WERAM Information

Tag Content
WERAM ID WERAM-Mum-0106
Ensembl Protein ID ENSMUSP00000005108.7
Uniprot Accession Q3UXZ9; KDM5A_MOUSE; Q3TM94; Q3UMI5; Q66JZ3
Genbank Protein ID NP_666109.2
Protein Name Lysine-specific demethylase 5A
Genbank Nucleotide ID NM_145997.2
Gene Name KDM5A;RBP2;JARID1A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030180.15 ENSMUST00000005108.9 ENSMUSP00000005108.7
ENSMUSG00000030180.15 ENSMUST00000135802.7 ENSMUSP00000145021.1
ENSMUSG00000030180.15 ENSMUST00000132009.3 ENSMUSP00000145375.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JARID Jmjc H3K4 K 26314709; 25015565
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JARID 2.00e-104 348.1 437 603
Me_Reader PHD 3.00e-29 102.5 295 1660
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1.
Domain Profile
  HDM JARID
             JARID.txt   1 eyaesgwnlnnlpvleesvlahinadisgvkvpwlyvgmcfsafcwhvedhwsysinylhfgepkvwygvpgsaaekleevlkklapel 89 
                           eya sgwnlnn+pvle+svlahin+disg+kvpwlyvgmcfs+fcwh+edhwsysinylh+gepk+wygvp++aae+leev+++lapel
  ENSMUSP00000005108.7 437 EYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPEL 525
                           79*************************************************************************************** PP
             JARID.txt  90 fesqpdllhqlvtllnpnilkeegvpvyrtnqkagefvitfprayhsgfnqgfnfaeavnfatvdwlaagreavesys 167
                           fesqpdllhqlvt++npn+l+e+gvpvyrtnq+agefv+tfprayhsgfnqg+nfaeavnf+t+dwl++gr++v++y+
  ENSMUSP00000005108.7 526 FESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYR 603
                           *****************************************************************************7 PP
  Me_Reader PHD
               PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52 
                           +C++Cg+ ++++k ++ Cd+Cdd +H+ C+ +pl  +p+g +w+Cp+C++
  ENSMUSP00000005108.7 295 VCMFCGRGNNEDK-LLLCDGCDDSYHTFCLLPPLPDVPKG-DWRCPKCVA 342
                           8****76666665.**************************.*******86 PP
               PHD.txt    2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg........kswyCpsCke 52  
                            ++C+ C+k+  g  +m+qC+ C+dwfH +Cv+lp+ss +++         +++Cp C++
  ENSMUSP00000005108.7 1162 KFCI-CRKTASG--FMLQCELCKDWFHNSCVPLPKSSSQKKgsswqakdVKFLCPLCMR 1217
                            69*9.*998888..8*******************8888855566666555566****97 PP
               PHD.txt    4 Clv..CgkddegekemvqCde.CddwfHlkCvklplsslpegkswyCpsCke 52  
                            C +  C+++ +++  +vqCd+ Cd+wfH+ Cv+++ + ++++ +++C +C +
  ENSMUSP00000005108.7 1610 CAAqnCQRPCKDKVDWVQCDGgCDEWFHQVCVGVSAEMAENE-DYICINCAK 1660
                            655558777777777********************5555555.9******86 PP
Protein Sequence
(Fasta)		MASVGPGGYA AEFVPPPECP VFEPSWEEFT DPLSFIGRIR PFAEKTGICK IRPPKDWQPP 60
FACEVKTFRF TPRVQRLNEL EAMTRVRLDF LDQLAKFWEL QGSTLKIPVV ERKILDLYAL 120
SKIVASKGGF EIVTKEKKWS KVGSRLGYLP GKGTGSLLKS HYERILYPYE LFQSGVSLMG 180
VQMPDLDLKE KVEAEVLSTD IQPSPERGTR MNIPPKRTRR VKSQSDSGEV NRNTELKKLQ 240
IFGAGPKVVG LAVGAKDKED EVTRRRKVTN RSDAFNMQMR QRKGTLSVNF VDLYVCMFCG 300
RGNNEDKLLL CDGCDDSYHT FCLLPPLPDV PKGDWRCPKC VAEECNKPRE AFGFEQAVRE 360
