WERAM Information

Tag Content
WERAM ID WERAM-Hos-0030
Ensembl Protein ID ENSP00000382688.2
Uniprot Accession P29375; KDM5A_HUMAN; A8MV76; Q4LE72; Q86XZ1
Genbank Protein ID NP_001036068.1
Protein Name Lysine-specific demethylase 5A
Genbank Nucleotide ID NM_001042603.2
Gene Name KDM5A;RBP2;JARID1A;RBBP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000073614.11 ENST00000399788.6 ENSP00000382688.2
ENSG00000073614.11 ENST00000382815.8 ENSP00000372265.5
ENSG00000073614.11 ENST00000544760.1 ENSP00000440622.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDM JARID Jmjc H3K4me1/2/3 K 20951770; 20951770; 24172249; 20889125
Me_Reader PHD PHD1 H3K4me0; H3K4me3 K 26496625
Status Reviewed
Classification
Type Family E-value Score Start End
HDM JARID 3.50e-104 348.2 437 603
Me_Reader PHD 7.10e-30 105.2 295 1660
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
Domain Profile
  HDM JARID
          JARID.txt   1 eyaesgwnlnnlpvleesvlahinadisgvkvpwlyvgmcfsafcwhvedhwsysinylhfgepkvwygvpgsaaekleevlkklapelfes 92 
                        eya sgwnlnn+pvle+svlahin+disg+kvpwlyvgmcfs+fcwh+edhwsysinylh+gepk+wygvp++aae+leev+++lapelfes
  ENSP00000382688.2 437 EYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFES 528
                        79****************************************************************************************** PP
          JARID.txt  93 qpdllhqlvtllnpnilkeegvpvyrtnqkagefvitfprayhsgfnqgfnfaeavnfatvdwlaagreavesys 167
                        qpdllhqlvt++npn+l+e+gvpvyrtnq+agefv+tfprayhsgfnqg+nfaeavnf+t+dwl++gr++v++y+
  ENSP00000382688.2 529 QPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYR 603
                        **************************************************************************7 PP
  Me_Reader PHD
            PHD.txt   3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsCke 52 
                        +C++Cg+ ++++k ++ Cd+Cdd +H+ C+ +pl  +p+g +w+Cp+C++
  ENSP00000382688.2 295 VCMFCGRGNNEDK-LLLCDGCDDSYHTFCLIPPLPDVPKG-DWRCPKCVA 342
                        8****76666665.**************************.*******86 PP
            PHD.txt    2 tiClvCgkddegekemvqCdeCddwfHlkCvklplsslpeg........kswyCpsCke 52  
                         ++C+ C+k+  g  +m+qC+ C+dwfH +Cv+lp+ss +++         +++Cp C++
  ENSP00000382688.2 1162 KFCI-CRKTASG--FMLQCELCKDWFHNSCVPLPKSSSQKKgsswqakeVKFLCPLCMR 1217
                         69*9.*998888..8*******************8888855566666555577****97 PP
            PHD.txt    4 Clv..CgkddegekemvqCde.CddwfHlkCvklplsslpegkswyCpsCke 52  
                         C +  C+++ +++  +vqCd+ Cd+wfH+ Cv+++ + ++++ +++C +C +
  ENSP00000382688.2 1610 CAAqnCQRPCKDKVDWVQCDGgCDEWFHQVCVGVSPEMAENE-DYICINCAK 1660
                         655558777777777********************5555555.9******86 PP
Protein Sequence
(Fasta)		MAGVGPGGYA AEFVPPPECP VFEPSWEEFT DPLSFIGRIR PLAEKTGICK IRPPKDWQPP 60
FACEVKSFRF TPRVQRLNEL EAMTRVRLDF LDQLAKFWEL QGSTLKIPVV ERKILDLYAL 120
SKIVASKGGF EMVTKEKKWS KVGSRLGYLP GKGTGSLLKS HYERILYPYE LFQSGVSLMG 180
VQMPNLDLKE KVEPEVLSTD TQTSPEPGTR MNILPKRTRR VKTQSESGDV SRNTELKKLQ 240
IFGAGPKVVG LAMGTKDKED EVTRRRKVTN RSDAFNMQMR QRKGTLSVNF VDLYVCMFCG 300
RGNNEDKLLL CDGCDDSYHT FCLIPPLPDV PKGDWRCPKC VAEECSKPRE AFGFEQAVRE 360
