WERAM Information

Tag Content
WERAM ID WERAM-Sac-0046
Ensembl Protein ID YPL015C
Uniprot Accession P53686; HST2_YEAST; D6W3Z7
Genbank Protein ID NP_015310.1
Protein Name NAD-dependent protein deacetylase HST2
Genbank Nucleotide ID NM_001183829.1
Gene Name HST2;YPL015C;LPA2C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YPL015C YPL015C YPL015C
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type H4K16 K 25288980
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 3.60e-86 287.1 15 285
Organism Saccharomyces cerevisiae
NCBI Taxa ID 559292
Functional Description
(View)		 NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export.
Domain Profile
  HDAC SIR2
  SIR2.txt   3 lakllk..kskkivvltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelekkgkllrlyt 100
               +a+++k   + k+++++GAGiSts+GIPDFRs ++Gly++l++ +lp+pea+fd+dff++dp +fy+lakelyp g+++P+k+Hy+l+++++k+ l+r+yt
   YPL015C  15 IAAHMKsnPNAKVIFMVGAGISTSCGIPDFRSpGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYP-GNFRPSKFHYLLKLFQDKDVLKRVYT 114
               666776556799**************************************************************.************************** PP
  SIR2.txt 101 QNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkak..ekvpkCekCkgvlkpdivffgenlpeefleeveed.............lke 186
               QNiD+Ler+ag+k+d ++e+HGs+a+++C+ C+k +p++++k+kl+++  +++ kC+ C++++kp ivffge+lp++f e++ +d             + +
   YPL015C 115 QNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHpiKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDsewlrekittsgkHPQ 215
               **********************************************999999*******************************9999*9999999998889 PP
  SIR2.txt 187 adlllvlGtSlkvepvaslvkkavkkkvpvllvnleevk....adkladlkllgdcdevveellkllglee 253
               + l++v+GtSl+v+p+asl+ + +++kv+++l+nle+v+    +++ +dl ++++ de++e+l+++lg++e
   YPL015C 216 QPLVIVVGTSLAVYPFASLP-EEIPRKVKRVLCNLETVGdfkaNKRPTDLIVHQYSDEFAEQLVEELGWQE 285
               9*******************.9*******************99999***********************86 PP
Protein Sequence
(Fasta)		MSVSTASTEM SVRKIAAHMK SNPNAKVIFM VGAGISTSCG IPDFRSPGTG LYHNLARLKL 60
PYPEAVFDVD FFQSDPLPFY TLAKELYPGN FRPSKFHYLL KLFQDKDVLK RVYTQNIDTL 120
ERQAGVKDDL IIEAHGSFAH CHCIGCGKVY PPQVFKSKLA EHPIKDFVKC DVCGELVKPA 180
IVFFGEDLPD SFSETWLNDS EWLREKITTS GKHPQQPLVI VVGTSLAVYP FASLPEEIPR 240
KVKRVLCNLE TVGDFKANKR PTDLIVHQYS DEFAEQLVEE LGWQEDFEKI LTAQGGMGDN 300
SKEQLLEIVH DLENLSLDQS EHESADKKDK KLQRLNGHDS DEDGASNSSS SQKAAKE 357
Nucleotide Sequence
(Fasta)		ATGTCTGTTT CTACCGCCTC TACAGAGATG TCGGTTAGGA AGATCGCTGC TCATATGAAA 60
AGCAACCCCA ACGCTAAAGT AATCTTTATG GTGGGTGCCG GGATATCCAC TTCTTGTGGG 120
ATACCAGACT TCCGATCTCC GGGAACTGGC CTGTACCATA ACTTGGCCAG GTTGAAGTTG 180
CCGTACCCTG AAGCAGTGTT CGATGTCGAT TTTTTCCAAT CGGATCCTTT GCCATTTTAC 240