YTLQSFGEMA DNFKSDYFNM PVHMVPTELV EKEFWRLVSS IEEDVIVEYG ADISSKDFGS 420
GFPKKDGQRK MLPEEEEYAL SGWNLNNMPV LEQSVLAHIN VDISGMKVPW LYVGMCFSSF 480
CWHIEDHWSY SINYLHWGEP KTWYGVPSHA AEQLEEVMRE LAPELFESQP DLLHQLVTIM 540
NPNVLMEHGV PVYRTNQCAG EFVVTFPRAY HSGFNQGYNF AEAVNFCTAD WLPIGRQCVN 600
HYRRLRRHCV FSHEELIFKM AADPECLDVG LAAMVCKELT LMTEEETRLR ESVVQMGVVM 660
SEEEVFELVP DDERQCSACR TTCFLSALTC SCNPERLVCL YHPTDLCSCP MQNKCLRYRY 720
PLEDLPSLLY GVKVRAQSYD TWVNRVTEAL SASFNHKKDL IELRVMLEDA EDRKYPENDL 780
FRKLRDAVKE AETCGSVAQL LLSKKQKHRQ SSDSGKTRTK LTVEELKAFV QQLVSLPCVI 840
SQTRQVKNLL DDVEEFHERA QEAMMDETPD SSKLQMLIDM GSSLYVELPE LPRLKQELQQ 900
ARWLDEVRLT LSDPQQVTLD VMKKLIDSGV GLAPHHAVEK AMAELQELLT VSERWEEKAK 960
VCLQARPRHS MANLENIVNE AKNIPAFLPN VLSLKEALQK AREWTAKVEA IQSGNNYAYL 1020
EQLESLSAKG RPIPVRLDAL PQVESQVAAA RAWRERTGRT FLKKNSSHTL LQVLSPRTDI 1080
GVYGSGKNRR KKVKEIIEKE KEKDLDLEPL SDLEEGLEES RDTAMVVAVF KEREQKEIEA 1140
MHSLRAANLA KMTIVERIEE VKFCICRKTA SGFMLQCELC KDWFHNSCVP LPKSSSQKKG 1200
SSWQAKDVKF LCPLCMRSRR PRLETILSLL VSLQKLPVRL PEGEALQCLT ERAMSWQDKA 1260
RQALATDELS SALAKLSVLS QRMVEQAARE KTEKIISAEL QKAAANPDLQ GHLPSFQQSA 1320
FNRVVSSVSS SPHQTMDYDD EETDSDEDIR ETYGYDMKDT ASVKSSSSLE PNLFCDEEIP 1380
IKSEEVVTHM WTAPSFCAEH AYSSASKSCS QGSSTPRKQP RKSPLVPRSL EPPVLELSPG 1440
AKAQLEELMM VGDLLEVSLD ETQHIWRILQ ATHPPSEDRF LHIMEDDSIE EKPLKMKGKD 1500
SSEKKRKRKL EKVEQLFGEG KQKTKELKKI DKPKKKKLKL NVDKSKELNK LAKKLAKEEE 1560
RKKKKEKAAA AKVELVKEST EKKRERKVLD IPSKYDWSGA EESDDENAVC AAQNCQRPCK 1620
DKVDWVQCDG GCDEWFHQVC VGVSAEMAEN EDYICINCAK KQGPDSPGQA PPPPFLMSYK 1680
LPMEDLKETS
Nucleotide Sequence
(Fasta)		GGAAGCGCGC GTTCCACCTT GCGGGGTAGC TTTTCCCTCG CCTCTCCTCG AGAGAGGTCG 60
CGGCGCCTTG AGGGGCCGCG CACCCGGGGT GGACGGAGGG CGCAGAACTT TGACAGGCAA 120
GCTGTGAGAA AACAAAAAAC CAAAATAAAA CAAAAAAGCT CCGCCGGCCG TCATGGAAGG 180
GAGCGAGGAG AGAAGACCCG ACTAGACGTG GCGGCGGTGG GATTTTGTTT CCTGCGGTGG 240
CGGACTGATT TAGCAGCACG TTAACTTCCG GGAGCGTCCT GCCCCTGAGA GGAAAAGCCC 300
TGAAGGAAAC AATAACAAAC GAGCGGAGGG AGAGCGGCTG GCGCTCCTGT GAGGACTCGT 360
TCTCGTCCTA AGAAGATGCG CTGCGGCCCC AGTGCGGGGA CGTGAGAGGG CTTTGGTGGC 420
CGTCAGCCAA GCCTTTCCTC GCTTGTGCAC CTCAGGCCCC CCTGGCTTTT TATTTTATTT 480
TTTGGTGACC ATGGCGTCCG TGGGCCCGGG GGGCTACGCG GCGGAGTTCG TGCCACCGCC 540
CGAGTGCCCG GTCTTTGAGC CCAGTTGGGA GGAGTTCACA GACCCGCTGA GTTTTATCGG 600
GCGCATCCGG CCCTTTGCGG AGAAAACGGG CATCTGCAAA ATCCGGCCAC CCAAGGATTG 660
GCAACCTCCA TTTGCCTGTG AAGTAAAAAC CTTCCGTTTC ACTCCTAGAG TCCAGCGCCT 720
GAATGAACTT GAGGCAATGA CTAGAGTAAG ATTGGACTTC TTGGATCAAC TGGCAAAATT 780
TTGGGAACTT CAAGGATCTA CATTGAAGAT CCCTGTGGTG GAGAGAAAAA TCCTGGATTT 840
GTATGCTTTA AGCAAGATTG TTGCCAGCAA AGGAGGTTTT GAAATAGTCA CCAAAGAGAA 900
GAAATGGTCT AAAGTGGGTA GCCGCTTGGG ATATCTGCCA GGAAAAGGAA CTGGGTCTCT 960
TTTGAAGTCA CACTATGAAA GAATTCTCTA CCCATATGAA CTTTTCCAAT CTGGTGTCAG 1020
CCTTATGGGT GTACAAATGC CTGATTTAGA TCTTAAAGAA AAAGTTGAGG CTGAGGTTCT 1080
CAGCACTGAC ATCCAGCCTT CCCCAGAGCG GGGAACAAGA ATGAATATTC CACCAAAGAG 1140
AACAAGACGA GTTAAGTCTC AGTCAGACTC TGGAGAAGTA AATAGAAACA CAGAACTGAA 1200
GAAACTTCAG ATTTTTGGGG CTGGACCCAA AGTTGTGGGC CTGGCAGTAG GAGCAAAAGA 1260
TAAAGAAGAT GAAGTCACCC GAAGAAGAAA AGTTACCAAC AGGTCAGATG CATTTAACAT 1320
GCAAATGAGA CAACGGAAAG GAACTCTCTC TGTTAACTTT GTTGATCTCT ATGTTTGCAT 1380
