WERAM Information

Tag Content
WERAM ID WERAM-Mum-0058
Ensembl Protein ID ENSMUSP00000025193.6
Uniprot Accession Q7JJ13; BRD2_MOUSE; O54795; O88411; Q3UGI0; Q5DTS6; Q794H7; Q794H9; Q99PC5
Genbank Protein ID NP_001191902.1; NP_034368.2; XP_006523721.1; XP_006525365.1
Protein Name Bromodomain-containing protein 2
Genbank Nucleotide ID NM_001204973.1; NM_010238.3; XM_006523658.2; XM_006525302.2
Gene Name BRD2;Fsrg1;Kiaa4005;Ring3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024335.19 ENSMUST00000025193.12 ENSMUSP00000025193.6
ENSMUSG00000024335.19 ENSMUST00000095347.11 ENSMUSP00000092990.6
ENSMUSG00000024335.19 ENSMUST00000114242.8 ENSMUSP00000109880.2
ENSMUSG00000024335.19 ENSMUST00000151986.1 ENSMUSP00000117359.1
ENSMUSG00000024335.19 ENSMUST00000173032.1 ENSMUSP00000134608.1
ENSMUSG00000024335.19 ENSMUST00000173204.1 ENSMUSP00000138431.1
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain H1.4K74; H4K5; H4K8; H4K12 K 24704920; 25769527; 22464331
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 4.50e-57 191.5 91 434
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis.
Domain Profile
  Ac_Reader Bromodomain
             BROMO.txt   2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                           +h++++pFr+pvd+  l +pdY++iik+Pmd+ tik+rle+++Y+ ++e+++D++ +f+N++ yn++ +++
  ENSMUSP00000025193.6  91 KHQFAWPFRQPVDAVkLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDI 161
                           79*****************************************************************9987 PP
             BROMO.txt   4 evsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                            +++pF +pvd+  l ++dY+diik+PmdLst+k+++e++ Y++++ef++Dvrl+f+N+++yn+++++v
  ENSMUSP00000025193.6 366 AYAWPFYKPVDASaLGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDV 434
                           679****************************************************************98 PP
Protein Sequence
(Fasta)		MLQNVTPHKL PGEGNAGLLG LGPEAAAPGK RIRKPSLLYE GFESPTMASV PALQLAPANP 60
PPPEVSNPKK PGRVTNQLQY LHKVVMKALW KHQFAWPFRQ PVDAVKLGLP DYHKIIKQPM 120
DMGTIKRRLE NNYYWAASEC MQDFNTMFTN CYIYNKPTDD IVLMAQTLEK IFLQKVASMP 180
QEEQELVVTI PKNSHKKGAK LAALQGSITS AHQVPAVSSV SHTALYTPPP EIPTTVLNIP 240
HPSVISSPLL KSLHSAGPPL LAVSAAPPAQ PLAKKKGVKR KADTTTPTPT AILAPGSPAS 300
PPGSLEPKAA RLPPMRRESG RPIKPPRKDL PDSQQQHQSS KKGKLSEQLK HCNGILKELL 360
SKKHAAYAWP FYKPVDASAL GLHDYHDIIK HPMDLSTVKR KMENRDYRDA QEFAADVRLM 420
FSNCYKYNPP DHDVVAMARK LQDVFEFRYA KMPDEPLEPG PLPVSTALPP GLTKSSSESS 480
SEESSSESSS EEEEEEEEDE DEEESESSDS EEERAHRLAE LQEQLRAVHE QLAALSQGPI 540
SKPKRKREKK EKKKKRKAEK HRGRIGIDED DKGPRAPRPP QPKKSKKAGG GGSNATTLSH 600
PGFGTSGGSS NKLPKKSQKT APPVLPTGYD SEEEEESRPM SYDEKRQLSL DINKLPGEKL 660
GRVVHIIQAR EPSLRDSNPE EIEIDFETLK PSTLRELERY VLSCLRKKPR KPYTIRKPVG 720
KTKEELALEK KRELEKRLQD VSGQLNSTKK PPKKASEKTE SSAQQVAVSR LSASSSSSDS 780
SSSSSSSSSS DTSDSDSG 798
