WERAM Information

Tag Content
WERAM ID WERAM-Mum-0172
Ensembl Protein ID ENSMUSP00000038138.7
Uniprot Accession Q80Y84; KDM5B_MOUSE; Q5DTR9; Q8BLU1; Q8JZL8
Genbank Protein ID NP_690855.2
Protein Name Lysine-specific demethylase 5B
Genbank Nucleotide ID NM_152895.2
Gene Name KDM5B;JARID1B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042207.17 ENSMUST00000047714.13 ENSMUSP00000038138.7
ENSMUSG00000042207.17 ENSMUST00000112198.2 ENSMUSP00000107817.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JARID Jmjc H3K4me3 K 26739753; 26453309
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JARID 2.50e-103 344.6 453 619
Me_Reader PHD 3.80e-27 95.7 311 1536
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Domain Profile
  HDM JARID
             JARID.txt   1 eyaesgwnlnnlpvleesvlahinadisgvkvpwlyvgmcfsafcwhvedhwsysinylhfgepkvwygvpgsaaekleevlkklapel 89 
                           ey +sgwnlnn+pv+e+svlahi+adi+g+k+pwlyvgmcfs+fcwh+edhwsysinylh+gepk+wygvpg+aae+le+v+kklapel
  ENSMUSP00000038138.7 453 EYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPEL 541
                           799************************************************************************************** PP
             JARID.txt  90 fesqpdllhqlvtllnpnilkeegvpvyrtnqkagefvitfprayhsgfnqgfnfaeavnfatvdwlaagreavesys 167
                           f sqpdllhqlvt++npn+l++++vpvyrtnq+agefvitfprayhsgfnqgfnfaeavnf+tvdwl+ gr++ve+y+
  ENSMUSP00000038138.7 542 FVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYR 619
                           *****************************************************************************7 PP
  Me_Reader PHD
               PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
                           +Cl+Cg  +++++ ++ Cd+Cdd +H+ C+ +pl+ +p+g +w+Cp+C 
  ENSMUSP00000038138.7 311 VCLLCGSGNDEDR-LLLCDGCDDSYHTFCLVPPLHDVPKG-DWRCPKCL 357
                           7****87777776.**************************.*******6 PP
               PHD.txt    2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg.kswyCpsCke 52  
                            ++Cl C ++   ++ m+qC+ C+d+fH++Cv  p  s++++ + w+Cp+C++
  ENSMUSP00000038138.7 1177 KVCL-C-QKTPATP-MIQCELCRDAFHTSCVAAP--SISQSsRIWLCPHCRR 1223
                            68*9.*.6666666.*******************..66644136******97 PP
               PHD.txt    3 iClv..CgkddegekemvqCde.CddwfHlkCvklplsslpegkswyCpsCk 51  
                            iC++  C +++ +e  +vqCd+ C++wfH+ Cv+++ + ++++ +++C +C+
  ENSMUSP00000038138.7 1486 ICPAvsCLQPEGDEVDWVQCDGsCNQWFHQVCVGVSPEMAEKE-DYICVRCT 1536
                            7877679999999889********************5555565.9******8 PP
Protein Sequence
(Fasta)		MEPATTLPPG PRPALPLGGP GPLGEFLPPP ECPVFEPSWE EFADPFAFIH KIRPIAEQTG 60
ICKVRPPPDW QPPFACDVDK LHFTPRIQRL NELEAQTRVK LNFLDQIAKY WELQGSTLKI 120
PHVERKILDL FQLNKLVAEE GGFAVVCKDR KWTKIATKMG FAPGKAVGSH IRGHYERILN 180
