WERAM Information

Tag Content
WERAM ID WERAM-Hos-0139
Ensembl Protein ID ENSP00000372191.4
Uniprot Accession Q9NTG7; SIR3_HUMAN; B7Z5U6; Q9Y6E8
Genbank Protein ID NP_001017524.1; NP_036371.1
Protein Name NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Genbank Nucleotide ID NM_001017524.2; NM_012239.5
Gene Name SIRT3;SIR2L3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000142082.14 ENST00000382743.8 ENSP00000372191.4
ENSG00000142082.14 ENST00000524564.5 ENSP00000432937.1
ENSG00000142082.14 ENST00000532956.5 ENSP00000433077.1
ENSG00000142082.14 ENST00000525319.5 ENSP00000435464.1
ENSG00000142082.14 ENST00000529382.5 ENSP00000437216.1
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type H3K14 K 19698979
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 1.30e-91 308.8 127 381
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.
Domain Profile
  HDAC SIR2
           SIR2.txt   2 klakllk..kskkivvltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaele 90 
                        ++a+l++   ++++vv++GAGiSt +GIPDFRs ++Glys+l++++lp+peaif+l ff ++pk+f++lakelyp g++kP++tHyfl++l+
  ENSP00000372191.4 127 DVAELIRarACQRVVVMVGAGISTPSGIPDFRSpGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYP-GNYKPNVTHYFLRLLH 217
                        67777776689****************************************************************.**************** PP
           SIR2.txt  91 kkgkllrlytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCekCkgvlkpdivffgenlpeefleevee 182
                        +kg+llrlytQNiDgLer +g++++klve+HG++a a+Ct C++ fp+e i+++++a+ +vp+C+ C+gv+kpdivffge lp++fl +v  
  ENSP00000372191.4 218 DKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMAD-RVPRCPVCTGVVKPDIVFFGEPLPQRFLLHV-V 307
                        **********************************************************.9*****************************9.8 PP
           SIR2.txt 183 dlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevk....adkladlkllgdcdevveellkllglee 253
                        d+  adlll+lGtSl+vep+asl+ +av+++vp+ll+n++ v+    + + +d+++lgd+ + ve+l++llg++e
  ENSP00000372191.4 308 DFPMADLLLILGTSLEVEPFASLT-EAVRSSVPRLLINRDLVGplawHPRSRDVAQLGDVVHGVESLVELLGWTE 381
                        99**********************.*********************999************************87 PP
Protein Sequence
(Fasta)		MAFWGWRAAA ALRLWGRVVE RVEAGGGVGP FQACGCRLVL GGRDDVSAGL RGSHGARGEP 60
LDPARPLQRP PRPEVPRAFR RQPRAAAPSF FFSSIKGGRR SISFSVGASS VVGSGGSSDK 120
GKLSLQDVAE LIRARACQRV VVMVGAGIST PSGIPDFRSP GSGLYSNLQQ YDLPYPEAIF 180
ELPFFFHNPK PFFTLAKELY PGNYKPNVTH YFLRLLHDKG LLLRLYTQNI DGLERVSGIP 240
ASKLVEAHGT FASATCTVCQ RPFPGEDIRA DVMADRVPRC PVCTGVVKPD IVFFGEPLPQ 300
