WERAM Information


Tag Content
WERAM ID WERAM-Fia-0122
Ensembl Protein ID ENSFALP00000010367.1
Gene Name PRDM2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSFALG00000009941.1 ENSFALT00000010408.1 ENSFALP00000010367.1
Status Unreviewed
Classification
Type Family E-value Score Start End
HMT RIZ 7.90e-39 132.1 29 141
Organism Ficedula albicollis
Domain Profile
  HMT RIZ

               RIZ.txt   2 evelaessipkeglgvyakkkiekgekfGPfvGekkileeveenanekliweisedkgevkyivDasdeeksnWlryvnvArskeeqNL 90 
+v+l++s+++k +lgv+a+k+i kg+kfGPfvG+kk++++v+ n ++we++ + + +++vDa+d+ek+nWlry+n+Ars +eqNL
ENSFALP00000010367.1 29 DVRLFPSAVDKSRLGVWATKSILKGKKFGPFVGDKKKRSQVKSNV---YMWEVY-YPNLGWMCVDATDPEKGNWLRYINWARSGKEQNL 113
79**************************************99998...******.********************************** PP
RIZ.txt 91 aalqineqifYktikdIepdeELLvwyk 118
++l+in+ i+Yk++k+I+ +LL+ yk
ENSFALP00000010367.1 114 FPLEINRTIYYKSLKPIQLTLDLLLNYK 141
************************9996 PP

Protein Sequence
(Fasta)
MNQNTSDSPV AVETLDDVPE HVLRGLPEDV RLFPSAVDKS RLGVWATKSI LKGKKFGPFV 60
GDKKKRSQVK SNVYMWEVYY PNLGWMCVDA TDPEKGNWLR YINWARSGKE QNLFPLEINR 120
TIYYKSLKPI QLTLDLLLNY KGVDRKAYTA AQESWRENTR SSINSPSKRK GKKKTQEGKN 180
KGKKAADTKQ KKTDSDSTSA DMRDSKEGHK EEDETPSVSA VLSLEQTAVI QEMVNQDVLP 240
KLMIPSPTNE PQVVTEDKEG EAINCASDDL DDDEEDDEEE EDEEEMEDAN MPKESAEMPL 300
MCEEKLDSLE EQKSTSEESP ESSPKKKLMV KIPKAQGESN GDVQEIFMFP CQHCERKFTT 360
KQGLERHMHI HISTLSHAFK CRYCGKAFGT QINRRRHERR HEAGPKRKPF LTLTSSQHLD 420
NVADNQVVVD DGLKDDLNVS SLVQDSVLES EKVSQEMSNS AFAEENKEPK ELHPCKYCKK 480
VFGTHTNMRR HQRRVHERHL IPKGVRRKGF FTEEPPLPTE PAPAVQSVYI ASTEIEEEGE 540
GDDVYLMDIS SNISENLNYY IDGKIQSNSN TSNCDVIQME SNSADLYGLN CIISPVTVEI 600
SSNLKVTQTH VNEAAKEPSS SGSSEPKKRR TASPPLVPKI KTEIDPEPIT PTSSLNLPLS 660
ISTESLPFHK EKGVYLSSKL KQLLQTQDNK KITPSSEIPK IGPSVTSSPI LPPVSSRFKR 720
RTSSPPSSPQ HSPVLRDFVK SGEGKTVWND NIRSSKMPKL ESHSNSPAWS LTGREDKETL 780
SPLCFEEYKI SKDWTAAPTF GNVCNQQPLD LSSGMKQRSD VKSKTQVPWE SVLDLSVHKK 840
PCSDAEIREY KENSTQPTCS GVKKKKPTTC MLQKVLLNEY NGTEAALESG LGTDSAASPG 900
RAPEPPAEPE AHPPVPAPSA TATQPLGSCA SPVPQAPAAP ACQLPPLLTP TNPPSPPPCP 960
PVLTVATSPP PLLPTVPLPV ADVSASATNT SSCPSPLSNT TTQSPLPVLS PTVSPSPSPV 1020
PSVEPLISAA SPGPPTLSSS SSSSSSSSFS SSSSSSSPSP PPLSVVSSVV SSADNLESSL 1080