PYNLFLSGDS LRCLQKPNLT SDTKDKEYKP HDIPQRQSVQ PAETCPPARR AKRMRAEAMN 240
IKIEPEEATE ARTHNLRRRM GCTTPKWENE KEMKSTIKQE PTEKKDCELE SEKEKPKSRA 300
KKTATAVDLY VCLLCGSGND EDRLLLCDGC DDSYHTFCLV PPLHDVPKGD WRCPKCLAQE 360
CNKPQEAFGF EQAARDYTLR TFGEMADAFK SDYFNMPVHM VPTELVEKEF WRLVSTIEED 420
VTVEYGADIA SKEFGSGFPV RDGKIKISPE EEEYLDSGWN LNNMPVMEQS VLAHITADIC 480
GMKLPWLYVG MCFSSFCWHI EDHWSYSINY LHWGEPKTWY GVPGYAAEQL ENVMKKLAPE 540
LFVSQPDLLH QLVTIMNPNT LMTHEVPVYR TNQCAGEFVI TFPRAYHSGF NQGFNFAEAV 600
NFCTVDWLPL GRQCVEHYRL LHRYCVFSHD EMICKMASKA DVLDVVVAST VQKDMAIMIE 660
DEKALRETVR KLGVIDSERM DFELLPDDER QCIKCKTTCF MSAISCSCKP GLLVCLHHVK 720
ELCSCPPYKY NLRYRYTLDD LYPMMNALKL RAESYNEWAL NVNEALEAKI NKKKSLVSFK 780
ALIEESEMKK FPDNDLLRHL RLVTQDAEKC ASVAQQLLNG KRQTRYRSGG GKSQNQLTVN 840
ELRQFVTQLY ALPCVLSQTP LLKDLLNRVE DFQQQSQKLL SEEMPSAAEL QELLDVSFEF 900
DVELPQLTEM RIRLEQARWL EEVQQACLDS SSLSLDDMRR LIDLGVGLAP YSAVEKAMAR 960
LQELLTVSEH WDDKAKSLLR ARPRHSLSSL ATAVKEMEEI PAYLPNGTVL KDSVQRARDW 1020
VQDVDALQAG GRVPVLETLI ELVARGRSIP VHLNSLPRLE MLVAEVHAWK ECAAKTFLPE 1080
NSTYSLLEVL CPRCDIGLLG LKRKQRKLKE PLPSGKKRST KLESLSDLER ALMESKETAA 1140
AMATLGEARL REMEALQSLR FANEEKLLSP VQDLEMKVCL CQKTPATPMI QCELCRDAFH 1200
TSCVAAPSIS QSSRIWLCPH CRRSEKPPLE KILPLLASLQ RIRVRLPEGD ALRYMIERTV 1260
NWQHRAQQLL SSGNLKLVQD QVGSGLLSSR WPASAGQASA TDKVSQPPGT TSFSLPDDWD 1320
NRTSYLHSPF STGQSCLPLH GLSPEVNELL MEAQLLQVSL PEIQELYQTL LTKPSSVQQA 1380
DRSSPVRSSS EKNDCLRGKR DAINSPERKL KRRPEREGLP SERWDRVKHM RTPQKKKIKL 1440
SHPKDMDSFK LERERSYDLV RNAETHSLPS DTSYSEQEDS EDEDAICPAV SCLQPEGDEV 1500
DWVQCDGSCN QWFHQVCVGV SPEMAEKEDY ICVRCTGKDA PSRK 1544
Nucleotide Sequence
(Fasta)		GGCAAGACGT CGTCGGAGGA AGGCTGAAAA AGCCCTAGGT GTTGCCGTTG CTAGTAGAAG 60
TCGGACCTGT CGCCCGAGCT GTGCGTCTGC ACGGGTTTCG GACGGAGCGG AGCTCGCTGC 120
CGCGGTTGCG GAGCCTGCCC TGTGCTCGCC CCTGCCCAGG TCGCGGTGAT GGAGCCGGCC 180
ACCACGCTGC CCCCAGGCCC GCGCCCGGCG CTGCCCCTCG GGGGCCCGGG CCCGCTGGGA 240
GAGTTCCTGC CTCCCCCCGA GTGTCCGGTC TTCGAGCCGA GCTGGGAAGA GTTCGCGGAC 300
CCCTTCGCTT TCATCCACAA GATCCGGCCC ATAGCCGAGC AGACTGGGAT CTGTAAGGTG 360
CGGCCGCCGC CGGATTGGCA GCCACCATTC GCTTGTGATG TCGATAAACT TCATTTCACC 420
CCGCGGATCC AGAGGCTGAA TGAGCTGGAG GCCCAAACAC GTGTAAAATT GAATTTCCTG 480
GACCAGATTG CAAAGTATTG GGAGCTACAA GGAAGTACTC TGAAGATTCC CCACGTGGAG 540
AGAAAGATCT TAGACTTGTT CCAGCTAAAT AAGTTAGTCG CAGAAGAAGG TGGGTTTGCA 600
GTTGTTTGCA AGGATAGAAA ATGGACCAAA ATTGCCACCA AGATGGGTTT TGCTCCTGGT 660
AAAGCTGTGG GCTCACATAT CAGGGGACAT TATGAGCGAA TACTCAATCC ATACAATTTG 720
TTCCTGTCTG GAGACAGTCT GAGGTGTCTT CAGAAGCCTA ACCTGACCTC CGACACAAAG 780
GACAAGGAGT ACAAACCCCA TGATATTCCC CAGAGGCAGT CTGTGCAGCC CGCAGAAACC 840
TGTCCTCCGG CCCGCCGAGC AAAGCGCATG AGAGCAGAGG CTATGAATAT TAAAATTGAG 900
CCAGAAGAGG CAACAGAAGC CAGGACTCAT AATCTGAGAC GCCGAATGGG TTGCACAACT 960
CCAAAATGGG AAAATGAGAA AGAAATGAAA AGCACCATCA AGCAAGAGCC CACTGAGAAG 1020
AAAGACTGCG AGTTAGAAAG TGAGAAGGAG AAGCCCAAGA GCCGGGCCAA GAAAACGGCC 1080