RFLLHVVDFP MADLLLILGT SLEVEPFASL TEAVRSSVPR LLINRDLVGP LAWHPRSRDV 360
AQLGDVVHGV ESLVELLGWT EEMRDLVQRE TGKLDGPDK 399
Nucleotide Sequence
(Fasta)		CGGAGGCGGG GCTGGGGCGC CGGGGGCGGG GGTGGGAGGC GGAGGCGGGG CCGGGGCGCC 60
GGGGGCGGGG CGAGTCCGGA GGACTCCTTG GACTGCGCGG AACATGGCGT TCTGGGGTTG 120
GCGCGCCGCG GCAGCCCTCC GGCTGTGGGG CCGGGTAGTT GAACGGGTCG AGGCCGGGGG 180
AGGCGTGGGG CCGTTTCAGG CCTGCGGCTG TCGGCTGGTG CTTGGCGGCA GGGACGATGT 240
GAGTGCGGGG CTGAGAGGCA GCCATGGGGC CCGCGGTGAG CCCTTGGACC CGGCGCGCCC 300
CTTGCAGAGG CCTCCCAGAC CCGAGGTGCC CAGGGCATTC CGGAGGCAGC CGAGGGCAGC 360
AGCTCCCAGT TTCTTCTTTT CGAGTATTAA AGGTGGAAGA AGGTCCATAT CTTTTTCTGT 420
GGGTGCTTCA AGTGTTGTTG GAAGTGGAGG CAGCAGTGAC AAGGGGAAGC TTTCCCTGCA 480
GGATGTAGCT GAGCTGATTC GGGCCAGAGC CTGCCAGAGG GTGGTGGTCA TGGTGGGGGC 540
CGGCATCAGC ACACCCAGTG GCATTCCAGA CTTCAGATCG CCGGGGAGTG GCCTGTACAG 600
CAACCTCCAG CAGTACGATC TCCCGTACCC CGAGGCCATT TTTGAACTCC CATTCTTCTT 660
TCACAACCCC AAGCCCTTTT TCACTTTGGC CAAGGAGCTG TACCCTGGAA ACTACAAGCC 720
CAACGTCACT CACTACTTTC TCCGGCTGCT TCATGACAAG GGGCTGCTTC TGCGGCTCTA 780
CACGCAGAAC ATCGATGGGC TTGAGAGAGT GTCGGGCATC CCTGCCTCAA AGCTGGTTGA 840
AGCTCATGGA ACCTTTGCCT CTGCCACCTG CACAGTCTGC CAAAGACCCT TCCCAGGGGA 900
GGACATTCGG GCTGACGTGA TGGCAGACAG GGTTCCCCGC TGCCCGGTCT GCACCGGCGT 960
TGTGAAGCCC GACATTGTGT TCTTTGGGGA GCCGCTGCCC CAGAGGTTCT TGCTGCATGT 1020
GGTTGATTTC CCCATGGCAG ATCTGCTGCT CATCCTTGGG ACCTCCCTGG AGGTGGAGCC 1080
TTTTGCCAGC TTGACCGAGG CCGTGCGGAG CTCAGTTCCC CGACTGCTCA TCAACCGGGA 1140
CTTGGTGGGG CCCTTGGCTT GGCATCCTCG CAGCAGGGAC GTGGCCCAGC TGGGGGACGT 1200
GGTTCACGGC GTGGAAAGCC TAGTGGAGCT TCTGGGCTGG ACAGAAGAGA TGCGGGACCT 1260
TGTGCAGCGG GAAACTGGGA AGCTTGATGG ACCAGACAAA TAGGATGATG GCTGCCCCCA 1320
CACAATAAAT GGTAACATAG GAGACATCCA CATCCCAATT CTGACAAGAC CTCATGCCTG 1380
AAGACAGCTT GGGCAGGTGA AACCAGAATA TGTGAACTGA GTGGACACCC GAGGCTGCCA 1440
CTGGAATGTC TTCTCAGGCC ATGAGCTGCA GTGACTGGTA GGGCTGTGTT TACAGTCAGG 1500
GCCACCCCGT CACATATACA AAGGAGCTGC CTGCCTGTTT GCTGTGTTGA ACTCTTCACT 1560
CTGCTGAAGC TCCTAATGGA AAAAGCTTTC TTCTGACTGT GACCCTCTTG AACTGAATCA 1620
GACCAACTGG AATCCCAGAC CGAGTCTGCT TTCTGTGCCT AGTTGAACGG CAAGCTCGGC 1680
ATCTGTTGGT TACAAGATCC AGACTTGGGC CGAGCGGTCC CCAGCCCTCT TCATGTTCCG 1740
AAGTGTAGTC TTGAGGCCCT GGTGCCGCAC TTCTAGCATG TTGGTCTCCT TTAGTGGGGC 1800
TATTTTTAAT GAGAGAAAAT CTGTTCTTTC CAGCATGAAA TACATTTAGT CTCCTCAAAG 1860
GGACTGCAGG TGTTGACATG AGTTGGAAAG GGAACCCTGG GATACGTGGC GTCCCCTCTA 1920
TTGGAACAGT CTGAGGACTG AAGGCATTTG TCCCTGGATT TATTGGAGAC GGCCCAGCTC 1980
CTCCCTCTGA AGGTGGTCAC ATTCTGTTGA CTCTCCATAC TCAGCCTCTC CTCCAGAAAC 2040
AGATCTGTTC CAGAACATTC CAGCACTTTC TATCTGGCCT CCTTGTCCCC ACACTACGCC 2100