YTLQSFGEMA DNFKSDYFNM PVHMVPTELV EKEFWRLVSS IEEDVIVEYG ADISSKDFGS 420
GFPVKDGRRK ILPEEEEYAL SGWNLNNMPV LEQSVLAHIN VDISGMKVPW LYVGMCFSSF 480
CWHIEDHWSY SINYLHWGEP KTWYGVPSHA AEQLEEVMRE LAPELFESQP DLLHQLVTIM 540
NPNVLMEHGV PVYRTNQCAG EFVVTFPRAY HSGFNQGYNF AEAVNFCTAD WLPIGRQCVN 600
HYRRLRRHCV FSHEELIFKM AADPECLDVG LAAMVCKELT LMTEEETRLR ESVVQMGVLM 660
SEEEVFELVP DDERQCSACR TTCFLSALTC SCNPERLVCL YHPTDLCPCP MQKKCLRYRY 720
PLEDLPSLLY GVKVRAQSYD TWVSRVTEAL SANFNHKKDL IELRVMLEDA EDRKYPENDL 780
FRKLRDAVKE AETCASVAQL LLSKKQKHRQ SPDSGRTRTK LTVEELKAFV QQLFSLPCVI 840
SQARQVKNLL DDVEEFHERA QEAMMDETPD SSKLQMLIDM GSSLYVELPE LPRLKQELQQ 900
ARWLDEVRLT LSDPQQVTLD VMKKLIDSGV GLAPHHAVEK AMAELQELLT VSERWEEKAK 960
VCLQARPRHS VASLESIVNE AKNIPAFLPN VLSLKEALQK AREWTAKVEA IQSGSNYAYL 1020
EQLESLSAKG RPIPVRLEAL PQVESQVAAA RAWRERTGRT FLKKNSSHTL LQVLSPRTDI 1080
GVYGSGKNRR KKVKELIEKE KEKDLDLEPL SDLEEGLEET RDTAMVVAVF KEREQKEIEA 1140
MHSLRAANLA KMTMVDRIEE VKFCICRKTA SGFMLQCELC KDWFHNSCVP LPKSSSQKKG 1200
SSWQAKEVKF LCPLCMRSRR PRLETILSLL VSLQKLPVRL PEGEALQCLT ERAMSWQDRA 1260
RQALATDELS SALAKLSVLS QRMVEQAARE KTEKIISAEL QKAAANPDLQ GHLPSFQQSA 1320
FNRVVSSVSS SPRQTMDYDD EETDSDEDIR ETYGYDMKDT ASVKSSSSLE PNLFCDEEIP 1380
IKSEEVVTHM WTAPSFCAEH AYSSASKSCS QGSSTPRKQP RKSPLVPRSL EPPVLELSPG 1440
AKAQLEELMM VGDLLEVSLD ETQHIWRILQ ATHPPSEDRF LHIMEDDSME EKPLKVKGKD 1500
SSEKKRKRKL EKVEQLFGEG KQKSKELKKM DKPRKKKLKL GADKSKELNK LAKKLAKEEE 1560
RKKKKEKAAA AKVELVKEST EKKREKKVLD IPSKYDWSGA EESDDENAVC AAQNCQRPCK 1620
DKVDWVQCDG GCDEWFHQVC VGVSPEMAEN EDYICINCAK KQGPVSPGPA PPPSFIMSYK 1680
LPMEDLKETS
Nucleotide Sequence
(Fasta)		GCAGAACTTT GGCGGGCAAG GAGACAAACA GCCACACTGT GCTGCCGGGG AAGAGAAGAA 60
GAAGGAAAGG CCAGACACAC AGGCGTCGTG CAGCTGCGGA AGGATTCCGT TTCCTGCAGG 120
GGGCGGAGGG ATTTGACAGC ACGGTAACTT CCGGAAAAGT CCTGAACCTC AGTGGAAAAG 180
CCTTGCAAGA AACAATAACA AACGGGAGGA GGAAGCGATT CTGGGGTTTC TGTGTTGAAC 240
GGTTCTTGTC CGCGAAGATG CGCTTCGGCC TCTGTCAGGG GACTTGAACG GGCTTAGTGG 300
GCTTCAGCCA GCTTTTCTCC ACCGGTTCCC CACGGGGACC CCCCCCCCCC CCCGGCCGTT 360
GCAATGGCGG GCGTGGGGCC GGGGGGCTAC GCGGCGGAGT TCGTGCCACC GCCAGAGTGC 420
CCCGTCTTTG AGCCGAGTTG GGAGGAGTTC ACAGATCCGC TCAGCTTTAT CGGCCGCATC 480
CGGCCTTTGG CGGAGAAAAC CGGCATCTGC AAAATTCGGC CGCCCAAGGA CTGGCAGCCT 540
CCATTTGCCT GTGAAGTAAA AAGCTTTCGT TTCACTCCAA GAGTCCAGCG CCTGAATGAA 600
CTTGAGGCAA TGACCAGAGT GAGATTGGAT TTCTTGGATC AACTAGCAAA ATTTTGGGAA 660
CTTCAAGGAT CTACTCTGAA GATCCCTGTG GTAGAGAGAA AAATCCTGGA TCTGTATGCT 720
TTGAGCAAGA TTGTTGCCAG CAAAGGAGGT TTTGAAATGG TCACCAAAGA GAAGAAATGG 780
TCTAAAGTGG GTAGTCGCTT GGGATATCTG CCAGGAAAAG GAACTGGGTC TCTTTTGAAG 840
TCACATTATG AAAGAATTCT CTACCCATAT GAGCTTTTCC AGTCTGGTGT GAGCCTTATG 900
GGTGTGCAGA TGCCTAATTT AGATCTTAAA GAAAAAGTGG AGCCTGAGGT TCTCAGCACT 960
GATACCCAAA CTTCCCCAGA GCCAGGCACA AGGATGAACA TTCTGCCGAA GAGAACAAGA 1020
CGTGTGAAGA CTCAGTCAGA ATCTGGAGAT GTGAGTAGAA ACACGGAACT GAAGAAACTT 1080
CAGATTTTTG GGGCTGGGCC CAAGGTTGTG GGCTTGGCAA TGGGAACAAA AGATAAAGAA 1140
GATGAGGTCA CCCGAAGACG AAAAGTTACC AACAGGTCAG ACGCATTTAA CATGCAAATG 1200
AGACAACGGA AAGGCACTCT CTCTGTTAAC TTTGTTGATC TCTATGTTTG TATGTTTTGT 1260
GGTCGGGGAA ACAATGAAGA TAAATTGCTT TTGTGTGATG GATGTGATGA CAGCTATCAT 1320