ACTTTGGCTA AAGAGTTGTA TCCCGGAAAT TTCAGACCTT CTAAGTTTCA CTATCTTTTG 300
AAATTGTTTC AAGACAAAGA CGTTTTGAAG AGAGTATATA CCCAGAATAT AGACACTTTA 360
GAAAGACAGG CCGGTGTTAA GGATGATCTG ATCATCGAGG CCCATGGCAG TTTTGCTCAC 420
TGTCATTGTA TCGGATGTGG TAAAGTTTAT CCCCCACAGG TTTTCAAATC CAAGCTGGCA 480
GAGCATCCTA TAAAGGATTT TGTCAAGTGT GATGTGTGCG GTGAACTGGT AAAGCCGGCA 540
ATAGTTTTTT TTGGCGAAGA TCTACCGGAT TCCTTTTCGG AAACTTGGTT AAACGATTCA 600
GAGTGGCTTC GTGAAAAAAT CACGACATCT GGAAAACATC CTCAGCAGCC TCTTGTCATC 660
GTCGTTGGCA CCTCACTAGC CGTTTATCCC TTTGCGTCTC TGCCCGAAGA AATTCCTCGA 720
AAGGTAAAAA GAGTTCTGTG CAATTTGGAA ACGGTGGGCG ATTTTAAAGC TAACAAGAGG 780
CCTACAGATT TAATAGTTCA TCAGTACTCG GATGAGTTTG CCGAGCAACT CGTTGAAGAA 840
TTAGGTTGGC AAGAAGATTT CGAAAAGATA CTTACGGCCC AAGGTGGAAT GGGGGATAAC 900
TCTAAAGAGC AATTACTTGA AATTGTACAT GATTTAGAGA ATTTGAGTTT GGATCAATCT 960
GAACATGAGA GTGCAGACAA GAAGGATAAG AAGCTACAGC GTCTCAATGG CCATGACAGC 1020
GATGAAGATG GAGCAAGCAA CTCCTCTTCT TCACAAAAAG CCGCTAAAGA ATAA 1075
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR017328--Sirtuin_class_I
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0070403--F:NAD+ binding
GO:0017136--F:NAD-dependent histone deacetylase activity
GO:0046970--F:NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0008270--F:zinc ion binding
GO:0000183--P:chromatin silencing at rDNA
GO:0001300--P:chronological cell aging
GO:0070933--P:histone H4 deacetylation
GO:0031939--P:negative regulation of chromatin silencing at telomere
GO:0045950--P:negative regulation of mitotic recombination
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Cag-0026 CAG62123 Candida glabrata 52 1e-96 350
WERAM-Asg-0028 AAS54472 Ashbya gossypii 55 3e-93 339
WERAM-Kll-0027 CAG98291 Kluyveromyces lactis 55 2e-90 330
WERAM-Kop-0007 CAY68156 Komagataella pastoris 49 4e-74 275
WERAM-Caa-0033 KGT64755 Candida albicans 49 6e-73 271
WERAM-Pyt-0039 EFQ86136 Pyrenophora teres 43 1e-66 250
WERAM-Scp-0042 SPCC132.02.1:pep Schizosaccharomyces pombe 41 7e-66 248
WERAM-Mod-0192 ENSMODP00000026476.2 Monodelphis domestica 46 8e-66 248
WERAM-Dar-0028 ENSDARP00000003412.6 Danio rerio 42 8e-66 248
WERAM-Asc-0030 CADACLAP00006830 Aspergillus clavatus 46 3e-65 246
WERAM-Mao-0040 MGG_17827T0 Magnaporthe oryzae 47 4e-65 246
WERAM-Asn-0005 CADANIAP00000554 Aspergillus nidulans 47 4e-65 245
WERAM-Ast-0036 CADATEAP00009630 Aspergillus terreus 46 1e-64 244
WERAM-Lab-0008 EDR12994 Laccaria bicolor 43 1e-64 244
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 44 1e-64 244
WERAM-Asm-0153 ENSAMXP00000015326.1 Astyanax mexicanus 42 1e-64 243
WERAM-Trr-0018 EGR46788 Trichoderma reesei 42 2e-64 243
WERAM-Cis-0075 ENSCSAVP00000016120.1 Ciona savignyi 43 2e-64 243
WERAM-Aso-0005 CADAORAP00000633 Aspergillus oryzae 46 3e-64 243