CCCCCACCCT CGCCAGGGCT TCCTCTAGTG ACACTGTTAG AGCTAATCTC TGAGACAGGG 2160
AAGGCATTAC TCACTTAAAA CCCAGGCTGA GTCCTGGCCA CCTGCTGGAT TGTGACATAG 2220
GAGGTGGAAT CCACTGAACT GCTACTTCTG CACAGGCTCC TTCTCCTGGG GCTGTACCCA 2280
GGCCCAGCCC TGATGGCTCA CCCTGTCAGG CACCAGCTGC TCCCTCCTGG GCTCTCACCC 2340
ACCTGCACAT CCTCCTTCCT AGCATCACAT TACCTGCGTG TTTCCCCAGA CAAAAGCACT 2400
TCCCATTCTT GAACCTTGCC TACCCTGGGC TGAGCTGACG GCAATAGATT TAATGACAGT 2460
GACTCCCAGG AAGGGGGTCC TGTGACTTTG CGCCTTAATA AGAACAAAAG GTGGAATTGG 2520
TGACCTAGGA AAACTGTTGA ATT 2544
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0520--NAD
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0862--Zinc
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0003950--F:NAD+ ADP-ribosyltransferase activity
GO:0070403--F:NAD+ binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0008270--F:zinc ion binding
GO:0009060--P:aerobic respiration
GO:0007005--P:mitochondrion organization
GO:2000757--P:negative regulation of peptidyl-lysine acetylation
GO:0034983--P:peptidyl-lysine deacetylation
GO:0006471--P:protein ADP-ribosylation
GO:0006476--P:protein deacetylation
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0191 ENSPPYP00000022355.1 Pongo abelii 98 5e-177 617
WERAM-Gog-0146 ENSGGOP00000012824.2 Gorilla gorilla 99 5e-175 611
WERAM-Nol-0170 ENSNLEP00000018956.1 Nomascus leucogenys 93 2e-173 605
WERAM-Paa-0056 ENSPANP00000005782.1 Papio anubis 94 3e-169 592
WERAM-Chs-0140 ENSCSAP00000007481.1 Chlorocebus sabaeus 93 8e-168 587
WERAM-Ict-0131 ENSSTOP00000013488.2 Ictidomys tridecemlineatus 89 4e-137 484
WERAM-Eqc-0017 ENSECAP00000002534.1 Equus caballus 90 9e-135 477
WERAM-Otg-0196 ENSOGAP00000020777.1 Otolemur garnettii 90 1e-134 476
WERAM-Tub-0067 ENSTBEP00000008310.1 Tupaia belangeri 89 2e-134 476
WERAM-Orc-0194 ENSOCUP00000019306.2 Oryctolagus cuniculus 89 2e-134 476
WERAM-Mim-0058 ENSMICP00000005750.1 Microcebus murinus 84 2e-133 472
WERAM-Mup-0089 ENSMPUP00000008357.1 Mustela putorius furo 86 2e-132 469
WERAM-Ran-0088 ENSRNOP00000018861.5 Rattus norvegicus 86 4e-131 465
WERAM-Caf-0076 ENSCAFP00000009649.3 Canis familiaris 85 2e-130 463
WERAM-Ptv-0186 ENSPVAP00000016701.1 Pteropus vampyrus 83 4e-130 461
WERAM-Sus-0110 ENSSSCP00000015488.2 Sus scrofa 85 7e-130 461
WERAM-Aim-0043 ENSAMEP00000003493.1 Ailuropoda melanoleuca 85 9e-130 460
WERAM-Cap-0199 ENSCPOP00000018954.1 Cavia porcellus 85 7e-129 457
WERAM-Caj-0061 ENSCJAP00000010311.1 Callithrix jacchus 90 2e-128 456
WERAM-Fec-0035 ENSFCAP00000002455.2 Felis catus 83 3e-128 455
WERAM-Bot-0022 ENSBTAP00000002648.3 Bos taurus 83 9e-128 454
WERAM-Mam-0066 ENSMMUP00000011129.2 Macaca mulatta 95 1e-127 453
