WERAM Information

Tag Content
WERAM ID WERAM-Hos-0095
Ensembl Protein ID ENSP00000356234.3
Uniprot Accession Q9UGL1; KDM5B_HUMAN; O95811; Q15752; Q9Y3Q5
Genbank Protein ID NP_001300971.1; NP_006609.3; XP_011507389.1
Protein Name Lysine-specific demethylase 5B
Genbank Nucleotide ID NM_001314042.1; NM_006618.4; XM_011509087.1
Gene Name KDM5B;PLU-1;JARID1B;PLU1;RBBP2H1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000117139.16 ENST00000367265.7 ENSP00000356234.3
ENSG00000117139.16 ENST00000235790.8 ENSP00000235790.4
ENSG00000117139.16 ENST00000367264.6 ENSP00000356233.2
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JARID Jmjc H3K4 K 20951770; 20951770; 24172249; 20889125
Me_Reader PHD PHD1 H3K4me0 K 24952722
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JARID 4.20e-103 344.7 453 619
Me_Reader PHD 3.20e-29 103.1 311 1536
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
Domain Profile
  HDM JARID
          JARID.txt   1 eyaesgwnlnnlpvleesvlahinadisgvkvpwlyvgmcfsafcwhvedhwsysinylhfgepkvwygvpgsaaekleevlkklapelfes 92 
                        ey +sgwnlnn+pv+e+svlahi+adi+g+k+pwlyvgmcfs+fcwh+edhwsysinylh+gepk+wygvpg+aae+le+v+kklapelf s
  ENSP00000356234.3 453 EYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVS 544
                        799***************************************************************************************** PP
          JARID.txt  93 qpdllhqlvtllnpnilkeegvpvyrtnqkagefvitfprayhsgfnqgfnfaeavnfatvdwlaagreavesys 167
                        qpdllhqlvt++npn+l++++vpvyrtnq+agefvitfprayhsgfnqgfnfaeavnf+tvdwl+ gr++ve+y+
  ENSP00000356234.3 545 QPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYR 619
                        **************************************************************************7 PP
  Me_Reader PHD
            PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
                        +Cl+Cg  +++++ ++ Cd+Cdd +H+ C+ +pl+ +p+g +w+Cp+C 
  ENSP00000356234.3 311 VCLLCGSGNDEDR-LLLCDGCDDSYHTFCLIPPLHDVPKG-DWRCPKCL 357
                        7****87777776.**************************.*******6 PP
            PHD.txt    2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg.kswyCpsCke 52  
                         +iCl C ++   ++ m+qC+ C+d+fH++Cv +p  s+++g + w+Cp+C++
  ENSP00000356234.3 1177 KICL-C-QKAPAAP-MIQCELCRDAFHTSCVAVP--SISQGlRIWLCPHCRR 1223
                         79*9.*.6666667.*******************..99999455******97 PP
            PHD.txt    3 iClv..CgkddegekemvqCde.CddwfHlkCvklplsslpegkswyCpsCk 51  
                         iC++  C +++ +e  +vqCd+ C++wfH+ Cv+++ + ++++ +++C +C+
  ENSP00000356234.3 1486 ICPAvsCLQPEGDEVDWVQCDGsCNQWFHQVCVGVSPEMAEKE-DYICVRCT 1536
                         7877679999999889********************5555565.9******8 PP
Protein Sequence
(Fasta)		MEAATTLHPG PRPALPLGGP GPLGEFLPPP ECPVFEPSWE EFADPFAFIH KIRPIAEQTG 60
ICKVRPPPDW QPPFACDVDK LHFTPRIQRL NELEAQTRVK LNFLDQIAKY WELQGSTLKI 120
PHVERKILDL FQLNKLVAEE GGFAVVCKDR KWTKIATKMG FAPGKAVGSH IRGHYERILN 180
PYNLFLSGDS LRCLQKPNLT TDTKDKEYKP HDIPQRQSVQ PSETCPPARR AKRMRAEAMN 240
IKIEPEETTE ARTHNLRRRM GCPTPKCENE KEMKSSIKQE PIERKDYIVE NEKEKPKSRS 300
KKATNAVDLY VCLLCGSGND EDRLLLCDGC DDSYHTFCLI PPLHDVPKGD WRCPKCLAQE 360
