WERAM Information

Tag Content
WERAM ID WERAM-Drm-0042
Ensembl Protein ID FBpp0311492
Uniprot Accession Q9VMJ7; KDM5_DROME
Genbank Protein ID NP_001245908.1; NP_001245909.1; NP_001245910.1; NP_001285649.1; NP_523486.1; NP_723140.1
Protein Name Lysine-specific demethylase lid
Genbank Nucleotide ID NM_001258979.2; NM_001258980.1; NM_001258981.2; NM_001298720.1; NM_078762.6; NM_164671.1
Gene Name KDM5;lid;CG9088
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0031759 FBtr0345336 FBpp0311492
FBgn0031759 FBtr0079231 FBpp0078862
FBgn0031759 FBtr0079232 FBpp0078863
FBgn0031759 FBtr0307069 FBpp0297912
FBgn0031759 FBtr0307070 FBpp0297913
FBgn0031759 FBtr0307071 FBpp0297914
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JARID Jmjc H3K4 K 17311883; 26207949; 21205864
Me_Reader PHD PHD1 H3K4 K 17311883; 26207949; 21205864
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JARID 4.30e-99 329.9 591 757
Me_Reader PHD 7.30e-31 106.7 113 1807
Organism Drosophila melanogaster
NCBI Taxa ID 7227
Functional Description
(View)		 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry.
Domain Profile
  HDM JARID
    JARID.txt   1 eyaesgwnlnnlpvleesvlahinadisgvkvpwlyvgmcfsafcwhvedhwsysinylhfgepkvwygvpgsaaekleevlkklapelfesqpdllh 98 
                  eyaes+wnlnnlp+le+s+l+hinadisg++ pw+yvgmcf+afcwh edhwsysinylh+gepk+wygvpgs+ae++ee++k++apelf+sqpdllh
  FBpp0311492 591 EYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLH 688
                  7************************************************************************************************* PP
    JARID.txt  99 qlvtllnpnilkeegvpvyrtnqkagefvitfprayhsgfnqgfnfaeavnfatvdwlaagreavesys 167
                  qlvt++npnil++++vpv+rt+q+agefvitfprayh+gfnqg+nfaeavnfa++dwl++gre+v++ys
  FBpp0311492 689 QLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYS 757
                  ********************************************************************7 PP
  Me_Reader PHD
      PHD.txt  25 dwfHlkCvklplsslpeg 42 
                  + +H +C +++ +++p g
  FBpp0311492 113 KKYHNSCPHPTPTPAPTG 130
                  569*******98888866 PP
      PHD.txt   2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCk 51 
                   iC +C++ d +e+ m+ Cd+Cdd +H+ C+ +pl+s+p+g +w+Cp+C+
  FBpp0311492 449 YICHICNRGDVEES-MLLCDGCDDSYHTFCLLPPLTSIPKG-EWLCPRCV 496
                  69****77766665.**************************.*******8 PP
      PHD.txt    2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg............kswyCpsCke 52  
                   ++Cl C k+++++  m++C+ C+dwfH +Cv++p  + ++g             +w+CpsC++
  FBpp0311492 1294 MFCL-C-KSEFRNL-MFNCQLCRDWFHEDCVPPPSATNQNGivnggsgpgtnrPKWLCPSCVR 1353
                   79*9.*.9999987.*******************5555566**********9999******97 PP