PIIKQEEAES EQQKAREDPH TSSQLGVVQE TFNKSFVCNV CESPFLSIKD LTKHLSIHAE 1140
EWPFKCEFCV QLFRDKTDLS EHRFLLHGVG NIFVCSVCKK EFAFLCNLQQ HQRDLHPDKE 1200
CSHHEFESGT LRPQNFTDPS KANAEHMQSL PEDSLEPSKE EEDEDLNDSS EELYTTIKIM 1260
ASGVKSKDPD VRMGLNQHYP SFKPPPFQYH HRNPMGIGVT ATNFTTHNIP QTFTTAIRCT 1320
KCGKSVDNMP ELHKHILACA SASDKKRYTP KKNPVPLKQT VQPKNGMVVI AGPGKNAFRR 1380
MGQPKRLNFN VEISKMSSNK LKMSALKKKN QLVQKAILQK KKSAQQKAEL KNNSSETDSH 1440
ICPYCNREFT YIGSLNKHAS YSCPKKPISP SSKKNSSKKS AASSPANSDK GSNQRRRTAD 1500
AEIKMQSTQP HLGKTRARTS GPAQLQLPSA SFKSKQNVKF VPSIRSKKPN SSSSLRNSSP 1560
VRVSKMSHVD GKKTKVVSKN NSSGISSKAS RKLHIRIQRN NKAVLPSKSV ASKKKADRFS 1620
VKSRERIGGP ITRSLQQAAN AEAAENKRDE SSTKQELKDF SFANFL 1666
Nucleotide Sequence
(Fasta)
ATATTACAAT TGTCTGTTTT TCTTTTTAGG GTTCATGTAA TCAAAGGAGT TTCTTTGTTG 60
TATCTTTTCA GAACACAACA GGAATTCAAA ATGAATCAGA ACACAAGTGA CTCCCCTGTT 120
GCTGTGGAAA CCTTGGATGA TGTTCCTGAG CACGTGCTTA GGGGCCTTCC TGAGGATGTG 180
AGGCTCTTCC CATCTGCTGT TGACAAGAGT CGGCTTGGTG TCTGGGCAAC AAAGTCAATT 240
TTGAAAGGCA AGAAGTTTGG ACCATTTGTT GGTGACAAGA AAAAAAGATC TCAAGTTAAG 300
AGCAATGTGT ACATGTGGGA GGTGTATTAC CCCAACCTGG GCTGGATGTG TGTGGATGCC 360
ACTGACCCAG AGAAGGGCAA CTGGCTGCGC TACATCAACT GGGCCCGCTC AGGGAAGGAG 420
CAGAACCTCT TCCCTCTGGA GATCAACAGG ACCATTTACT ACAAGAGTTT GAAGCCAATA 480
CAATTGACAT TAGATTTACT GTTAAACTAC AAGGGAGTAG ATAGAAAAGC ATATACAGCA 540
GCTCAGGAGT CCTGGAGGGA AAACACGAGA TCTTCCATTA ATTCTCCTTC TAAGAGAAAG 600
GGAAAGAAGA AGACTCAGGA AGGTAAAAAC AAGGGAAAGA AGGCAGCAGA TACAAAACAG 660
AAAAAGACTG ATTCGGATTC TACTTCTGCA GATATGAGGG ATTCTAAAGA GGGTCATAAA 720
GAAGAAGATG AAACGCCTTC TGTTTCTGCT GTGCTGTCTC TGGAACAAAC AGCTGTGATT 780
CAGGAAATGG TAAATCAAGA TGTACTTCCA AAGCTGATGA TCCCCAGTCC GACGAATGAG 840
CCACAAGTGG TAACTGAAGA CAAAGAAGGA GAAGCAATAA ACTGTGCATC AGATGATTTA 900
GATGATGACG AAGAGGACGA TGAAGAAGAG GAAGATGAAG AGGAGATGGA AGATGCCAAT 960
ATGCCTAAAG AAAGCGCTGA AATGCCTTTG ATGTGTGAAG AAAAGTTGGA CTCCTTGGAA 1020
GAACAAAAGA GTACGTCAGA GGAATCTCCA GAAAGCTCTC CAAAGAAAAA ACTCATGGTG 1080
AAAATTCCAA AAGCGCAGGG GGAATCCAAC GGTGATGTTC AGGAAATATT CATGTTTCCC 1140
TGCCAGCATT GTGAGAGGAA GTTTACAACA AAGCAAGGCC TGGAGCGCCA CATGCACATC 1200
CACATATCCA CCCTGAGCCA CGCCTTCAAG TGCCGTTACT GCGGGAAAGC CTTTGGCACC 1260