ACTGCGGTGG ACCTGTATGT GTGCCTCTTA TGTGGAAGTG GCAATGACGA GGACCGACTC 1140
CTACTGTGTG ACGGCTGTGA TGACAGTTAC CACACCTTCT GCCTGGTTCC CCCTCTCCAT 1200
GACGTTCCCA AGGGAGACTG GAGGTGTCCT AAGTGTTTGG CTCAAGAATG TAATAAGCCA 1260
CAAGAAGCTT TTGGTTTTGA ACAAGCAGCA AGGGACTATA CACTTCGTAC ATTTGGAGAA 1320
ATGGCAGATG CATTCAAATC TGATTACTTC AACATGCCAG TCCATATGGT TCCCACAGAG 1380
CTGGTGGAGA AGGAGTTTTG GCGGCTCGTA AGCACTATTG AAGAAGACGT CACGGTGGAG 1440
TATGGAGCTG ATATTGCTTC AAAAGAGTTT GGCAGTGGCT TTCCTGTTCG AGATGGGAAA 1500
ATCAAGATTT CTCCTGAGGA AGAGGAATAC CTGGATAGTG GCTGGAATTT GAACAACATG 1560
CCAGTGATGG AGCAGTCTGT CCTTGCTCAT ATTACTGCTG ATATATGTGG CATGAAACTC 1620
CCCTGGTTGT ATGTGGGCAT GTGCTTTTCT TCATTCTGTT GGCACATTGA AGACCACTGG 1680
AGCTATTCAA TCAACTACCT ACACTGGGGT GAGCCAAAAA CCTGGTATGG AGTTCCAGGC 1740
TACGCTGCTG AGCAGCTAGA AAACGTGATG AAGAAGCTCG CTCCTGAGCT CTTTGTGTCC 1800
CAGCCGGACC TGCTCCACCA GCTGGTGACC ATCATGAACC CCAACACTCT GATGACTCAT 1860
GAAGTGCCTG TTTATCGAAC GAATCAGTGT GCTGGGGAGT TTGTAATTAC GTTTCCAAGA 1920
GCCTACCACA GTGGCTTCAA CCAAGGTTTT AATTTTGCCG AGGCTGTTAA CTTCTGCACT 1980
GTTGATTGGC TGCCATTGGG CCGCCAGTGT GTGGAGCATT ATCGCTTGCT GCACCGTTAT 2040
TGTGTCTTTT CCCACGATGA AATGATATGC AAAATGGCTT CTAAGGCTGA TGTATTAGAC 2100
GTTGTGGTAG CGTCAACTGT TCAGAAGGAC ATGGCCATCA TGATCGAGGA CGAGAAAGCT 2160
TTAAGGGAAA CTGTTCGGAA ATTGGGAGTA ATTGATTCTG AAAGAATGGA TTTTGAGCTG 2220
TTGCCAGATG ATGAGCGGCA GTGTATAAAA TGCAAAACTA CATGCTTCAT GTCTGCCATC 2280
TCCTGCTCTT GTAAACCTGG CCTACTTGTT TGCCTACATC ATGTGAAAGA ATTGTGTTCT 2340
TGCCCCCCGT ATAAGTATAA CCTGCGGTAT AGATACACTC TGGATGATCT CTATCCAATG 2400
ATGAATGCAT TAAAGCTTCG AGCAGAGTCT TACAATGAAT GGGCCTTAAA TGTGAATGAA 2460
GCCTTGGAAG CAAAGATCAA TAAGAAGAAA AGTCTTGTCA GCTTTAAAGC TTTGATTGAA 2520
GAATCAGAAA TGAAAAAATT CCCAGACAAT GATCTTTTGC GTCACCTTCG ACTAGTCACG 2580
CAGGATGCAG AAAAGTGTGC CTCTGTTGCC CAGCAGTTGC TTAATGGCAA AAGGCAAACA 2640
AGGTATCGAT CTGGTGGAGG AAAGTCTCAG AATCAGCTGA CGGTGAATGA ACTTAGACAG 2700
TTTGTGACTC AGCTGTATGC TCTGCCGTGC GTCCTTAGTC AGACACCGTT GCTAAAGGAT 2760
CTCTTGAATC GTGTGGAAGA TTTCCAACAG CAAAGCCAAA AACTACTGTC TGAGGAAATG 2820
CCTAGCGCTG CCGAGCTACA GGAGTTGCTG GATGTCAGCT TTGAATTTGA TGTTGAGCTT 2880
CCACAGCTCA CTGAGATGCG CATTCGCTTA GAGCAGGCCC GCTGGCTGGA AGAGGTTCAG 2940
CAGGCTTGCC TGGACTCCAG CTCCCTTTCT TTGGATGATA TGAGACGACT CATAGACTTA 3000
GGGGTGGGGC TGGCTCCATA TTCTGCTGTG GAGAAAGCTA TGGCCCGCCT GCAGGAGCTG 3060
CTAACAGTGT CAGAACACTG GGACGACAAA GCCAAGAGTC TCCTCAGAGC AAGACCACGG 3120
CATTCTTTGA GTAGCCTTGC TACAGCAGTC AAAGAGATGG AGGAGATCCC CGCCTACCTG 3180
CCCAATGGTA CAGTCCTGAA GGATTCTGTG CAAAGAGCCA GAGACTGGGT TCAGGATGTG 3240
GATGCATTGC AGGCAGGAGG ACGTGTGCCA GTGTTAGAGA CACTCATTGA ACTTGTTGCA 3300
AGAGGCCGAT CTATCCCAGT ACATCTCAAT TCTTTACCAA GATTGGAAAT GTTAGTAGCT 3360
GAAGTTCATG CATGGAAAGA ATGTGCTGCT AAAACATTCT TGCCTGAGAA TTCTACATAT 3420
TCTCTGTTAG AGGTTCTTTG CCCTCGGTGT GACATTGGCC TTTTGGGGCT GAAAAGGAAA 3480
CAGAGAAAGT TGAAGGAGCC CTTGCCGAGT GGAAAGAAGA GAAGCACCAA GTTAGAGAGC 3540