CSKPQEAFGF EQAARDYTLR TFGEMADAFK SDYFNMPVHM VPTELVEKEF WRLVSTIEED 420
VTVEYGADIA SKEFGSGFPV RDGKIKLSPE EEEYLDSGWN LNNMPVMEQS VLAHITADIC 480
GMKLPWLYVG MCFSSFCWHI EDHWSYSINY LHWGEPKTWY GVPGYAAEQL ENVMKKLAPE 540
LFVSQPDLLH QLVTIMNPNT LMTHEVPVYR TNQCAGEFVI TFPRAYHSGF NQGFNFAEAV 600
NFCTVDWLPL GRQCVEHYRL LHRYCVFSHD EMICKMASKA DVLDVVVAST VQKDMAIMIE 660
DEKALRETVR KLGVIDSERM DFELLPDDER QCVKCKTTCF MSAISCSCKP GLLVCLHHVK 720
ELCSCPPYKY KLRYRYTLDD LYPMMNALKL RAESYNEWAL NVNEALEAKI NKKKSLVSFK 780
ALIEESEMKK FPDNDLLRHL RLVTQDAEKC ASVAQQLLNG KRQTRYRSGG GKSQNQLTVN 840
ELRQFVTQLY ALPCVLSQTP LLKDLLNRVE DFQQHSQKLL SEETPSAAEL QDLLDVSFEF 900
DVELPQLAEM RIRLEQARWL EEVQQACLDP SSLTLDDMRR LIDLGVGLAP YSAVEKAMAR 960
LQELLTVSEH WDDKAKSLLK ARPRHSLNSL ATAVKEIEEI PAYLPNGAAL KDSVQRARDW 1020
LQDVEGLQAG GRVPVLDTLI ELVTRGRSIP VHLNSLPRLE TLVAEVQAWK ECAVNTFLTE 1080
NSPYSLLEVL CPRCDIGLLG LKRKQRKLKE PLPNGKKKST KLESLSDLER ALTESKETAS 1140
AMATLGEARL REMEALQSLR LANEGKLLSP LQDVDIKICL CQKAPAAPMI QCELCRDAFH 1200
TSCVAVPSIS QGLRIWLCPH CRRSEKPPLE KILPLLASLQ RIRVRLPEGD ALRYMIERTV 1260
NWQHRAQQLL SSGNLKFVQD RVGSGLLYSR WQASAGQVSD TNKVSQPPGT TSFSLPDDWD 1320
NRTSYLHSPF STGRSCIPLH GVSPEVNELL MEAQLLQVSL PEIQELYQTL LAKPSPAQQT 1380
DRSSPVRPSS EKNDCCRGKR DGINSLERKL KRRLEREGLS SERWERVKKM RTPKKKKIKL 1440
SHPKDMNNFK LERERSYELV RSAETHSLPS DTSYSEQEDS EDEDAICPAV SCLQPEGDEV 1500
DWVQCDGSCN QWFHQVCVGV SPEMAEKEDY ICVRCTVKDA PSRK 1544
Nucleotide Sequence
(Fasta)		TTCAGTCTGT TGAAGGATAC CCCGTTGTGT ATTTCTACCT GTATGTACCA GAGACACCTC 60
AAATTCAAAA TGTCCAGAAA TGAACACAGT ATCTTCTTCC CTTGAGTAAC TCGCCTTCTG 120
TATATAATTG GGGTGAATGT TCCAGCAATG CCAACGGGCT AGCATCTACT CAGGCAGGTA 180
CGCCAGACAT CTGAATCTTA ATACCTCGTC GTCCCCCCTC AATCTGTCAC TATGTCCTAA 240
TTTTATTTCC TACCTTTGCA TCCCTTCCTC ATAATTATCA GCACCACTGC CTTAATTTAG 300
ATCCTATCAT TCCTTGTCTG GATTATTTCA AGTCTTTCGC CCCTCTCAAG TCTGACCTCG 360
TCATAGACTG TTTGTGGATG ATTATTTTCC CTGCAACATC TCCACCTCCC AATAGTCTCC 420
ATCACTTATT AGCCATGTGA ATTATGGCAA ATTGCTTAAC CTACCTATGC CTCACTTTCC 480
TTATTGTAAA GTGGAAATAA GAGTACCTAT CTCATAGGGT TGTGTGATTA ATCATGCGAT 540
GCAATTAGAA CAGTGCCTAG GATATGAAAG TGCCCCAAAA TGTTACGTTA TTATTATTAT 600
TACTACTATT GCCTTCTCAT GAACATGCTA TGTGTATGTT CAAGCTGTTA TCTCTACTGG 660
AAAATCCTTC TCCGTTTCCA ATACTCTTTC CAAAACCCCC TCCTGGGTTT TACTGCACCT 720
ACCATTGTGT ACTGACGTGA TTGAATGATT GGCTTATGGG ACTGATCCTT TCTACCAGAC 780
TTAACTTCTT CAGGGCAGGA ACTCTGATAC ATAGTAAATG GTCAATAAAA GTTGGCTCAA 840
CTGAAACCCT AAGGATAAAC TCCATCCACA GCGGAAGGCG CGGCCCCGCC CGATTCGGGG 900
GCGGGGCGGG GAGCCGCGCG CGGAGGGTGG GTCGATGGGG GTGGGGTGGG ACTCTTTTTC 960
CTCGCCGTGG CGGCGGAGGC GCACGGCGTG GGCTTGCGGC GAGACGTCGT CGTCGGAGGC 1020
TGAAAAAGCC CAAGGTGCTG CCGTTGCCCG TACAACTCGG ACTTGCTGTT GCTCGAGCCG 1080
CGTCTGCACG GGTCTCGGAC CGAGCGGAGC TCGCAGCCTC GGTCCCGGAG CCCACCTTCG 1140
CCTCGCCCTT GCCCAGCCTG CGGTGATGGA GGCGGCCACC ACACTGCACC CAGGCCCGCG 1200
CCCGGCGCTG CCCCTCGGGG GCCCGGGCCC GCTGGGCGAG TTCCTGCCTC CACCCGAGTG 1260
CCCGGTCTTC GAACCCAGCT GGGAAGAGTT CGCGGACCCC TTCGCTTTCA TCCACAAGAT 1320
CCGGCCCATA GCCGAGCAGA CTGGCATCTG TAAGGTGCGG CCGCCGCCGG ATTGGCAGCC 1380
ACCATTTGCA TGTGATGTTG ATAAACTTCA TTTTACGCCA CGTATCCAGA GACTGAATGA 1440