CAAATCAACA GGCGGCGGCA CGAGCGGCGC CACGAGGCCG GGCCGAAAAG GAAACCATTC 1320
CTGACACTGA CCTCCTCACA GCACTTGGAT AACGTTGCTG ATAACCAGGT GGTTGTGGAT 1380
GATGGTCTTA AAGATGACCT GAATGTTTCC AGTCTTGTGC AAGACTCTGT TTTGGAGTCT 1440
GAGAAAGTTT CCCAGGAAAT GTCAAACTCT GCGTTTGCTG AGGAAAATAA GGAGCCCAAA 1500
GAATTGCATC CGTGCAAATA CTGCAAAAAG GTTTTTGGTA CTCACACCAA CATGAGGAGG 1560
CATCAGCGTA GGGTTCATGA ACGTCATCTT ATTCCCAAAG GTGTCAGAAG AAAAGGATTC 1620
TTCACTGAGG AGCCACCTCT CCCGACAGAG CCAGCCCCTG CAGTGCAGAG TGTGTACATA 1680
GCGAGCACAG AAATAGAGGA GGAAGGTGAA GGAGATGATG TCTATCTTAT GGATATATCC 1740
AGCAATATCT CTGAGAATTT AAATTACTAC ATTGATGGTA AAATTCAGTC CAATAGCAAC 1800
ACTAGCAATT GTGATGTGAT TCAGATGGAG TCCAACTCTG CAGACTTGTA TGGATTGAAC 1860
TGTATCATCA GTCCGGTGAC AGTGGAAATT TCCTCCAATT TAAAGGTTAC ACAAACACAT 1920
GTGAATGAAG CTGCTAAGGA ACCCTCTAGC AGTGGGAGCA GTGAACCCAA AAAGAGAAGA 1980
ACTGCTAGCC CTCCTCTTGT ACCAAAAATA AAAACTGAAA TAGACCCAGA ACCTATAACT 2040
CCTACTAGTT CTTTAAATCT TCCTCTTAGC ATTTCAACAG AAAGCTTACC TTTTCATAAA 2100
GAAAAAGGAG TTTATTTGTC ATCAAAATTA AAGCAGCTTC TTCAGACACA GGACAATAAG 2160
AAGATAACTC CATCAAGTGA AATCCCTAAA ATAGGACCTT CTGTTACATC ATCACCTATT 2220
TTGCCTCCAG TATCCAGCAG GTTTAAAAGA AGGACCAGCT CTCCTCCCAG TTCTCCACAG 2280
CACAGTCCAG TGCTTCGAGA CTTTGTCAAA TCAGGTGAGG GGAAAACTGT GTGGAATGAT 2340
AATATTCGGA GTTCAAAAAT GCCAAAGTTA GAAAGCCACA GCAACTCACC TGCTTGGAGC 2400
TTGACTGGAA GGGAGGACAA AGAGACTTTG AGCCCTCTTT GCTTTGAAGA ATATAAAATA 2460
TCTAAAGACT GGACAGCAGC TCCAACTTTT GGCAACGTGT GCAACCAGCA GCCACTGGAT 2520
TTATCCAGTG GTATGAAACA AAGGTCTGAT GTCAAAAGCA AGACTCAGGT TCCCTGGGAA 2580
TCCGTTCTAG ATCTAAGCGT GCATAAGAAG CCCTGCAGCG ATGCTGAAAT CAGGGAATAC 2640
AAAGAAAATT CCACACAACC AACGTGTAGT GGTGTTAAGA AGAAGAAACC CACCACTTGC 2700
ATGCTGCAGA AGGTTCTGCT GAATGAGTAC AACGGGACAG AGGCAGCCCT AGAGAGCGGG 2760
CTGGGCACGG ACAGCGCCGC CAGCCCCGGC AGGGCCCCGG AGCCTCCAGC AGAGCCCGAG 2820
GCCCATCCCC CTGTGCCGGC GCCGTCTGCC ACCGCCACTC AGCCCCTCGG CTCCTGCGCG 2880
TCCCCCGTGC CACAGGCGCC TGCTGCGCCT GCCTGCCAGC TGCCTCCATT GCTGACGCCC 2940
ACCAACCCCC CCTCCCCGCC GCCCTGCCCC CCTGTGTTAA CAGTGGCCAC CTCGCCTCCC 3000
CCCCTGCTCC CCACCGTGCC CTTACCCGTT GCAGATGTCT CTGCCAGTGC CACTAACACT 3060
TCCTCCTGTC CCTCGCCACT CTCCAACACT ACTACCCAAT CCCCGCTACC AGTTCTTTCA 3120
