WERAM Information

Tag Content
WERAM ID WERAM-Hos-0271
Ensembl Protein ID ENSP00000483819.1
Uniprot Accession Q16637; SMN_HUMAN; A8K0V4; Q13119; Q549U5; Q96J51
Genbank Protein ID NP_000335.1; NP_001284644.1; NP_059107.1; NP_075012.1; NP_075013.1; NP_075014.1; NP_075015.1
Protein Name Survival motor neuron protein
Genbank Nucleotide ID NM_000344.3; NM_001297715.1; NM_017411.3; NM_022874.2; NM_022875.2; NM_022876.2; NM_022877.2
Gene Name SMN;SMN1SMNT;SMN2;SMNC
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000277773.4 ENST00000618661.2 ENSP00000483819.1
ENSG00000277773.4 ENST00000612446.4 ENSP00000478274.1
ENSG00000277773.4 ENST00000618251.4 ENSP00000483515.1
ENSG00000277773.4 ENST00000611442.4 ENSP00000483768.1
ENSG00000277773.4 ENST00000624634.3 ENSP00000485595.1
ENSG00000277773.4 ENST00000629741.2 ENSP00000485830.1
Details
Type Family Domain Substrates AA References (PMIDs)
Me_Reader Tudor Tudor H3R17me2a; H3K79me1,2 R 21172665
Status Reviewed
Classification
Type Family E-value Score Start End
Me_Reader Tudor 2.80e-11 45.8 91 143
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Domain Profile
  Me_Reader Tudor
          Tudor.txt   1 nskvGlrVvakwssdGyfYsgkiVvkghrvesgeeyysikyedqrkwyilsLekgnr 57 
                        ++kvG+++ a ws+dG++Y+++i    ++++ ++e++++ y ++++ ++ +L +  +
  ENSP00000483819.1  91 QWKVGDKCSAIWSEDGCIYPATI----ASIDFKRETCVVVYTGYGNREEQNLSDLLS 143
                        59*********************....*********************999987655 PP
Protein Sequence
(Fasta)		MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF KHALKNGDIC 60
ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA IWSEDGCIYP ATIASIDFKR 120
ETCVVVYTGY GNREEQNLSD LLSPICEVAN NIEQNAQENE NESQVSTDES ENSRSPGNKS 180
DNIKPKSAPW NSFLPPPPPM PGPRLGPGKP GLKFNGPPPP PPPPPPHLLS CWLPPFPSGP 240
PIIPPPPPIC PDSLDDADAL GSMLISWYMS GYHTGYYMGF RQNQKEGRCS HSLN 294
Nucleotide Sequence
(Fasta)		ATGGCGATGA GCAGCGGCGG CAGTGGTGGC GGCGTCCCGG AGCAGGAGGA TTCCGTGCTG 60
TTCCGGCGCG GCACAGGCCA GAGCGATGAT TCTGACATTT GGGATGATAC AGCACTGATA 120
AAAGCATATG ATAAAGCTGT GGCTTCATTT AAGCATGCTC TAAAGAATGG TGACATTTGT 180
GAAACTTCGG GTAAACCAAA AACCACACCT AAAAGAAAAC CTGCTAAGAA GAATAAAAGC 240
CAAAAGAAGA ATACTGCAGC TTCCTTACAA CAGTGGAAAG TTGGGGACAA ATGTTCTGCC 300
ATTTGGTCAG AAGACGGTTG CATTTACCCA GCTACCATTG CTTCAATTGA TTTTAAGAGA 360
GAAACCTGTG TTGTGGTTTA CACTGGATAT GGAAATAGAG AGGAGCAAAA TCTGTCCGAT 420
CTACTTTCCC CAATCTGTGA AGTAGCTAAT AATATAGAAC AGAATGCTCA AGAGAATGAA 480
AATGAAAGCC AAGTTTCAAC AGATGAAAGT GAGAACTCCA GGTCTCCTGG AAATAAATCA 540
GATAACATCA AGCCCAAATC TGCTCCATGG AACTCTTTTC TCCCTCCACC ACCCCCCATG 600
CCAGGGCCAA GACTGGGACC AGGAAAGCCA GGTCTAAAAT TCAATGGCCC ACCACCGCCA 660
CCGCCACCAC CACCACCCCA CTTACTATCA TGCTGGCTGC CTCCATTTCC TTCTGGACCA 720
CCAATAATTC CCCCACCACC TCCCATATGT CCAGATTCTC TTGATGATGC TGATGCTTTG 780
GGAAGTATGT TAATTTCATG GTACATGAGT GGCTATCATA CTGGCTATTA TATGGGTTTC 840
AGACAAAATC AAAAAGAAGG AAGGTGCTCA CATTCCTTAA ATTAAGGAGT AAGTCTGCCA 900
901
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0523--Neurodegeneration
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0694--RNA-binding
--
Interpro