GTTTTGTGGT CGAGGAAATA ATGAGGATAA ACTGCTTTTG TGTGATGGGT GCGATGACAG 1440
CTATCATACA TTTTGTCTAC TTCCACCACT ACCTGATGTC CCCAAAGGAG ACTGGAGGTG 1500
TCCTAAATGT GTTGCTGAGG AATGTAACAA ACCTCGAGAA GCCTTTGGAT TTGAGCAAGC 1560
TGTAAGAGAA TATACACTTC AAAGCTTTGG AGAGATGGCA GATAATTTTA AATCTGATTA 1620
TTTCAATATG CCAGTCCATA TGGTTCCTAC AGAGCTAGTA GAAAAAGAAT TCTGGCGGCT 1680
AGTAAGTAGC ATTGAAGAAG ATGTTATTGT AGAGTATGGA GCTGATATCT CTTCAAAAGA 1740
TTTTGGAAGT GGATTTCCTA AAAAGGATGG TCAAAGAAAG ATGTTGCCAG AAGAAGAGGA 1800
ATATGCACTT TCTGGTTGGA ATTTGAATAA CATGCCTGTT CTGGAGCAGT CCGTTCTTGC 1860
ACATATTAAT GTGGACATTT CTGGTATGAA GGTGCCATGG CTCTATGTGG GAATGTGCTT 1920
TTCTTCTTTT TGCTGGCATA TTGAAGATCA CTGGAGTTAT TCCATTAACT ACTTGCATTG 1980
GGGCGAGCCA AAGACATGGT ATGGTGTACC ATCTCATGCT GCAGAACAAC TGGAGGAGGT 2040
GATGAGGGAG CTGGCCCCTG AGTTATTTGA ATCCCAGCCT GATCTCCTAC ATCAGTTAGT 2100
AACCATCATG AACCCAAATG TGCTCATGGA GCATGGTGTG CCTGTGTACA GGACTAATCA 2160
GTGTGCTGGA GAGTTTGTGG TGACGTTTCC TCGTGCCTAT CACTCTGGAT TTAACCAGGG 2220
ATACAACTTT GCCGAAGCGG TGAACTTCTG TACTGCTGAC TGGTTGCCCA TTGGACGTCA 2280
GTGTGTAAAT CACTATCGAC GGCTCAGGCG CCATTGTGTC TTTTCACATG AGGAACTCAT 2340
TTTCAAGATG GCAGCAGATC CAGAATGCTT AGATGTGGGG CTGGCTGCCA TGGTATGCAA 2400
AGAGTTGACT CTCATGACTG AAGAAGAAAC ACGATTGAGA GAATCAGTTG TTCAAATGGG 2460
TGTCGTGATG TCAGAAGAAG AAGTCTTTGA ACTTGTTCCT GATGATGAGC GGCAGTGTTC 2520
AGCATGCAGA ACTACATGTT TTCTCTCAGC TCTCACATGC TCCTGTAATC CGGAGCGACT 2580
TGTATGTCTG TATCATCCAA CTGATTTGTG CTCTTGCCCC ATGCAGAACA AATGTCTTAG 2640
GTACCGCTAT CCACTAGAAG ACCTTCCATC TCTGCTTTAT GGTGTCAAAG TGAGAGCACA 2700
ATCCTATGAC ACTTGGGTCA ATCGTGTTAC AGAAGCATTG TCAGCTAGCT TCAACCATAA 2760
GAAAGATTTG ATTGAATTGA GAGTAATGCT GGAAGATGCT GAGGATAGGA AATACCCAGA 2820
GAATGATCTC TTTCGAAAGC TCAGGGACGC GGTGAAAGAA GCTGAGACCT GTGGTTCTGT 2880
GGCTCAGCTG CTTCTGAGCA AAAAGCAAAA ACACAGGCAG AGCTCAGATA GTGGGAAGAC 2940
TCGGACCAAA CTGACAGTAG AAGAATTGAA GGCCTTTGTC CAACAACTTG TTAGTCTTCC 3000
GTGTGTCATC AGCCAAACTC GACAAGTAAA GAATCTGCTG GATGATGTAG AAGAATTTCA 3060
TGAACGTGCC CAGGAGGCCA TGATGGATGA AACCCCAGAT TCTTCCAAAC TCCAAATGTT 3120
AATAGACATG GGCTCTAGTC TCTATGTGGA GCTACCTGAA TTGCCCCGAC TAAAGCAAGA 3180
GCTCCAGCAG GCTCGATGGC TGGATGAAGT AAGGCTAACT CTATCAGATC CACAACAAGT 3240
CACTTTGGAT GTCATGAAGA AATTGATTGA CTCTGGCGTA GGCTTGGCAC CTCACCATGC 3300
TGTAGAAAAA GCAATGGCCG AACTACAGGA ACTCCTTACA GTCTCTGAAC GATGGGAAGA 3360
GAAGGCTAAG GTCTGCCTGC AAGCAAGACC TCGGCACAGT ATGGCAAATT TAGAAAATAT 3420
TGTGAATGAA GCCAAGAACA TTCCAGCCTT TCTACCCAAT GTGTTGTCCT TAAAAGAAGC 3480
CTTACAAAAG GCTCGTGAAT GGACAGCTAA AGTGGAAGCT ATTCAGAGTG GCAACAACTA 3540
TGCTTACTTG GAACAGCTTG AGAGCCTATC TGCTAAAGGA CGCCCTATCC CTGTGCGTCT 3600
TGATGCCTTG CCTCAAGTGG AGTCACAGGT AGCAGCAGCA CGGGCCTGGA GAGAACGTAC 3660
TGGGCGGACC TTCCTTAAAA AGAATTCCAG CCATACATTG TTACAGGTGC TAAGTCCACG 3720
AACTGACATT GGTGTATATG GGAGTGGTAA AAACAGGAGG AAAAAGGTAA AAGAAATAAT 3780
AGAAAAAGAA AAGGAGAAGG ACCTCGACCT TGAGCCTTTG AGTGACTTAG AGGAAGGACT 3840
GGAGGAGTCA AGAGATACAG CCATGGTGGT GGCAGTTTTC AAAGAACGAG AGCAAAAGGA 3900
GATTGAAGCC ATGCATTCCC TCAGAGCAGC CAACCTAGCC AAGATGACAA TTGTGGAGCG 3960
CATAGAAGAA GTGAAATTTT GTATTTGCCG CAAGACAGCC AGTGGGTTTA TGCTACAGTG 4020
TGAGCTCTGC AAAGACTGGT TCCATAACAG CTGTGTTCCC CTTCCTAAAT CAAGTTCCCA 4080