CCCACAGTTT CTCCTTCTCC ATCCCCTGTC CCTTCTGTTG AACCTCTTAT TTCTGCTGCT 3180
TCACCTGGCC CCCCTACACT GTCTTCATCT TCTTCCTCCT CCTCTTCCTC CTCTTTCTCA 3240
TCCTCTTCCT CCTCATCGTC TCCATCTCCA CCTCCTCTTT CTGTAGTTTC TTCTGTTGTT 3300
TCCTCTGCTG ATAACCTTGA AAGTTCTCTC CCAATAATAA AGCAGGAAGA AGCTGAAAGC 3360
GAGCAGCAGA AAGCAAGAGA AGATCCTCAT ACTTCCAGTC AATTAGGAGT AGTGCAGGAA 3420
ACCTTCAACA AGAGCTTTGT GTGCAATGTC TGCGAATCAC CTTTCCTTTC CATTAAAGAC 3480
CTAACGAAGC ATTTATCCAT TCATGCTGAG GAATGGCCCT TCAAATGTGA ATTCTGTGTA 3540
CAGCTTTTTA GGGATAAAAC AGACTTGTCA GAGCATCGCT TTCTGCTTCA TGGAGTAGGG 3600
AATATCTTTG TTTGTTCAGT GTGTAAAAAG GAATTTGCTT TTTTGTGCAA TTTGCAACAG 3660
CATCAACGGG ATCTCCATCC AGATAAAGAG TGCTCGCATC ATGAGTTTGA AAGTGGGACT 3720
TTGAGACCCC AGAATTTTAC TGACCCCAGT AAGGCGAATG CAGAGCACAT GCAGAGCCTG 3780
CCAGAAGATT CTTTGGAACC CTCAAAAGAG GAGGAAGATG AAGATCTAAA TGATTCTTCT 3840
GAAGAGCTTT ATACTACTAT AAAAATAATG GCTTCTGGAG TGAAATCTAA AGATCCAGAT 3900
GTTCGTATGG GCCTCAATCA ACACTACCCA AGCTTTAAAC CACCTCCGTT CCAGTATCAC 3960
CATCGTAATC CTATGGGTAT TGGAGTTACT GCAACAAACT TCACAACCCA CAATATCCCA 4020
CAGACTTTTA CTACTGCCAT TCGATGCACA AAATGTGGAA AAAGTGTTGA TAACATGCCT 4080
GAGTTACACA AACACATACT GGCCTGTGCA TCTGCTAGTG ATAAAAAGAG ATACACACCG 4140
AAAAAAAATC CAGTACCCCT CAAACAGACA GTGCAGCCTA AGAATGGCAT GGTGGTTATT 4200
GCTGGGCCTG GGAAGAACGC CTTCAGACGA ATGGGTCAGC CTAAAAGACT CAATTTCAAT 4260
GTTGAGATTA GCAAAATGTC CTCCAATAAA CTAAAAATGA GTGCATTGAA AAAGAAAAAC 4320
CAGCTTGTCC AGAAAGCTAT CCTGCAAAAA AAGAAATCTG CCCAGCAGAA GGCAGAACTG 4380
AAAAATAACT CATCTGAGAC GGACTCTCAC ATCTGCCCCT ACTGTAACAG AGAGTTCACA 4440
TACATTGGGA GTTTGAACAA ACACGCATCA TACAGCTGTC CCAAAAAACC CATCTCTCCC 4500
TCCTCCAAAA AGAATTCTTC CAAAAAAAGT GCAGCTTCTT CACCTGCAAA CAGTGACAAA 4560
GGCAGCAACC AGCGCAGGCG AACAGCAGAT GCAGAAATCA AAATGCAGAG CACTCAGCCT 4620
CACCTGGGCA AGACGAGAGC ACGAACCTCA GGACCTGCAC AGCTCCAGCT CCCCTCTGCC 4680
TCCTTCAAGT CCAAGCAAAA CGTTAAATTT GTACCTTCCA TACGATCTAA AAAGCCAAAT 4740
TCATCTTCAT CGTTGAGGAA CTCTAGTCCT GTAAGAGTGT CTAAAATGTC CCATGTTGAT 4800
GGGAAAAAAA CTAAGGTGGT TTCTAAGAAC AATTCCTCTG GAATCTCCAG CAAAGCGTCC 4860
CGGAAATTGC ACATCAGAAT ACAAAGGAAT AATAAAGCTG TTTTGCCAAG TAAATCTGTG 4920
GCGAGTAAGA AAAAGGCAGA CAGGTTCAGT GTAAAATCTA GAGAGAGGAT TGGAGGACCA 4980