ATTGGAGGCC CAAACTCGTG TAAAATTGAA TTTCTTGGAC CAGATTGCAA AGTACTGGGA 1500
GTTACAGGGA AGTACTCTGA AAATTCCACA TGTGGAGAGG AAGATCTTGG ACTTATTTCA 1560
GCTTAATAAG TTAGTTGCAG AAGAAGGTGG ATTTGCAGTT GTTTGCAAGG ATAGAAAATG 1620
GACCAAAATT GCTACCAAGA TGGGGTTTGC TCCTGGCAAA GCAGTGGGCT CACATATCAG 1680
AGGGCATTAT GAACGAATTC TCAACCCCTA CAACTTATTC CTGTCCGGAG ACAGCCTAAG 1740
GTGTTTGCAG AAGCCAAACC TGACCACAGA CACTAAGGAC AAGGAGTACA AACCCCATGA 1800
TATTCCCCAG AGGCAGTCTG TGCAGCCTTC GGAAACGTGC CCCCCAGCCC GACGAGCAAA 1860
ACGCATGAGA GCAGAGGCCA TGAATATTAA AATAGAACCC GAGGAGACAA CGGAAGCCAG 1920
AACTCATAAT CTGAGACGTC GAATGGGTTG TCCAACTCCA AAATGTGAAA ATGAGAAAGA 1980
AATGAAGAGT AGCATCAAGC AAGAACCTAT TGAGAGGAAA GATTATATTG TAGAAAATGA 2040
GAAGGAAAAG CCCAAGAGTC GATCTAAAAA AGCCACCAAT GCTGTGGACC TGTATGTCTG 2100
TCTTTTATGT GGCAGTGGCA ATGATGAAGA CCGGCTACTG TTGTGTGATG GCTGTGATGA 2160
CAGTTACCAT ACCTTTTGCT TGATCCCACC TCTCCATGAT GTTCCCAAGG GAGACTGGAG 2220
GTGTCCTAAG TGTTTGGCTC AGGAATGTAG TAAGCCACAA GAAGCATTTG GCTTTGAACA 2280
AGCAGCCAGG GACTATACCC TCCGTACTTT TGGGGAAATG GCAGATGCGT TCAAATCTGA 2340
TTACTTCAAC ATGCCAGTCC ATATGGTCCC CACAGAGCTT GTTGAGAAAG AATTTTGGAG 2400
ACTAGTAAGC ACTATTGAGG AGGATGTCAC AGTGGAATAT GGAGCTGACA TTGCCTCAAA 2460
GGAATTTGGC AGTGGCTTTC CTGTCCGAGA TGGGAAAATC AAACTCTCAC CTGAGGAAGA 2520
GGAGTATCTT GATAGTGGCT GGAATTTGAA CAACATGCCA GTGATGGAGC AGTCTGTCCT 2580
TGCACATATT ACTGCTGATA TATGTGGCAT GAAACTTCCT TGGTTGTATG TGGGAATGTG 2640
CTTTTCTTCA TTCTGTTGGC ACATTGAAGA CCACTGGAGC TATTCAATTA ACTACTTGCA 2700
CTGGGGTGAG CCAAAAACCT GGTATGGAGT CCCAGGGTAT GCTGCTGAGC AGCTAGAAAA 2760
TGTAATGAAG AAACTAGCTC CAGAACTCTT TGTGTCCCAG CCGGATCTCC TCCATCAGCT 2820
TGTGACCATC ATGAACCCCA ATACCCTGAT GACTCATGAA GTGCCTGTTT ACCGAACTAA 2880
TCAGTGTGCT GGGGAGTTTG TGATTACATT TCCAAGAGCC TACCACAGTG GTTTTAACCA 2940
GGGTTTTAAT TTTGCTGAGG CTGTTAACTT CTGCACTGTT GATTGGCTGC CATTAGGCCG 3000
ACAGTGTGTG GAGCATTATC GCTTGCTTCA TCGATATTGT GTGTTTTCCC ACGATGAGAT 3060
GATCTGCAAG ATGGCTTCCA AGGCTGATGT ATTAGATGTT GTAGTGGCTT CAACTGTTCA 3120
GAAAGACATG GCCATTATGA TTGAGGATGA GAAAGCTTTA AGAGAAACTG TCCGTAAATT 3180
GGGAGTGATT GATTCGGAAA GAATGGATTT TGAGCTGTTG CCAGATGATG AACGTCAGTG 3240
TGTAAAATGC AAAACTACAT GCTTCATGTC TGCCATCTCC TGTTCTTGTA AACCTGGCCT 3300
TCTTGTTTGC CTGCATCATG TAAAAGAATT GTGTTCCTGT CCTCCTTACA AATATAAATT 3360
GCGGTATAGG TACACGCTGG ATGATCTCTA CCCTATGATG AATGCATTGA AGCTTCGAGC 3420
AGAATCTTAC AACGAATGGG CCTTGAATGT GAATGAAGCT TTGGAGGCAA AGATCAACAA 3480
GAAGAAAAGC CTTGTCAGCT TCAAGGCTTT AATTGAAGAA TCTGAAATGA AGAAATTCCC 3540
AGACAATGAT CTTTTGCGAC ACCTTCGCCT AGTCACACAG GATGCAGAGA AGTGTGCCTC 3600
TGTTGCGCAG CAGTTGCTTA ATGGCAAAAG GCAAACTAGA TATCGATCTG GTGGAGGGAA 3660
ATCCCAAAAT CAGTTGACAG TGAATGAGCT CCGGCAGTTT GTAACACAGC TGTATGCTCT 3720
TCCATGTGTC CTCAGTCAGA CACCATTACT AAAGGATCTC TTGAATCGTG TAGAAGATTT 3780
TCAACAGCAT AGTCAGAAAC TACTCTCTGA GGAAACGCCT AGTGCTGCGG AGCTGCAGGA 3840
CTTGCTAGAT GTCAGCTTTG AATTTGATGT TGAACTTCCA CAGCTTGCTG AGATGCGTAT 3900
CCGTTTGGAA CAAGCCCGTT GGCTAGAAGA GGTGCAGCAA GCTTGCCTAG ACCCCAGCTC 3960
CCTTACTTTA GATGATATGA GACGTCTCAT AGACCTAGGG GTAGGGCTGG CCCCGTATTC 4020
AGCAGTGGAG AAAGCTATGG CCCGGCTGCA GGAACTGCTC ACAGTGTCAG AGCACTGGGA 4080
CGACAAAGCC AAGAGTCTCC TCAAGGCCAG GCCACGACAT TCATTGAATA GCCTTGCTAC 4140
