA SPCKPLDPQP DPDLGLNSSS SAAVVESPPD 900
VSSSSPALQP PSLSCGPPLL TPTTPSSPPP CPPVLTVATP PPPLLPTVVL PAPSAGASPH 960
PCPSPLSNAT AQSPLPILSP TVSPSPSPIP SVEPVMSGAS PGPPTLSSSS SSSSSSSFSS 1020
SSSSSSPSPP PLSAVSSVVS SGDNLETSLP MISFKQEELE SEDLKAREEA PSAAEQEIVQ 1080
ETFNRNFVCN VCESPFLSIK DLTKHLSIHA EEWPFKCEFC VQLFKVKTDL SEHRFMLHGV 1140
GNIFVCSVCK KEFAFLCNLQ QHQRDLHPDK VCTHHEFESG TLRPQNFTDP SKAHVEHMQS 1200
LPEDPLEASK EEEELNDSSE ELYTTIKIMA SGMKTKDPDV RLGLNQHYPS FKPPPFQYHH 1260
RSPLGIGVTA TNFTTHNIPQ TFTTAIRCTK CGKGVDNMPE LHKHILACAS ASDKKRYTPK 1320
KNPVPLKQTV QPKNGVVVLD NSGKNAFRRM GQPKRLNFSV ELSKMSSNKL KLNALKKKNQ 1380
LVQKAILQKN KSAKQKADLK TTPESSSHVC PYCHREFTYI GSLNKHAAFS CPKKPLSPSK 1440
KKLSHSSKKG GHPSPAGSDR NNSSSHRRRT ADAEIKMQSM QAPLGKTRAR SSGPSQVPPP 1500
ASSFRSKQNV KFATSVKSKK PSSSLRNSSP IRMAKMTHSE SKKPKAAAKN HAAPLSGKTS 1560
RSLHVRAQKS RAVLQSKSAL AGKKRTDRFS VKSRERSGGP ITRSLQLAAS ADPSENRKED 1620
GSGKQELKDL RSKVISLFIL CSRAGASARI AVKC 1654
Nucleotide Sequence
(Fasta)
TTGCAGAACG CAGCTGAGCC TGTGGCAACC ACGGAGACCC TGGCCGAGGT ACCTGAACAT 60
GTGCTTCGAG GACTTCCGGA GGAAGTGAGG CTTTTCCCAT CTGCTGTTGA CAAAACTCGG 120
ATTGGTGTCT GGGCCACTAA ACCAATTTTA AAAGGCAAAA AGTTTGGGCC ATTTGTCGGT 180
GACAAGAAAA AAAGATCTCA GGTTAAGAAT AATGTATACA TGTGGGAGGT CTATTACCCA 240
AATTTGGGAT GGATGTGCAT TGATGCCACC GATCCAGAGA AGGGGAACTG GCTGCGCTAT 300
GTGAATTGGG CTTGCTCAGG AGAAGAGCAA AATTTATTTC CACTGGAAAT CAACAGGGCC 360
ATTTACTATA AAACTTTAAA GCCAGATGTT GAAGACAGGC AGCTGACAGA AACTTTAAAT 420
AGTCCCCGAG ATCCTGAGAT CAGGATAATA GTGAGTGACC AAATGAACAA ACAGACAAGC 480
AAACAAATAA ATAAATATTG TGTTTCAGGG AAGAAAAAAT CCCAAGAAAG TAAAAACAAA 540
GCAAACAAAA CCGAAGACGT ACAGCTGAAG ACAAGTGAGC CAGATCCCAG CCCTGCAAAT 600
ATGAGAGATT CTGCGGAAGG CCCCAAAGAC GAAGACGAGA AGCCTTCCGC TTCCGCCACC 660
GAGCAACCAG CCGTCCCTCA GGAGATCGTG AACCAGGATG TGCCTCCGGA GTTCGCCCTC 720
CCTCCCCCTG CCCACGAGCC CCAGACAGGA CCAGACGCAG AGCAGGAAGC AGTGCTCTGT 780
GAGGCGAATG AGGTGGTGGA GGAGGAGGAG GAGGAGGAAG AGGAGGAGCT GGAAGAAGAT 840
GGGGACGAAG CAGCTGATGT GCCAAATGAA AGTTCCCTGA GAGAGCCGGA GATCCGGTGT 900
GATGAGAAGC CCGAGGATTT GTTAGAAGAA CCAAAAACTG TTTCAAAGGA AACCCTTGAA 960
GACTCTGCGG AGGCAGCCCC TGTTGTGAAA ACTCCCAGAG CCAGGGAAGA GGCCAACGGG 1020
GACGTGTTTG AAACGTTTCT GTTCCCATGT CAGCACTGCG AGAGGAAGTT CACGACCAAG 1080
