WERAM Information

Tag Content
WERAM ID WERAM-Cae-0070
Ensembl Protein ID Y119C1B.8a
Uniprot Accession Q95Y80; BET1_CAEEL; H2KZI7
Genbank Protein ID NP_491384.3; NP_871879.1
Protein Name Bromodomain-containing protein bet-1
Genbank Nucleotide ID NM_058983.3; NM_182079.3
Gene Name BET1;Y119C1B.8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00022473 Y119C1B.8a Y119C1B.8a
WBGene00022473 Y119C1B.8b Y119C1B.8b
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain H4K5; H4K8; H4K12; H4K16 K 25254151; 20181741
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 1.10e-46 157.4 57 347
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View)		 Required for the establishment and maintenance of stable cell fate in several lineages including V5.pa, T, Z1/Z4 and QR lineages probably by repressing the expression of cell fate determinants (PubMed:20181741, PubMed:24346701). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the htz-1-mediated repression of transcription factor ceh-22. Regulates the subnuclear localization of histone variant htz-1 in somatic gonadal cells (PubMed:24346701). Plays a role in the attenuation of the let-60/ras pathway, probably by preventing expression of activators of the pathway (PubMed:24285704, PubMed:24349540). Involved in adult locomotion. Acts together with the sumoylation pathway to prevent muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression (PubMed:24285704). May play a role in vulva development (PubMed:24349540).
Domain Profile
  Ac_Reader Bromodomain
   BROMO.txt   2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                 +h++ +pF++pvd+  l ip Y++ + +PmdL+ti++rl++ +Y+ ++e+++D++ +f+N++++n+++++v
  Y119C1B.8a  57 KHKHVWPFQKPVDAVaLCIPLYHERVARPMDLKTIENRLKSTYYTCAQECIDDIETVFQNCYTFNGKEDDV 127
                 6999****************************************************************997 PP
   BROMO.txt   2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkss 70 
                  +e+++pF+epvd++ l ++dY++iikePmdL+ +k+++e+g Y++p++f +Dvrl+++N+  yn+ ++ 
  Y119C1B.8a 278 YQEFAWPFNEPVDAEqLGLHDYHKIIKEPMDLKSMKAKMESGAYKEPSDFEHDVRLMLRNCFLYNPVGDP 347
                 5799*************************************************************97776 PP
Protein Sequence
(Fasta)		MSEGSGDQSQ QRPWASPRQQ PIKGIVQPRV LPPFGKPTRH TNKLDYIMTT VLKEAGKHKH 60
VWPFQKPVDA VALCIPLYHE RVARPMDLKT IENRLKSTYY TCAQECIDDI ETVFQNCYTF 120
NGKEDDVTIM AQNVHEVIKK SLEQAPREEH DMDVYWGKNK KKPAKSDGGS KSSSSKKNDA 180
RGPSEAPSEA GSEVSSVTTA SAAAPTVSES ASVAAKPERK VAGKKTGKRK AESEDDEKPE 240
PLRAKREVAV VKKEVHQPLL PSMKPCLKLL NDFSTKKYQE FAWPFNEPVD AEQLGLHDYH 300
KIIKEPMDLK SMKAKMESGA YKEPSDFEHD VRLMLRNCFL YNPVGDPVHS FGLRFQEVFD 360
RRWAELGDSS SRASSVAPQS APIAPTPKVA KSSAPKEPKE SRKEHKKETT FEASGAKSED 420
LMQINNALSM IREREEKLKA ELAAAQAIKD KLTSVKNRRE DNPNEPFPEK LINETRALCT 480
TQVGQNASSS SASSAALRNG RSKKAASARL YGYEFDSDDE DNKMALTYEE KRNLSNLINN 540
LPNNQLNTII SIIQRRERSA LMQQQLDDSE VELDFESLGD MCLREMGAFI KTIPTLNGNG 600