GGCAGTAAAG GAAATCGAAG AGATCCCTGC ATATCTGCCC AATGGTGCGG CTCTGAAAGA 4200
CTCAGTGCAG AGAGCCAGAG ACTGGCTTCA GGATGTAGAG GGCCTGCAGG CTGGAGGACG 4260
TGTGCCAGTG TTAGACACAC TCATAGAACT TGTTACACGA GGCCGATCTA TCCCCGTACA 4320
TCTGAATTCT TTGCCAAGAC TGGAAACCCT AGTAGCTGAG GTTCAGGCTT GGAAAGAATG 4380
TGCTGTTAAT ACATTCTTGA CTGAGAATTC TCCATATTCT CTCTTAGAGG TGCTGTGTCC 4440
TCGATGTGAT ATTGGCCTTT TGGGATTGAA AAGGAAGCAG AGAAAGTTAA AGGAGCCCTT 4500
GCCAAATGGA AAGAAAAAAA GCACCAAATT AGAGAGTCTG AGTGACCTGG AGAGAGCTTT 4560
AACTGAAAGC AAGGAGACTG CTTCAGCTAT GGCAACTCTT GGGGAAGCTC GCCTAAGGGA 4620
AATGGAAGCC TTGCAGTCTC TCAGACTCGC CAATGAAGGG AAATTGCTGT CGCCTCTCCA 4680
AGATGTGGAT ATAAAAATCT GCCTATGTCA GAAGGCCCCA GCTGCCCCTA TGATTCAATG 4740
TGAACTCTGC AGGGATGCTT TCCACACCAG TTGTGTGGCG GTACCCAGTA TTTCACAGGG 4800
CCTGCGAATC TGGCTTTGTC CCCATTGTCG GAGGTCAGAG AAACCTCCAT TAGAGAAAAT 4860
TCTGCCCCTG CTCGCCTCCC TTCAGCGTAT CCGAGTTCGC CTTCCTGAGG GAGATGCACT 4920
TCGATATATG ATTGAAAGAA CCGTGAACTG GCAGCACAGA GCCCAGCAAC TGCTTTCGTC 4980
AGGGAATCTT AAATTTGTGC AAGATCGAGT GGGCTCAGGA CTGTTATATA GCAGATGGCA 5040
AGCCTCAGCA GGACAGGTGT CAGACACAAA CAAGGTATCT CAACCTCCTG GCACAACATC 5100
ATTTTCTTTG CCTGATGACT GGGACAACAG AACCTCATAT TTGCACTCCC CCTTCTCAAC 5160
TGGACGAAGT TGTATCCCCC TCCATGGTGT TAGTCCAGAA GTGAATGAAC TATTGATGGA 5220
AGCCCAGCTG CTCCAGGTAT CCCTTCCTGA AATTCAGGAA CTTTACCAGA CTTTACTTGC 5280
AAAGCCAAGC CCTGCTCAGC AGACTGACCG AAGCTCACCA GTGAGACCCA GCAGTGAGAA 5340
GAATGACTGT TGCCGAGGGA AGCGAGATGG AATTAACAGT CTTGAGAGAA AACTGAAGAG 5400
ACGCCTGGAA AGAGAGGGCC TCTCCAGTGA GCGGTGGGAA CGAGTTAAGA AAATGCGGAC 5460
CCCCAAAAAG AAGAAAATCA AACTGAGCCA CCCCAAGGAC ATGAACAATT TCAAGTTAGA 5520
GAGAGAGCGT AGCTATGAAT TAGTTCGTTC TGCTGAAACT CATTCCCTGC CCTCAGACAC 5580
ATCCTATTCC GAACAGGAAG ACTCTGAGGA TGAAGATGCC ATCTGCCCAG CTGTGAGCTG 5640
CCTGCAGCCA GAAGGAGATG AGGTGGACTG GGTCCAGTGT GATGGCAGCT GCAATCAGTG 5700
GTTTCATCAG GTCTGTGTTG GTGTCTCCCC AGAGATGGCA GAGAAAGAAG ACTACATCTG 5760
TGTGCGCTGT ACTGTGAAGG ACGCACCAAG CCGAAAGTAA AAACACAAAA ACAGATACCC 5820
CCCTACTTAA TGTAATTCAG GACTCCAACC AAGAGGATTT CTTCAAATCT CAGCAAAGCT 5880
ACAGGACTGG TACTCAAGCC AGCCTGTAAA CGGTGCTATT TCTATTCCTT ATGGGATCAT 5940
TTTTCCAGGA CTCTTTGAAG AAAAGAAAAA ACAACTAAAA AAATTTTTGA CACTTTTTGT 6000
ATTTTTTCCT TAAGAGCTAT TTGTGGTTGT TGAGGTTTGA AAAGCTGACT GTTTTTTTTG 6060
CAGGGGTTCC CACCAATTTG GAAGGCATTG AAGCTTGCAC CTTTTCATGT ACAGCATTAA 6120
AATTTTACCT CTCTCTGGGA TTTACCAGCT TAAGAGTCCA ACTCACTTCC AGTGCCCAAA 6180
AGGGCACCCA CCAGAAATTC CAGTAAATCC TCATTTGAGG AAGCTCTCCC TTGTTTACTC 6240
TGTTACCACA TTGGGGAAAT TTTTAAGTTT TTCACTTTGG GAGTTTTTGT TTGTTTCTTC 6300
TTTTCCTTTA TCCACTTTTC TTCTTCCTGG TAGACTAGGT TTATTTATCT GAGCAATAAC 6360
TTCTATGTTG GTTTCAGTGG CTGGAATTAA AACAAAACAA AACAAACTTC CAAACAGTGT 6420
GTTGGTGCTT TAGCGATTGA TTGATGTACA GAACACAAAT GTCTAGTTTC TAGTGTCACT 6480
GATGAACTAG TGATGTAGAA AAGAGACTTC TCTGTAAGTA ATTGCCACAG CTGTATTTTG 6540
GCTTTCTCCC TGTCCCTTCC TTTCTCCCCT ATTTTTTGGT AGCTTGTATC AAATGTTACA 6600
GTTTATATTG TGGAATAAAT CCTTCGTCCT AACATAACAC TAAATGCTGA TTATTTAGAG 6660
CCATTAGAGC ACAGCTTCTT CTGCCCCTCT ACTGTTGCAC AGCCAGAAGG GGCTGCTTGC 6720
TTTTGCCTCT GCCCAACCAG GTTGCAGTAG CAGTGGATGT TAGCCTGCAA ACAACATTAG 6780