CAGGGGCTGG AGCGGCACAC GCACATCCAC ATGTCCACGG CCAGCCACGC CTTCAAGTGC 1140
AAGTACTGCG GGCCGGCCGG CAGCAAGGCA CCCAGCGACG ATGCTCCTCC CCAGGATGAC 1200
ACACAGCCCC CCGGTCTTGG GCAGGACGGC CTGACCTTGA GTTCAGAGAA GGTGTCCCAG 1260
GACTCAGTGA CTCCTTCCGT CGTAGAAGAG AATGGCGAAG CTAAAGAGCT TCACCCGTGC 1320
AAGTACTGTA AGAAGGTTTT CGGCACTCAC ACGAATATGA GACGGCATCA GCGTAGAGTT 1380
CACGAGCGGC ACCTGATTCC CAAGGGGGTG CGGCGGAAAG GGGGCCTCCT GGAAGAGCCA 1440
CAGCCCCCAG CAGAGCAGGC CCCTCCCGCC CCGAGTGTCT ATGTCCCCAG CACAGACCCA 1500
GAGGAGGAAG GGGAGGCGGA CGATGTGTAC ATCATGGATA TTTCCAGCAA TATCTCTGAG 1560
AACCTAAATT ACTACATTGA TGGTAAAATT CAGACCAGCA GCAGCACCAG TAACTGTGAC 1620
GTTATTGAGA TGGAATCCAA TTCGGCAGAC TTGTACGGAA TAAACTGTCT GCTCACTCCA 1680
GTCACAGTGG AAATAACTCA GAACATAAAG ACCACGCAGG TCCCTATAAC CGATGATCTC 1740
CCTAAAGAGC CTTCCAGCAG CACAAACAGC GAGTCCAAGA AACGGAGGAC TGCTAGTCCG 1800
CCTGTGTTAC CCAAAATTAA AGCCGAGACT GAGTCTGATC CTGCCACACC TTCGTGTTCC 1860
TTGAGTCTGC CTCTCAGCAT ATCAACCACA GAGGCGGTGT CTTTCCACAA AGAGAAAAGC 1920
GTGTATTTGT CATCAAAGCT CAAACAGCTT CTTCAGACCC AGGATAAATT AACTCCTCCT 1980
GCAGGGATTT CAGCCACTGA GATACCCAAA TTAGGCCCTG TCTGCGTGTC CGCTCCTGCG 2040
TCAATGCTAC CTGTGACTTC AAGCAGGTTT AAGAGGCGAA CCAGCTCTCC CCCCAGCTCT 2100
CCCCAGCACA GCCCTGCCCT GCGAGACTTT GGAAAACCAG GAGATGGGAA AGCCGTGTGG 2160
ACTGAGGCAG TTCTAAGCTC CAAAAAACCC AAATTAGAGA GTCACAGCAA CTCACCAGCA 2220
TGGAGTTTGT CTGGGAGAGA TGAGAGAGAA ACTGGGAGCC CGCCGGGCTT TGATGAATAT 2280
AAGGTGTCTA ACGAATGGGC AGCTAGCTCT GCTTTTAGCA GTGTGTGCAA CCAGCAGCCA 2340
CTGGATTTGT CCAGTGGTGT GAAACAGAAG GCTGAGGGGC CAGGCAGGGC TCCGGTCCAG 2400
TGGGAAGCTG TGTTAGATCT CAGTGTGCAT AAAAAGCCCT GTGGTGACTC TGAAGGCAAG 2460
GAATTCAAAG AAAACCATGT GCTGCAGCCA TCCTGCAGTG CTGTGAAGAA AAGGAAACCC 2520
ACCACCTGCA TGCTGCAGAA GGTCCTTCTC AACGAATACA ACGGTGTCGA CCTCCCTGTG 2580
GAAAACGCTC CAGAGGCATC CGGAAGCGCC AGTCCCTGTA AACCTCTAGA TCCTCAGCCA 2640
GACCCTGACC TTGGTCTCAA CTCCAGCTCG TCTGCCGCTG TTGTCGAGTC TCCTCCTGAC 2700
GTTTCCTCAT CGTCACCTGC CCTGCAACCA CCTTCCCTCT CTTGCGGGCC GCCTCTCTTG 2760
ACCCCCACCA CCCCCTCCTC TCCTCCGCCC TGCCCCCCCG TGTTAACGGT TGCCACTCCG 2820
CCCCCTCCGC TGCTTCCTAC TGTCGTTCTT CCAGCCCCCT CTGCTGGGGC ATCCCCCCAC 2880
CCGTGTCCCT CCCCACTCTC GAATGCCACC GCACAGTCCC CACTTCCAAT TCTCTCCCCG 2940