GAAAAAGGGA TCCAGCTGGC AGGCTAAAGA TGTAAAATTC CTTTGCCCTC TTTGCATGAG 4140
ATCTCGGAGG CCAAGGCTAG AGACTATTCT GTCACTCCTG GTATCCCTTC AGAAGTTGCC 4200
TGTACGGTTG CCGGAAGGAG AAGCACTGCA GTGTTTGACA GAACGTGCCA TGAGTTGGCA 4260
AGATAAAGCA CGCCAAGCTT TAGCCACAGA TGAACTGTCC TCTGCCCTGG CCAAGCTCTC 4320
TGTGCTAAGC CAGCGTATGG TGGAACAAGC AGCTAGAGAA AAAACTGAAA AGATTATCAG 4380
TGCAGAACTC CAAAAAGCAG CTGCCAATCC AGATTTACAG GGACACTTAC CTAGTTTCCA 4440
GCAGTCTGCT TTTAACCGGG TGGTGAGCAG TGTATCATCT TCCCCCCACC AAACAATGGA 4500
CTATGATGAT GAAGAAACAG ATTCTGATGA AGATATTCGG GAGACATACG GCTATGACAT 4560
GAAGGATACA GCCAGCGTGA AGTCCTCTAG TAGTCTGGAA CCCAATCTCT TTTGTGATGA 4620
AGAGATTCCC ATCAAGTCTG AGGAAGTGGT GACTCACATG TGGACGGCAC CGTCATTCTG 4680
TGCAGAGCAT GCATATTCTT CTGCTTCAAA GAGTTGTTCT CAAGGTTCTA GCACTCCAAG 4740
AAAGCAGCCT CGGAAGAGCC CTTTGGTTCC CAGAAGTTTG GAGCCTCCAG TATTGGAATT 4800
GTCTCCTGGA GCAAAAGCCC AGTTGGAAGA ACTCATGATG GTTGGAGACC TCCTAGAAGT 4860
GTCTCTGGAT GAGACACAAC ACATTTGGCG GATTTTGCAG GCCACACATC CACCCTCAGA 4920
GGACAGATTC TTACATATCA TGGAGGATGA TAGCATAGAA GAGAAACCAT TAAAAATGAA 4980
AGGAAAGGAC TCTTCAGAGA AGAAACGGAA ACGGAAGCTA GAAAAGGTAG AACAGCTTTT 5040
TGGAGAAGGA AAACAGAAGA CCAAGGAGCT AAAGAAAATA GATAAACCTA AAAAGAAGAA 5100
ATTAAAATTA AATGTGGACA AATCAAAAGA GCTGAATAAA TTGGCCAAGA AGTTAGCTAA 5160
AGAAGAAGAG CGAAAGAAAA AGAAAGAAAA GGCTGCTGCC GCCAAAGTGG AGCTTGTGAA 5220
AGAGAGCACG GAGAAGAAAC GGGAGAGGAA GGTGTTGGAT ATCCCCTCAA AGTATGACTG 5280
GTCGGGGGCA GAGGAGTCTG ATGATGAGAA TGCTGTGTGT GCAGCCCAAA ACTGCCAAAG 5340
GCCGTGTAAG GACAAGGTAG ACTGGGTACA GTGTGATGGT GGCTGTGATG AGTGGTTTCA 5400
TCAAGTTTGT GTTGGTGTAT CCGCAGAAAT GGCTGAAAAT GAAGATTACA TCTGTATAAA 5460
CTGTGCAAAG AAGCAGGGGC CAGATAGCCC AGGCCAAGCA CCACCTCCTC CCTTCCTAAT 5520
GAGCTACAAA CTACCAATGG AGGATCTTAA AGAGACCAGT TAGCAGATGT CTGGTTAGCT 5580
TGCAACATGG GGGGAAGTGG ACCACATTGA GACCTTACTC ATCAAGCAGA GTGGTTCCGA 5640
CCACTCAGAA TGTTGTTTCC AAAGATGAAT GGACTTCAGA AAAAGTCCTC TTAGTGCTGG 5700
CTTCCTCTCT GCATGGATTG TGTGGGCTCC ATTCTCTTAT CATCTGTGCA GAGGATGTCT 5760
TCTTTGGTGC AGCAGCCAAG TATTTCAACT CTTGATTCGT TGAGTGTGGT TTGCTGAATT 5820
AAGGTCAGGT TCTAATGGAA CTCTCAGGAG GCTGTTTGGC ATTAATACAT TGATGTGCTT 5880
AGTGGGGCAT ATAAGAAGTG GCTTTCGACC AACTGATACT TGTTGTAGAC GGTTACAACC 5940
TACAGGTGGT GCCATTGGAA GGCCCTGACC GTTTAAATAT CCTTAGTTAG GATAATTGGA 6000
CAGGAGTCAG AGCACAACTT TGTAATTACT GACATTTATG CCCTACTGAT CCAGTTAAGA 6060
GAAGCAGGCC AAAGTTATCC CTTCTAGAAG TCTTGGAGTG GCAGTGCAGT CTATGACCTC 6120
AGCTGCTTGT GTTTATTTAG ACCAATAAGA AAATCCTCCA AAAGATCCCC TCACTTTCCT 6180
CAGGAGGATG TCAAGCAGGT TAGAATATCT GATTAGACTG GATTCTGGGA AGAAGGGGTT 6240
TTTTTTTTGT TTGTTTGTTT GGTTTGGTTT GGTTTTTTCT TACTTCAAGG CAAGTAGGCC 6300
ATTGGTTTGA GAAGTCCATC TGGGTCTGTG TTTTAGAAAA GAAAGGTAGG TACACAGATC 6360
CAGGTTTCTG GAGGGAGTAG GGATGACTAA TGAGAATGTT TTACTGAGCC TCGGTGATGC 6420
ATGCTTATCT GGGAAACCCT CATTCACAAG TATTCCAGAC TCCACCATGC TTCACGCATG 6480
GCCATGAGCA AGACTGGCAG ATAACAGCTT TTGCCTTGCA GCCCTAACCC CAATGCCTGT 6540
AGTTTCCAAC ATGGCCTCAG CAGATATTTG TGAATAACAC CATGGCTTCA TCAGAGGATG 6600
TGGGGCTGTA GGTCCTCTGG GTGTGAAGCT GTTCTAGTAA ACCCATTTTT AAAAAGAAAG 6660
ACTTGTTTTT ACTTTTTTCT AAATGTCTCT GACTACTGAC TGTTCTATAG ATTATTTTTC 6720
CTTTTTTGAT ATACATATAT GAATATAGAT ATATATATAT ATATTTACTG TTACCAGCAG 6780