      PHD.txt    4 Clv..CgkddegekemvqCde.CddwfHlkCvklplsslpegkswyCpsCke 52  
                   C++  C+k+  +e  +vqCd+ C++wfH++Cv+l++s+++ +++++C +C++
  FBpp0311492 1756 CRAenCHKPTGREVDWVQCDGgCNEWFHMYCVGLNRSQIKPDDDYICIRCTK 1807
                   666669999999999********************999996669******86 PP
Protein Sequence
(Fasta)		MSAKTEADNT TAANSGGGGV GSGTSSGGGA SANGTATPAR RLRTRNSTGN GTNSGSESVK 60
KSNANDEPST PVTPAGATGS HTHAPPGISP AVMERPMPSV PMNHASSSVS ASKKYHNSCP 120
HPTPTPAPTG HKKSVHTQPH SSNKFDQGKN EEFHFDTPPE CPVFRPTTEE FKNPLAYISK 180
IRSIAEKCGI AKILPPATWS PPFAVDVDKL RFVPRVQRLN ELEAKTRVKL NFLDQIAKFW 240
ELQGSSLKIP MVERKALDLY TLHRIVQEEG GMEQTTKDRK WAKVANRMQY PSSKSVGATL 300
KAHYERILHP FEVYTSGKVL GPTPTSSGSG STPVKLEDGG GTDYKAHEIP TRQQIAPPNE 360
TNTRRSKRFG NSNASCGLSG VTPTTKPSAG VFVKTETKEE FKRDLLSSFN AVNSGGSPLA 420
TGTTANTRGA SQKKGGEPPA LIVDPLMKYI CHICNRGDVE ESMLLCDGCD DSYHTFCLLP 480
PLTSIPKGEW LCPRCVVEEV SKPQEAFGFE QAEREYTLQQ FGQMADQFKQ EYFRKPVHLV 540
PTEMVEREFW RIVSSIDEDV TVEYGADLHT MDHGSGFPTK SSLYLLPGDQ EYAESSWNLN 600
NLPLLEDSIL GHINADISGM NAPWMYVGMC FAAFCWHNED HWSYSINYLH WGEPKTWYGV 660
PGSCAEQFEE TMKQAAPELF SSQPDLLHQL VTIMNPNILM NNRVPVFRTD QHAGEFVITF 720
PRAYHAGFNQ GYNFAEAVNF APADWLKMGR ECVNHYSMLR RFCVFSHDEL VCKMALEPAK 780
LTFGIATACY IDMAEMVDTE KKLRKSLLEW GVTRAERRAF ELVNDDERHC QECNTTCFLS 840
AVACECNDKL IVCLRHYTVL CGCAPEKHTL IYRYTLDEMP LMLQKLKVKA HSFERWLSRC 900
RDIVDAHTPT SVTLQELQEL CKEAETKKFP SSLLIDRLNA AAVEAEKCVT VIQQLGINKV 960
RTRSDHNQEA AQYKLTMEEL ELFVQEIDNL CCIIDEGASV RELLVLGKQF VERSESQLQL 1020
SLESLEESEL ETLINEGSSL RIELQQLDLL QKRLKQCKWY KRSQGLRETS SKLTYQDVKN 1080
LLHIAAADLD PTDPYVDKEM RKLQQIGADI EAWESQAAKY FRRLTQQHEL GEIEQFLKSA 1140
SDINGQVPSH GLLKDALRKA REWLRAVEQL QQNNHVTYCH TLEAMIERGL NIPIQLEELS 1200
RMQGHLNSAH QWKDNTACAF LKKGTFYTLL EVLMPRSDAI NIDSDLKPRF QDDFLKEKNP 1260
AEIVASFKHA EEQELLDMRE LRRQNMNKNP MRDMFCLCKS EFRNLMFNCQ LCRDWFHEDC 1320
VPPPSATNQN GIVNGGSGPG TNRPKWLCPS CVRSKRPRLE TILPLLVQLQ QLPIRLPEDE 1380
ALRCLAERAM NWQDRARKAL SSPDVSAAQE AIMAQQQQKR RSEGGAGVGN ISSPRKPRRR 1440
GSLTKEASGS TESDADDDDD EDECRLRIVE DNFSNDEDEP RTAPATSTVN SDLLKLLSDS 1500
EIENLLDLMM EGDLLEVSLD ETQELWRILE TMPPTLLQAE AMERVVQYMQ RQRQQHTNPL 1560
PTSGAEDSND SLMVQNSPNS NSNSGGATGS ASNSGRNKKR RSNDTGGNSA VPRKKQSTPK 1620
QTPGKKGSAA AARKSDAKAS PAASTTPGAD ADAENKQANG GNTNSSTGSG GGNSATTTPT 1680
PGSTHKKRKR TSTTATNNNN NNNNNSTNNS NSSTNLNSNT TSGQGAATGG NNATGGQKKH 1740
AQRSQQAAQE DDEEECRAEN CHKPTGREVD WVQCDGGCNE WFHMYCVGLN RSQIKPDDDY 1800
ICIRCTKTVA IGTQGSGHSM SVASTTTPGK QRAVQSAR 1838
Nucleotide Sequence
(Fasta)		GGCAGATCGA CGTTTCCGGC ACTTCGACGA CGGGTCACAC TGGACACATG TAGCAGGAAA 60
AAACGCAGAC ATCGGAGAAA GAAATCAGAA AAGTAAATTC GCATTAAAGC CACCTCGCCA 120
