| Tag |
Content |
| WERAM ID |
WERAM-Sac-0031 |
| Ensembl Protein ID |
YLR399C |
| Uniprot Accession |
P35817; BDF1_YEAST; D6VZ34; Q06048
|
| Genbank Protein ID |
NP_013503.1
|
| Protein Name |
Bromodomain-containing factor 1 |
| Genbank Nucleotide ID |
NM_001182287.1
|
| Gene Name |
BDF1;YLR399C;L8084.18 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| Ac_Reader |
Bromodomain |
Bromodomain |
H4K5; H4K8; H4K12; H4K16 |
K |
11911891
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Ac_Reader |
Bromodomain |
5.30e-44 |
146.6 |
167 |
401 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation. |
Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA-damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation.
|
| Domain Profile |
Ac_Reader Bromodomain
BROMO.txt 3 hevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenks 69
+++ pF +pvdp l+ip Y++ ik+PmdLsti+++l+ g Y+ pe+ +D++l++nN+ ++n++++
YLR399C 167 LKDARPFLQPVDPVkLDIPFYFNYIKRPMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNGPNA 234
5799************************************************************9976 PP
BROMO.txt 6 sepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenks 69
pF epvdp ++p Y+d +kePmdL ti ++l+ +Y+++e+f +Dvrl+f+N++++n++++
YLR399C 337 NYPFLEPVDPVsMNLPTYFDYVKEPMDLGTIAKKLNDWQYQTMEDFERDVRLVFKNCYTFNPDGT 401
579**********************************************************9986 PP
|
Protein Sequence
(Fasta) | MTDITPVQND VDVNGNNVND DVSSNLKRPI DQGDPSNGLA EEENPANNQL HLKKARLDGD 60
ALTSSPAGLA ENGIEGATLA ANGENGYNAT GSGAEDEQQG LKKEEGGQGT KQEDLDENSK 120
QELPMEVPKE PAPAPPPEPD MNNLPQNPIP KHQQKHALLA IKAVKRLKDA RPFLQPVDPV 180
KLDIPFYFNY IKRPMDLSTI ERKLNVGAYE VPEQITEDFN LMVNNSIKFN GPNAGISQMA 240
RNIQASFEKH MLNMPAKDAP PVIAKGRRSS AQEDAPIVIR RAQTHNGRPK RTIHPPKSKD 300
IYPYESKKPK SKRLQQAMKF CQSVLKELMA KKHASYNYPF LEPVDPVSMN LPTYFDYVKE 360
PMDLGTIAKK LNDWQYQTME DFERDVRLVF KNCYTFNPDG TIVNMMGHRL EEVFNSKWAD 420
RPNLDDYDSD EDSRTQGDYD DYESEYSESD IDETIITNPA IQYLEEQLAR MKVELQQLKK 480
QELEKIRKER RLARGSKKRG KRSKGRSGSK NASSKGRRDK KNKLKTVVTY DMKRIITERI 540
NDLPTSKLER AIDIIKKSMP NISEDDEVEL DLDTLDNHTI LTLYNTFFRQ YESSSGASNG 600
LDGTSGVTRD ASSLSPTSAG SRKRRSKALS QEEQSRQIEK IKNKLAILDS ASPLSQNGSP 660