CGTATGATAG AGTTTGAGCA TCAGAAATCC ATTTGGAAGC TTGCATTTTC TTTCTGCTTT 6840
TTGATAAAGA AATCCCATTC CTTCCTTGTA GTACAAGGAG TTAGCACTTC CTTCTTCATT 6900
CTCACCTAAA CATATCTTCC ACTTTTCTTC TATTCAAATA GATAATATAT TTCCTCCATG 6960
TTGGGACTTG TCCCTGTCTG TTGGGCAGCT TGGTCTTATT CTAGTCAGTG CTGAATGTTT 7020
TGTATGTCTG AAACTATGGT GCTGTGCCCC CCCCCCCTGC CCCTATTGGG TTCTGTGTTC 7080
TTACAAAGGT CTTAGGTGGA CTCTGTAAAC TCCTGCTAGA AGGAGAATAA TATATTTTAA 7140
AGGACAAAAA GGTTTTCTAA AAATGGTGTT TATCTTCACT ATCCTTTGTT CTTTATTTTG 7200
GTTTAAGAAT CTGCAATTTA ACTTAAACTC ATCACTTGTC CTGTTAAAGG GGCATTGAGC 7260
AAACCTAGGA AGTTTGTAGC CTCTGTTCCC CTTTACTCCA GTCTCTTAAA TAAATGTCTT 7320
CTAGTAACTA GAAGTGAGAT GTACTGTCCA GTTACAGACT GTGTGGGTAT GAGGGCTACC 7380
TCAAAAGGCA TCTTAGGAAA AGAAAAGGTT TTCTTACAAA ACCCTTTATC CCAAGTGCTA 7440
ACCAGGCTTG GCCCTGCTTA GCTTCCAAGG TCAGAGGAGA CATACACGTG CAGGTGGTAC 7500
GGCTATAGGT ACAACATCCA ATTTCTGAAA ATACTTTCTC TGGTTTATAC TACCTACTTT 7560
TTGGTCTCTT CACTTAATGT TAAGTAACAT ATCTTGACCA GTTATGTTGT TTGAATGTGT 7620
TGCTGTGCTT GTATCTTGAA TTTCCATCTC AATGTGAGTG TGAGCTAAGA TTTCAGTAAT 7680
GGTTACAAGG TTAATTAAGT AAATAGTTAA TTTCACACAT TTTCATTTTG CCAAACATGA 7740
AGATTATCAC GTAAGAATTT TATTTGGTTA TTGTTATAAT GAAAAAAAGC ACAATATTTC 7800
TTAACTTTTA GTCTTTGTAA AAGACTTGAG ATACTTGTGG TTTAAAATTG AGTGTACACC 7860
AACCCTTCAG AAATTTACAA TGTAAGTGAT AGAATCCCAG AATACATTTT ACAATTTTGA 7920
TTTTCCTTCC AGTTAACTAC TTTTCATTAA CTGTGTTATC AATAGTAAGG AGTCATGAGG 7980
ATACTGAAAG GTGACTGTTT TGAGTAATTT GTGTTCTTTG TACAGTGTTT GTCTGTTGGA 8040
GACCTCAGAC ATAGGCAGTC TGTACCTGTG AATAGCTGCC TGTCATCTTC TGATGTTTTG 8100
AAACTTTTAA ATATATAATT TAATTGATTC ATTCGGCTCT TCTGTACTTA TTTGAAGACT 8160
TTGATATCTT AACCATAGAT TTAGACAAAA ACTCAAAAGA CCATAAGGGA GGGGGTGGAA 8220
AGATGACTCA ACGGTTAAGA ATCCTGGCTG CTCTTCCAGA GGACCCAGGT TCAGTTCTCA 8280
GCACTACATG GTGGCTCACA GCCATCTGTA ATGTCCTCTT CTGGACGTTA CTGCACTGTA 8340
CACATGTGGC ATACAGACAT CTATTCTGGA AAATACTCAA AACACAAATA CAAGTAATTA 8400
AAATCTTTTT TTAAAAAATT AAGGATATAA GAGAAACTAG CACTCTACCC ACAAATTAAA 8460
AACCCTATAG TTTGTGAGTT AATGAAATAA AGAGTCATCT ATTTAAGGAA AAGTAGATGT 8520
TCTAATGTAA AGCTTTGTTT CACAAGAATT GCAAGTAACT CCATTCTTCT GTACTGTTTG 8580
TTTACATTTT GTATTAAAAC TTGATTTATG TTTCTTTCTG ACTCCTCAAA GTTGCACTTC 8640
TTCGTTATTA AGTGTTTAAT ATTTTTTAAG CTATTTCTCA CTGCCTTCAT TATACTTTAA 8700
CAAAGGTAAC GGAATGAAAA AAGTTGGAAG TCTGCCTGGT GTTTTGGCAC ACACACTAAG 8760
TCCTAGCACT TGGGAGTCAG AGGCAGAAGA TTTAAGTCCA GTGAGTTCTA CACTAGCCAG 8820
GGCTACATAA TAAGAAAGAA AAGAAAAGGT AGTAGGTCAT TTAGAACTCT ACAGAAATAC 8880
AAGGTAGCAG TCGTTACAGG TCCCTAGTTG TTGGAGAAGA GGCAGATGTT TGTTTCACCT 8940
CCTGTTATTG CTGCAGAAAC CATGAGCAGT GGCTGCTGTG AACCAGCTCT GCCTGGCTGA 9000
CTCTGACTTG AGCCGCAGTG AGATTATGAA TTACAGTGTG GCATACTTAG AAGAACTGGG 9060
AGGCAAACAT TCAATCTGTG ATTGCCCATG ACCTGAGGAA CATGGCAGAC ACTGCCAGAT 9120
CTGAGAGATG GATGTGATTT CACAAGTCCT TCCCTTCCTT TCCAGCTCCG CCTTTGGTCC 9180
TCAACAGGGT CCAAGAAATG TCAATTTGTT TTTCTTAGTT TGCTGGACAC AGTTCAGTGA 9240
ATATAAAGAA ACTGCTTGTC AGCTGGGCAT GGTAGTATAT ACTTAATCCT GGCACTCGGG 9300
AGACATAGGC AGATTGGTCT ATATAGTGTG TTCTAAGACA GCCAGAGCTG CATAATAGAA 9360
CTTGTCACCA AAAAAAAAAA AAAAAAAGGA AAAGAAACTG CCTGTCAGCC ATTAAAATAG 9420
AAATAATGGA AAAATAAAGC CTGCCTTTTG CCAAGCAGTT ATGAAGCACA CCTTTATTTC 9480