WERAM-Asf-0024 CADAFLAP00010064 Aspergillus flavus 46 3e-64 243
WERAM-Zyt-0001 Mycgr3P100618 Zymoseptoria tritici 48 3e-64 243
WERAM-Tub-0067 ENSTBEP00000008310.1 Tupaia belangeri 44 6e-64 241
WERAM-Pof-0038 ENSPFOP00000003166.2 Poecilia formosa 42 7e-64 241
WERAM-Xim-0026 ENSXMAP00000002581.1 Xiphophorus maculatus 42 9e-64 241
WERAM-Crn-0031 AAW44797 Cryptococcus neoformans 46 1e-63 241
WERAM-Orn-0200 ENSONIP00000020932.1 Oreochromis niloticus 44 1e-63 240
WERAM-Miv-0009 MVLG_01362T0 Microbotryum violaceum 44 1e-63 240
WERAM-Tar-0064 ENSTRUP00000012981.1 Takifugu rubripes 42 1e-63 240
WERAM-Pytr-0009 EDU41553 Pyrenophora triticirepentis 43 2e-63 240
WERAM-Scj-0005 EEB06048 Schizosaccharomyces japonicus 42 6e-63 238
WERAM-Trv-0012 EHK19002 Trichoderma virens 45 8e-63 238
WERAM-Leo-0146 ENSLOCP00000017602.1 Lepisosteus oculatus 41 1e-62 238
WERAM-Fuo-0021 FOXG_06023P0 Fusarium oxysporum 46 2e-62 237
WERAM-Pem-0066 ENSPMAP00000007192.1 Petromyzon marinus 40 2e-62 236
WERAM-Gaa-0062 ENSGACP00000007590.1 Gasterosteus aculeatus 41 2e-62 236
WERAM-Ran-0088 ENSRNOP00000018861.5 Rattus norvegicus 40 3e-62 236
WERAM-Chs-0140 ENSCSAP00000007481.1 Chlorocebus sabaeus 43 3e-62 236
WERAM-Asni-0009 CADANGAP00002892 Aspergillus niger 50 6e-62 235
WERAM-Soa-0118 ENSSARP00000011447.1 Sorex araneus 43 6e-62 235
WERAM-Anp-0145 ENSAPLP00000015403.1 Anas platyrhynchos 44 1e-61 234
WERAM-Anc-0100 ENSACAP00000009519.3 Anolis carolinensis 41 1e-61 234
WERAM-Coi-0005 EAS35645 Coccidioides immitis 42 1e-61 234
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 46 1e-61 234
WERAM-Ict-0131 ENSSTOP00000013488.2 Ictidomys tridecemlineatus 44 2e-61 233
WERAM-Gam-0155 ENSGMOP00000015228.1 Gadus morhua 47 2e-61 233
WERAM-Meg-0026 ENSMGAP00000002050.2 Meleagris gallopavo 42 2e-61 233
WERAM-Fia-0142 ENSFALP00000011956.1 Ficedula albicollis 47 2e-61 233
WERAM-Gaga-0047 ENSGALP00000006674.4 Gallus gallus 42 3e-61 233
WERAM-Mup-0089 ENSMPUP00000008357.1 Mustela putorius furo 43 3e-61 233
WERAM-Cii-0054 ENSCINP00000012226.3 Ciona intestinalis 42 3e-61 233
WERAM-Sus-0110 ENSSSCP00000015488.2 Sus scrofa 41 5e-61 232
WERAM-Poa-0191 ENSPPYP00000022355.1 Pongo abelii 43 5e-61 232
WERAM-Orla-0002 ENSORLP00000000105.1 Oryzias latipes 42 6e-61 231
WERAM-Lem-0007 CBY02082 Leptosphaeria maculans 45 7e-61 231
WERAM-Ova-0092 ENSOARP00000009476.1 Ovis aries 42 9e-61 231
WERAM-Bot-0022 ENSBTAP00000002648.3 Bos taurus 43 1e-60 231
WERAM-Paa-0056 ENSPANP00000005782.1 Papio anubis 43 1e-60 231
WERAM-Cap-0199 ENSCPOP00000018954.1 Cavia porcellus 42 1e-60 231
WERAM-Nol-0170 ENSNLEP00000018956.1 Nomascus leucogenys 42 1e-60 230
WERAM-Gog-0146 ENSGGOP00000012824.2 Gorilla gorilla 42 1e-60 230
WERAM-Caf-0076 ENSCAFP00000009649.3 Canis familiaris 43 1e-60 230
WERAM-Lac-0044 ENSLACP00000006675.2 Latimeria chalumnae 42 2e-60 230