CTGAGCGATC TGGAGAGGGC TCTGATGGAG AGCAAAGAGA CTGCGGCAGC TATGGCAACT 3600
CTTGGGGAAG CTCGCCTACG AGAGATGGAA GCTTTGCAGT CTCTCAGATT TGCCAATGAA 3660
GAGAAATTGC TGTCACCTGT CCAAGACTTA GAGATGAAAG TCTGCTTGTG TCAGAAGACT 3720
CCAGCCACTC CCATGATTCA GTGTGAACTC TGCAGGGATG CTTTCCATAC TAGTTGTGTG 3780
GCAGCACCCA GTATTTCACA AAGCTCCCGA ATCTGGCTTT GTCCTCACTG TCGGAGGTCA 3840
GAGAAGCCTC CATTAGAGAA AATTCTGCCT CTGCTGGCCT CCCTACAGCG TATACGAGTT 3900
CGTCTTCCTG AAGGAGATGC ACTCCGATAC ATGATTGAAA GAACCGTGAA CTGGCAACAT 3960
AGAGCCCAGC AGCTGCTTTC TTCAGGGAAT CTAAAACTTG TGCAAGACCA AGTGGGTTCT 4020
GGACTGTTGT CTAGCAGATG GCCAGCCTCA GCAGGACAGG CATCAGCAAC AGACAAGGTG 4080
TCTCAGCCTC CTGGCACAAC ATCCTTTTCA TTGCCCGATG ACTGGGACAA CAGAACCTCA 4140
TATTTACACT CTCCCTTCTC TACTGGACAG AGTTGTCTCC CCCTCCATGG TTTGAGTCCA 4200
GAAGTGAATG AATTGCTGAT GGAAGCCCAG CTGCTCCAGG TATCCCTTCC TGAAATTCAG 4260
GAGCTTTATC AGACTCTACT TACTAAGCCA AGCTCTGTTC AGCAAGCTGA CCGAAGTTCA 4320
CCAGTTAGAT CCAGCAGTGA GAAGAACGAT TGCCTTCGAG GGAAACGAGA TGCAATCAAC 4380
AGTCCTGAGA GGAAACTGAA AAGGCGCCCA GAAAGAGAAG GCCTTCCTAG CGAGCGGTGG 4440
GATCGAGTTA AACACATGCG GACCCCCCAA AAGAAGAAAA TCAAACTGAG TCACCCCAAG 4500
GACATGGACA GTTTCAAGTT AGAAAGAGAG CGTAGCTATG ACTTAGTGCG TAATGCTGAA 4560
ACTCATTCCC TGCCCTCAGA CACATCCTAC TCCGAACAGG AGGACTCTGA GGATGAAGAT 4620
GCCATCTGTC CAGCTGTGAG CTGCCTGCAG CCAGAAGGAG ATGAGGTGGA CTGGGTCCAG 4680
TGTGATGGCA GCTGCAATCA GTGGTTTCAC CAGGTCTGTG TTGGTGTCTC TCCAGAGATG 4740
GCAGAGAAGG AAGACTACAT CTGTGTGCGC TGTACTGGGA AGGACGCACC AAGCCGAAAG 4800
TAAAAACAAA ACACACACTC ACTTCATGTA ATTCAGGACT CCAATAAAGA AGATTTCCTC 4860
AATCTCAGCA AAGCTACAGG ACTGGGGTCG AGCCAGCCTG TACACGGTGC TATTTCTATT 4920
CCTTATGGGA TCATTTTTCC AGAACTCTTT GAAAAAAAGA AAAAACAACT AAAAAAATTT 4980
TGACACTTTT TTGTAATTTT TTTCCTTAAA AGCTGTTTGT GGTTGTTGAA GTTTAAAATG 5040
CTGACTGTTT TTTGCAGGGG TCTCTACTGA TTACGAAGGT ATTGGAGTTT GCACCTTTTT 5100
GTGTACAGCA AAACATTGTA CTTCTGCCTG GGATATGCCG GCTTAAGAGT CCAACTCAGT 5160
TTCAGAGCCC AGCAGGGGCA CCAGAATTCC AGTAACCCTC ACAGAGCAGC CGCGCTCCTT 5220
TGTCTGTCAC CACATTGGGG GGATTTTAAG TTTTTACTTT GGGGTTTTTG TTCCTTTCTT 5280
TCTCCCCTTT TCCTTTCTGG TAGGCTAGGT TTATTTATCT CAGCAATAAC TTCTATGTTG 5340
GTTTCAGTGG CTGGAATTAA AACAAAACAA ACTTCTAAAC AGTGTGTTGG TGCTTTAGCA 5400
TTTGGCTCAT GTACAGAAAG CAAATGTCTA GTTTCTGGTG TCACTGCACT AGTGATTTAG 5460
GAAGAGACTG CGCTGTAAGT AATCGCCCGC CACGGCTGTA TTTTGGCTTT CTCCCTACTC 5520
AGTCCCCCAC CCCCACCCTT TTTTTTTTTT TTTTTTTTTG GTAGAATGTA TCAAATGTTG 5580
CAGTTTATAT TGTGGAATAA TAAATCCTTG GTCCTATTCT AACACTAGAC TACAGCTTCT 5640
TCTGCCCTTC CACCTCGTGG GCCTGCAGAA CCAGAAGGGT TGCTTGCTTC TGCTTCTTCC 5700
CAGGCAGGCA GCCGCAGAAG TGTGTTTGCT CTAGGAGACT CTGTAGCCTT ATTCTCTGGG 5760
TGGGCCTGTG CCTTCATGCC CCACTAATAA AGAATCCCTG TCTTTAAAGA CCAGAGCCAG 5820
TCCTTTAAGC CATGTTCTTT TTCAGTAAGC CCTCAGAATA TTGGAGTGGT CCCCAAATCA 5880
CTCCAGACTG TAAGACAGCT CTCCTATGGA ATGCTTTTAT TGTCATTGAA TTGACAGGGA 5940
AGTTTGGTTG AGATGTGGTC CATCATCTTA GAGGCTCAGA TCTGTTGTAT CAGTTGAGGG 6000