IPR010304--Survival_motor_neuron
IPR002999--Tudor
PROSITE

PS50304--TUDOR
Pfam

PF06003--SMN
Gene Ontology

GO:0015030--C:Cajal body
GO:0005737--C:cytoplasm
GO:0036464--C:cytoplasmic ribonucleoprotein granule
GO:0005829--C:cytosol
GO:0097504--C:Gemini of coiled bodies
GO:0043005--C:neuron projection
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043204--C:perikaryon
GO:0032797--C:SMN complex
GO:0034719--C:SMN-Sm protein complex
GO:0030018--C:Z disc
GO:0042802--F:identical protein binding
GO:0003723--F:RNA binding
GO:0006353--P:DNA-templated transcription, termination
GO:0007399--P:nervous system development
GO:0051170--P:nuclear import
GO:0000245--P:spliceosomal complex assembly
GO:0000387--P:spliceosomal snRNP assembly
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Nol-0044 ENSNLEP00000005396.1 Nomascus leucogenys 99 6e-95 344
WERAM-Mam-0188 ENSMMUP00000026612.2 Macaca mulatta 98 3e-93 338
WERAM-Chs-0190 ENSCSAP00000011744.1 Chlorocebus sabaeus 97 6e-92 334
WERAM-Paa-0002 ENSPANP00000011285.1 Papio anubis 92 2e-87 319
WERAM-Poa-0138 ENSPPYP00000017360.2 Pongo abelii 99 1e-85 313
WERAM-Eqc-0118 ENSECAP00000013134.1 Equus caballus 88 2e-80 296
WERAM-Gog-0039 ENSGGOP00000003799.2 Gorilla gorilla 100 2e-76 283
WERAM-Pat-0137 ENSPTRP00000029048.4 Pan troglodytes 100 4e-76 281
WERAM-Mum-0038 ENSMUSP00000022147.8 Mus musculus 80 1e-75 280
WERAM-Caj-0170 ENSCJAP00000015046.2 Callithrix jacchus 95 2e-70 262
WERAM-Mup-0166 ENSMPUP00000014360.1 Mustela putorius furo 89 4e-66 248
WERAM-Caf-0088 ENSCAFP00000011560.3 Canis familiaris 87 5e-66 248
WERAM-Ptv-0052 ENSPVAP00000005647.1 Pteropus vampyrus 87 1e-65 246
WERAM-Aim-0044 ENSAMEP00000003514.1 Ailuropoda melanoleuca 87 3e-65 246
WERAM-Fec-0184 ENSFCAP00000019138.1 Felis catus 88 6e-65 244
WERAM-Tub-0020 ENSTBEP00000002061.1 Tupaia belangeri 87 8e-65 244
WERAM-Ict-0106 ENSSTOP00000011013.2 Ictidomys tridecemlineatus 86 1e-64 243
WERAM-Sus-0126 ENSSSCP00000017979.2 Sus scrofa 87 3e-64 242
WERAM-Tut-0062 ENSTTRP00000004775.1 Tursiops truncatus 86 3e-63 239
WERAM-Loa-0042 ENSLAFP00000002850.3 Loxodonta africana 83 7e-63 238
WERAM-Orc-0164 ENSOCUP00000014693.2 Oryctolagus cuniculus 84 1e-62 236
WERAM-Myl-0120 ENSMLUP00000009660.2 Myotis lucifugus 87 1e-62 236
WERAM-Chh-0057 ENSCHOP00000006505.1 Choloepus hoffmanni 74 1e-60 230
WERAM-Bot-0062 ENSBTAP00000007547.5 Bos taurus 80 1e-58 223
WERAM-Otg-0211 ENSOGAP00000018509.1 Otolemur garnettii 77 3e-58 222
WERAM-Ran-0117 ENSRNOP00000024456.3 Rattus norvegicus 74 3e-56 216