GQIQSAAHNG FSSSSDDDVS SESEEE 686Protein Fasta Sequence
>YLR399C|BDF1;YLR399C;L8084.18|Saccharomyces cerevisiae
MTDITPVQNDVDVNGNNVNDDVSSNLKRPIDQGDPSNGLAEEENPANNQLHLKKARLDGDALTSSPAGLAENGIEGATLAANGENGYNATGSGAEDEQQGLKKEEGGQGTKQEDLDENSKQELPMEVPKEPAPAPPPEPDMNNLPQNPIPKHQQKHALLAIKAVKRLKDARPFLQPVDPVKLDIPFYFNYIKRPMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNGPNAGISQMARNIQASFEKHMLNMPAKDAPPVIAKGRRSSAQEDAPIVIRRAQTHNGRPKRTIHPPKSKDIYPYESKKPKSKRLQQAMKFCQSVLKELMAKKHASYNYPFLEPVDPVSMNLPTYFDYVKEPMDLGTIAKKLNDWQYQTMEDFERDVRLVFKNCYTFNPDGTIVNMMGHRLEEVFNSKWADRPNLDDYDSDEDSRTQGDYDDYESEYSESDIDETIITNPAIQYLEEQLARMKVELQQLKKQELEKIRKERRLARGSKKRGKRSKGRSGSKNASSKGRRDKKNKLKTVVTYDMKRIITERINDLPTSKLERAIDIIKKSMPNISEDDEVELDLDTLDNHTILTLYNTFFRQYESSSGASNGLDGTSGVTRDASSLSPTSAGSRKRRSKALSQEEQSRQIEKIKNKLAILDSASPLSQNGSPGQIQSAAHNGFSSSSDDDVSSESEEE |
Nucleotide Sequence
(Fasta) | ATGACCGATA TCACACCCGT ACAGAACGAT GTGGATGTCA ATGGTAATAA TGTCAATGAC 60
GACGTTTCCA GTAATCTAAA GAGGCCTATA GATCAAGGGG ATCCTTCGAA TGGACTCGCA 120
GAAGAAGAAA ACCCCGCCAA TAACCAGTTG CATCTCAAAA AGGCTAGACT GGATGGAGAT 180
GCTCTAACAT CATCGCCTGC TGGACTTGCA GAGAACGGTA TTGAAGGCGC CACCCTGGCG 240
GCTAACGGGG AAAATGGGTA TAACGCCACC GGAAGTGGCG CAGAAGACGA ACAGCAGGGG 300
TTGAAGAAGG AAGAAGGAGG ACAAGGTACC AAACAAGAGG ATTTAGATGA AAACTCAAAA 360
CAAGAACTTC CGATGGAGGT TCCAAAGGAA CCTGCCCCTG CTCCTCCTCC AGAGCCCGAT 420
ATGAATAATC TCCCTCAGAA TCCAATACCA AAGCACCAGC AGAAACATGC ATTGCTTGCG 480
ATTAAAGCTG TCAAACGCTT GAAGGATGCG AGACCCTTTC TACAACCTGT TGACCCAGTG 540
AAATTGGATA TTCCCTTTTA CTTTAACTAC ATAAAGAGGC CAATGGACTT GTCTACTATA 600
GAGAGGAAGT TGAACGTAGG CGCTTATGAA GTTCCGGAGC AAATCACGGA GGATTTCAAT 660
CTCATGGTTA ACAACAGTAT TAAATTCAAC GGTCCAAATG CGGGCATATC ACAAATGGCA 720
AGAAACATAC AAGCTTCTTT CGAGAAACAT ATGCTAAATA TGCCTGCTAA GGATGCTCCA 780
CCTGTAATAG CCAAGGGACG GCGGTCTAGT GCCCAAGAGG ATGCCCCAAT TGTAATTAGA 840
CGAGCCCAAA CTCATAATGG GAGGCCGAAA AGGACTATAC ATCCGCCGAA ATCAAAGGAT 900
ATTTATCCTT ATGAATCGAA GAAACCGAAA TCCAAAAGAC TACAACAAGC AATGAAATTT 960
TGTCAGAGTG TGCTAAAGGA ATTGATGGCC AAGAAGCACG CCTCTTATAA CTACCCATTT 1020
TTGGAACCAG TAGACCCAGT TTCTATGAAT TTGCCGACTT ATTTCGATTA TGTTAAAGAG 1080