CAGCACTCAG GAGCCAGAGG CAGGAGGATC TTTCTTGAGT TCGAGGCCTG TCTGGTATAC 9540
AGAACTTGTT CAAGAGCAGC CAAAGCTACA GAGAGACCCT GCCTTTCAAA AGGTTACATC 9600
AGAATACTTT TGGGAGAAAG TAACAATTTG GAGTGGGTTT TGAAAATTGC AAGGTGTAAA 9660
GATTTTAAGT TGTTTAAGTC CCAAATAACC CTAAACCAAG TCCAATGAAG TTTCATTTAT 9720
GAAGTTTCAA ATGTGAATTC GCTTTATGTG TGTAGAATGT TGCTTTTAGC GTAGGTCCTT 9780
GAGCACAGTA CCTTTCAGAC ATCCTGTCCC TTTAAATCAA ACCACACCGT TACTTTGAAT 9840
ATGGATTTAC TACGTGGTAT TTATAGCACA AGAGGGAAAG AATGGACTTT GATGTCTGAG 9900
ACTGGAGTAT TCTCTTGGCC GGGATCCACT CACCGCTGTG CGGCATAGGA TGTGCACCGG 9960
GAAGGGACAC AACATCTTAT ACAATGATAT GTCTGTCTAA ACAGGAATAT ATTTTAAGAA 10020
CTTGAACCTC CCCCGGTTGA TGATTCCCTT ACATGTTCAT TAAATTTTAC CAGGGTTTTT 10080
GGTTGTGTGT AAGAGTAACT TTTAGTCGTC TGGCTTAATT GTTCTCAGGC TTACTGCCTC 10140
CCTCTGCTAA CCTAAGCTTA GAATATATTC ACCTCCGAGA CTTTGTGCTT GCCCTTTCTA 10200
GCTCTTTGTG AACTCTGGCT TTACTCTCTG CTCTGCTTGA ATTGCTCTGC TAACTCTAGC 10260
AATCTGTTCC AAACTTCTGG CTCCTTTTCA TTCTCTGGCT CATTCTGTCT TCACCTGTCT 10320
CTGTAAAATT AACTCTCCCA GTAAACTGCC TCTGAATTCC ACGAACTCAG CTCCACTGCC 10380
TGCCTTTGAA CTGACTCAAC CGAAATGACT AAAGAGAACT AACTAGCACT GAGAAATCTG 10440
CATGCCTCTC TCTCCTGAGG GCTGGGATTA AGAGTGTGTA CCCCCACGTC TGGACTTGAG 10500
CTTCTTGTTA CCTGAAGTTT GCTGTGTACC AGGCTGGCCT TGAATCCAGA GATCTGTTTG 10560
TCTATGTCTC TGGGATTAAA GGCATGTCTG TATTCCAGCC AGATCACAGA GACCTAGAAG 10620
GTCTTTGGAT GTGATCTCTT GGCAGAGCAG CCATGTTCTG AATTAAAATT ACTCCACAGT 10680
TGTGCCTTAC AGAAATTGTA ACTTGATTTC ATGATGTTTG AGCATCTGGT TTTTTGTTTT 10740
TTGTTTTTGT CTGAACTGTA GCTAATTTTA CTACATTGTT TGCCATTATG TCTGTGCTCA 10800
AGATTCCCCA CCCAACTCTC AGCCAATCCC ATTATTTGTA TTGGTGGTGA TTTCAAATGG 10860
TTACCAAGTA AATGTAAATT CTAGAATGAG TACTGAAAAT CCTGAGGAAA AATAGCCAAT 10920
AAACAGGAGC CACTTTTAAC CAGG 10945
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0223--Dioxygenase
KW-0903--Direct protein sequencing
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
Gene Ontology

GO:0019907--C:cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0032993--C:protein-DNA complex
GO:0003682--F:chromatin binding
GO:0031490--F:chromatin DNA binding
GO:0003677--F:DNA binding
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0032922--P:circadian regulation of gene expression
GO:0034720--P:histone H3-K4 demethylation
GO:0008584--P:male gonad development
GO:1901726--P:negative regulation of histone deacetylase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Nol-0018 ENSNLEP00000002465.1 Nomascus leucogenys 97 0.0 2962
WERAM-Poa-0038 ENSPPYP00000004709.1 Pongo abelii 97 0.0 2945
WERAM-Hos-0030 ENSP00000382688.2 Homo sapiens 97 0.0 2943
WERAM-Fec-0141 ENSFCAP00000013303.3 Felis catus 95 0.0 2942
WERAM-Orc-0129 ENSOCUP00000011159.2 Oryctolagus cuniculus 94 0.0 2939
WERAM-Pat-0036 ENSPTRP00000056131.1 Pan troglodytes 96 0.0 2935
WERAM-Aim-0056 ENSAMEP00000004769.1 Ailuropoda melanoleuca 97 0.0 2933
WERAM-Myl-0067 ENSMLUP00000005634.2 Myotis lucifugus 96 0.0 2922
WERAM-Bot-0174 ENSBTAP00000027280.5 Bos taurus 95 0.0 2920
WERAM-Soa-0132 ENSSARP00000013044.1 Sorex araneus 95 0.0 2915
WERAM-Caf-0163 ENSCAFP00000023208.3 Canis familiaris 96 0.0 2910
WERAM-Ova-0126 ENSOARP00000012800.1 Ovis aries 95 0.0 2909