GGGATTCTTC TTTTGTGTCC TGCTCTGTTT GGTGGGCCAT ATGCCTACAG CCCTCACTAA 6840
CAAAGAACCC CTCTGTCTTC AAGGACTAGA ACCTATCTTT AAAGCCGTGC TCTTTTAAAA 6900
TAAGCTTTCT CAGAATGTTG GCAAATCACT TCAATCCTCA AATCAGTCTT CCTTGTGGAA 6960
TGCTGCCTTT ATTATATTTG AATTGACAGG GGAACTTGGT TTAGGGTTAA GACGTTGGAA 7020
GGAAATCTAA GGAAAATTAA TCCTCACAGA GGTCCGGGTT TAGTATATGT CTTGAGAGGA 7080
GACTTGTGAA TTCCCAGACT CTGCCTCCTG GTTTCCTTTC TCATTTCTTT CTAACTGTAG 7140
CTATCATTAC TGGCTGTGGA TAGCCCATAG CTATTTTCCT TGCTTTTCTT TTTTAAAGGG 7200
GTCTGTTCTG CAGTGGAGAA GACATTCTGG TGACCAGACT TTTGCTTACC TTTTCCTATT 7260
CTGTTGCCAA TTTTTGTTTT CCCCACATTC TATAGCCATA AACCTGAAGA TGAGTAAAAC 7320
TGGTGGGTCT TTAATAAAAC AACAACAAAA ACAGCAGTTT GTGATATAGC AGAGGTTTAA 7380
ATGTACCCTC CCCTTTTATG CACTTCAAAT AATTAAATCT CTTTAAGAAT GACTTCTAGT 7440
TGTCTGCAGT TTTCTGCAGT TGTTGTGATG TTTCTCTTCG TCTGATGGTG GTTCTGGGGC 7500
CAATAGAGAA GAATAGTCTC CAGAGTACAA TTTGGAATCA TCGTGGTTTG GCCTTGTTAG 7560
TATTCAAATT CTTAGAATCC CCTCCATCAC CCCCGACTTT GAGATAGGAT GCCAACTGTC 7620
CCAGTCCTCA CCTTCCATTG AGAAATTAAG CTTAAAAGGA GACCCTGCTG CTAATATAAA 7680
GCCACTGCCT TTAGAGAGCT TTTGCCATCT TAGTAAGCAC AACCCCTACC CCCATCCCCA 7740
CTAGTTTTTC TTCTTCACCT GTGGGTGGTG GTACACAGTC CCTGACAATA GCATCTTTGA 7800
GGAAGTCAGA TCTTTGTATC TCTGAGTGAG TTAGAAAAGG TAGGCATGTG TGTATTTGAA 7860
CCACTCCCTC CCTGGATGAG AACCACTGAT CATTTTATGT GTGATGATGC TGAATTTAAA 7920
GAGAATGTCA GTTGCCCAAA GCTACACTGT ACTACTAGTA AATAACAAAG CCTGGGTTTT 7980
ATCTTCCAGT TTTCCTACAG TATTCCTCCT ACCTTGTACA CCATCACACT ACTAATGAAC 8040
ACAGATAACG TTTACTTTCC AGTTTATGCC TTTGTTGTAT CCCTAAAATG ACTACAGACT 8100
GATGTGATCT AAAAACCATG TTTCATTGTG TGTTAGCTGT GAAGCTGGCC TGTACCAGAG 8160
AAACCTCTGA ACTTGTAGGG GAAAATGATA AAATGCACAT GGAAACTGAC ACTTCAGTTT 8220
CCATCTCAGT AGTCCTGCAG CTTTGTGAGG TGGGAGAGGG GAAGGGACTG TGTTAAGTTA 8280
GAGCCTGAAC CAGAAGGAGG GTCAGTGGGT AAAGAAAGAA AGGGTAGATG AGGTGTGCCT 8340
TCCACCTCAC CTAAATGAAT ACTGTTTGTT TTTTGTTTTT CCTTCCAGAT TAGACTTTGG 8400
GGGATTTCTT ATATAGAATA AAGGGCTTGA TTATATGTAG CCTCTATCCT GGAGAAAGGT 8460
TATGTAATTT GGACTATGTA AAGGAAGTTG ACTTCTTTAC AGCTTCGTTT CAGTATCCTA 8520
GGAGGTGGGA TTCATTTTTC TATCTTAAGT TAACCTAAAG GAGAGATGCC ACTTGTGGTG 8580
ATGGAGGTTG TTAAAAACCT GAATTTCCCT GCTTCATTCT CCAGTGAAGA GCTTAAGAAA 8640
ATGAGGCTTT GGATATTTTG GCAGAAGTGT CTGAAATGCA CCTGATTTGC CATTATACCC 8700
ACCATCAAAA GCAACATGGC CCTTTGGGTA TTAGTGCAAG ATTAGCCTAA GAATAGAGTA 8760
GATCTCTACC TGGAAGAGGG TGAAACATGG CTCTCTACTG ATTTGGGTTG TACTCTGAAG 8820
GCCCTTTGTA ATGGGTTTCT GCCTCTTTGT ATTTCACTTA AAAAATCTTG ATGGATATTT 8880
GGCAGTCTGT TAAGACCTGC TTCTGGCTTG GAGCAGGTAT TGATTGGTAT TTAGTACCCA 8940
TGGGTGTTTT TCTGGGCTCA GTCTTGCCTA TGTTTCTTGC CATATGACAC ATACCGGAAT 9000
GGATTCCAGA TGCTATATAC CTGTAACAGG AGACAGAATT GGACAACAAG GATTTTAAGA 9060
GTCATTGCCC ATTGTAAAGC ATTAAGCCAG AGCTGGTTAT TCATTATCAG ACTAACTACA 9120
TACTAGTCCA TGCTAGTGTC AGCCTATATT AAAATAGTCT TTCCTTGCCA TAGTGCTGGC 9180
GAAAACCCAA TCCCTTCTGA TGAAACATTG CTTCTTGGGA AGACAAGCTG AGGAAAGCAA 9240
TGAAGATCCC AGTGTCGGCC TTTATTGAGC TATGTATGAG GGTCAGGGTC CCTCAACTCC 9300
TAGTGACTAT GAAGCAGCAG TGTGATGGCT TCGCCCTCTT TGCCCCTCTG TCATCAATCC 9360
TTTGCATGTG GCTATTTTAA GCTTCTCAGC TTTCTTTTGG GAGGCTTCAT GTGTAACTTA 9420