ACGGTGTCCC CCTCGCCGTC CCCCATTCCC TCCGTGGAGC CTGTTATGTC TGGTGCTTCA 3000
CCGGGGCCTC CAACACTCTC CTCATCTTCC TCCTCCTCTT CCTCCTCTTC CTTCTCATCT 3060
TCCTCCTCCT CCTCTTCCCC TTCACCACCT CCTCTCTCAG CAGTGTCATC CGTGGTTTCC 3120
TCTGGGGACA ATCTGGAAAC CTCTCTCCCC ATGATATCTT TTAAGCAGGA GGAACTAGAG 3180
AGTGAAGACC TGAAAGCCAG GGAGGAAGCC CCATCCGCCG CTGAGCAGGA GATCGTCCAG 3240
GAGACATTCA ACAGGAACTT TGTCTGCAAT GTCTGTGAAT CACCTTTTCT TTCCATTAAG 3300
GATCTAACCA AACATTTATC CATTCACGCT GAGGAATGGC CCTTCAAATG TGAATTTTGT 3360
GTGCAGCTCT TCAAGGTGAA AACTGATCTG TCAGAACATC GCTTTATGCT TCACGGCGTT 3420
GGGAACATCT TCGTGTGTTC AGTTTGTAAA AAGGAGTTTG CATTCTTGTG CAATCTGCAG 3480
CAGCACCAGC GAGATCTCCA CCCAGATAAG GTGTGCACGC ACCACGAGTT TGAAAGCGGC 3540
ACCCTGAGGC CCCAGAACTT CACGGATCCC AGCAAGGCCC ATGTTGAGCA CATGCAGAGT 3600
TTGCCAGAAG ACCCTCTAGA AGCGTCTAAA GAAGAGGAGG AGCTGAACGA TTCTTCCGAA 3660
GAGCTCTACA CGACCATCAA AATAATGGCT TCCGGAATGA AGACAAAGGA TCCAGATGTT 3720
CGATTGGGCC TCAACCAACA TTACCCAAGC TTTAAACCAC CCCCATTTCA GTACCATCAC 3780
CGCAGCCCCC TGGGCATTGG TGTGACGGCC ACAAACTTCA CTACGCACAA CATCCCACAG 3840
ACATTTACCA CCGCCATCCG CTGCACCAAG TGCGGGAAAG GCGTGGACAA CATGCCTGAA 3900
CTGCACAAAC ACATCCTGGC ATGTGCCTCT GCGAGTGACA AGAAGAGGTA TACCCCCAAG 3960
AAAAACCCGG TCCCACTGAA GCAGACTGTG CAACCCAAAA ATGGCGTGGT GGTTCTGGAC 4020
AACTCTGGGA AAAACGCCTT CAGACGAATG GGCCAGCCCA AAAGGCTGAA CTTTAGTGTG 4080
GAGCTCAGCA AAATGTCCTC GAATAAGCTC AAGTTAAACG CGTTGAAGAA AAAGAACCAG 4140
CTCGTCCAGA AAGCAATCCT ACAGAAAAAC AAGTCTGCAA AGCAAAAGGC TGACCTAAAA 4200
ACCACTCCCG AGTCGTCCTC GCACGTCTGC CCATACTGCC ACAGAGAGTT CACGTACATC 4260
GGGAGCCTGA ATAAGCATGC TGCTTTCAGC TGTCCCAAAA AACCTCTTTC TCCTTCCAAA 4320
AAAAAACTTT CCCACTCTTC CAAGAAAGGG GGGCACCCGT CACCTGCCGG GAGTGACAGA 4380
AACAACAGCA GCAGCCACCG CAGACGGACA GCAGACGCCG AGATCAAAAT GCAGAGCATG 4440
CAGGCACCTC TGGGCAAGAC CAGAGCTCGC AGCTCGGGCC CCTCACAGGT CCCACCACCC 4500
GCCTCGTCCT TCAGGTCCAA GCAGAACGTT AAATTCGCCA CTTCGGTCAA GTCCAAAAAA 4560
CCAAGCTCCT CTTTAAGGAA CTCGAGCCCC ATACGAATGG CCAAAATGAC TCACAGCGAG 4620
AGCAAGAAGC CCAAAGCTGC AGCCAAGAAC CATGCAGCTC CCCTCTCAGG CAAGACGTCG 4680
AGGAGCCTGC ACGTGCGGGC GCAGAAAAGC AGAGCCGTCT TACAGAGCAA GTCGGCCTTG 4740
GCCGGTAAGA AACGGACAGA CAGGTTCAGT GTAAAATCCA GAGAACGGAG TGGGGGGCCG 4800
ATCACCCGAA GCCTGCAGCT GGCGGCTTCT GCCGACCCCA GTGAGAACAG GAAGGAGGAC 4860