ACATTTTGTC TAATTCCTCC ACTACCTGAT GTGCCCAAAG GAGACTGGAG GTGTCCTAAA 1380
TGTGTCGCCG AGGAATGTAG CAAACCTCGA GAAGCCTTTG GATTTGAACA AGCTGTACGA 1440
GAGTATACAC TTCAGAGCTT TGGAGAGATG GCAGATAATT TTAAGTCTGA TTATTTTAAT 1500
ATGCCAGTCC ATATGGTTCC CACAGAACTA GTAGAAAAGG AATTTTGGCG GCTGGTAAGC 1560
AGCATTGAAG AAGATGTTAT TGTGGAATAT GGAGCAGATA TCTCCTCAAA AGACTTTGGA 1620
AGTGGATTTC CGGTGAAGGA TGGGCGGAGA AAGATTCTGC CAGAAGAAGA GGAATATGCA 1680
CTTTCTGGTT GGAATTTGAA TAACATGCCT GTCCTGGAAC AGTCTGTTCT TGCACATATT 1740
AATGTGGACA TCTCTGGTAT GAAAGTGCCG TGGCTCTATG TGGGAATGTG CTTCTCTTCT 1800
TTTTGCTGGC ACATTGAGGA TCACTGGAGT TATTCCATCA ACTACTTGCA CTGGGGGGAG 1860
CCAAAGACAT GGTATGGTGT GCCATCTCAT GCTGCAGAGC AACTGGAGGA GGTGATGAGA 1920
GAGCTGGCCC CCGAGTTATT TGAATCCCAG CCTGATCTTC TGCATCAGTT AGTTACCATC 1980
ATGAACCCCA ACGTGCTAAT GGAGCATGGT GTGCCTGTGT ACAGGACCAA TCAGTGTGCT 2040
GGCGAGTTTG TTGTGACATT TCCTCGTGCC TATCACTCTG GATTTAACCA GGGCTACAAC 2100
TTTGCTGAAG CTGTGAACTT CTGTACTGCT GACTGGTTGC CCATTGGACG TCAATGTGTA 2160
AATCATTACC GACGCCTAAG GCGCCACTGT GTCTTTTCAC ACGAGGAACT AATTTTCAAG 2220
ATGGCAGCAG ATCCAGAATG CTTAGATGTG GGGCTGGCTG CCATGGTCTG CAAAGAATTG 2280
ACTCTCATGA CTGAAGAAGA AACACGATTA AGAGAGTCTG TTGTACAGAT GGGTGTCCTG 2340
ATGTCAGAAG AAGAAGTGTT TGAACTTGTT CCTGATGATG AGCGGCAGTG TTCAGCATGC 2400
AGAACCACAT GTTTTCTCTC TGCTCTCACA TGTTCCTGTA ATCCTGAGCG GCTTGTATGT 2460
CTCTACCATC CAACTGATCT GTGCCCCTGC CCCATGCAGA AGAAATGTCT TAGATATCGC 2520
TACCCATTAG AAGACCTCCC TTCTCTGCTA TATGGTGTAA AAGTCAGGGC ACAGTCCTAT 2580
GACACTTGGG TCAGTCGTGT TACAGAAGCA TTGTCTGCTA ACTTCAACCA CAAAAAAGAT 2640
TTGATTGAAT TGCGAGTAAT GCTGGAAGAT GCTGAGGATA GGAAATACCC AGAGAATGAT 2700
CTCTTTCGAA AACTCAGGGA TGCTGTAAAA GAAGCTGAGA CCTGTGCTTC TGTGGCTCAG 2760
CTGCTTCTGA GCAAAAAGCA GAAACACAGA CAGAGCCCAG ATAGTGGGAG GACTCGGACC 2820
AAACTGACAG TGGAAGAATT GAAGGCCTTT GTCCAACAAC TTTTTAGTCT TCCGTGTGTC 2880
ATCAGCCAAG CTCGGCAAGT AAAGAATCTG CTAGATGATG TGGAAGAGTT TCATGAACGT 2940
GCTCAGGAGG CCATGATGGA TGAAACCCCA GATTCTTCCA AACTCCAGAT GTTGATAGAT 3000
ATGGGCTCTA GTCTCTATGT GGAACTCCCT GAATTACCAC GACTGAAGCA AGAGCTACAA 3060
CAGGCTCGGT GGTTGGACGA AGTAAGACTG ACCTTATCAG ATCCGCAACA AGTCACTTTG 3120
GATGTCATGA AGAAGCTGAT AGACTCTGGG GTAGGGTTGG CACCCCACCA TGCTGTGGAG 3180
AAAGCAATGG CTGAACTACA GGAGCTCCTT ACAGTCTCTG AACGATGGGA AGAAAAGGCT 3240
AAGGTCTGCC TACAGGCAAG ACCGAGGCAC AGTGTGGCAA GTTTAGAAAG CATTGTGAAT 3300
GAAGCCAAGA ACATTCCAGC CTTTCTACCC AATGTGTTGT CCTTGAAAGA AGCCTTACAA 3360
AAGGCTCGAG AATGGACCGC TAAAGTGGAA GCTATTCAGA GTGGCAGCAA TTACGCTTAT 3420
TTGGAGCAGC TTGAGAGCTT GTCTGCGAAA GGACGCCCTA TTCCTGTGCG TCTTGAAGCA 3480
CTGCCGCAAG TGGAATCACA GGTAGCAGCA GCACGGGCAT GGAGAGAACG GACTGGGCGG 3540
ACGTTTCTTA AGAAGAATTC TAGCCATACA TTGTTACAGG TGCTGAGCCC CCGGACCGAC 3600
ATTGGTGTAT ATGGGAGTGG CAAAAATAGG AGGAAAAAAG TAAAAGAACT AATAGAAAAA 3660
GAAAAAGAAA AGGATCTGGA CCTGGAGCCT CTGAGTGATC TGGAGGAAGG ATTGGAGGAA 3720
ACCAGAGATA CAGCCATGGT GGTGGCAGTT TTCAAAGAAC GGGAGCAAAA AGAGATTGAA 3780
GCCATGCATT CTCTCAGAGC AGCCAACCTA GCCAAGATGA CAATGGTGGA CCGCATAGAA 3840
GAAGTAAAAT TTTGCATTTG CCGCAAGACA GCCAGTGGGT TTATGCTACA GTGTGAGCTC 3900
TGCAAAGACT GGTTCCATAA CAGCTGTGTT CCTCTTCCTA AATCAAGTTC CCAAAAAAAA 3960