GTGCCGTGCT CGGTGGTTTT ATGGAACACT CATTTCGATC ACATACCGAG CGTGCGCGTC 180
TTCCAACGAC TTCCTATGAC GACAAACCGA GCGGAATAAA TTTAATCTGA ACTCATCTTA 240
AAGCTATGTC CGCCAAAACT GAGGCGGACA ACACGACGGC CGCCAACTCC GGCGGCGGAG 300
GAGTCGGGAG CGGCACCTCA TCCGGCGGGG GCGCATCCGC GAATGGAACA GCAACTCCGG 360
CACGTCGTCT GCGTACCCGA AACTCAACGG GCAACGGGAC TAATAGTGGA AGTGAGTCCG 420
TAAAGAAATC CAATGCTAAC GACGAGCCCT CGACCCCAGT CACCCCGGCA GGAGCAACAG 480
GATCTCACAC CCATGCTCCG CCAGGCATTT CTCCGGCGGT AATGGAACGG CCTATGCCCA 540
GTGTTCCCAT GAATCACGCC AGCAGCAGTG TGTCAGCCAG CAAAAAGTAC CATAATAGTT 600
GTCCTCATCC CACGCCCACG CCTGCGCCCA CTGGGCACAA GAAGTCGGTC CACACGCAGC 660
CGCACAGCAG CAACAAGTTT GACCAGGGAA AGAACGAGGA GTTCCACTTT GACACGCCGC 720
CAGAGTGCCC TGTGTTCCGG CCCACAACTG AGGAGTTCAA GAATCCACTG GCCTACATCA 780
GCAAGATCCG CTCCATAGCT GAGAAGTGTG GAATCGCAAA GATCCTGCCG CCGGCAACCT 840
GGTCGCCGCC GTTTGCAGTG GACGTGGACA AGCTACGCTT TGTGCCACGT GTCCAGCGGC 900
TGAATGAGCT CGAGGCAAAG ACGCGCGTCA AACTCAACTT CCTTGATCAG ATCGCAAAGT 960
TCTGGGAGCT GCAAGGCTCT TCACTAAAGA TCCCAATGGT GGAGCGAAAG GCTCTCGACT 1020
TGTACACACT GCACCGCATC GTTCAGGAGG AGGGGGGCAT GGAGCAAACC ACAAAGGATC 1080
GCAAGTGGGC CAAGGTGGCC AACCGGATGC AGTACCCCTC AAGCAAAAGT GTTGGCGCAA 1140
CCCTGAAGGC ACACTACGAA CGCATCTTGC ACCCCTTTGA GGTATACACT TCGGGAAAGG 1200
TTCTAGGACC CACACCAACG TCGTCTGGAT CTGGTAGCAC ACCCGTCAAA TTGGAGGACG 1260
GAGGTGGAAC CGATTACAAA GCCCATGAAA TTCCCACACG GCAGCAGATT GCGCCGCCCA 1320
ACGAGACAAA CACACGTCGC TCCAAGCGTT TCGGAAATTC CAATGCCAGC TGCGGCCTGA 1380
GTGGTGTTAC ACCCACAACA AAGCCATCAG CGGGCGTATT TGTCAAGACG GAGACCAAGG 1440
AAGAATTTAA GAGGGATCTT CTCAGCAGTT TCAATGCTGT CAACAGCGGC GGATCGCCAT 1500
TAGCCACAGG TACTACGGCA AACACTCGCG GAGCCAGCCA GAAGAAGGGA GGAGAGCCTC 1560
CAGCACTTAT CGTAGACCCA CTGATGAAGT ACATTTGCCA CATCTGCAAT CGCGGCGACG 1620
TCGAGGAGTC AATGCTGCTT TGCGATGGCT GCGACGACAG CTACCACACC TTTTGCCTGT 1680
TGCCGCCTCT GACCAGCATA CCCAAAGGCG AATGGCTTTG CCCGCGCTGC GTCGTCGAGG 1740
AAGTAAGCAA ACCGCAGGAG GCGTTTGGTT TTGAACAGGC AGAGAGGGAA TACACTCTGC 1800
AACAATTTGG ACAAATGGCT GACCAGTTCA AGCAAGAATA CTTCCGCAAG CCGGTGCACT 1860
TGGTGCCCAC TGAGATGGTG GAGCGCGAGT TTTGGCGCAT CGTGTCATCT ATCGATGAAG 1920
ACGTTACCGT TGAGTATGGG GCGGACTTGC ACACAATGGA TCACGGCTCT GGTTTTCCCA 1980
CTAAGAGCTC GTTATATTTG TTGCCGGGCG ACCAAGAGTA TGCAGAGTCA AGCTGGAACC 2040
TTAACAACTT GCCGTTGCTG GAGGATTCCA TTCTTGGTCA CATCAATGCC GACATTAGCG 2100
GCATGAACGC TCCGTGGATG TATGTGGGCA TGTGCTTCGC AGCCTTCTGC TGGCACAACG 2160
AGGACCACTG GAGCTACTCC ATCAACTATC TTCACTGGGG AGAACCTAAA ACCTGGTACG 2220
GTGTTCCGGG GTCCTGTGCT GAGCAGTTTG AAGAGACCAT GAAGCAGGCA GCTCCAGAAC 2280
TTTTTTCATC ACAGCCCGAT CTGCTTCACC AGCTGGTGAC CATTATGAAC CCGAACATTT 2340
TGATGAACAA TCGTGTACCG GTATTCCGAA CCGATCAGCA TGCAGGCGAG TTTGTGATCA 2400
CCTTTCCCAG GGCCTATCAC GCAGGCTTTA ACCAAGGCTA TAACTTCGCG GAGGCCGTCA 2460