GGACCTTGGG CCTGCCTGGG ATTTCTCTGC CATCTATGTA ATTTCATCAG TCTCTCTGGT 6060
TGTGGACAGC CGATACCAGT TTCCCCTGAT CTGCAGAGAG GAAGACTTCC AGTGAGCAGA 6120
ACAGGCTCTT GCTCACTTTT CTCCTAAGTT GTTGCAAGCT CTTGTTTTCC TCACTGTCTG 6180
TAGCCATAAG CCTGATGGTG GGCAGAGTTA GCAGACCTTT AATAAAACAT CAAAAAGCAG 6240
TTTGTGAAAT AGCGAAAATT TAAATGTACT GTCCCCTATG CAATCCAGGT AATTAAATCT 6300
GTTTAAGAAT AACCCAGTGG TCTGCAGTGT CCTGCAGTGC TGTGATGTCT CTTCTTGTCT 6360
GGGGATGAAA GTAAGCTTTG AAGAGGGCAT TACTGAGCCT GGGGTGCACC TTAGTGGGAG 6420
AGCACAAGCA AGACTCTGCT TCCTATGCGT GGCACTGTCC AAGGAAGTAA ATATGTGTCA 6480
AAGAAGATGG GATGCTGCTG AAACCCAGTC TGATGGCTGA GAACTTTCAC CCATTGAGAT 6540
GAGCCCTCTG TGTAGGCCTG GCTGTCCTGG AACTCACTCT GCAGACCAGG CTGGCCTCTC 6600
ACTTAGAGAT CCACCTGCCT CTGCCTCCTG AGTGCTGAGA TTAAAGCCAT GTTCCACCAC 6660
CACCACCGAG TTCCCTCTGG GTCTTAATGG TTGTTTTGCT TATTCATTTG AATTTTAATG 6720
GGGTCCAATC TAGCTCTGTA GCCAAGAGTG ACCTTGAACT TCTGAATTCG TTCTGAATTC 6780
TTCTGACGAT GTTTTTAATT CTGTAGCTAA AACGTGTGCA TCACTGTGCC CAATTTCTGT 6840
GGTGTCAGGG ATCAAATGTG AGGGCCTTGT GCATGCCAGG CAAGCACTCT GCCAAGTGGA 6900
CTATATATGC GCCCTCACCA GCTTTTCTTT GTGTAAGCCT TGTGTATCAT GTGTATCTGA 6960
TATTAGCAGA TTTGCTGATA TGATAGGAGA TAGAACCATC CCCTTCCCAA GTGGGAATCA 7020
TGGTTTGTTT GTATGTGTTG ATACCAAGTC TGAAATGTCA GCTGTGTAAA ATGAAATGAA 7080
CCCTGGGATT GCTTCAGCTT TGCCAGTGCA TCCTACCCTG TGCAGTACCA ACACTGCACA 7140
CACTGAAGAC ATCCAGTTTC AACTCAGGCC ACCCGTGTGC CTGACAGAAG CTAAGGTTTT 7200
ATAAAAAGAA CACATTTTAC TATGTTAGCT TTGAAGCTTG CTGATACCTT AGAGTAGTGG 7260
TTCTTAATGA GTTGGTCACA ACCCCTTTGG CAAACCAGTC TCCAAAAATA CAATACAAAA 7320
ATACAAACAG AAGCAAGGTT ACAGTTATGA AGTAGCAGTG GAATAAATAA CTTTATGGTC 7380
AGGAATCACC GCAACCTGAG GAACTGTGTT AAAGAGTCAC AGCGTTAGGA AGGCTGAGAA 7440
CCACTGCCAT GGAGGAATGC TGGATAAATG GAGAAAGAAG GTAAAGTAAA ATAGCCACTG 7500
AGTTTCTACC TTAAGAGGCC CTGCAGGAGA GAGGACTGGA GTTAGCACCT GAGTCAGGAA 7560
GACGATGGCA GATTGGGCAG ATAGACTAGA GAAGTCTACT AGCTAGACCA GAGAGAGTGA 7620
AGTTCCAGTT TTAATGGCGG ACAAAACTAC AAACCTTCAT TCTGTCACTG AGCATGGAAT 7680
CCCGGATTTT GCCTCAGTTG AAGGTCCACT TGGATTAAGT AGCATGAGCC TATATAAAAA 7740
TCAAAACACG GAAAGAGAGG GGTTAATAGC TTCTGGTTTG GTAGAATGAC TAAGATACAT 7800
CCAGGCTGCC CACCGCTGAA AGTGGGGTTG TAATCCCAGC ACCTAGGATG CTGGGTCAAG 7860
AGGACTGTGG GGCCGCAGCC ATCCTGGGGG ACAAAGTGCA AACAGTGTTG GTGGGTGATT 7920
AGTGTGTGAT TAGCTGAATA AACAGTATTC ATTTCTGTGG CCGTGGTAGA AACTGGGCCT 7980
CTCAGCAGGG CCGTACCATA AGTAAAAGTC CCGTGGACTC TATTATCTCC CACCCTAACC 8040
AGGCTTCTGC AACAAGCACC TTTCCCCACG AGCCATTGCC AGCCCTGAGG CCTTGTGCAA 8100
TGGATATTTG GCAGACTTAG AAGACCTGCT TGTGTCTTGG GATGGACATG GAGAAGTTTT 8160
TGGTGCCCAT GGATGTTTTA CTGGGCCCAG TCCTGCCTAG GGTTGTTCAT GTAATTTGAC 8220
TCTTAATAGA TTCCTATATA CATGAAACAG GAGGTGTATT GGACAGCAGG TATTTTAAAT 8280
GGGCACAAAG CATGAAGCCA GAGCTGAGCA GTAGTAGCTG ACATAAGCTA GTCAGCATAT 8340
ATTAAAATGT TCTGTTGAGC TGGGATGAAA CTCGGGAAAA CCACTTGCCA AGGACCAGAG 8400