GGATCCAGCT GGCAAGCTAA AGAAGTAAAA TTCCTTTGCC CTCTTTGTAT GCGGTCTCGA 4020
AGGCCCAGGC TAGAGACTAT TCTGTCACTC CTGGTATCCC TTCAGAAGTT GCCCGTACGG 4080
TTGCCTGAAG GAGAGGCCCT GCAGTGTTTG ACAGAACGTG CTATGAGTTG GCAAGATAGA 4140
GCGCGGCAGG CTCTAGCCAC AGATGAACTA TCCTCTGCCC TGGCCAAACT ATCTGTGTTG 4200
AGCCAGCGTA TGGTGGAACA GGCGGCTCGA GAAAAAACTG AAAAGATCAT CAGTGCAGAA 4260
CTCCAAAAAG CAGCTGCCAA TCCAGACTTA CAGGGACACT TACCTAGTTT CCAGCAGTCT 4320
GCTTTTAACC GGGTGGTGAG CAGTGTGTCA TCTTCTCCTC GACAAACAAT GGACTATGAT 4380
GATGAAGAAA CAGACTCTGA TGAAGACATT CGAGAGACAT ATGGCTACGA CATGAAGGAC 4440
ACAGCCAGTG TGAAGTCCTC TAGTAGTCTT GAACCCAATC TTTTTTGTGA TGAAGAGATT 4500
CCCATCAAAT CCGAGGAGGT GGTGACCCAC ATGTGGACAG CACCTTCATT TTGTGCAGAG 4560
CATGCTTATT CTTCTGCTTC TAAGAGTTGT TCTCAAGGTT CTAGCACCCC AAGGAAACAA 4620
CCTCGGAAGA GCCCTTTGGT GCCCCGAAGT TTGGAACCTC CAGTGCTGGA GTTGTCACCT 4680
GGAGCTAAGG CACAACTGGA AGAACTTATG ATGGTTGGAG ATCTCCTGGA AGTATCTCTG 4740
GACGAGACTC AACACATATG GCGGATTTTG CAGGCCACAC ACCCACCCTC TGAAGACAGA 4800
TTCTTGCATA TCATGGAGGA TGACAGCATG GAAGAGAAAC CACTAAAAGT GAAAGGAAAG 4860
GACTCTTCAG AGAAGAAACG GAAACGGAAG CTAGAAAAGG TAGAGCAACT TTTTGGAGAA 4920
GGAAAACAGA AGTCCAAGGA GTTAAAGAAA ATGGACAAAC CTAGAAAGAA GAAATTAAAA 4980
TTAGGTGCAG ACAAATCAAA GGAGCTGAAT AAACTGGCCA AGAAACTAGC AAAAGAAGAA 5040
GAGAGAAAGA AAAAGAAGGA GAAGGCTGCT GCAGCCAAAG TTGAACTTGT GAAAGAGAGC 5100
ACTGAAAAGA AAAGAGAGAA AAAGGTGCTG GACATCCCCT CAAAGTATGA CTGGTCAGGA 5160
GCAGAGGAGT CTGATGATGA GAATGCTGTG TGCGCAGCAC AGAACTGCCA AAGGCCCTGC 5220
AAGGACAAGG TAGACTGGGT ACAATGTGAT GGTGGCTGTG ATGAGTGGTT TCATCAAGTT 5280
TGTGTGGGTG TATCTCCAGA AATGGCTGAA AATGAAGATT ACATCTGTAT AAACTGTGCA 5340
AAGAAGCAGG GGCCAGTTAG CCCAGGTCCA GCACCACCTC CTTCCTTCAT AATGAGCTAC 5400
AAACTACCAA TGGAGGATCT TAAAGAGACC AGTTAGCAGA TGCTTGGTTA GTTTGGGACA 5460
TGGGGGGACA TGGACCACAT TGAGACCTTA GTCATCAAGT AGAGTGGTTT ATATCCACTT 5520
GGAATGTTGC TTCCAAAGAT GAATGGCCTT CAGAGAAAGT CCCCTTAGTG CTGGCTTCCT 5580
CTTTGCATGG ACTCTGTGGG TTACATTCTC TATCAACATA TCTATGCAGA GGGTGTCTTC 5640
TTTGGTACAA CAGCCAATAT TTCATGTCTC CTTTGAGTGT GGTTTACTGC ATTAAGGCCA 5700
GATGCTTAAT TGAGCTCTAG GGTGGCTGGT TAGTATTAAT ACATTGGTGT GCTAACAGGG 5760
CATATAGGAT GTGGCTTTTG TCCAGCTGAT AGTAGTTAGA GGCTTACAAC TTAGGAGCAG 5820
CACCAACTGA AGGTGCTAAT TGCTTGGATC TCCTTCATTG GGATAGTTGG AGAGGGATTG 5880
GAGTACCACT TTCCTTCCAC TGTTACCTGG TACTTAATGC CCTAAAGATA CAACTAGGAG 5940
TAACAGGGCC AAAGTTATTT CTGTTAGACG TCAAGGAATG GTATCACAGT CTATTGACCT 6000
CAGCGATTTG TGCTTGTTTG TGCTAGAAGA ACATCCCAAA TAGGAGAACC TCTCACAAGC 6060
TGGGGCAGGT CACCTTATCT TTGTAAGATG AGGATATCAT CTAGATCAGA AATCTGACTA 6120
GATTGGATTC TGAGGAGAAG AACCTACTAC AAGGCAAGGA GCCGTTTTTT GGCTTTGAAA 6180
AGTCTTGCTG TCTTGGGTCT ACATTTTAGG GAAGAGCAGG TACATGGATC CAGGCTTCTG 6240
CCAAAAAAAA AAAGAGAAGA AGATGACGAT GATGACCAGT CGTACTATCT TACTGAGCCA 6300
CAGTGATGCA TGCTTTTCGG GGAAAACTTC ATTCACAAGT ATTCCAGACA CCAGGCTTCA 6360
GGCATGGCCA TGAGCAAGAC CAGCAAATAA CAGCTTTTTG CCTTGCAGCC CTGACCCCAA 6420
TGTCTGCTGT TTCCAACACT GGTGATTTCT AACTACGGCC CACAGCAGAT GCTGTTGAAT 6480
AACACCATGG CTTCATCAGA GGATGTGGGG TTGTAGTACC TCTGGGTGAT GAAGTTGTTT 6540
TAGTAAATCC ATTTTTAAAA AAAAAAAAGG ACTTGTTTTT ACTTTTTTCT AAATGTCTCT 6600
GACTACTGAC TGTTCTATAC ATAGATTATT TTTCCTTTTT TAATATACAT ATATGAATAT 6660