ATTTTGCACC TGCCGATTGG CTGAAGATGG GGCGCGAGTG TGTTAACCAC TATTCCATGC 2520
TGCGACGTTT CTGTGTCTTT TCGCACGACG AGCTCGTTTG CAAGATGGCC CTGGAGCCAG 2580
CGAAACTCAC ATTTGGCATC GCTACTGCCT GCTACATCGA CATGGCCGAA ATGGTCGACA 2640
CGGAGAAGAA ACTGCGCAAA TCGCTTTTGG AGTGGGGCGT TACCCGCGCA GAGCGTCGCG 2700
CCTTCGAGCT AGTAAACGAC GATGAGCGCC ATTGCCAAGA GTGCAACACC ACGTGCTTCC 2760
TGTCGGCGGT GGCCTGCGAG TGCAACGACA AGTTGATTGT CTGTTTGCGC CACTATACGG 2820
TACTCTGCGG CTGTGCTCCT GAGAAGCACA CTCTGATATA TCGTTATACA CTGGACGAGA 2880
TGCCGCTGAT GCTGCAGAAA CTTAAGGTGA AGGCGCACAG CTTCGAGCGA TGGCTTTCAC 2940
GTTGCCGTGA CATAGTCGAT GCACATACAC CCACCTCGGT GACCCTGCAG GAGCTGCAGG 3000
AATTGTGCAA GGAGGCCGAG ACGAAAAAGT TTCCCTCCTC GCTGCTCATC GATCGCCTTA 3060
ATGCTGCGGC CGTTGAGGCA GAGAAATGTG TCACAGTCAT ACAGCAACTG GGTATCAATA 3120
AGGTGCGAAC TCGCTCGGAC CACAACCAGG AGGCTGCTCA GTACAAGCTA ACCATGGAGG 3180
AGCTAGAGTT GTTCGTTCAA GAAATCGATA ATCTCTGCTG CATCATTGAC GAGGGCGCTT 3240
CGGTGCGAGA GCTGCTTGTT TTGGGAAAAC AGTTTGTGGA GCGGTCCGAG AGCCAGCTGC 3300
AATTATCGCT GGAGTCTCTG GAGGAGAGTG AGCTGGAAAC GTTAATAAAC GAAGGCAGCT 3360
CCTTACGCAT CGAACTGCAA CAGCTCGACC TACTGCAAAA GCGACTGAAG CAGTGCAAGT 3420
GGTACAAGCG CTCGCAGGGA TTGAGGGAGA CCAGCTCGAA GCTGACCTAC CAAGACGTGA 3480
AGAACCTGTT ACACATTGCG GCTGCTGACC TTGATCCCAC GGATCCGTAT GTCGACAAGG 3540
AGATGCGAAA ATTGCAACAG ATCGGTGCAG ATATCGAAGC CTGGGAGTCG CAGGCGGCCA 3600
AGTATTTCCG GCGACTGACC CAACAGCACG AACTGGGCGA AATTGAGCAG TTCTTGAAAT 3660
CGGCCTCCGA CATCAACGGT CAAGTGCCTT CGCATGGACT GCTGAAGGAT GCACTACGAA 3720
AGGCGCGTGA GTGGCTACGG GCCGTTGAGC AGCTACAGCA AAACAACCAC GTCACATATT 3780
GCCACACACT GGAGGCAATG ATCGAGCGCG GCTTGAACAT ACCCATCCAG CTGGAGGAGC 3840
TGAGCCGAAT GCAGGGACAC CTAAATAGTG CACATCAATG GAAGGACAAT ACAGCGTGCG 3900
CCTTCCTCAA GAAGGGCACC TTCTATACGC TCTTGGAGGT TCTCATGCCC CGGTCGGACG 3960
CCATCAACAT AGACTCGGAT CTCAAGCCGC GCTTCCAGGA TGATTTTCTG AAAGAGAAAA 4020
ATCCGGCGGA GATTGTGGCC AGCTTCAAGC ACGCTGAGGA GCAGGAGCTG CTCGATATGC 4080
GCGAACTTCG GCGGCAAAAT ATGAACAAGA ATCCCATGCG CGATATGTTC TGCTTGTGCA 4140
AGTCCGAGTT CCGAAACTTA ATGTTCAATT GTCAGTTGTG CCGCGATTGG TTTCACGAGG 4200
ATTGCGTCCC ACCGCCATCA GCCACAAATC AAAATGGAAT TGTTAACGGC GGATCAGGAC 4260
CAGGTACCAA TCGACCCAAG TGGCTATGTC CGAGCTGTGT GCGCTCGAAG AGACCGCGCC 4320
TAGAAACCAT CCTTCCGCTA CTTGTCCAGC TGCAGCAACT GCCCATCCGT CTGCCCGAGG 4380
ACGAAGCGTT GCGTTGCCTG GCGGAGCGTG CGATGAACTG GCAGGATCGG GCCAGGAAAG 4440
CTCTTAGCAG TCCTGACGTC AGTGCGGCTC AAGAAGCGAT TATGGCGCAG CAGCAGCAGA 4500
AGCGGCGCTC CGAGGGTGGA GCAGGGGTGG GAAATATCAG CAGTCCACGG AAGCCACGTC 4560
GACGGGGGAG CCTGACGAAA GAGGCAAGTG GTTCAACAGA GTCCGATGCC GACGACGATG 4620
ACGACGAGGA CGAATGTCGT CTTCGAATCG TCGAAGACAA CTTTAGTAAC GATGAAGATG 4680
AGCCTCGTAC CGCCCCCGCG ACCTCCACCG TCAACTCCGA TCTCCTCAAG CTGCTGTCCG 4740