AGAGGCCTTA GGTTTGGTTT CCAGAAACAT CAGAAGAAAA GGTTTCCTTC TGCCACAATG 8460
CTGCAGAAAT AGAATCTGGA ATATTGCTTG TTGAAGAGTT TCGGAAGAGA GCATTGAAGA 8520
CCCCATCGTC AGCATGTTAT GGGCTGGCTG CATTTGGAGC CATCCTTCCT CAACGTGACT 8580
GAAACACCGG AGTTTATGGC TTCTCCCCGT TTGGGCCTTC TGTCCTCAGT CCTTTGCCTG 8640
TGGCCCAAGT TTCTCAACTT CGAGAGATTT CATGTGTAAC TTGTAAAGAA AATGCTGCTT 8700
AAAACATTCT AAGC 8715
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0034648--F:histone demethylase activity (H3-dimethyl-K4 specific)
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0034647--F:histone demethylase activity (H3-trimethyl-K4 specific)
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0044344--P:cellular response to fibroblast growth factor stimulus
GO:0034720--P:histone H3-K4 demethylation
GO:0034721--P:histone H3-K4 demethylation, trimethyl-H3-K4-specific
GO:0070306--P:lens fiber cell differentiation
GO:0060763--P:mammary duct terminal end bud growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0010628--P:positive regulation of gene expression
GO:0033601--P:positive regulation of mammary gland epithelial cell proliferation
GO:0009791--P:post-embryonic development
GO:0042752--P:regulation of circadian rhythm
GO:2000864--P:regulation of estradiol secretion
GO:0060992--P:response to fungicide
GO:0048511--P:rhythmic process
GO:0007338--P:single fertilization
GO:0006351--P:transcription, DNA-templated
GO:0061038--P:uterus morphogenesis
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Hos-0095 ENSP00000356234.3 Homo sapiens 94 0.0 2779
WERAM-Paa-0101 ENSPANP00000008251.1 Papio anubis 94 0.0 2776
WERAM-Ict-0007 ENSSTOP00000000336.2 Ictidomys tridecemlineatus 94 0.0 2774
WERAM-Chs-0174 ENSCSAP00000010292.1 Chlorocebus sabaeus 94 0.0 2774
WERAM-Caj-0066 ENSCJAP00000011420.1 Callithrix jacchus 94 0.0 2769
WERAM-Pat-0014 ENSPTRP00000003106.4 Pan troglodytes 92 0.0 2768
WERAM-Dan-0026 ENSDNOP00000002490.3 Dasypus novemcinctus 94 0.0 2761
WERAM-Mup-0127 ENSMPUP00000011091.1 Mustela putorius furo 92 0.0 2727
WERAM-Mam-0137 ENSMMUP00000019971.2 Macaca mulatta 93 0.0 2724
WERAM-Nol-0196 ENSNLEP00000021988.1 Nomascus leucogenys 90 0.0 2724
WERAM-Fec-0131 ENSFCAP00000012150.3 Felis catus 94 0.0 2715
WERAM-Cap-0120 ENSCPOP00000009555.2 Cavia porcellus 94 0.0 2686
WERAM-Eqc-0105 ENSECAP00000012327.1 Equus caballus 94 0.0 2686
WERAM-Orc-0074 ENSOCUP00000006924.2 Oryctolagus cuniculus 91 0.0 2683
WERAM-Caf-0114 ENSCAFP00000015414.3 Canis familiaris 94 0.0 2678
WERAM-Aim-0135 ENSAMEP00000012770.1 Ailuropoda melanoleuca 93 0.0 2674
WERAM-Loa-0058 ENSLAFP00000004277.3 Loxodonta africana 92 0.0 2633
WERAM-Ora-0026 ENSOANP00000003977.2 Ornithorhynchus anatinus 88 0.0 2618
WERAM-Bot-0065 ENSBTAP00000028871.5 Bos taurus 90 0.0 2610
WERAM-Mod-0006 ENSMODP00000000907.3 Monodelphis domestica 88 0.0 2595
WERAM-Ova-0196 ENSOARP00000019777.1 Ovis aries 89 0.0 2583
WERAM-Myl-0169 ENSMLUP00000013690.2 Myotis lucifugus 85 0.0 2511