WERAM-Cap-0137 ENSCPOP00000011091.2 Cavia porcellus 79 5e-56 215
WERAM-Tas-0107 ENSTSYP00000011045.1 Tarsius syrichta 76 1e-54 210
WERAM-Prc-0042 ENSPCAP00000003902.1 Procavia capensis 80 3e-53 205
WERAM-Vip-0097 ENSVPAP00000009201.1 Vicugna pacos 89 1e-52 203
WERAM-Ere-0139 ENSEEUP00000014406.1 Erinaceus europaeus 84 1e-52 203
WERAM-Ocp-0020 ENSOPRP00000001850.1 Ochotona princeps 83 2e-52 203
WERAM-Mod-0015 ENSMODP00000001738.1 Monodelphis domestica 66 6e-51 198
WERAM-Dan-0193 ENSDNOP00000024307.1 Dasypus novemcinctus 67 1e-50 197
WERAM-Ova-0048 ENSOARP00000005820.1 Ovis aries 76 2e-50 196
WERAM-Ect-0019 ENSETEP00000001131.1 Echinops telfairi 70 8e-46 181
WERAM-Ora-0018 ENSOANP00000002597.3 Ornithorhynchus anatinus 66 7e-45 178
WERAM-Sah-0016 ENSSHAP00000001682.1 Sarcophilus harrisii 63 1e-44 177
WERAM-Dio-0066 ENSDORP00000006637.1 Dipodomys ordii 68 1e-43 174
WERAM-Tag-0024 ENSTGUP00000001599.1 Taeniopygia guttata 60 6e-42 168
WERAM-Gaga-0023 ENSGALP00000003813.3 Gallus gallus 71 2e-41 166
WERAM-Anc-0104 ENSACAP00000009875.2 Anolis carolinensis 64 2e-39 159
WERAM-Xet-0114 ENSXETP00000039449.3 Xenopus tropicalis 56 3e-38 156
WERAM-Pes-0139 ENSPSIP00000016587.1 Pelodiscus sinensis 62 3e-38 156
WERAM-Orn-0141 ENSONIP00000014853.1 Oreochromis niloticus 70 8e-37 151
WERAM-Fia-0151 ENSFALP00000012869.1 Ficedula albicollis 61 9e-37 151
WERAM-Xim-0015 ENSXMAP00000001532.1 Xiphophorus maculatus 67 1e-35 147
WERAM-Tar-0006 ENSTRUP00000001767.1 Takifugu rubripes 65 2e-35 146
WERAM-Pof-0089 ENSPFOP00000007795.2 Poecilia formosa 68 4e-35 145
WERAM-Orla-0110 ENSORLP00000013230.1 Oryzias latipes 67 6e-35 145
WERAM-Ten-0115 ENSTNIP00000012783.1 Tetraodon nigroviridis 65 2e-34 143
WERAM-Gaa-0108 ENSGACP00000014003.1 Gasterosteus aculeatus 68 3e-34 142
WERAM-Leo-0107 ENSLOCP00000013933.1 Lepisosteus oculatus 65 6e-32 135
WERAM-Dar-0043 ENSDARP00000017636.5 Danio rerio 65 2e-31 133
WERAM-Asm-0149 ENSAMXP00000014288.1 Astyanax mexicanus 63 2e-30 130
WERAM-Mae-0108 ENSMEUP00000010395.1 Macropus eugenii 58 3e-28 122
WERAM-Gam-0194 ENSGMOP00000018574.1 Gadus morhua 55 7e-28 121
WERAM-Pem-0048 ENSPMAP00000005497.1 Petromyzon marinus 50 6e-22 102
WERAM-Meg-0095 ENSMGAP00000009132.2 Meleagris gallopavo 75 6e-21 98.6
WERAM-Lac-0090 ENSLACP00000011146.1 Latimeria chalumnae 43 2e-20 96.7
WERAM-Anp-0092 ENSAPLP00000010654.1 Anas platyrhynchos 57 5e-20 95.5
WERAM-Cii-0058 ENSCINP00000026142.2 Ciona intestinalis 27 1e-06 50.8
WERAM-Soa-0056 ENSSARP00000005482.1 Sorex araneus 54 6e-06 48.9
Created Date 25-Jun-2016