ACAGTGAAAT TGAAAATTTG CTTGACCTGA TGATGGAGGG CGACCTGCTA GAGGTATCCT 4800
TAGATGAAAC GCAGGAGCTG TGGCGCATTC TAGAAACGAT GCCGCCCACG TTGCTGCAGG 4860
CGGAGGCCAT GGAGCGTGTT GTCCAGTACA TGCAGCGTCA GCGGCAACAG CATACAAATC 4920
CGCTGCCAAC ATCCGGCGCC GAAGACTCTA ACGATAGTCT GATGGTACAA AATAGTCCCA 4980
ATAGCAACAG CAATAGTGGC GGGGCAACGG GTTCTGCGAG CAACAGCGGA CGCAACAAGA 5040
AGAGGCGCTC CAACGACACC GGCGGCAACT CGGCAGTGCC GCGCAAGAAG CAGAGCACAC 5100
CGAAGCAGAC ACCGGGCAAG AAGGGATCAG CGGCAGCGGC ACGCAAGAGC GATGCCAAGG 5160
CATCGCCAGC AGCATCCACC ACTCCGGGTG CGGATGCCGA TGCCGAGAAT AAGCAGGCCA 5220
ACGGCGGTAA TACGAACTCC AGTACAGGAT CAGGTGGTGG CAATTCTGCG ACGACGACGC 5280
CCACACCCGG CTCGACGCAC AAAAAGCGAA AGCGCACCTC AACCACAGCC ACCAATAATA 5340
ACAACAACAA TAATAATAAC AGCACGAACA ATAGCAACAG CAGTACCAAT TTGAACAGCA 5400
ACACCACCAG CGGCCAGGGA GCAGCTACTG GAGGCAATAA TGCGACTGGC GGTCAGAAGA 5460
AGCACGCGCA ACGGTCTCAA CAGGCGGCGC AGGAGGACGA CGAGGAGGAG TGCCGGGCGG 5520
AGAACTGCCA CAAGCCAACC GGGCGAGAGG TGGACTGGGT GCAGTGCGAC GGCGGCTGCA 5580
ACGAATGGTT CCACATGTAC TGTGTGGGCC TCAATCGCAG CCAGATAAAG CCCGACGACG 5640
ACTATATCTG CATTCGATGC ACAAAGACAG TTGCCATCGG AACACAGGGC TCCGGTCACA 5700
GTATGAGCGT GGCGTCCACG ACGACGCCGG GCAAGCAGCG GGCGGTGCAA TCGGCGCGGT 5760
AGAGTAACGT ATATAGAGTC CAGGAGGTGC AGTAACAGCC GATTGTGTTT TACGCATGAT 5820
GTACTACTAA ATACCCGATA AAGGCCGTCT ACCGGTATTT ACTAAGTTTA GTAAAGTCAC 5880
TTGAGAGTTT TTGTAGTACA TATTTACCAA TTATCGCTAT ATTTACGCAT TAACAACGTA 5940
AAACACATTT GAAAGAAAAC GTCAGAAAAA AAAAAGAAAA GAACTACAAA AAAGAAAACA 6000
GAAGAAAAAT AAGAATCGAG AATAGGGATT AATAATTAAG CAAAAGATAT GAAATGCAAA 6060
CAAAGCAACA CAACTATTTG TTTTTGTACA ATTCAGCCCA TTTTTACGTT CGTTAAACGT 6120
TCTTTTAATT TTATAATATA TTTTACCATT ACCTGCTATT CTTAGTTTTT GTTAATTTAA 6180
TTCACTTTTT GTGTTCGCCT CTCGAGTTTT GGTTCAGTGC GCACGCAAAG TTTTCTTACG 6240
TTTTATTTGA CTTTTTCCTT TAATCAAAGG CGAAGGCGAC TCTCGTTTTA CTTTTGTACA 6300
TTTTTGTTTA CTTAAGGTTG CGAGCAAAAA CCCTCAAACA TTAAGAATCT TCCACTTTTA 6360
CGCGTGGCGC CTTGTAGACT CTCCCTTTCT TTGTATGTTC TTGTTTATTG CCCCAAATTA 6420
AAATATATAA AAAAGAAACA AAAAAAAAAA CGAAAACAAA ATCCTGTTAA TAAAACGATC 6480
ATACAAAAAC TAAAATTCAG TATACATTTA AGTTTACATT TAAAATACAA TGAAAAGTGT 6540
ATAATTTTTA ATTTATAATT AGTAAGTTGA CTAGAAATCC AACAAACGTG GAAGTAAAAA 6600
CAAATTACAA AAAAAAAACG AAACAAAAAA ATTGCAAAAC ATCTTGGTAA TATTAACGTA 6660
CAACAATAAA CACAGTGCTT AGAATTATGC AATTGAAAAA GCAGACAAAA AAACGAAAAA 6720
CACTTTGTAA AATCATTTTT TAAATGTGTA TAAAAACTCA AGCTGACAAA TGTGCAGGTT 6780
CTAATTGCAA GCAACCCAAG ATAAACGTTA ACGGAAACAA AACAGAGCCC TAAACATATT 6840
AAGGATAACA CTTTTATTTC ATTAAGCAGT AATGTACGAT TGATTTCAAT GAATGATCCA 6900
AAAATATAAA AACATTTTCC CTCACGATAC CTTCCCCCAA CAAGATATAT AATTCTATAA 6960
TTTAAATAAA TTATATATAA ATAGTATTTA AAAGAACACG TGTG 7005
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