GGGAGTGGCA AGCAGGAGCT GAAGGACCTC AGATCTAAGG TGATTTCTCT GTTTATTCTG 4920
TGTTCTAGGG CAGGAGCATC AGCTAGAATT GCTGTGAAGT GTTGA 4966
Sequence Source Ensembl
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Bot-0175 ENSBTAP00000027387.5 Bos taurus 89 0.0 1363
WERAM-Tut-0059 ENSTTRP00000004738.1 Tursiops truncatus 79 0.0 1241
WERAM-Chs-0010 ENSCSAP00000017181.1 Chlorocebus sabaeus 76 0.0 1227
WERAM-Eqc-0052 ENSECAP00000006928.1 Equus caballus 77 0.0 1219
WERAM-Poa-0014 ENSPPYP00000002150.2 Pongo abelii 75 0.0 1216
WERAM-Hos-0094 ENSP00000312352.5 Homo sapiens 75 0.0 1211
WERAM-Myl-0079 ENSMLUP00000006376.2 Myotis lucifugus 77 0.0 1203
WERAM-Gog-0062 ENSGGOP00000005565.2 Gorilla gorilla 75 0.0 1194
WERAM-Ptv-0104 ENSPVAP00000009366.1 Pteropus vampyrus 76 0.0 1192
WERAM-Dan-0095 ENSDNOP00000010065.3 Dasypus novemcinctus 75 0.0 1191
WERAM-Loa-0113 ENSLAFP00000010222.3 Loxodonta africana 75 0.0 1188
WERAM-Cap-0158 ENSCPOP00000013075.2 Cavia porcellus 73 0.0 1186
WERAM-Dio-0121 ENSDORP00000011807.1 Dipodomys ordii 73 0.0 1156
WERAM-Prc-0128 ENSPCAP00000011552.1 Procavia capensis 73 0.0 1147
WERAM-Ran-0182 ENSRNOP00000046011.3 Rattus norvegicus 74 0.0 1145
WERAM-Mim-0159 ENSMICP00000016213.1 Microcebus murinus 74 0.0 1143
WERAM-Mum-0203 ENSMUSP00000101404.1 Mus musculus 73 0.0 1134
WERAM-Ocp-0072 ENSOPRP00000006314.1 Ochotona princeps 70 0.0 1066
WERAM-Sah-0163 ENSSHAP00000017120.1 Sarcophilus harrisii 65 0.0 927
WERAM-Soa-0065 ENSSARP00000006475.1 Sorex araneus 88 0.0 917
WERAM-Mod-0102 ENSMODP00000035055.3 Monodelphis domestica 65 0.0 905
WERAM-Gaga-0044 ENSGALP00000006497.4 Gallus gallus 61 0.0 887
WERAM-Anp-0137 ENSAPLP00000014610.1 Anas platyrhynchos 59 0.0 883
WERAM-Meg-0061 ENSMGAP00000005838.2 Meleagris gallopavo 59 0.0 874
WERAM-Fia-0122 ENSFALP00000010367.1 Ficedula albicollis 60 0.0 845
WERAM-Ect-0043 ENSETEP00000004327.1 Echinops telfairi 81 0.0 828
WERAM-Mae-0058 ENSMEUP00000005635.1 Macropus eugenii 78 0.0 787
WERAM-Lac-0030 ENSLACP00000005070.2 Latimeria chalumnae 51 0.0 725
WERAM-Xet-0166 ENSXETP00000029499.3 Xenopus tropicalis 64 6e-177 619
WERAM-Dar-0174 ENSDARP00000098393.2 Danio rerio 39 7e-133 473
WERAM-Orn-0043 ENSONIP00000004947.1 Oreochromis niloticus 50 9e-131 466