ATAAATATAT ATATTTACTG TTACCAGCAG CATATGACAG AGTTTCAACA TCAAAAATCC 6720
ATTTGGGGGC TTGCTTTTTC TTTTTTGCTT TAAAAAAAAA AATCCCATTC CTTCTTTGTA 6780
GTACAAGGAG TTAGCACTCC CTCCTCCATC CCAGCCTGAC CAGATCTTCC ATTTTGCTTT 6840
TGTTCATATA GATAATTATA TGTCCTTTGT GTGTTGGGAC TTGTCCCTGT CTGTTGGGAA 6900
ACTTGGTCTC ACTCTAGTCT GTGCTGGCTC TTTTTTCTTT TGTGTGTGAA TGTTTGAAAC 6960
TATGGTGCTG TGTCCTCTTC CCTCCTGTTG TGTTCTCTGT TCTTCTTAAG GTATTAGGTA 7020
AGCTGTATGT AAACTCTTAT TAGAAGGGGA CTAATTTTTT TTTAAAGGAC AAAAAAAAAA 7080
ATGACTAAAA ATAGTGTTTT GTCATCACTG TCTGGTGTCT TTATTTTGGT TTAAAAAAAT 7140
CTGTGGTTTG ACTTAAATTC ATCAGTTTTC CTTTTAAAGG GGGGATTGGG GTGGACCTAG 7200
CAACAGCTTA TAGTTTCCTC TTCCCTTTTT GCCCCAGTCT CTTTTAAAGA ACTGTCTTCT 7260
AGTAACTAGA AGTGAAATGT ACTGTCCAGT TACAGTTTGA GTGGGTATGA GATTTAACTC 7320
AAAAGGAATC TTACAAAAAA AAAGATGTTT TCTTATAAAA TCCAATTTCT GTAAATGTTT 7380
TCTCTGAAGT TCATACTACC TACTTTTTAT TCATTCTTAA TACTGTATAA CATTTTGAGT 7440
GTTTTGACTT GTTCAGAGGT TTGTTAGTGT TGCTGTGCAT ATGTCTTGAG GTCTCATCTG 7500
AAGTAAGTTT GTGTATGATC GAAGATTTCA ATGGATATTG CAAGGTAACT AATTAACTGA 7560
TTTCATAAGT TTTCGTTTTG CCAAGCTAAC GATTATCAAT TAAGAATTTC CTCTGGTTGA 7620
TGTTATACAA GAAAGCACAA TATTTTTTGC CTGTTGATCT TCTTTGTAAC AGTCTTCAGA 7680
TATTTGTGGG TTAAAAATTG AATGTAATTT TAAGTGACAG ATGCCTGGAA TACATTTAAA 7740
ATTTTTATTT TTCCTTCCTA ATCATCCATT AACTATTCCA CTATCAGTGG AGAGTCATGA 7800
GGATGCTGAG AAAGTATGAA TAGCTTCCTG TCACCTTCTG ACGTTTTGAA ACTTAAATAT 7860
GTCTTTTCGT TGATACTGTG GGATTTTCTG TATTTACTTG ACAGTCATGG AGGATTTGGT 7920
ATGACTTGAC CACAGGTTTA GACCAAGGCT GAGAAGAACA GAAGGGAGAA ATTAATGGCA 7980
AAACAAAAAA TACACAAATC TGCGGTTTTG GAATTAATGA AACAAGATTC ATCTATTTAA 8040
AGAAATGTTG GTGTTCTAAT ACAAAGCATT ATTTTCACTT AGAGAAAATT ACTTACTTGC 8100
TCCCTTCTGT ATTGTAATAT TTTGTATTAA GACATGATTT AAAATGTCTT TCTACCCTTA 8160
TCTCCTCTAA ACTGCAACTG AAGTTGCAAT TCTTCATCAT TAGTATTTTA ACTCTGGCAA 8220
AGGTTATAGA AAGAAAAATG GAAATATGGT AGGCCTGTGG TATTCTTAAA AGCTAAGTCA 8280
TTAGAACTAT GCAGATCCCC AAGTTTAAAA GTACAAATAC AGCACCAGTA GTTAGCTTTC 8340
TAGCTGGGGG AGAAGACAGG AGATTTTTCT TCCACAGATG TTTATTTTGC TTCCTGATAG 8400
GTACTGCAGC AAAGCCATGT TGATGTGTAG ATGCATGACT TCCTCACTAA GCTGCTGCAC 8460
ACCAGCTTTG CCTGCATGAT TCAAATTTGT GCCTCAGTAA AATTATAAAT TATTGCATGT 8520
CATACCTTGA ATAATGGAAA CGGCAAACAT TAAACCTGTG ATTACCCATA ATGTACTTTA 8580
ATAATAAAAA ACATGGCAGC CAGGTGCAGT AGAGTGCACC TGTGGTCAGG AGGCTGAAGT 8640
GGGAAGATTG CTTCAACCTG TGAGTTTGAG TCCCGCCTGG TCAACAGCGA GACCCCATGT 8700
GTCTGTCTGT CTCTCTCTTT TTTTAAAGGA CAGAGGCTAA GCTGTAAGGT TAGCATGGTT 8760
CTGCCTGGGC TTTGCTTCTG TGCTTCTGTG CAGGCTGAGC TGTAAGGTTA GCATGGTTCT 8820
GCCTGGGCTT TGCTTCTGCG CTTCTGTGCA GGCTGAGCTG TAAGGTTAGC ATGGTTCTGC 8880
CTGGGCTTTG CTTCTGCGCT TCTGTGCAGG CTGAGCTGTA AGGTTAGCAT GGTTCTGCCT 8940
GGGCTTTGCT TCTGCGCTTC TGTGCTAGCA GGTGCCCACA AAATGTCTTT TTGAATTTCT 9000
TAATTTTTGG GTTCTGGATG CAATTCGTGC ACGCCAAGAA ACTACTTGCT TGTCAGTATT 9060
TTAATTCTGT AGTACATGTG TGTGAATATC AGCCAGTACT TACAGTAGGA GGATGAACAG 9120
AAAAACTGAG AAGACCTGTC TTTCAAAAGA TGGGTTTATC CACTTTTTAA GGGAAAAAGT 9180
GACAGTTTGG CATGGGATTT GAAAAGTGGA AATTGTGGAA AAATTGAGCT GTTGAAGTCC 9240
CACATATAAC CAGATTTAAT AAAGCTTCAC ATGTGAATTA GCTCCATATG TGTGTAGAAG 9300