WERAM-Sah-0089 ENSSHAP00000010517.1 Sarcophilus harrisii 47 2e-60 230
WERAM-Hos-0139 ENSP00000372191.4 Homo sapiens 42 2e-60 230
WERAM-Orc-0194 ENSOCUP00000019306.2 Oryctolagus cuniculus 43 2e-60 229
WERAM-Pes-0119 ENSPSIP00000014160.1 Pelodiscus sinensis 40 3e-60 229
WERAM-Tag-0102 ENSTGUP00000007081.1 Taeniopygia guttata 47 3e-60 229
WERAM-Gag-0013 GGTG_03219T0 Gaeumannomyces graminis 41 4e-60 229
WERAM-Pat-0091 ENSPTRP00000018763.5 Pan troglodytes 42 7e-60 228
WERAM-Otg-0196 ENSOGAP00000020777.1 Otolemur garnettii 44 1e-59 227
WERAM-Fec-0035 ENSFCAP00000002455.2 Felis catus 41 1e-59 227
WERAM-Xet-0018 ENSXETP00000005130.2 Xenopus tropicalis 42 2e-59 227
WERAM-Ptv-0186 ENSPVAP00000016701.1 Pteropus vampyrus 42 3e-59 226
WERAM-Eqc-0017 ENSECAP00000002534.1 Equus caballus 41 3e-59 226
WERAM-Asfu-0013 CADAFUAP00003392 Aspergillus fumigatus 46 6e-59 225
WERAM-Mel-0010 EGG12163 Melampsora laricipopulina 46 2e-58 223
WERAM-Aim-0043 ENSAMEP00000003493.1 Ailuropoda melanoleuca 43 2e-58 223
WERAM-Loa-0217 ENSLAFP00000022559.1 Loxodonta africana 45 3e-58 223
WERAM-Dan-0202 ENSDNOP00000027446.1 Dasypus novemcinctus 42 4e-58 222
WERAM-Caj-0143 ENSCJAP00000025706.2 Callithrix jacchus 41 6e-58 222
WERAM-Mum-0022 ENSMUSP00000072732.4 Mus musculus 41 8e-58 221
WERAM-Myl-0011 ENSMLUP00000000900.2 Myotis lucifugus 41 1e-57 221
WERAM-Drm-0067 FBpp0310647 Drosophila melanogaster 40 1e-57 221
WERAM-Ten-0144 ENSTNIP00000015099.1 Tetraodon nigroviridis 42 2e-57 219
WERAM-Pug-0030 EFP89251 Puccinia graminis 42 8e-57 218
WERAM-Usm-0036 UM05892P0 Ustilago maydis 41 4e-55 212
WERAM-Ocp-0048 ENSOPRP00000004238.2 Ochotona princeps 44 7e-55 211
WERAM-Spr-0042 CBQ70931 Sporisorium reilianum 47 9e-53 204
WERAM-Mam-0216 ENSMMUP00000031121.2 Macaca mulatta 40 7e-52 201
WERAM-Chg-0025 EAQ89546 Chaetomium globosum 43 2e-51 199
WERAM-Osl-0012 ABO98065 Ostreococcus lucimarinus 37 1e-49 194
WERAM-Ved-0011 EGY21147 Verticillium dahliae 47 2e-49 194
WERAM-Dio-0012 ENSDORP00000001437.1 Dipodomys ordii 37 1e-48 191
WERAM-Mim-0058 ENSMICP00000005750.1 Microcebus murinus 38 1e-48 191
WERAM-Mae-0115 ENSMEUP00000010974.1 Macropus eugenii 55 1e-47 187
WERAM-Cym-0017 CML119CT Cyanidioschyzon merolae 34 8e-45 178
WERAM-Tut-0151 ENSTTRP00000012839.1 Tursiops truncatus 54 2e-43 173
WERAM-Ere-0056 ENSEEUP00000004763.1 Erinaceus europaeus 42 5e-43 172
WERAM-Cae-0022 R11A8.4a Caenorhabditis elegans 39 1e-42 171
WERAM-Tas-0108 ENSTSYP00000011158.1 Tarsius syrichta 40 2e-40 163
WERAM-Ect-0047 ENSETEP00000005080.1 Echinops telfairi 33 2e-40 163
WERAM-Yal-0031 CAG78100 Yarrowia lipolytica 37 5e-38 155
WERAM-Vip-0121 ENSVPAP00000010985.1 Vicugna pacos 40 2e-36 150
WERAM-Phn-0017 SNOT_06735 Phaeosphaeria nodorum 33 3e-30 130
Created Date 25-Jun-2016