WERAM-Mod-0192 ENSMODP00000026476.2 Monodelphis domestica 83 4e-127 451
WERAM-Ova-0092 ENSOARP00000009476.1 Ovis aries 82 1e-126 450
WERAM-Dan-0202 ENSDNOP00000027446.1 Dasypus novemcinctus 85 2e-126 449
WERAM-Soa-0118 ENSSARP00000011447.1 Sorex araneus 78 9e-125 444
WERAM-Gaga-0047 ENSGALP00000006674.4 Gallus gallus 79 5e-123 438
WERAM-Pes-0119 ENSPSIP00000014160.1 Pelodiscus sinensis 79 4e-122 435
WERAM-Anp-0145 ENSAPLP00000015403.1 Anas platyrhynchos 79 4e-122 435
WERAM-Meg-0026 ENSMGAP00000002050.2 Meleagris gallopavo 78 2e-121 432
WERAM-Anc-0180 ENSACAP00000017235.2 Anolis carolinensis 75 6e-120 428
WERAM-Mum-0070 ENSMUSP00000026559.7 Mus musculus 86 9e-120 427
WERAM-Loa-0217 ENSLAFP00000022559.1 Loxodonta africana 85 3e-116 415
WERAM-Sah-0089 ENSSHAP00000010517.1 Sarcophilus harrisii 80 4e-114 408
WERAM-Fia-0142 ENSFALP00000011956.1 Ficedula albicollis 81 9e-114 407
WERAM-Tag-0102 ENSTGUP00000007081.1 Taeniopygia guttata 82 3e-113 405
WERAM-Tut-0151 ENSTTRP00000012839.1 Tursiops truncatus 77 4e-111 398
WERAM-Lac-0044 ENSLACP00000006675.2 Latimeria chalumnae 68 4e-110 395
WERAM-Leo-0013 ENSLOCP00000002849.1 Lepisosteus oculatus 70 1e-107 387
WERAM-Orn-0188 ENSONIP00000019610.1 Oreochromis niloticus 70 4e-106 382
WERAM-Dar-0078 ENSDARP00000051972.5 Danio rerio 71 5e-106 382
WERAM-Asm-0068 ENSAMXP00000007378.1 Astyanax mexicanus 70 1e-104 377
WERAM-Gam-0078 ENSGMOP00000008397.1 Gadus morhua 68 2e-103 373
WERAM-Pof-0013 ENSPFOP00000001321.2 Poecilia formosa 72 8e-103 371
WERAM-Gaa-0170 ENSGACP00000020749.1 Gasterosteus aculeatus 71 1e-102 370
WERAM-Xim-0222 ENSXMAP00000018428.1 Xiphophorus maculatus 71 1e-101 367
WERAM-Orla-0002 ENSORLP00000000105.1 Oryzias latipes 70 6e-100 361
WERAM-Tar-0146 ENSTRUP00000031533.1 Takifugu rubripes 74 3e-98 355
WERAM-Xet-0176 ENSXETP00000058774.1 Xenopus tropicalis 61 4e-88 322
WERAM-Ere-0056 ENSEEUP00000004763.1 Erinaceus europaeus 82 9e-88 321
WERAM-Pem-0044 ENSPMAP00000005386.1 Petromyzon marinus 61 6e-87 318
WERAM-Ten-0144 ENSTNIP00000015099.1 Tetraodon nigroviridis 56 2e-83 306
WERAM-Cii-0083 ENSCINP00000033928.1 Ciona intestinalis 56 5e-81 298
WERAM-Cis-0075 ENSCSAVP00000016120.1 Ciona savignyi 53 6e-80 295
WERAM-Drm-0067 FBpp0310647 Drosophila melanogaster 53 2e-73 273
WERAM-Tas-0032 ENSTSYP00000003226.1 Tarsius syrichta 92 2e-73 273
WERAM-Pat-0091 ENSPTRP00000018763.5 Pan troglodytes 50 6e-73 272
WERAM-Myl-0011 ENSMLUP00000000900.2 Myotis lucifugus 50 1e-72 270
WERAM-Trr-0018 EGR46788 Trichoderma reesei 53 2e-72 270
WERAM-Trv-0012 EHK19002 Trichoderma virens 52 3e-72 270
WERAM-Miv-0009 MVLG_01362T0 Microbotryum violaceum 49 1e-70 264