WERAM-Anc-0049 ENSACAP00000005126.2 Anolis carolinensis 81 0.0 2424
WERAM-Gaga-0003 ENSGALP00000000581.4 Gallus gallus 82 0.0 2374
WERAM-Meg-0012 ENSMGAP00000000890.1 Meleagris gallopavo 82 0.0 2362
WERAM-Sus-0075 ENSSSCP00000011653.2 Sus scrofa 93 0.0 2355
WERAM-Tag-0021 ENSTGUP00000001314.1 Taeniopygia guttata 83 0.0 2345
WERAM-Fia-0040 ENSFALP00000002732.1 Ficedula albicollis 82 0.0 2318
WERAM-Soa-0117 ENSSARP00000011095.1 Sorex araneus 88 0.0 2294
WERAM-Otg-0082 ENSOGAP00000006368.2 Otolemur garnettii 89 0.0 2293
WERAM-Ptv-0118 ENSPVAP00000010397.1 Pteropus vampyrus 84 0.0 2161
WERAM-Gog-0032 ENSGGOP00000003025.2 Gorilla gorilla 77 0.0 2141
WERAM-Mim-0054 ENSMICP00000005521.1 Microcebus murinus 94 0.0 2138
WERAM-Pes-0122 ENSPSIP00000014677.1 Pelodiscus sinensis 81 0.0 2128
WERAM-Poa-0002 ENSPPYP00000000382.2 Pongo abelii 92 0.0 2096
WERAM-Xet-0055 ENSXETP00000017471.2 Xenopus tropicalis 70 0.0 2090
WERAM-Tas-0106 ENSTSYP00000011121.1 Tarsius syrichta 92 0.0 2089
WERAM-Leo-0093 ENSLOCP00000012401.1 Lepisosteus oculatus 70 0.0 2088
WERAM-Anp-0064 ENSAPLP00000007396.1 Anas platyrhynchos 85 0.0 2086
WERAM-Ran-0255 ENSRNOP00000072712.1 Rattus norvegicus 98 0.0 1981
WERAM-Tut-0013 ENSTTRP00000001014.1 Tursiops truncatus 89 0.0 1967
WERAM-Lac-0113 ENSLACP00000013785.1 Latimeria chalumnae 66 0.0 1961
WERAM-Ere-0012 ENSEEUP00000000667.1 Erinaceus europaeus 75 0.0 1870
WERAM-Asm-0204 ENSAMXP00000019198.1 Astyanax mexicanus 62 0.0 1865
WERAM-Orn-0203 ENSONIP00000021125.1 Oreochromis niloticus 62 0.0 1862
WERAM-Dio-0026 ENSDORP00000002899.1 Dipodomys ordii 85 0.0 1858
WERAM-Xim-0141 ENSXMAP00000011505.1 Xiphophorus maculatus 62 0.0 1844
WERAM-Gaa-0123 ENSGACP00000015717.1 Gasterosteus aculeatus 62 0.0 1840
WERAM-Pof-0075 ENSPFOP00000007131.1 Poecilia formosa 62 0.0 1837
WERAM-Orla-0162 ENSORLP00000018794.1 Oryzias latipes 61 0.0 1826
WERAM-Dar-0006 ENSDARP00000023794.8 Danio rerio 61 0.0 1805
WERAM-Ten-0086 ENSTNIP00000009875.1 Tetraodon nigroviridis 61 0.0 1765
WERAM-Gam-0220 ENSGMOP00000021028.1 Gadus morhua 59 0.0 1738
WERAM-Ect-0130 ENSETEP00000014721.1 Echinops telfairi 88 0.0 1735
WERAM-Chh-0094 ENSCHOP00000010801.1 Choloepus hoffmanni 97 0.0 1697
WERAM-Prc-0069 ENSPCAP00000006593.1 Procavia capensis 88 0.0 1693
WERAM-Tar-0156 ENSTRUP00000033883.1 Takifugu rubripes 62 0.0 1690
WERAM-Vip-0061 ENSVPAP00000005616.1 Vicugna pacos 88 0.0 1495
WERAM-Tub-0047 ENSTBEP00000005645.1 Tupaia belangeri 87 0.0 1475
WERAM-Pem-0068 ENSPMAP00000007536.1 Petromyzon marinus 50 0.0 1297
WERAM-Ocp-0067 ENSOPRP00000005882.1 Ochotona princeps 49 0.0 1214
WERAM-Sah-0049 ENSSHAP00000005524.1 Sarcophilus harrisii 51 0.0 1194
WERAM-Mae-0078 ENSMEUP00000007759.1 Macropus eugenii 47 0.0 1188
WERAM-Cis-0007 ENSCSAVP00000000871.1 Ciona savignyi 40 0.0 1106
WERAM-Drm-0042 FBpp0311492 Drosophila melanogaster 43 0.0 1066