CCAATGGATT TAGGCACAAT CGCCAAGAAA TTAAATGACT GGCAGTATCA AACAATGGAG 1140
GATTTTGAGA GAGACGTGAG GTTGGTCTTT AAAAACTGCT ACACGTTCAA TCCGGATGGC 1200
ACGATCGTTA ATATGATGGG TCATCGTCTA GAGGAAGTTT TCAATTCCAA ATGGGCGGAT 1260
AGGCCTAATT TGGATGACTA CGATTCCGAT GAAGATTCGA GGACCCAAGG CGACTACGAC 1320
GATTATGAAT CTGAGTATTC AGAGTCTGAC ATCGATGAAA CTATAATTAC AAATCCAGCC 1380
ATCCAGTATT TGGAAGAACA ACTTGCTCGG ATGAAAGTGG AGTTGCAACA ATTAAAAAAG 1440
CAAGAACTGG AAAAAATAAG AAAAGAGAGG CGCTTAGCAC GTGGATCAAA GAAACGCGGC 1500
AAAAGATCGA AGGGAAGGAG TGGGTCTAAG AACGCTTCTT CGAAAGGAAG GCGAGATAAA 1560
AAGAATAAAT TGAAAACAGT AGTGACATAT GATATGAAAC GTATCATTAC AGAGAGGATC 1620
AATGATTTAC CAACTTCCAA ATTAGAAAGA GCAATCGACA TAATAAAAAA ATCCATGCCC 1680
AATATTTCTG AAGACGATGA AGTAGAACTT GACCTCGACA CTTTAGATAA TCACACCATC 1740
TTAACATTGT ACAACACTTT CTTTAGACAA TATGAAAGCT CATCCGGTGC TTCTAACGGT 1800
TTGGACGGTA CTTCAGGTGT TACGCGAGAT GCTTCGTCCT TGTCGCCTAC AAGTGCGGGA 1860
AGCAGAAAGA GAAGATCTAA GGCATTAAGC CAAGAGGAGC AGAGTAGGCA GATAGAAAAG 1920
ATAAAAAATA AACTAGCTAT CTTAGACAGT GCTTCACCTC TGAGCCAAAA CGGCTCCCCA 1980
GGCCAAATTC AAAGCGCTGC ACACAACGGG TTTTCCTCAT CTTCAGATGA CGATGTTAGC 2040
AGCGAAAGTG AAGAAGAGTG A
2062Nucleotide Fasta Sequence
>YLR399C|Bromodomain|Saccharomyces cerevisiae
ATGACCGATATCACACCCGTACAGAACGATGTGGATGTCAATGGTAATAATGTCAATGACGACGTTTCCAGTAATCTAAAGAGGCCTATAGATCAAGGGGATCCTTCGAATGGACTCGCAGAAGAAGAAAACCCCGCCAATAACCAGTTGCATCTCAAAAAGGCTAGACTGGATGGAGATGCTCTAACATCATCGCCTGCTGGACTTGCAGAGAACGGTATTGAAGGCGCCACCCTGGCGGCTAACGGGGAAAATGGGTATAACGCCACCGGAAGTGGCGCAGAAGACGAACAGCAGGGGTTGAAGAAGGAAGAAGGAGGACAAGGTACCAAACAAGAGGATTTAGATGAAAACTCAAAACAAGAACTTCCGATGGAGGTTCCAAAGGAACCTGCCCCTGCTCCTCCTCCAGAGCCCGATATGAATAATCTCCCTCAGAATCCAATACCAAAGCACCAGCAGAAACATGCATTGCTTGCGATTAAAGCTGTCAAACGCTTGAAGGATGCGAGACCCTTTCTACAACCTGTTGACCCAGTGAAATTGGATATTCCCTTTTACTTTAACTACATAAAGAGGCCAATGGACTTGTCTACTATAGAGAGGAAGTTGAACGTAGGCGCTTATGAAGTTCCGGAGCAAATCACGGAGGATTTCAATCTCATGGTTAACAACAGTATTAAATTCAACGGTCCAAATGCGGGCATATCACAAATGGCAAGAAACATACAAGCTTCTTTCGAGAAACATATGCTAAATATGCCTGCTAAGGATGCTCCACCTGTAATAGCCAAGGGACGGCGGTCTAGTGCCCAAGAGGATGCCCCAATTGTAATTAGACGAGCCCAAACTCATAATGGGAGGCCGAAAAGGACTATACATCCGCCGAAATCAAAGGATATTTATCCTTATGAATCGAAGAAACCGAAATCCAAAAGACTACAACAAGCAATGAAATTTTGTCAGAGTGTGCTAAAGGAATTGATGGCCAAGAAGCACGCCTCTTATAACTACCCATTTTTGGAACCAGTAGACCCAGTTTCTATGAATTTGCCGACTTATTTCGATTATGTTAAAGAGCCAATGGATTTAGGCACAATCGCCAAGAAATTAAATGACTGGCAGTATCAAACAATGGAGGATTTTGAGAGAGACGTGAGGTTGGTCTTTAAAAACTGCTACACGTTCAATCCGGATGGCACGATCGTTAATATGATGGGTCATCGTCTAGAGGAAGTTTTCAATTCCAAATGGGCGGATAGGCCTAATTTGGATGACTACGATTCCGATGAAGATTCGAGGACCCAAGGCGACTACGACGATTATGAATCTGAGTATTCAGAGTCTGACATCGATGAAACTATAATTACAAATCCAGCCATCCAGTATTTGGAAGAACAACTTGCTCGGATGAAAGTGGAGTTGCAACAATTAAAAAAGCAAGAACTGGAAAAAATAAGAAAAGAGAGGCGCTTAGCACGTGGATCAAAGAAACGCGGCAAAAGATCGAAGGGAAGGAGTGGGTCTAAGAACGCTTCTTCGAAAGGAAGGCGAGATAAAAAGAATAAATTGAAAACAGTAGTGACATATGATATGAAACGTATCATTACAGAGAGGATCAATGATTTACCAACTTCCAAATTAGAAAGAGCAATCGACATAATAAAAAAATCCATGCCCAATATTTCTGAAGACGATGAAGTAGAACTTGACCTCGACACTTTAGATAATCACACCATCTTAACATTGTACAACACTTTCTTTAGACAATATGAAAGCTCATCCGGTGCTTCTAACGGTTTGGACGGTACTTCAGGTGTTACGCGAGATGCTTCGTCCTTGTCGCCTACAAGTGCGGGAAGCAGAAAGAGAAGATCTAAGGCATTAAGCCAAGAGGAGCAGAGTAGGCAGATAGAAAAGATAAAAAATAAACTAGCTATCTTAGACAGTGCTTCACCTCTGAGCCAAAACGGCTCCCCAGGCCAAATTCAAAGCGCTGCACACAACGGGTTTTCCTCATCTTCAGATGACGATGTTAGCAGCGAAAGTGAAGAAGAGTGA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0749--Sporulation
KW-0804--Transcription
KW-0805--Transcription regulation
--
|
| Interpro |
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR027353--NET_dom
|
| PROSITE |
PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51525--NET
|
| Pfam |
PF17035--BET
PF00439--Bromodomain
|
| Gene Ontology |
GO:0000790--C:nuclear chromatin
GO:0000812--C:Swr1 complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0070577--F:lysine-acetylated histone binding
GO:0001094--F:TFIID-class transcription factor binding
GO:0006338--P:chromatin remodeling
GO:0006281--P:DNA repair
GO:0031452--P:negative regulation of heterochromatin assembly
GO:1900051--P:positive regulation of histone exchange
GO:0090054--P:regulation of chromatin silencing at silent mating-type cassette
GO:0031938--P:regulation of chromatin silencing at telomere
GO:0009301--P:snRNA transcription
GO:0030435--P:sporulation resulting in formation of a cellular spore
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