TTATAGAAAT GTTACTGAAA AGCTGCCTAA ACAAAAAATT GTATAAAGTA GGAATTTGTA 9480
TAAAGTAATA CTGTTGTAAA TCCATCTTCA AGATGTAAAG AATCAATTTG TAAAGTGTAT 9540
ATTTTCACTT CTCCCTTCAA ATTTATGTGA ACAAGTTTTT CATGTTTCAA TATTGCTTAC 9600
ATAGGAATAC ACCTTACGTT TTTATCAGTA TAAATGGAAC ATTTAAAACC AGTCAACAAC 9660
AGAACAGATA ATCCAGCTCC CTGTTTGTGT TCTGGGTTAA TTTTGCAAGG ATGAAGGGCT 9720
AGAAAGTGGT GAGTTTCGGT GTGTTTCTTA TTTTCAGGAT AACCGGCTGC ATTGCAGTAG 9780
AGGAATGGAA TGGTGAGGTC ATTTGACCTG TTCCAGGTGA GTGGAGGCCA AAGAACATTC 9840
TTTCTGCCTC CCCTTGGATG GGAAAATTGA GAAATTAAAA AGTTGCCTTT CTGAGGAAAC 9900
AAAAGTTATT TTCTCTATTT AAAATAAATG TCCAAAGGCA CCCCTCTAAA CACCAAAACT 9960
TTTAGCTCCT GGCAAACTTA CCTAGCTAGA AGTTGGAGAA GAGTGCGGTT TCAAACCATG 10020
CTTCCTTTCT GCCCTTGCCA ATACGTTCTC ACTGACTGTG ATTCTGCTGT GAACACACAC 10080
ACACACACAA ACACACACAC AAGCCCCTTC TGTGTATGAT CAGGACAAGT AGTTCAACAG 10140
TTAATAAAAA AGTTAAATTA TTGGATGAGA AAGATATATT TAACCTAAAT CATAAATATG 10200
TATATCCATT TAATAAACAC TAAAATTGAG AAAAATTAGT TTGGGGATGA GGGCCTTCAT 10260
TCATAATAGC CATAATGCAT TATCTATGAT GTGAGCTTGA TTGAGCTTCT TTAAAATGCA 10320
TAAAGAATTT GAACAACAAA AGAAA 10346
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0032452--F:histone demethylase activity
GO:0034648--F:histone demethylase activity (H3-dimethyl-K4 specific)
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0034647--F:histone demethylase activity (H3-trimethyl-K4 specific)
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0003714--F:transcription corepressor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0044344--P:cellular response to fibroblast growth factor stimulus
GO:0034720--P:histone H3-K4 demethylation
GO:0034721--P:histone H3-K4 demethylation, trimethyl-H3-K4-specific
GO:0070306--P:lens fiber cell differentiation
GO:0060763--P:mammary duct terminal end bud growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0010628--P:positive regulation of gene expression
GO:0033601--P:positive regulation of mammary gland epithelial cell proliferation
GO:0009791--P:post-embryonic development
GO:2000864--P:regulation of estradiol secretion
GO:0060992--P:response to fungicide
GO:0048511--P:rhythmic process
GO:0007338--P:single fertilization
GO:0006351--P:transcription, DNA-templated
GO:0061038--P:uterus morphogenesis
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Paa-0101 ENSPANP00000008251.1 Papio anubis 99 0.0 2922
WERAM-Chs-0174 ENSCSAP00000010292.1 Chlorocebus sabaeus 99 0.0 2920
WERAM-Pat-0014 ENSPTRP00000003106.4 Pan troglodytes 97 0.0 2910
WERAM-Caj-0066 ENSCJAP00000011420.1 Callithrix jacchus 99 0.0 2899
WERAM-Ict-0007 ENSSTOP00000000336.2 Ictidomys tridecemlineatus 98 0.0 2879
WERAM-Nol-0196 ENSNLEP00000021988.1 Nomascus leucogenys 96 0.0 2869
WERAM-Mam-0137 ENSMMUP00000019971.2 Macaca mulatta 98 0.0 2869
WERAM-Dan-0026 ENSDNOP00000002490.3 Dasypus novemcinctus 97 0.0 2856
WERAM-Mup-0127 ENSMPUP00000011091.1 Mustela putorius furo 95 0.0 2839
WERAM-Fec-0131 ENSFCAP00000012150.3 Felis catus 98 0.0 2803
WERAM-Eqc-0105 ENSECAP00000012327.1 Equus caballus 97 0.0 2793
WERAM-Aim-0135 ENSAMEP00000012770.1 Ailuropoda melanoleuca 97 0.0 2784
WERAM-Caf-0114 ENSCAFP00000015414.3 Canis familiaris 97 0.0 2782