DDEKPKTSSN PTSSGATGSK GSSSLESKNG KKKKNFNMSE SSDDETSNSR KRRKRESSES 660
QSSSSSDDDS DDEDRPSIPR KSGQPPSTSR EWNQSSAPPP RMGGMGGQPP MSRVPASSST 720
SVSAIGKNNA AASSNSYQAP KPAPVPAPTS SRPPAAPRPP SKPKKTGGAS ILDTLLPDTF 780
GASPPQFFQS QPTTSATIRS PTESQPGNGE DEQTRIQRMR MEAKRARQKE DEGSVSLSNQ 840
MEMMAAFEFD NTY 853
Nucleotide Sequence
(Fasta)		ATGTCTGAGG GCAGCGGAGA CCAATCACAA CAACGACCAT GGGCAAGTCC GCGACAGCAA 60
CCAATCAAAG GAATCGTACA GCCACGAGTA CTTCCACCAT TCGGAAAGCC AACACGACAC 120
ACAAACAAAC TGGACTACAT TATGACAACA GTACTCAAAG AGGCTGGAAA ACATAAACAT 180
GTCTGGCCGT TTCAGAAGCC CGTCGATGCG GTTGCTTTAT GTATTCCTCT ATATCACGAG 240
AGAGTCGCCC GACCAATGGA CTTGAAAACA ATCGAGAATA GACTGAAAAG TACTTATTAC 300
ACATGTGCTC AAGAATGCAT TGATGATATC GAAACAGTTT TCCAAAACTG CTACACATTC 360
AATGGGAAAG AGGACGACGT GACAATTATG GCCCAAAATG TGCACGAAGT GATAAAAAAG 420
TCACTGGAAC AAGCACCTCG CGAAGAGCAT GATATGGATG TTTATTGGGG AAAAAATAAG 480
AAAAAACCGG CAAAAAGTGA CGGTGGATCG AAATCTTCGT CGAGCAAGAA GAATGATGCT 540
CGTGGACCAT CTGAAGCACC GTCAGAGGCT GGAAGTGAAG TTTCGTCTGT AACAACAGCA 600
TCAGCAGCAG CCCCGACGGT TTCTGAGTCT GCGAGTGTTG CCGCGAAGCC AGAACGAAAA 660
GTGGCCGGAA AGAAGACGGG AAAACGAAAA GCCGAATCAG AAGATGACGA GAAGCCGGAA 720
CCTTTGAGAG CAAAACGAGA GGTGGCTGTT GTCAAAAAAG AAGTTCATCA GCCATTGCTC 780
CCAAGTATGA AGCCCTGTCT GAAGCTGCTC AATGATTTTT CTACAAAAAA ATATCAGGAA 840
TTTGCTTGGC CATTCAACGA ACCAGTAGAC GCTGAACAAC TGGGACTCCA TGATTATCAT 900
AAAATTATCA AAGAACCAAT GGATCTGAAA TCAATGAAAG CAAAAATGGA AAGTGGAGCA 960
TACAAGGAAC CTTCAGATTT CGAGCATGAT GTTCGTTTAA TGCTCAGGAA TTGTTTTCTT 1020
TATAATCCAG TCGGTGATCC GGTTCACAGT TTTGGTCTTA GGTTTCAAGA AGTTTTTGAT 1080
AGACGATGGG CTGAACTAGG TGATTCGAGT TCTCGTGCTT CATCAGTTGC ACCTCAATCA 1140
GCTCCGATTG CTCCAACTCC GAAAGTAGCA AAATCAAGTG CTCCAAAAGA ACCGAAAGAG 1200
TCTCGAAAAG AGCATAAAAA GGAGACGACT TTTGAAGCAA GCGGTGCAAA ATCGGAGGAT 1260
TTAATGCAGA TAAACAACGC GTTGAGCATG ATTCGAGAAC GTGAGGAAAA GCTTAAAGCA 1320
GAGCTCGCCG CTGCACAAGC GATAAAGGAT AAACTGACGA GTGTGAAGAA TCGACGAGAA 1380
GATAATCCGA ATGAGCCATT TCCGGAGAAG CTTATCAATG AGACAAGAGC CTTGTGCACG 1440
ACGCAAGTTG GACAAAATGC TTCAAGTTCT TCAGCTTCTT CTGCTGCTTT GAGGAACGGA 1500
CGAAGCAAAA AAGCAGCATC CGCACGTCTC TATGGTTACG AATTTGATTC GGATGATGAG 1560
GATAATAAGA TGGCACTGAC TTATGAGGAA AAACGAAACT TGAGCAATCT GATTAATAAT 1620
TTACCCAACA ATCAACTCAA CACCATAATT TCGATTATTC AACGGAGAGA ACGAAGCGCT 1680
CTGATGCAAC AACAACTCGA TGACAGTGAG GTTGAACTGG ATTTCGAATC ACTTGGAGAT 1740
ATGTGCCTGA GAGAAATGGG TGCATTTATC AAAACAATTC CAACATTAAA CGGAAATGGC 1800
GATGATGAGA AGCCGAAAAC GTCTTCGAAT CCGACATCTT CTGGAGCAAC AGGATCAAAG 1860
GGTTCGTCGT CGTTGGAGAG CAAAAATGGA AAGAAAAAGA AAAACTTCAA TATGTCCGAA 1920
TCCTCGGATG ATGAGACGTC GAATAGTCGA AAACGTCGAA AGAGAGAGAG CAGTGAATCA 1980
CAGAGCTCTT CGTCCAGTGA TGATGATTCA GATGATGAGG ATAGGCCGAG TATTCCCCGT 2040
AAATCAGGTC AACCACCATC AACATCACGT GAATGGAATC AATCATCAGC TCCTCCACCA 2100
CGAATGGGAG GAATGGGAGG ACAACCACCA ATGTCACGAG TACCTGCATC ATCATCCACA 2160
TCTGTATCAG CAATCGGAAA GAACAACGCA GCCGCCTCGT CGAATTCATA TCAAGCTCCA 2220