ATCACTCGGA GCCTGCAGCA GGCAGCAAAT GCAGAGGCAG CAGAAAACAA AAGAGATGAA 5040
AGCAGTACAA AGCAAGAACT AAAAGATTTC AGTTTTGCCA ATTTTCTT 5089
Sequence Source Ensembl
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Anp-0137 ENSAPLP00000014610.1 Anas platyrhynchos 86 0.0 1299
WERAM-Gaga-0044 ENSGALP00000006497.4 Gallus gallus 87 0.0 1254
WERAM-Meg-0061 ENSMGAP00000005838.2 Meleagris gallopavo 83 0.0 1248
WERAM-Mod-0102 ENSMODP00000035055.3 Monodelphis domestica 69 0.0 988
WERAM-Dan-0095 ENSDNOP00000010065.3 Dasypus novemcinctus 66 0.0 957
WERAM-Chs-0010 ENSCSAP00000017181.1 Chlorocebus sabaeus 65 0.0 956
WERAM-Eqc-0052 ENSECAP00000006928.1 Equus caballus 65 0.0 952
WERAM-Sah-0163 ENSSHAP00000017120.1 Sarcophilus harrisii 66 0.0 951
WERAM-Loa-0113 ENSLAFP00000010222.3 Loxodonta africana 66 0.0 949
WERAM-Ptv-0104 ENSPVAP00000009366.1 Pteropus vampyrus 64 0.0 947
WERAM-Myl-0079 ENSMLUP00000006376.2 Myotis lucifugus 65 0.0 947
WERAM-Hos-0094 ENSP00000312352.5 Homo sapiens 64 0.0 937
WERAM-Poa-0014 ENSPPYP00000002150.2 Pongo abelii 64 0.0 936
WERAM-Cap-0158 ENSCPOP00000013075.2 Cavia porcellus 63 0.0 928
WERAM-Bot-0175 ENSBTAP00000027387.5 Bos taurus 64 0.0 925
WERAM-Prc-0128 ENSPCAP00000011552.1 Procavia capensis 63 0.0 921
WERAM-Tut-0059 ENSTTRP00000004738.1 Tursiops truncatus 64 0.0 919
WERAM-Ran-0182 ENSRNOP00000046011.3 Rattus norvegicus 64 0.0 914
WERAM-Dio-0121 ENSDORP00000011807.1 Dipodomys ordii 62 0.0 905
WERAM-Mum-0203 ENSMUSP00000101404.1 Mus musculus 63 0.0 901
WERAM-Mim-0159 ENSMICP00000016213.1 Microcebus murinus 63 0.0 897
WERAM-Gog-0062 ENSGGOP00000005565.2 Gorilla gorilla 60 0.0 879
WERAM-Lac-0030 ENSLACP00000005070.2 Latimeria chalumnae 57 0.0 840
WERAM-Ova-0117 ENSOARP00000011454.1 Ovis aries 58 0.0 811
WERAM-Xet-0166 ENSXETP00000029499.3 Xenopus tropicalis 56 0.0 785
WERAM-Soa-0065 ENSSARP00000006475.1 Sorex araneus 74 0.0 773
WERAM-Mae-0058 ENSMEUP00000005635.1 Macropus eugenii 79 0.0 769
WERAM-Ect-0043 ENSETEP00000004327.1 Echinops telfairi 75 0.0 753
WERAM-Ocp-0072 ENSOPRP00000006314.1 Ochotona princeps 69 0.0 736
WERAM-Orn-0043 ENSONIP00000004947.1 Oreochromis niloticus 51 4e-136 484
WERAM-Dar-0174 ENSDARP00000098393.2 Danio rerio 41 3e-132 471