WERAM-Cap-0120 ENSCPOP00000009555.2 Cavia porcellus 96 0.0 2771
WERAM-Mum-0172 ENSMUSP00000038138.7 Mus musculus 94 0.0 2768
WERAM-Orc-0074 ENSOCUP00000006924.2 Oryctolagus cuniculus 93 0.0 2759
WERAM-Loa-0058 ENSLAFP00000004277.3 Loxodonta africana 95 0.0 2728
WERAM-Ora-0026 ENSOANP00000003977.2 Ornithorhynchus anatinus 90 0.0 2689
WERAM-Mod-0006 ENSMODP00000000907.3 Monodelphis domestica 90 0.0 2684
WERAM-Bot-0065 ENSBTAP00000028871.5 Bos taurus 92 0.0 2656
WERAM-Ova-0196 ENSOARP00000019777.1 Ovis aries 91 0.0 2631
WERAM-Myl-0169 ENSMLUP00000013690.2 Myotis lucifugus 86 0.0 2558
WERAM-Anc-0049 ENSACAP00000005126.2 Anolis carolinensis 82 0.0 2451
WERAM-Sus-0075 ENSSSCP00000011653.2 Sus scrofa 95 0.0 2447
WERAM-Gaga-0003 ENSGALP00000000581.4 Gallus gallus 83 0.0 2420
WERAM-Otg-0082 ENSOGAP00000006368.2 Otolemur garnettii 93 0.0 2404
WERAM-Meg-0012 ENSMGAP00000000890.1 Meleagris gallopavo 83 0.0 2398
WERAM-Soa-0117 ENSSARP00000011095.1 Sorex araneus 91 0.0 2394
WERAM-Tag-0021 ENSTGUP00000001314.1 Taeniopygia guttata 84 0.0 2391
WERAM-Fia-0040 ENSFALP00000002732.1 Ficedula albicollis 83 0.0 2370
WERAM-Ptv-0118 ENSPVAP00000010397.1 Pteropus vampyrus 86 0.0 2248
WERAM-Gog-0032 ENSGGOP00000003025.2 Gorilla gorilla 81 0.0 2243
WERAM-Mim-0054 ENSMICP00000005521.1 Microcebus murinus 98 0.0 2235
WERAM-Poa-0002 ENSPPYP00000000382.2 Pongo abelii 96 0.0 2214
WERAM-Pes-0122 ENSPSIP00000014677.1 Pelodiscus sinensis 83 0.0 2190
WERAM-Tas-0106 ENSTSYP00000011121.1 Tarsius syrichta 95 0.0 2157
WERAM-Anp-0064 ENSAPLP00000007396.1 Anas platyrhynchos 86 0.0 2148
WERAM-Xet-0055 ENSXETP00000017471.2 Xenopus tropicalis 71 0.0 2130
WERAM-Leo-0093 ENSLOCP00000012401.1 Lepisosteus oculatus 71 0.0 2105
WERAM-Tut-0013 ENSTTRP00000001014.1 Tursiops truncatus 91 0.0 2033
WERAM-Ere-0012 ENSEEUP00000000667.1 Erinaceus europaeus 77 0.0 1971
WERAM-Ran-0255 ENSRNOP00000072712.1 Rattus norvegicus 96 0.0 1962
WERAM-Dio-0026 ENSDORP00000002899.1 Dipodomys ordii 87 0.0 1917
WERAM-Lac-0113 ENSLACP00000013785.1 Latimeria chalumnae 68 0.0 1905
WERAM-Orn-0203 ENSONIP00000021125.1 Oreochromis niloticus 63 0.0 1893
WERAM-Xim-0141 ENSXMAP00000011505.1 Xiphophorus maculatus 62 0.0 1879
WERAM-Pof-0075 ENSPFOP00000007131.1 Poecilia formosa 62 0.0 1874
WERAM-Gaa-0123 ENSGACP00000015717.1 Gasterosteus aculeatus 62 0.0 1868
WERAM-Ect-0130 ENSETEP00000014721.1 Echinops telfairi 91 0.0 1831
WERAM-Dar-0006 ENSDARP00000023794.8 Danio rerio 61 0.0 1831
WERAM-Asm-0204 ENSAMXP00000019198.1 Astyanax mexicanus 66 0.0 1825
WERAM-Orla-0162 ENSORLP00000018794.1 Oryzias latipes 64 0.0 1768
WERAM-Gam-0220 ENSGMOP00000021028.1 Gadus morhua 59 0.0 1766
WERAM-Prc-0069 ENSPCAP00000006593.1 Procavia capensis 92 0.0 1757
WERAM-Tar-0156 ENSTRUP00000033883.1 Takifugu rubripes 63 0.0 1726
WERAM-Ten-0086 ENSTNIP00000009875.1 Tetraodon nigroviridis 65 0.0 1723
WERAM-Chh-0094 ENSCHOP00000010801.1 Choloepus hoffmanni 99 0.0 1719
WERAM-Vip-0061 ENSVPAP00000005616.1 Vicugna pacos 90 0.0 1566
WERAM-Tub-0047 ENSTBEP00000005645.1 Tupaia belangeri 90 0.0 1556
WERAM-Pem-0068 ENSPMAP00000007536.1 Petromyzon marinus 50 0.0 1302
WERAM-Ocp-0067 ENSOPRP00000005882.1 Ochotona princeps 51 0.0 1233