WERAM-Cii-0031 ENSCINP00000012442.3 Ciona intestinalis 43 0.0 901
WERAM-Cae-0018 ZK593.4a Caenorhabditis elegans 35 3e-161 567
WERAM-Lab-0033 EDR12730 Laccaria bicolor 35 7e-133 473
WERAM-Miv-0011 MVLG_01737T0 Microbotryum violaceum 34 2e-125 448
WERAM-Arl-0119 scaffold_200168.1 Arabidopsis lyrata 29 8e-123 439
WERAM-Brd-0017 BRADI1G29247.1 Brachypodium distachyon 30 1e-119 429
WERAM-Amt-0017 ERM95079 Amborella trichopoda 34 3e-119 427
WERAM-Bro-0173 Bo9g029100.1 Brassica oleracea 35 2e-117 421
WERAM-Coi-0029 EAS31076 Coccidioides immitis 35 5e-116 417
WERAM-Asfu-0009 CADAFUAP00002555 Aspergillus fumigatus 31 4e-115 414
WERAM-Asc-0001 CADACLAP00000026 Aspergillus clavatus 31 4e-114 410
WERAM-Ast-0008 CADATEAP00004027 Aspergillus terreus 31 5e-112 404
WERAM-Asn-0018 CADANIAP00004258 Aspergillus nidulans 35 1e-110 399
WERAM-Asf-0028 CADAFLAP00010689 Aspergillus flavus 30 3e-110 397
WERAM-Aso-0031 CADAORAP00009644 Aspergillus oryzae 30 3e-110 397
WERAM-Ors-0063 OS06T0731600-00 Oryza sativa 35 2e-109 395
WERAM-Asni-0025 CADANGAP00007970 Aspergillus niger 35 4e-109 394
WERAM-Tum-0032 CAZ86330 Tuber melanosporum 34 6e-109 394
WERAM-Crn-0020 AAW43237 Cryptococcus neoformans 29 2e-108 392
WERAM-Pytr-0035 EDU44093 Pyrenophora triticirepentis 30 2e-108 392
WERAM-Scs-0004 EDN96551 Sclerotinia sclerotiorum 36 4e-107 387
WERAM-Pyt-0008 EFQ94561 Pyrenophora teres 30 1e-106 386
WERAM-Phn-0021 SNOT_11200 Phaeosphaeria nodorum 30 7e-106 383
WERAM-Glm-0121 GLYMA11G02580.4 Glycine max 45 6e-105 380
WERAM-Brr-0139 Bra027644.1-P Brassica rapa 44 3e-104 378
WERAM-Met-0120 AES94050 Medicago truncatula 42 6e-104 377
WERAM-Thc-0041 EOY24718 Theobroma cacao 40 6e-103 374
WERAM-Aet-0037 EMT30548 Aegilops tauschii 36 7e-103 373
WERAM-Tru-0011 TRIUR3_05779-P1 Triticum urartu 36 2e-102 372
WERAM-Trr-0012 EGR49606 Trichoderma reesei 35 3e-102 371
WERAM-Mao-0014 MGG_04878T0 Magnaporthe oryzae 33 4e-102 371
WERAM-Sol-0104 Solyc08g081000.2.1 Solanum lycopersicum 43 1e-101 369
WERAM-Sei-0018 Si005667m Setaria italica 34 2e-101 369
WERAM-Prp-0007 EMJ11636 Prunus persica 43 7e-101 367
WERAM-Tra-0285 Traes_7AL_6B05A3754.1 Triticum aestivum 33 1e-100 366
WERAM-Lem-0001 CBY01560 Leptosphaeria maculans 35 2e-100 365
WERAM-Usm-0016 UM02582P0 Ustilago maydis 27 3e-100 365
WERAM-Trv-0029 EHK20007 Trichoderma virens 35 8e-100 363
WERAM-Map-0012 MAPG_04048T0 Magnaporthe poae 33 9e-100 363
WERAM-Nec-0020 EFNCRP00000004299 Neurospora crassa 33 4e-99 360
WERAM-Zyt-0030 Mycgr3P74352 Zymoseptoria tritici 29 5e-99 360
WERAM-Orm-0066 OMERI06G28260.1 Oryza meridionalis 34 1e-98 359
WERAM-Spr-0023 CBQ72974 Sporisorium reilianum 31 1e-97 356
WERAM-Php-0053 PP1S235_2V6.1 Physcomitrella patens 47 5e-97 354
WERAM-Gag-0021 GGTG_06066T0 Gaeumannomyces graminis 33 7e-97 353
WERAM-Org-0069 ORGLA06G0289500.1 Oryza glaberrima 36 5e-93 340
WERAM-Sot-0035 PGSC0003DMT400029865 Solanum tuberosum 42 9e-93 340
Created Date 25-Jun-2016