WERAM-Orla-0041 ENSORLP00000004978.1 Oryzias latipes 48 2e-125 448
WERAM-Tar-0175 ENSTRUP00000037071.1 Takifugu rubripes 49 2e-125 448
WERAM-Gaa-0013 ENSGACP00000001573.1 Gasterosteus aculeatus 49 2e-124 445
WERAM-Ten-0181 ENSTNIP00000017818.1 Tetraodon nigroviridis 47 1e-122 439
WERAM-Xim-0213 ENSXMAP00000017089.1 Xiphophorus maculatus 56 5e-118 424
WERAM-Pof-0174 ENSPFOP00000024474.1 Poecilia formosa 55 5e-117 420
WERAM-Fec-0210 ENSFCAP00000022446.1 Felis catus 81 2e-74 279
WERAM-Mam-0159 ENSMMUP00000025737.2 Macaca mulatta 80 3e-74 278
WERAM-Caj-0142 ENSCJAP00000025355.2 Callithrix jacchus 75 6e-65 247
WERAM-Mup-0197 ENSMPUP00000016975.1 Mustela putorius furo 36 7e-15 81.3
WERAM-Caf-0202 ENSCAFP00000028796.4 Canis familiaris 33 4e-13 75.5
WERAM-Tub-0028 ENSTBEP00000003557.1 Tupaia belangeri 28 1e-12 74.3
WERAM-Asm-0040 ENSAMXP00000005078.1 Astyanax mexicanus 34 1e-12 73.9
WERAM-Ict-0141 ENSSTOP00000014774.2 Ictidomys tridecemlineatus 31 1e-12 73.9
WERAM-Sus-0027 ENSSSCP00000004716.2 Sus scrofa 32 2e-12 73.2
WERAM-Paa-0092 ENSPANP00000006501.1 Papio anubis 35 3e-12 72.8
WERAM-Chh-0087 ENSCHOP00000009921.1 Choloepus hoffmanni 32 4e-12 72.4
WERAM-Leo-0172 ENSLOCP00000020417.1 Lepisosteus oculatus 27 5e-12 72.0
WERAM-Aim-0023 ENSAMEP00000001570.1 Ailuropoda melanoleuca 32 5e-12 72.0
WERAM-Pat-0154 ENSPTRP00000031523.3 Pan troglodytes 33 1e-11 70.9
WERAM-Anc-0054 ENSACAP00000005392.3 Anolis carolinensis 38 1e-11 70.9
WERAM-Otg-0147 ENSOGAP00000012568.2 Otolemur garnettii 28 1e-11 70.9
WERAM-Nol-0147 ENSNLEP00000016062.1 Nomascus leucogenys 33 1e-11 70.5
WERAM-Orc-0152 ENSOCUP00000013310.2 Oryctolagus cuniculus 35 2e-11 70.1
WERAM-Vip-0114 ENSVPAP00000010581.1 Vicugna pacos 31 2e-11 70.1
WERAM-Pes-0005 ENSPSIP00000002371.1 Pelodiscus sinensis 34 2e-11 70.1
WERAM-Ora-0042 ENSOANP00000006627.1 Ornithorhynchus anatinus 35 4e-11 68.9
WERAM-Ere-0093 ENSEEUP00000009413.1 Erinaceus europaeus 30 4e-11 68.9
WERAM-Tas-0102 ENSTSYP00000010720.1 Tarsius syrichta 37 1e-10 67.8
WERAM-Tag-0018 ENSTGUP00000001146.1 Taeniopygia guttata 30 6e-10 65.1
WERAM-Gam-0122 ENSGMOP00000012899.1 Gadus morhua 34 6e-10 65.1
WERAM-Pem-0083 ENSPMAP00000008984.1 Petromyzon marinus 31 1e-09 63.9
Created Date 25-Jun-2016