Gene Ontology

GO:0005634--C:nucleus
GO:0070822--C:Sin3-type complex
GO:0003677--F:DNA binding
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0034647--F:histone demethylase activity (H3-trimethyl-K4 specific)
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0006325--P:chromatin organization
GO:0032922--P:circadian regulation of gene expression
GO:0016577--P:histone demethylation
GO:0034720--P:histone H3-K4 demethylation
GO:0034721--P:histone H3-K4 demethylation, trimethyl-H3-K4-specific
GO:0043970--P:histone H3-K9 acetylation
GO:0007526--P:larval somatic muscle development
GO:0045475--P:locomotor rhythm
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Paa-0010 ENSPANP00000008905.1 Papio anubis 48 0.0 1138
WERAM-Chs-0147 ENSCSAP00000008231.1 Chlorocebus sabaeus 47 0.0 1135
WERAM-Mup-0210 ENSMPUP00000017918.1 Mustela putorius furo 48 0.0 1133
WERAM-Aim-0056 ENSAMEP00000004769.1 Ailuropoda melanoleuca 48 0.0 1132
WERAM-Myl-0067 ENSMLUP00000005634.2 Myotis lucifugus 47 0.0 1131
WERAM-Fec-0141 ENSFCAP00000013303.3 Felis catus 48 0.0 1130
WERAM-Mam-0119 ENSMMUP00000017950.2 Macaca mulatta 47 0.0 1127
WERAM-Poa-0038 ENSPPYP00000004709.1 Pongo abelii 47 0.0 1126
WERAM-Nol-0018 ENSNLEP00000002465.1 Nomascus leucogenys 47 0.0 1125
WERAM-Pat-0036 ENSPTRP00000056131.1 Pan troglodytes 47 0.0 1125
WERAM-Orc-0129 ENSOCUP00000011159.2 Oryctolagus cuniculus 47 0.0 1123
WERAM-Hos-0030 ENSP00000382688.2 Homo sapiens 47 0.0 1123
WERAM-Mod-0172 ENSMODP00000022937.3 Monodelphis domestica 47 0.0 1121
WERAM-Caf-0163 ENSCAFP00000023208.3 Canis familiaris 47 0.0 1120
WERAM-Orn-0119 ENSONIP00000012262.1 Oreochromis niloticus 47 0.0 1118
WERAM-Anc-0002 ENSACAP00000000033.2 Anolis carolinensis 47 0.0 1117
WERAM-Mum-0106 ENSMUSP00000005108.7 Mus musculus 47 0.0 1113
WERAM-Gaa-0205 ENSGACP00000025092.2 Gasterosteus aculeatus 47 0.0 1113
WERAM-Pof-0121 ENSPFOP00000010723.2 Poecilia formosa 46 0.0 1112
WERAM-Tag-0155 ENSTGUP00000013014.1 Taeniopygia guttata 46 0.0 1112
WERAM-Orla-0119 ENSORLP00000014356.1 Oryzias latipes 47 0.0 1111
WERAM-Gaga-0123 ENSGALP00000021168.4 Gallus gallus 46 0.0 1111
WERAM-Soa-0132 ENSSARP00000013044.1 Sorex araneus 47 0.0 1107
WERAM-Ova-0126 ENSOARP00000012800.1 Ovis aries 47 0.0 1107
WERAM-Ict-0017 ENSSTOP00000001099.2 Ictidomys tridecemlineatus 46 0.0 1105
WERAM-Bot-0174 ENSBTAP00000027280.5 Bos taurus 47 0.0 1104
WERAM-Otg-0056 ENSOGAP00000003880.2 Otolemur garnettii 46 0.0 1103
WERAM-Gog-0089 ENSGGOP00000007521.2 Gorilla gorilla 46 0.0 1103
WERAM-Dan-0159 ENSDNOP00000027101.1 Dasypus novemcinctus 46 0.0 1103
WERAM-Eqc-0209 ENSECAP00000022585.1 Equus caballus 46 0.0 1102
WERAM-Fia-0057 ENSFALP00000004074.1 Ficedula albicollis 46 0.0 1100