WERAM-Sah-0178 ENSSHAP00000018525.1 Sarcophilus harrisii 59 0.0 1211
WERAM-Mae-0078 ENSMEUP00000007759.1 Macropus eugenii 47 0.0 1197
WERAM-Cis-0007 ENSCSAVP00000000871.1 Ciona savignyi 41 0.0 1087
WERAM-Drm-0042 FBpp0311492 Drosophila melanogaster 42 0.0 1067
WERAM-Cii-0031 ENSCINP00000012442.3 Ciona intestinalis 43 0.0 919
WERAM-Cae-0018 ZK593.4a Caenorhabditis elegans 35 4e-162 570
WERAM-Lab-0033 EDR12730 Laccaria bicolor 34 3e-132 471
WERAM-Usm-0016 UM02582P0 Ustilago maydis 26 3e-124 444
WERAM-Miv-0011 MVLG_01737T0 Microbotryum violaceum 34 7e-124 443
WERAM-Arl-0119 scaffold_200168.1 Arabidopsis lyrata 30 7e-123 440
WERAM-Spr-0023 CBQ72974 Sporisorium reilianum 29 9e-123 439
WERAM-Brd-0017 BRADI1G29247.1 Brachypodium distachyon 30 4e-120 431
WERAM-Amt-0017 ERM95079 Amborella trichopoda 34 1e-118 426
WERAM-Coi-0029 EAS31076 Coccidioides immitis 36 1e-117 422
WERAM-Asc-0001 CADACLAP00000026 Aspergillus clavatus 32 2e-117 421
WERAM-Bro-0173 Bo9g029100.1 Brassica oleracea 35 3e-117 421
WERAM-Asfu-0009 CADAFUAP00002555 Aspergillus fumigatus 31 1e-116 419
WERAM-Ast-0008 CADATEAP00004027 Aspergillus terreus 31 5e-114 410
WERAM-Asf-0028 CADAFLAP00010689 Aspergillus flavus 31 1e-113 409
WERAM-Asn-0018 CADANIAP00004258 Aspergillus nidulans 34 1e-113 409
WERAM-Aso-0031 CADAORAP00009644 Aspergillus oryzae 31 1e-113 409
WERAM-Crn-0020 AAW43237 Cryptococcus neoformans 30 3e-113 408
WERAM-Pytr-0035 EDU44093 Pyrenophora triticirepentis 31 3e-113 407
WERAM-Pyt-0008 EFQ94561 Pyrenophora teres 31 2e-111 402
WERAM-Asni-0025 CADANGAP00007970 Aspergillus niger 32 2e-111 402
WERAM-Tum-0032 CAZ86330 Tuber melanosporum 34 6e-111 400
WERAM-Ors-0063 OS06T0731600-00 Oryza sativa 29 1e-110 399
WERAM-Phn-0021 SNOT_11200 Phaeosphaeria nodorum 31 1e-109 396
WERAM-Scs-0004 EDN96551 Sclerotinia sclerotiorum 34 4e-107 387
WERAM-Glm-0121 GLYMA11G02580.4 Glycine max 33 2e-106 385
WERAM-Met-0120 AES94050 Medicago truncatula 33 3e-106 384
WERAM-Mao-0014 MGG_04878T0 Magnaporthe oryzae 33 6e-106 384
WERAM-Map-0012 MAPG_04048T0 Magnaporthe poae 30 1e-104 379
WERAM-Lem-0001 CBY01560 Leptosphaeria maculans 32 6e-104 377
WERAM-Aet-0037 EMT30548 Aegilops tauschii 33 1e-103 376
WERAM-Brr-0139 Bra027644.1-P Brassica rapa 43 2e-103 375
WERAM-Tru-0011 TRIUR3_05779-P1 Triticum urartu 33 6e-103 374
WERAM-Trr-0012 EGR49606 Trichoderma reesei 33 2e-102 371
WERAM-Thc-0041 EOY24718 Theobroma cacao 42 3e-102 371
WERAM-Zyt-0030 Mycgr3P74352 Zymoseptoria tritici 29 3e-102 371
WERAM-Sol-0104 Solyc08g081000.2.1 Solanum lycopersicum 42 1e-101 369
WERAM-Prp-0007 EMJ11636 Prunus persica 31 2e-101 368
WERAM-Gag-0021 GGTG_06066T0 Gaeumannomyces graminis 29 3e-101 368
WERAM-Tra-0285 Traes_7AL_6B05A3754.1 Triticum aestivum 33 6e-101 367
WERAM-Nec-0020 EFNCRP00000004299 Neurospora crassa 33 9e-101 366
WERAM-Sei-0018 Si005667m Setaria italica 33 1e-100 366
WERAM-Trv-0029 EHK20007 Trichoderma virens 32 3e-100 364
WERAM-Orm-0066 OMERI06G28260.1 Oryza meridionalis 29 4e-99 361
WERAM-Sob-0138 Sb10g031260.1 Sorghum bicolor 35 2e-98 359
WERAM-Lep-0069 LPERR06G23820.1 Leersia perrieri 29 5e-98 357
WERAM-Php-0053 PP1S235_2V6.1 Physcomitrella patens 47 8e-97 353
Created Date 25-Jun-2016