GTTGCTTTTA TAGCAGGTCC TTAAGTACTC CTTTTGAAAT TCCTCCTTTT TTTTTAAGTC 9360
ATACCATTAC TTCTTTGGAT ATGAATGTCC CAAGTGGTAT CTCCTACTGT AGTATGAGGA 9420
AGAATGGCTG TTAATGTATT TTTTGAATTT TGGTCTTGTC TTGGCCTGGA TCATATCCAG 9480
TCACCACTAT GCAACAAATG ATGTGCACTG GGCAAGGATA TGATGGGTTA TGAAAGCTGT 9540
ATCTTGTTTG TTTTTTCTTT TGCAGTACTC CAAGTGGTCT AAACAGGAAT GTCTTGTAAA 9600
ACCTCAAGAC TCCCTATTGA TTATTCCCTT ACATATTTAT TTACAATTTA TCAGGGTAAT 9660
TGGTGGTGCC TTATGAAAAG TATAACTCGA TTTCTTGATC TTTGAGCATG TTTTGTGTTT 9720
CTTGTGTTTT CTAAAAGAAT ATTAGATATG GTTAATTGCA TTACATCTAA AAGATTTAAA 9780
AAATTGTGTG TATGCTCAGG TTCCCCACAC CCATACCCAC CCTAACCCCT GTCATTTACA 9840
TTGGTGGCAA CTTTAAATGG TAACCAAGCA AAAGTACATT TTGATAATGA GTATTGATAA 9900
TCCTGAGGAA AACTAGTGAG TATATGGGAG CCACCTTTGA CCTGTGCCAA AGCAGTTTCT 9960
AATTTCATTT GCTAACTATA AAATAAAGAA CTGAGCCAAA ATAATTTGAT CAGTGGTGTG 10020
ATTAGCCTAT TATCATTGCT GAGAATAGTG TTTTTGGAGT GTGAAGTGAT TCCTGAAGAT 10080
TTCACCTGCC TTCTGTTTCC AGCAAGAATC CAGTGATGAC CAACACATTT CCTCACTTTT 10140
GGTTCTTGAG AAGTTTATCC CTTTGCAACA AACCATTAAT AGGGAAAACA AGGAAATGCT 10200
TTCCCTTTCT CTTTGGCTTC TTAAAGCTCA CAACCAATTC AGACCCCAAG TTACTTCAGA 10260
GAAGCAAATG GCACCTTTTC CCCATTGCCA AGGATCCCAG CTTATGCAGA TATGAAGGAC 10320
GGATCATTTC TGAAAATGTT AAGACTCTGC TTGCAGTGGA CTTGGCCTCA GTTTCATGAA 10380
ATGTGTAACT CTGTATGTGT ATGTTAGGAG GAGGGTTGGT TGAAAGAGCG GGGGCAGGGA 10440
GGGGAATCTG ATTACCTCTT GGGAAATAAT TTTCTTGCCA ACAAAAAGAT ACACTTGAAG 10500
TTTCTTAAGG TGGCAAGTCC ATTAAAAAAA AAAATTGTGT TGGACCCTCC CAGTTTAGAT 10560
CAAGTATTTC TTGGGGGTCT TGCTATTGTG GTTGATACCA ATAAATGGAA GATCCAGAAT 10620
ATTTTCATTT AAAGCTCAAC CATTAATTGG AACATGGTGA AACATTGTAC ACATTGTAAA 10680
AGTAGGGAAC AGTACAAAAG AATGGAATCA AATACTATAT TATGTGAATA AACTAGAGTG 10740
ATTTTGGAAT TTCACTCTCT TCA 10764
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0032993--C:protein-DNA complex
GO:0031490--F:chromatin DNA binding
GO:0003677--F:DNA binding
GO:0032452--F:histone demethylase activity
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0032922--P:circadian regulation of gene expression
GO:0034720--P:histone H3-K4 demethylation
GO:0008584--P:male gonad development
GO:1901726--P:negative regulation of histone deacetylase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0007283--P:spermatogenesis
GO:0006366--P:transcription from RNA polymerase II promoter
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Nol-0018 ENSNLEP00000002465.1 Nomascus leucogenys 100 0.0 3027
WERAM-Poa-0038 ENSPPYP00000004709.1 Pongo abelii 100 0.0 3024
WERAM-Pat-0036 ENSPTRP00000056131.1 Pan troglodytes 99 0.0 3016
WERAM-Fec-0141 ENSFCAP00000013303.3 Felis catus 97 0.0 2999
WERAM-Aim-0056 ENSAMEP00000004769.1 Ailuropoda melanoleuca 99 0.0 2989
WERAM-Orc-0129 ENSOCUP00000011159.2 Oryctolagus cuniculus 96 0.0 2983
WERAM-Myl-0067 ENSMLUP00000005634.2 Myotis lucifugus 98 0.0 2978
WERAM-Soa-0132 ENSSARP00000013044.1 Sorex araneus 97 0.0 2973
WERAM-Bot-0174 ENSBTAP00000027280.5 Bos taurus 97 0.0 2970
WERAM-Caf-0163 ENSCAFP00000023208.3 Canis familiaris 98 0.0 2966
WERAM-Ova-0126 ENSOARP00000012800.1 Ovis aries 97 0.0 2952
WERAM-Mum-0106 ENSMUSP00000005108.7 Mus musculus 97 0.0 2943
WERAM-Eqc-0173 ENSECAP00000019283.1 Equus caballus 97 0.0 2942