WERAM-Gaa-0013 ENSGACP00000001573.1 Gasterosteus aculeatus 50 2e-130 465
WERAM-Orla-0041 ENSORLP00000004978.1 Oryzias latipes 49 3e-127 454
WERAM-Tar-0175 ENSTRUP00000037071.1 Takifugu rubripes 51 3e-126 451
WERAM-Pof-0174 ENSPFOP00000024474.1 Poecilia formosa 48 3e-124 444
WERAM-Xim-0213 ENSXMAP00000017089.1 Xiphophorus maculatus 57 7e-124 443
WERAM-Ten-0181 ENSTNIP00000017818.1 Tetraodon nigroviridis 50 1e-123 442
WERAM-Mam-0159 ENSMMUP00000025737.2 Macaca mulatta 75 2e-71 269
WERAM-Fec-0210 ENSFCAP00000022446.1 Felis catus 73 2e-67 255
WERAM-Caj-0142 ENSCJAP00000025355.2 Callithrix jacchus 71 1e-60 233
WERAM-Mup-0197 ENSMPUP00000016975.1 Mustela putorius furo 35 1e-16 87.4
WERAM-Paa-0092 ENSPANP00000006501.1 Papio anubis 34 6e-15 81.6
WERAM-Caf-0042 ENSCAFP00000005506.3 Canis familiaris 34 6e-14 78.2
WERAM-Pes-0005 ENSPSIP00000002371.1 Pelodiscus sinensis 33 7e-14 78.2
WERAM-Orc-0206 ENSOCUP00000023211.2 Oryctolagus cuniculus 32 9e-14 77.8
WERAM-Sus-0183 ENSSSCP00000023246.1 Sus scrofa 32 1e-13 77.8
WERAM-Chh-0087 ENSCHOP00000009921.1 Choloepus hoffmanni 35 4e-13 75.9
WERAM-Leo-0172 ENSLOCP00000020417.1 Lepisosteus oculatus 35 6e-13 75.1
WERAM-Otg-0147 ENSOGAP00000012568.2 Otolemur garnettii 33 6e-13 75.1
WERAM-Vip-0114 ENSVPAP00000010581.1 Vicugna pacos 34 6e-13 75.1
WERAM-Ora-0042 ENSOANP00000006627.1 Ornithorhynchus anatinus 35 7e-13 74.7
WERAM-Asm-0040 ENSAMXP00000005078.1 Astyanax mexicanus 35 8e-13 74.7
WERAM-Tas-0087 ENSTSYP00000008844.1 Tarsius syrichta 33 8e-13 74.7
WERAM-Ict-0141 ENSSTOP00000014774.2 Ictidomys tridecemlineatus 35 1e-12 74.3
WERAM-Aim-0023 ENSAMEP00000001570.1 Ailuropoda melanoleuca 33 1e-12 74.3
WERAM-Nol-0097 ENSNLEP00000011114.2 Nomascus leucogenys 30 1e-12 74.3
WERAM-Tub-0028 ENSTBEP00000003557.1 Tupaia belangeri 33 1e-12 73.9
WERAM-Ere-0093 ENSEEUP00000009413.1 Erinaceus europaeus 32 1e-12 73.9
WERAM-Anc-0054 ENSACAP00000005392.3 Anolis carolinensis 32 1e-12 73.9
WERAM-Pat-0132 ENSPTRP00000028170.4 Pan troglodytes 30 1e-12 73.9
WERAM-Pem-0083 ENSPMAP00000008984.1 Petromyzon marinus 34 5e-12 72.0
WERAM-Tag-0018 ENSTGUP00000001146.1 Taeniopygia guttata 32 4e-11 68.9
WERAM-Gam-0122 ENSGMOP00000012899.1 Gadus morhua 32 8e-11 68.2
Created Date 25-Jun-2016