WERAM-Mao-0040 MGG_17827T0 Magnaporthe oryzae 51 4e-70 262
WERAM-Fuo-0021 FOXG_06023P0 Fusarium oxysporum 49 2e-69 260
WERAM-Coi-0005 EAS35645 Coccidioides immitis 50 2e-68 256
WERAM-Zyt-0001 Mycgr3P100618 Zymoseptoria tritici 51 3e-68 256
WERAM-Scp-0042 SPCC132.02.1:pep Schizosaccharomyces pombe 50 9e-68 254
WERAM-Lab-0008 EDR12994 Laccaria bicolor 47 2e-67 253
WERAM-Pyt-0039 EFQ86136 Pyrenophora teres 50 4e-67 252
WERAM-Lem-0007 CBY02082 Leptosphaeria maculans 50 5e-67 252
WERAM-Pytr-0009 EDU41553 Pyrenophora triticirepentis 50 8e-67 251
WERAM-Asn-0005 CADANIAP00000554 Aspergillus nidulans 50 1e-66 250
WERAM-Ast-0036 CADATEAP00009630 Aspergillus terreus 49 2e-66 250
WERAM-Gag-0013 GGTG_03219T0 Gaeumannomyces graminis 50 3e-66 249
WERAM-Aso-0005 CADAORAP00000633 Aspergillus oryzae 48 4e-66 249
WERAM-Asf-0024 CADAFLAP00010064 Aspergillus flavus 48 4e-66 249
WERAM-Usm-0036 UM05892P0 Ustilago maydis 45 9e-66 248
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 50 1e-65 248
WERAM-Asfu-0013 CADAFUAP00003392 Aspergillus fumigatus 52 2e-65 246
WERAM-Asc-0030 CADACLAP00006830 Aspergillus clavatus 50 1e-64 244
WERAM-Ocp-0048 ENSOPRP00000004238.2 Ochotona princeps 55 1e-64 244
WERAM-Pug-0030 EFP89251 Puccinia graminis 46 5e-64 242
WERAM-Crn-0031 AAW44797 Cryptococcus neoformans 45 1e-63 241
WERAM-Asni-0009 CADANGAP00002892 Aspergillus niger 50 2e-63 239
WERAM-Mel-0010 EGG12163 Melampsora laricipopulina 50 3e-63 239
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 48 6e-63 238
WERAM-Scj-0005 EEB06048 Schizosaccharomyces japonicus 49 1e-62 238
WERAM-Spr-0042 CBQ70931 Sporisorium reilianum 47 1e-61 234
WERAM-Dio-0012 ENSDORP00000001437.1 Dipodomys ordii 46 8e-61 231
WERAM-Asg-0028 AAS54472 Ashbya gossypii 46 1e-59 227
WERAM-Caa-0033 KGT64755 Candida albicans 45 3e-59 226
WERAM-Kop-0007 CAY68156 Komagataella pastoris 49 5e-59 225
WERAM-Cag-0026 CAG62123 Candida glabrata 44 2e-58 223
WERAM-Chg-0025 EAQ89546 Chaetomium globosum 46 6e-56 215
WERAM-Sac-0046 YPL015C Saccharomyces cerevisiae 42 4e-55 213
WERAM-Ved-0011 EGY21147 Verticillium dahliae 47 6e-54 208
WERAM-Kll-0027 CAG98291 Kluyveromyces lactis 41 1e-53 207
WERAM-Osl-0012 ABO98065 Ostreococcus lucimarinus 45 5e-52 202
WERAM-Ect-0047 ENSETEP00000005080.1 Echinops telfairi 40 1e-50 197
WERAM-Mae-0115 ENSMEUP00000010974.1 Macropus eugenii 58 7e-49 191
WERAM-Cae-0022 R11A8.4a Caenorhabditis elegans 45 8e-49 191
WERAM-Cym-0017 CML119CT Cyanidioschyzon merolae 42 8e-44 175
WERAM-Vip-0121 ENSVPAP00000010985.1 Vicugna pacos 41 9e-42 168
WERAM-Yal-0031 CAG78100 Yarrowia lipolytica 43 5e-41 166
WERAM-Phn-0017 SNOT_06735 Phaeosphaeria nodorum 36 2e-36 150
Created Date 25-Jun-2016