WERAM-Eqc-0173 ENSECAP00000019283.1 Equus caballus 96 0.0 2899
WERAM-Otg-0005 ENSOGAP00000000280.2 Otolemur garnettii 95 0.0 2865
WERAM-Tut-0099 ENSTTRP00000008413.1 Tursiops truncatus 94 0.0 2864
WERAM-Paa-0010 ENSPANP00000008905.1 Papio anubis 92 0.0 2862
WERAM-Mup-0210 ENSMPUP00000017918.1 Mustela putorius furo 97 0.0 2861
WERAM-Mam-0119 ENSMMUP00000017950.2 Macaca mulatta 93 0.0 2852
WERAM-Chs-0147 ENSCSAP00000008231.1 Chlorocebus sabaeus 97 0.0 2841
WERAM-Gaga-0123 ENSGALP00000021168.4 Gallus gallus 91 0.0 2823
WERAM-Tag-0155 ENSTGUP00000013014.1 Taeniopygia guttata 88 0.0 2794
WERAM-Pes-0046 ENSPSIP00000007266.1 Pelodiscus sinensis 91 0.0 2781
WERAM-Mod-0172 ENSMODP00000022937.3 Monodelphis domestica 95 0.0 2773
WERAM-Anc-0002 ENSACAP00000000033.2 Anolis carolinensis 89 0.0 2773
WERAM-Anp-0001 ENSAPLP00000000531.1 Anas platyrhynchos 91 0.0 2767
WERAM-Chh-0061 ENSCHOP00000006896.1 Choloepus hoffmanni 92 0.0 2745
WERAM-Caj-0077 ENSCJAP00000012842.1 Callithrix jacchus 96 0.0 2728
WERAM-Dan-0105 ENSDNOP00000012063.3 Dasypus novemcinctus 96 0.0 2712
WERAM-Ptv-0043 ENSPVAP00000004523.1 Pteropus vampyrus 90 0.0 2701
WERAM-Loa-0097 ENSLAFP00000008306.3 Loxodonta africana 90 0.0 2551
WERAM-Sah-0178 ENSSHAP00000018525.1 Sarcophilus harrisii 93 0.0 2506
WERAM-Fia-0057 ENSFALP00000004074.1 Ficedula albicollis 91 0.0 2455
WERAM-Meg-0132 ENSMGAP00000014160.2 Meleagris gallopavo 82 0.0 2410
WERAM-Gog-0048 ENSGGOP00000004481.2 Gorilla gorilla 97 0.0 2285
WERAM-Xet-0029 ENSXETP00000007871.4 Xenopus tropicalis 77 0.0 2257
WERAM-Orn-0119 ENSONIP00000012262.1 Oreochromis niloticus 75 0.0 2164
WERAM-Asm-0193 ENSAMXP00000018348.1 Astyanax mexicanus 74 0.0 2163
WERAM-Gaa-0205 ENSGACP00000025092.2 Gasterosteus aculeatus 75 0.0 2159
WERAM-Leo-0177 ENSLOCP00000021020.1 Lepisosteus oculatus 75 0.0 2155
WERAM-Xim-0048 ENSXMAP00000004574.1 Xiphophorus maculatus 75 0.0 2129
WERAM-Pof-0121 ENSPFOP00000010723.2 Poecilia formosa 74 0.0 2129
WERAM-Orla-0119 ENSORLP00000014356.1 Oryzias latipes 74 0.0 2125
WERAM-Lac-0117 ENSLACP00000014279.1 Latimeria chalumnae 74 0.0 2060
WERAM-Ora-0095 ENSOANP00000017333.1 Ornithorhynchus anatinus 79 0.0 2004
WERAM-Cap-0148 ENSCPOP00000012388.2 Cavia porcellus 96 0.0 1997
WERAM-Tar-0025 ENSTRUP00000005009.1 Takifugu rubripes 75 0.0 1887
WERAM-Ten-0082 ENSTNIP00000000323.1 Tetraodon nigroviridis 73 0.0 1830
WERAM-Dar-0234 ENSDARP00000134924.1 Danio rerio 76 0.0 1678
WERAM-Prc-0003 ENSPCAP00000000272.1 Procavia capensis 93 0.0 1660
WERAM-Ict-0017 ENSSTOP00000001099.2 Ictidomys tridecemlineatus 56 0.0 1440
WERAM-Vip-0105 ENSVPAP00000009684.1 Vicugna pacos 88 0.0 1438
WERAM-Sus-0075 ENSSSCP00000011653.2 Sus scrofa 56 0.0 1404
WERAM-Ran-0254 ENSRNOP00000073953.1 Rattus norvegicus 54 0.0 1374
WERAM-Mae-0078 ENSMEUP00000007759.1 Macropus eugenii 55 0.0 1362
WERAM-Mim-0074 ENSMICP00000007161.1 Microcebus murinus 53 0.0 1359
WERAM-Ocp-0067 ENSOPRP00000005882.1 Ochotona princeps 90 0.0 1335
WERAM-Gam-0221 ENSGMOP00000021154.1 Gadus morhua 54 0.0 1333
WERAM-Pem-0068 ENSPMAP00000007536.1 Petromyzon marinus 53 0.0 1308
WERAM-Tas-0091 ENSTSYP00000009583.1 Tarsius syrichta 96 0.0 1290
WERAM-Dio-0108 ENSDORP00000010702.1 Dipodomys ordii 95 0.0 1218