AAACCTGCAC CAGTACCAGC ACCAACATCA TCAAGACCTC CGGCAGCACC GAGACCACCG 2280
TCAAAACCAA AGAAAACGGG TGGAGCGAGT ATTCTTGATA CTCTACTTCC AGATACATTT 2340
GGAGCATCAC CTCCCCAGTT TTTCCAGTCG CAACCAACAA CGTCGGCTAC GATTAGATCA 2400
CCAACGGAAA GCCAACCCGG GAATGGTGAA GACGAGCAGA CCAGGATTCA GAGGATGCGG 2460
ATGGAGGCAA AGCGAGCCCG CCAAAAAGAA GACGAAGGCA GTGTCTCGTT GTCAAACCAA 2520
ATGGAAATGA TGGCTGCATT TGAATTTGAT AATACATATT AATAATATTT CAGCCCCGG 2580
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
--
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR027353--NET_dom
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51525--NET
Pfam

PF17035--BET
PF00439--Bromodomain
Gene Ontology

GO:0005694--C:chromosome
GO:0070090--C:metaphase plate
GO:0005634--C:nucleus
GO:0070577--F:lysine-acetylated histone binding
GO:0032183--F:SUMO binding
GO:0001708--P:cell fate specification
GO:0014018--P:neuroblast fate specification
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0040028--P:regulation of vulval development
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Drm-0012 FBpp0071074 Drosophila melanogaster 44 2e-34 145
WERAM-Gaa-0105 ENSGACP00000013356.1 Gasterosteus aculeatus 30 3e-29 127
WERAM-Cap-0031 ENSCPOP00000002556.2 Cavia porcellus 44 4e-29 127
WERAM-Xet-0088 ENSXETP00000028569.3 Xenopus tropicalis 40 7e-29 127
WERAM-Otg-0077 ENSOGAP00000005790.2 Otolemur garnettii 43 8e-29 126
WERAM-Anc-0036 ENSACAP00000004148.2 Anolis carolinensis 43 8e-29 126
WERAM-Leo-0065 ENSLOCP00000008328.1 Lepisosteus oculatus 43 8e-29 126
WERAM-Orla-0148 ENSORLP00000017453.1 Oryzias latipes 47 9e-29 126
WERAM-Eqc-0079 ENSECAP00000010277.1 Equus caballus 43 9e-29 126
WERAM-Ect-0061 ENSETEP00000006671.1 Echinops telfairi 43 1e-28 126
WERAM-Caj-0224 ENSCJAP00000040148.2 Callithrix jacchus 43 1e-28 126
WERAM-Lac-0047 ENSLACP00000006835.1 Latimeria chalumnae 41 1e-28 126
WERAM-Ptv-0132 ENSPVAP00000011321.1 Pteropus vampyrus 43 1e-28 126
WERAM-Vip-0081 ENSVPAP00000007489.1 Vicugna pacos 43 1e-28 126
WERAM-Dio-0036 ENSDORP00000004207.1 Dipodomys ordii 43 1e-28 126
WERAM-Paa-0136 ENSPANP00000012397.1 Papio anubis 43 1e-28 126
WERAM-Ran-0004 ENSRNOP00000000535.4 Rattus norvegicus 43 1e-28 126
WERAM-Mum-0058 ENSMUSP00000025193.6 Mus musculus 43 1e-28 126
WERAM-Loa-0152 ENSLAFP00000013518.3 Loxodonta africana 43 1e-28 126
WERAM-Bot-0108 ENSBTAP00000014704.5 Bos taurus 43 1e-28 126
WERAM-Caf-0006 ENSCAFP00000001265.3 Canis familiaris 43 1e-28 126
WERAM-Prc-0094 ENSPCAP00000008495.1 Procavia capensis 43 1e-28 126
WERAM-Mup-0018 ENSMPUP00000001938.1 Mustela putorius furo 43 1e-28 126
WERAM-Mam-0211 ENSMMUP00000030455.2 Macaca mulatta 43 1e-28 126
WERAM-Tut-0048 ENSTTRP00000004025.1 Tursiops truncatus 43 1e-28 125
WERAM-Poa-0157 ENSPPYP00000019309.1 Pongo abelii 43 1e-28 125
WERAM-Hos-0245 ENSP00000382443.1 Homo sapiens 43 1e-28 125
WERAM-Pat-0149 ENSPTRP00000030782.4 Pan troglodytes 43 1e-28 125