WERAM-Tut-0063 ENSTTRP00000004859.1 Tursiops truncatus 46 0.0 1100
WERAM-Lac-0120 ENSLACP00000014409.1 Latimeria chalumnae 46 0.0 1090
WERAM-Pes-0046 ENSPSIP00000007266.1 Pelodiscus sinensis 47 0.0 1082
WERAM-Ran-0254 ENSRNOP00000073953.1 Rattus norvegicus 46 0.0 1078
WERAM-Ten-0082 ENSTNIP00000000323.1 Tetraodon nigroviridis 46 0.0 1078
WERAM-Leo-0177 ENSLOCP00000021020.1 Lepisosteus oculatus 46 0.0 1062
WERAM-Caj-0066 ENSCJAP00000011420.1 Callithrix jacchus 45 0.0 1059
WERAM-Anp-0001 ENSAPLP00000000531.1 Anas platyrhynchos 46 0.0 1059
WERAM-Ora-0111 ENSOANP00000021438.1 Ornithorhynchus anatinus 46 0.0 1057
WERAM-Sus-0075 ENSSSCP00000011653.2 Sus scrofa 45 0.0 1053
WERAM-Xet-0049 ENSXETP00000015599.3 Xenopus tropicalis 45 0.0 1043
WERAM-Chh-0061 ENSCHOP00000006896.1 Choloepus hoffmanni 45 0.0 1040
WERAM-Xim-0221 ENSXMAP00000018338.1 Xiphophorus maculatus 44 0.0 1039
WERAM-Mim-0074 ENSMICP00000007161.1 Microcebus murinus 45 0.0 1035
WERAM-Asm-0204 ENSAMXP00000019198.1 Astyanax mexicanus 43 0.0 1034
WERAM-Tar-0003 ENSTRUP00000000685.1 Takifugu rubripes 45 0.0 1031
WERAM-Sah-0049 ENSSHAP00000005524.1 Sarcophilus harrisii 46 0.0 1026
WERAM-Ptv-0043 ENSPVAP00000004523.1 Pteropus vampyrus 44 0.0 1014
WERAM-Gam-0221 ENSGMOP00000021154.1 Gadus morhua 44 0.0 1010
WERAM-Mae-0078 ENSMEUP00000007759.1 Macropus eugenii 43 0.0 1005
WERAM-Pem-0068 ENSPMAP00000007536.1 Petromyzon marinus 44 0.0 1005
WERAM-Cap-0120 ENSCPOP00000009555.2 Cavia porcellus 44 0.0 1004
WERAM-Meg-0012 ENSMGAP00000000890.1 Meleagris gallopavo 44 0.0 991
WERAM-Dar-0006 ENSDARP00000023794.8 Danio rerio 42 0.0 986
WERAM-Loa-0058 ENSLAFP00000004277.3 Loxodonta africana 44 0.0 976
WERAM-Vip-0044 ENSVPAP00000003974.1 Vicugna pacos 49 0.0 890
WERAM-Ere-0114 ENSEEUP00000012051.1 Erinaceus europaeus 48 0.0 874
WERAM-Prc-0127 ENSPCAP00000011494.1 Procavia capensis 48 0.0 872
WERAM-Cii-0031 ENSCINP00000012442.3 Ciona intestinalis 41 0.0 808
WERAM-Cis-0007 ENSCSAVP00000000871.1 Ciona savignyi 42 0.0 764
WERAM-Tas-0106 ENSTSYP00000011121.1 Tarsius syrichta 46 0.0 749
WERAM-Tub-0140 ENSTBEP00000015071.1 Tupaia belangeri 59 0.0 703
WERAM-Dio-0006 ENSDORP00000000973.1 Dipodomys ordii 44 0.0 700
WERAM-Ect-0130 ENSETEP00000014721.1 Echinops telfairi 40 5e-179 626
WERAM-Ocp-0067 ENSOPRP00000005882.1 Ochotona princeps 52 4e-175 613
WERAM-Cae-0018 ZK593.4a Caenorhabditis elegans 37 1e-158 559
WERAM-Aso-0031 CADAORAP00009644 Aspergillus oryzae 35 1e-143 509
WERAM-Asc-0001 CADACLAP00000026 Aspergillus clavatus 34 3e-143 508
WERAM-Asf-0028 CADAFLAP00010689 Aspergillus flavus 35 4e-143 507
WERAM-Asni-0025 CADANGAP00007970 Aspergillus niger 34 1e-139 496
WERAM-Lab-0033 EDR12730 Laccaria bicolor 36 4e-138 491