WERAM-Cis-0007 ENSCSAVP00000000871.1 Ciona savignyi 48 0.0 1207
WERAM-Ere-0114 ENSEEUP00000012051.1 Erinaceus europaeus 58 0.0 1166
WERAM-Drm-0042 FBpp0311492 Drosophila melanogaster 47 0.0 1093
WERAM-Cii-0031 ENSCINP00000012442.3 Ciona intestinalis 49 0.0 1085
WERAM-Ect-0130 ENSETEP00000014721.1 Echinops telfairi 53 0.0 931
WERAM-Tub-0140 ENSTBEP00000015071.1 Tupaia belangeri 68 0.0 801
WERAM-Cae-0018 ZK593.4a Caenorhabditis elegans 36 1e-155 549
WERAM-Lab-0033 EDR12730 Laccaria bicolor 33 1e-142 505
WERAM-Crn-0020 AAW43237 Cryptococcus neoformans 29 7e-134 476
WERAM-Usm-0016 UM02582P0 Ustilago maydis 31 4e-130 464
WERAM-Spr-0023 CBQ72974 Sporisorium reilianum 30 7e-126 450
WERAM-Amt-0017 ERM95079 Amborella trichopoda 31 3e-122 438
WERAM-Arl-0119 scaffold_200168.1 Arabidopsis lyrata 31 3e-120 431
WERAM-Pytr-0035 EDU44093 Pyrenophora triticirepentis 29 3e-120 431
WERAM-Tum-0032 CAZ86330 Tuber melanosporum 34 4e-120 431
WERAM-Miv-0011 MVLG_01737T0 Microbotryum violaceum 35 8e-119 426
WERAM-Pyt-0008 EFQ94561 Pyrenophora teres 29 6e-118 423
WERAM-Coi-0029 EAS31076 Coccidioides immitis 35 4e-117 421
WERAM-Met-0120 AES94050 Medicago truncatula 31 4e-117 421
WERAM-Sei-0018 Si005667m Setaria italica 29 4e-116 417
WERAM-Brd-0017 BRADI1G29247.1 Brachypodium distachyon 30 1e-115 416
WERAM-Asc-0001 CADACLAP00000026 Aspergillus clavatus 35 2e-114 412
WERAM-Asn-0018 CADANIAP00004258 Aspergillus nidulans 33 1e-113 409
WERAM-Asfu-0009 CADAFUAP00002555 Aspergillus fumigatus 34 3e-113 408
WERAM-Ast-0008 CADATEAP00004027 Aspergillus terreus 34 4e-112 404
WERAM-Asni-0025 CADANGAP00007970 Aspergillus niger 34 7e-112 403
WERAM-Asf-0028 CADAFLAP00010689 Aspergillus flavus 34 1e-111 402
WERAM-Aso-0031 CADAORAP00009644 Aspergillus oryzae 34 1e-111 402
WERAM-Bro-0173 Bo9g029100.1 Brassica oleracea 29 1e-107 389
WERAM-Phn-0021 SNOT_11200 Phaeosphaeria nodorum 33 1e-107 389
WERAM-Lem-0001 CBY01560 Leptosphaeria maculans 29 2e-107 389
WERAM-Zyt-0030 Mycgr3P74352 Zymoseptoria tritici 31 2e-107 388
WERAM-Scs-0004 EDN96551 Sclerotinia sclerotiorum 33 2e-106 385
WERAM-Sem-0146 EFJ11616 Selaginella moellendorffii 39 9e-105 380
WERAM-Ors-0063 OS06T0731600-00 Oryza sativa 30 1e-103 376
WERAM-Mao-0014 MGG_04878T0 Magnaporthe oryzae 32 3e-103 374
WERAM-Php-0054 PP1S235_45V6.1 Physcomitrella patens 38 2e-102 372
WERAM-Brr-0139 Bra027644.1-P Brassica rapa 31 5e-102 370
WERAM-Glm-0009 GLYMA01G42890.2 Glycine max 32 1e-101 369
WERAM-Thc-0041 EOY24718 Theobroma cacao 32 2e-101 369
WERAM-Trr-0012 EGR49606 Trichoderma reesei 32 1e-100 366
WERAM-Sob-0138 Sb10g031260.1 Sorghum bicolor 37 2e-100 365
WERAM-Map-0012 MAPG_04048T0 Magnaporthe poae 33 2e-100 365
WERAM-Prp-0007 EMJ11636 Prunus persica 32 1e-99 363
WERAM-Gag-0021 GGTG_06066T0 Gaeumannomyces graminis 33 4e-99 361
WERAM-Sol-0104 Solyc08g081000.2.1 Solanum lycopersicum 32 4e-98 358
WERAM-Trv-0029 EHK20007 Trichoderma virens 30 9e-98 357
WERAM-Orm-0066 OMERI06G28260.1 Oryza meridionalis 37 3e-96 352
WERAM-Aet-0037 EMT30548 Aegilops tauschii 31 1e-95 349
WERAM-Org-0069 ORGLA06G0289500.1 Oryza glaberrima 37 2e-95 348
WERAM-Lep-0069 LPERR06G23820.1 Leersia perrieri 37 4e-95 348
Created Date 25-Jun-2016