WERAM-Gog-0065 ENSGGOP00000005721.2 Gorilla gorilla 43 1e-28 125
WERAM-Sus-0016 ENSSSCP00000001595.1 Sus scrofa 43 1e-28 125
WERAM-Ova-0082 ENSOARP00000008629.1 Ovis aries 43 1e-28 125
WERAM-Aim-0029 ENSAMEP00000002041.1 Ailuropoda melanoleuca 43 1e-28 125
WERAM-Meg-0083 ENSMGAP00000000014.2 Meleagris gallopavo 44 1e-28 125
WERAM-Fec-0108 ENSFCAP00000008990.2 Felis catus 43 1e-28 125
WERAM-Mim-0036 ENSMICP00000003366.1 Microcebus murinus 43 1e-28 125
WERAM-Nol-0068 ENSNLEP00000008263.2 Nomascus leucogenys 43 2e-28 125
WERAM-Dan-0048 ENSDNOP00000004798.3 Dasypus novemcinctus 43 2e-28 125
WERAM-Asm-0188 ENSAMXP00000018107.1 Astyanax mexicanus 42 2e-28 125
WERAM-Chs-0114 ENSCSAP00000005694.1 Chlorocebus sabaeus 43 2e-28 125
WERAM-Gaga-0001 ENSGALP00000000211.4 Gallus gallus 44 2e-28 125
WERAM-Myl-0112 ENSMLUP00000009060.2 Myotis lucifugus 43 2e-28 125
WERAM-Ocp-0044 ENSOPRP00000003823.1 Ochotona princeps 43 2e-28 125
WERAM-Tar-0198 ENSTRUP00000040915.1 Takifugu rubripes 45 3e-28 125
WERAM-Ict-0092 ENSSTOP00000009696.2 Ictidomys tridecemlineatus 42 3e-28 124
WERAM-Orc-0025 ENSOCUP00000002687.2 Oryctolagus cuniculus 43 3e-28 124
WERAM-Dar-0182 ENSDARP00000101616.2 Danio rerio 45 3e-28 124
WERAM-Sah-0013 ENSSHAP00000001287.1 Sarcophilus harrisii 43 3e-28 124
WERAM-Mod-0128 ENSMODP00000017862.3 Monodelphis domestica 43 3e-28 124
WERAM-Pof-0102 ENSPFOP00000009161.2 Poecilia formosa 43 4e-28 124
WERAM-Xim-0164 ENSXMAP00000013480.1 Xiphophorus maculatus 50 5e-28 124
WERAM-Ten-0035 ENSTNIP00000006103.1 Tetraodon nigroviridis 45 8e-28 123
WERAM-Mae-0088 ENSMEUP00000008845.1 Macropus eugenii 42 1e-27 122
WERAM-Orn-0021 ENSONIP00000002329.1 Oreochromis niloticus 39 2e-27 122
WERAM-Ora-0083 ENSOANP00000013848.2 Ornithorhynchus anatinus 42 2e-27 122
WERAM-Anp-0078 ENSAPLP00000009547.1 Anas platyrhynchos 43 2e-27 122
WERAM-Fia-0022 ENSFALP00000001679.1 Ficedula albicollis 43 3e-27 121
WERAM-Soa-0112 ENSSARP00000010657.1 Sorex araneus 48 1e-26 119
WERAM-Chh-0100 ENSCHOP00000011481.1 Choloepus hoffmanni 48 1e-26 119
WERAM-Gam-0073 ENSGMOP00000007682.1 Gadus morhua 39 2e-26 118
WERAM-Mel-0021 EGG12926 Melampsora laricipopulina 47 3e-26 118
WERAM-Pem-0074 ENSPMAP00000008062.1 Petromyzon marinus 44 3e-26 118
WERAM-Pes-0007 ENSPSIP00000002650.1 Pelodiscus sinensis 43 9e-26 116
WERAM-Tub-0130 ENSTBEP00000014498.1 Tupaia belangeri 47 2e-25 115
WERAM-Scj-0016 EEB07414 Schizosaccharomyces japonicus 45 2e-25 115
WERAM-Tas-0039 ENSTSYP00000004094.1 Tarsius syrichta 47 2e-25 115
WERAM-Zem-0093 GRMZM2G167718_P01 Zea mays 39 3e-25 115
WERAM-Ere-0096 ENSEEUP00000009790.1 Erinaceus europaeus 47 3e-25 115
WERAM-Cii-0085 ENSCINP00000034825.1 Ciona intestinalis 45 6e-25 114
WERAM-Sei-0009 Si001167m Setaria italica 38 1e-24 113
WERAM-Tag-0083 ENSTGUP00000005921.1 Taeniopygia guttata 46 2e-24 112
WERAM-Lep-0003 LPERR01G06860.1 Leersia perrieri 37 2e-24 111
WERAM-Brr-0127 Bra025948.1-P Brassica rapa 50 3e-24 111
Created Date 25-Jun-2016