WERAM-Spr-0023 CBQ72974 Sporisorium reilianum 32 9e-138 489
WERAM-Crn-0020 AAW43237 Cryptococcus neoformans 33 3e-131 468
WERAM-Usm-0016 UM02582P0 Ustilago maydis 35 2e-130 465
WERAM-Miv-0011 MVLG_01737T0 Microbotryum violaceum 36 2e-125 449
WERAM-Amt-0017 ERM95079 Amborella trichopoda 36 9e-121 433
WERAM-Brd-0017 BRADI1G29247.1 Brachypodium distachyon 35 2e-120 432
WERAM-Sei-0018 Si005667m Setaria italica 35 8e-115 413
WERAM-Tum-0032 CAZ86330 Tuber melanosporum 43 8e-115 413
WERAM-Trr-0012 EGR49606 Trichoderma reesei 33 4e-114 411
WERAM-Map-0012 MAPG_04048T0 Magnaporthe poae 32 1e-111 402
WERAM-Asn-0018 CADANIAP00004258 Aspergillus nidulans 32 2e-111 402
WERAM-Asfu-0009 CADAFUAP00002555 Aspergillus fumigatus 39 4e-111 401
WERAM-Ors-0063 OS06T0731600-00 Oryza sativa 29 6e-111 400
WERAM-Pyt-0008 EFQ94561 Pyrenophora teres 31 5e-110 397
WERAM-Scs-0004 EDN96551 Sclerotinia sclerotiorum 30 5e-110 397
WERAM-Gag-0021 GGTG_06066T0 Gaeumannomyces graminis 33 6e-110 397
WERAM-Pytr-0035 EDU44093 Pyrenophora triticirepentis 30 1e-109 396
WERAM-Coi-0029 EAS31076 Coccidioides immitis 40 5e-109 394
WERAM-Mao-0014 MGG_04878T0 Magnaporthe oryzae 32 3e-108 391
WERAM-Trv-0029 EHK20007 Trichoderma virens 41 2e-107 388
WERAM-Ast-0008 CADATEAP00004027 Aspergillus terreus 39 3e-107 388
WERAM-Phn-0021 SNOT_11200 Phaeosphaeria nodorum 31 4e-107 388
WERAM-Sob-0138 Sb10g031260.1 Sorghum bicolor 35 9e-106 383
WERAM-Lep-0069 LPERR06G23820.1 Leersia perrieri 33 7e-104 377
WERAM-Orm-0066 OMERI06G28260.1 Oryza meridionalis 28 2e-103 375
WERAM-Thc-0041 EOY24718 Theobroma cacao 43 3e-102 371
WERAM-Nec-0020 EFNCRP00000004299 Neurospora crassa 36 4e-102 371
WERAM-Lem-0001 CBY01560 Leptosphaeria maculans 31 7e-102 370
WERAM-Met-0120 AES94050 Medicago truncatula 44 1e-101 370
WERAM-Sol-0104 Solyc08g081000.2.1 Solanum lycopersicum 44 1e-101 369
WERAM-Zyt-0030 Mycgr3P74352 Zymoseptoria tritici 39 2e-101 369
WERAM-Tru-0011 TRIUR3_05779-P1 Triticum urartu 42 8e-100 363
WERAM-Aet-0037 EMT30548 Aegilops tauschii 41 2e-99 362
WERAM-Arl-0119 scaffold_200168.1 Arabidopsis lyrata 41 3e-99 362
WERAM-Prp-0007 EMJ11636 Prunus persica 41 2e-98 359
WERAM-Glm-0121 GLYMA11G02580.4 Glycine max 43 4e-98 358
WERAM-Org-0069 ORGLA06G0289500.1 Oryza glaberrima 35 3e-97 355
WERAM-Ved-0033 EGY18973 Verticillium dahliae 31 4e-97 354
WERAM-Brr-0139 Bra027644.1-P Brassica rapa 41 4e-97 354
WERAM-Bro-0173 Bo9g029100.1 Brassica oleracea 40 2e-96 352
WERAM-Orbr-0078 OB06G36110.1 Oryza brachyantha 33 2e-96 352
WERAM-Php-0053 PP1S235_2V6.1 Physcomitrella patens 47 2e-96 352
WERAM-Tra-0285 Traes_7AL_6B05A3754.1 Triticum aestivum 43 3e-95 348
WERAM-Scp-0001 SPAC1002.05c.1:pep Schizosaccharomyces pombe 31 2e-94 345
Created Date 25-Jun-2016