WERAM-Paa-0010 ENSPANP00000008905.1 Papio anubis 95 0.0 2937
WERAM-Mam-0119 ENSMMUP00000017950.2 Macaca mulatta 96 0.0 2925
WERAM-Tut-0099 ENSTTRP00000008413.1 Tursiops truncatus 96 0.0 2919
WERAM-Chs-0147 ENSCSAP00000008231.1 Chlorocebus sabaeus 100 0.0 2908
WERAM-Mup-0210 ENSMPUP00000017918.1 Mustela putorius furo 98 0.0 2907
WERAM-Otg-0005 ENSOGAP00000000280.2 Otolemur garnettii 96 0.0 2895
WERAM-Gaga-0123 ENSGALP00000021168.4 Gallus gallus 92 0.0 2843
WERAM-Tag-0155 ENSTGUP00000013014.1 Taeniopygia guttata 90 0.0 2819
WERAM-Mod-0172 ENSMODP00000022937.3 Monodelphis domestica 96 0.0 2803
WERAM-Pes-0046 ENSPSIP00000007266.1 Pelodiscus sinensis 92 0.0 2802
WERAM-Anc-0002 ENSACAP00000000033.2 Anolis carolinensis 90 0.0 2797
WERAM-Caj-0077 ENSCJAP00000012842.1 Callithrix jacchus 99 0.0 2794
WERAM-Anp-0001 ENSAPLP00000000531.1 Anas platyrhynchos 92 0.0 2786
WERAM-Chh-0061 ENSCHOP00000006896.1 Choloepus hoffmanni 93 0.0 2778
WERAM-Ptv-0043 ENSPVAP00000004523.1 Pteropus vampyrus 92 0.0 2759
WERAM-Dan-0105 ENSDNOP00000012063.3 Dasypus novemcinctus 98 0.0 2741
WERAM-Loa-0097 ENSLAFP00000008306.3 Loxodonta africana 91 0.0 2593
WERAM-Sah-0178 ENSSHAP00000018525.1 Sarcophilus harrisii 94 0.0 2535
WERAM-Fia-0057 ENSFALP00000004074.1 Ficedula albicollis 92 0.0 2472
WERAM-Meg-0132 ENSMGAP00000014160.2 Meleagris gallopavo 83 0.0 2414
WERAM-Gog-0048 ENSGGOP00000004481.2 Gorilla gorilla 100 0.0 2352
WERAM-Leo-0177 ENSLOCP00000021020.1 Lepisosteus oculatus 75 0.0 2301
WERAM-Xet-0029 ENSXETP00000007871.4 Xenopus tropicalis 77 0.0 2264
WERAM-Orn-0119 ENSONIP00000012262.1 Oreochromis niloticus 75 0.0 2174
WERAM-Asm-0193 ENSAMXP00000018348.1 Astyanax mexicanus 75 0.0 2173
WERAM-Gaa-0205 ENSGACP00000025092.2 Gasterosteus aculeatus 76 0.0 2169
WERAM-Orla-0119 ENSORLP00000014356.1 Oryzias latipes 75 0.0 2141
WERAM-Pof-0121 ENSPFOP00000010723.2 Poecilia formosa 75 0.0 2137
WERAM-Xim-0048 ENSXMAP00000004574.1 Xiphophorus maculatus 75 0.0 2137
WERAM-Lac-0117 ENSLACP00000014279.1 Latimeria chalumnae 75 0.0 2066
WERAM-Cap-0148 ENSCPOP00000012388.2 Cavia porcellus 98 0.0 2022
WERAM-Ora-0095 ENSOANP00000017333.1 Ornithorhynchus anatinus 80 0.0 2021
WERAM-Tar-0025 ENSTRUP00000005009.1 Takifugu rubripes 75 0.0 1888
WERAM-Ten-0082 ENSTNIP00000000323.1 Tetraodon nigroviridis 74 0.0 1840
WERAM-Dar-0234 ENSDARP00000134924.1 Danio rerio 77 0.0 1685
WERAM-Prc-0003 ENSPCAP00000000272.1 Procavia capensis 95 0.0 1674
WERAM-Vip-0105 ENSVPAP00000009684.1 Vicugna pacos 90 0.0 1464
WERAM-Ict-0017 ENSSTOP00000001099.2 Ictidomys tridecemlineatus 56 0.0 1443
WERAM-Sus-0075 ENSSSCP00000011653.2 Sus scrofa 56 0.0 1413
WERAM-Ran-0254 ENSRNOP00000073953.1 Rattus norvegicus 54 0.0 1384
WERAM-Mae-0078 ENSMEUP00000007759.1 Macropus eugenii 55 0.0 1369
WERAM-Ocp-0067 ENSOPRP00000005882.1 Ochotona princeps 92 0.0 1366
WERAM-Mim-0074 ENSMICP00000007161.1 Microcebus murinus 54 0.0 1363
WERAM-Gam-0221 ENSGMOP00000021154.1 Gadus morhua 53 0.0 1330
WERAM-Tas-0091 ENSTSYP00000009583.1 Tarsius syrichta 99 0.0 1318
WERAM-Pem-0068 ENSPMAP00000007536.1 Petromyzon marinus 53 0.0 1308
WERAM-Dio-0108 ENSDORP00000010702.1 Dipodomys ordii 96 0.0 1228
WERAM-Cis-0007 ENSCSAVP00000000871.1 Ciona savignyi 48 0.0 1209
WERAM-Ere-0114 ENSEEUP00000012051.1 Erinaceus europaeus 58 0.0 1167
WERAM-Drm-0042 FBpp0311492 Drosophila melanogaster 47 0.0 1104
WERAM-Cii-0031 ENSCINP00000012442.3 Ciona intestinalis 49 0.0 1090
WERAM-Ect-0130 ENSETEP00000014721.1 Echinops telfairi 53 0.0 936
WERAM-Tub-0018 ENSTBEP00000001814.1 Tupaia belangeri 99 0.0 808
WERAM-Cae-0018 ZK593.4a Caenorhabditis elegans 33 2e-156 551
WERAM-Lab-0033 EDR12730 Laccaria bicolor 33 3e-141 501
WERAM-Crn-0020 AAW43237 Cryptococcus neoformans 29 2e-131 468
WERAM-Usm-0016 UM02582P0 Ustilago maydis 30 7e-129 460
WERAM-Spr-0023 CBQ72974 Sporisorium reilianum 30 2e-125 449
WERAM-Pytr-0035 EDU44093 Pyrenophora triticirepentis 30 2e-123 441
WERAM-Amt-0017 ERM95079 Amborella trichopoda 31 1e-121 436
WERAM-Pyt-0008 EFQ94561 Pyrenophora teres 30 1e-121 436
WERAM-Tum-0032 CAZ86330 Tuber melanosporum 36 4e-120 431
WERAM-Miv-0011 MVLG_01737T0 Microbotryum violaceum 35 9e-120 429
WERAM-Arl-0119 scaffold_200168.1 Arabidopsis lyrata 30 5e-119 427
WERAM-Coi-0029 EAS31076 Coccidioides immitis 33 9e-118 423
WERAM-Sei-0018 Si005667m Setaria italica 29 2e-116 418
WERAM-Asc-0001 CADACLAP00000026 Aspergillus clavatus 35 1e-115 416
WERAM-Brd-0017 BRADI1G29247.1 Brachypodium distachyon 30 1e-114 412
WERAM-Asn-0018 CADANIAP00004258 Aspergillus nidulans 34 2e-114 412
WERAM-Asfu-0009 CADAFUAP00002555 Aspergillus fumigatus 34 1e-113 409
WERAM-Ast-0008 CADATEAP00004027 Aspergillus terreus 33 1e-113 409
WERAM-Asni-0025 CADANGAP00007970 Aspergillus niger 34 2e-112 405
WERAM-Asf-0028 CADAFLAP00010689 Aspergillus flavus 34 2e-112 405
WERAM-Aso-0031 CADAORAP00009644 Aspergillus oryzae 34 2e-112 405
WERAM-Lem-0001 CBY01560 Leptosphaeria maculans 29 2e-111 402
WERAM-Phn-0021 SNOT_11200 Phaeosphaeria nodorum 34 2e-108 392
WERAM-Zyt-0030 Mycgr3P74352 Zymoseptoria tritici 32 6e-108 390
WERAM-Bro-0173 Bo9g029100.1 Brassica oleracea 30 5e-107 387
WERAM-Scs-0004 EDN96551 Sclerotinia sclerotiorum 33 2e-106 385
WERAM-Gag-0021 GGTG_06066T0 Gaeumannomyces graminis 30 5e-106 384
WERAM-Sem-0146 EFJ11616 Selaginella moellendorffii 39 6e-104 377
WERAM-Ors-0063 OS06T0731600-00 Oryza sativa 30 8e-104 377
WERAM-Met-0120 AES94050 Medicago truncatula 33 1e-102 373
WERAM-Mao-0014 MGG_04878T0 Magnaporthe oryzae 33 1e-102 373
WERAM-Sob-0138 Sb10g031260.1 Sorghum bicolor 37 2e-101 369
WERAM-Thc-0041 EOY24718 Theobroma cacao 32 3e-101 368
WERAM-Brr-0139 Bra027644.1-P Brassica rapa 32 9e-101 366
WERAM-Trr-0012 EGR49606 Trichoderma reesei 32 1e-100 366
WERAM-Nec-0020 EFNCRP00000004299 Neurospora crassa 33 3e-100 365
WERAM-Glm-0121 GLYMA11G02580.4 Glycine max 32 5e-100 364
WERAM-Map-0012 MAPG_04048T0 Magnaporthe poae 33 3e-99 362
WERAM-Prp-0007 EMJ11636 Prunus persica 32 3e-98 358
WERAM-Trv-0029 EHK20007 Trichoderma virens 32 4e-98 358
WERAM-Sol-0104 Solyc08g081000.2.1 Solanum lycopersicum 32 9e-98 356
WERAM-Orm-0066 OMERI06G28260.1 Oryza meridionalis 29 1e-95 349
WERAM-Orbr-0078 OB06G36110.1 Oryza brachyantha 34 2e-95 348
WERAM-Org-0069 ORGLA06G0289500.1 Oryza glaberrima 37 3e-95 348
WERAM-Lep-0069 LPERR06G23820.1 Leersia perrieri 29 9e-95 347
Created Date 25-Jun-2016