Nucleotide Sequence
(Fasta)		ACCCCCAGCG GCTAGGGAAG GGAGGGGCTG GGGGCTACGC CCCCTCCCCC AACGCCTTCT 60
CGGCTTCCGG GGGGGTTGAC ACCCCGGATT CCTTGCTCCC CCCCCAGCCG GGCTGAGGGC 120
GACTTTCGAG GGCCCCCCCG TGGCTCCTGG ATCCAGATTC TCCACTGCGG CGGCCTCGCA 180
GCCAAGAACC TTTCGCCCGC CCCGCCCGCG CGACCCGTCC CACTCTGCGC CCCGCCCGCG 240
CCGCCAATGG AAAAGCTGCA AATGGCGCGA CCAGCCTGCC GCGGGCGACC GGCAGAAATT 300
CGGTGTGTGC AAGCCCGGGA AGGCTCCGTC AGACCTGGAG GTGGGGACAG CGTGTTGCAG 360
GCCCCGGGGA GATGGCGCCT ACACGCCGTT CGGCCTCCAT CTCTCCCAGG GTTCGCCAAG 420
CCACGGCGCA GCCAATTGGC TCGGAGACAT GGCGGGGTGC CTTTTCGCCT TGGCTCTCTG 480
CGGCACTCTG CTGCCGATAA TCGACGCCTT GGAACTGGAG TTTGTGACGT CATCCTTCGA 540
GCGGACCAAT AGGAAAGGCT CCCGCGAAGA GGCGGGCCTG CCCCCTCGCC TTTGCTTCTC 600
CAGGCGCGTG AGCGGGCGAG CACGCGCGGA GGGGGCGGGG GAGCTCGCGA GCAGGGTGGC 660
GCGCATGAGC AGCGAAGCTC CGCCCCTCCG GCTATATATA AAGCGCTGGC GCGGGGCTCG 720
GCGGCGCCAT TTCGCGCTGG AGTGGAGCAG CCTCTAGGAC GAGCTGGAGG ATTGCGCCTA 780
CTGACCCAGC GTCTCGGAGC CTCTGCGGGC CGCCAGTACA ATCCACGTCC ATCCGCTTGG 840
AAATGGACTT CGTCCCGGCC CGCGACCGCT CCCGGCGGAC AGTGCAGACC CCATAGAAGC 900
CCCCGAGGCT CCCCTTTCTC GGGCCCCGCC CAGTCCTCGG TGTCTGTCCA CCCCTCTACT 960
CCGCCCTCAA GAGGATTTCA AAGATGGAGG CGGCGGCTCT CTGAAACCCC TTTTTGGTGC 1020
TCATCCGCCT CCATCGGAGG TCTGACGCGG CTCTCGTGAC CCCCCGGCGA CCGCGGCGGG 1080
AAGAGGGGAC CCCTGTCCAC CGGCGGCAGG CCGAATTGAC GACGGTGTCC AGTTTCGGGG 1140
ACTGCCGGGT TTGCAGACTG CGTTCTCCTG TGGCTCGCCG GCCGGCAGAG GCCGCCGCCA 1200
TTTTCCTGCT GTCGCCGCCT GCGGAGCGTG CAAAGCTGCC GGAGTTGCGG GGAGGACGGC 1260
GCAGGAGACA GCGTTCCCGC CGGTCCCGCA ACGAGGCTGA CGCCTGGAGG GCCAAGGGCA 1320
GCGGCCTTCC CCCCACTTCC CGGGTTATGC TGGGCCCGGC GGTGAGGGGA GCCGAGGCTA 1380
CCCGGACTTC ACGCAGCTGA GCGGCGGCGG TTCCCTGAGG TCAAGATGCT GCAAAACGTG 1440
ACTCCCCACA AGCTCCCTGG GGAAGGGAAT GCAGGGTTAC TGGGGCTGGG CCCAGAGGCA 1500
GCAGCACCAG GGAAAAGGAT TCGAAAGCCT TCTCTGCTGT ATGAGGGATT TGAGAGCCCC 1560
ACAATGGCTT CTGTACCAGC TTTACAACTG GCCCCTGCCA ATCCACCACC CCCTGAGGTG 1620
TCCAATCCCA AAAAGCCAGG ACGGGTAACA AACCAACTGC AGTACCTGCA CAAGGTAGTG 1680
ATGAAGGCTC TGTGGAAGCA TCAGTTTGCA TGGCCATTCC GGCAGCCTGT GGACGCTGTG 1740
AAGCTGGGTT TGCCGGATTA TCACAAAATT ATAAAACAGC CTATGGACAT GGGTACTATC 1800
AAGAGGAGAC TTGAAAACAA TTACTACTGG GCTGCCTCAG AATGTATGCA GGATTTTAAT 1860
ACTATGTTTA CCAACTGTTA CATTTATAAC AAGCCCACCG ATGATATTGT CCTAATGGCA 1920
CAGACACTGG AAAAGATCTT CCTACAGAAA GTAGCATCCA TGCCACAAGA GGAGCAAGAG 1980
CTTGTGGTGA CCATCCCTAA AAACAGCCAT AAGAAGGGGG CCAAGTTAGC AGCACTCCAG 2040
GGCAGTATTA CCAGTGCCCA TCAGGTGCCT GCTGTCTCTT CTGTGTCGCA TACAGCCCTG 2100
TATACACCAC CACCTGAAAT ACCTACCACT GTCCTCAACA TTCCCCACCC ATCAGTCATC 2160
TCTTCTCCTC TTCTTAAGTC CCTGCATTCT GCTGGACCCC CACTCCTTGC TGTATCAGCA 2220
GCGCCTCCAG CTCAGCCCCT TGCCAAGAAA AAAGGCGTTA AACGGAAAGC GGATACTACC 2280
ACCCCTACAC CCACAGCCAT CCTGGCTCCT GGTTCCCCAG CTAGTCCTCC TGGGAGTCTT 2340
GAGCCAAAGG CAGCAAGGCT CCCTCCTATG CGCAGAGAGA GTGGCCGCCC AATCAAACCC 2400
CCACGAAAAG ACTTGCCTGA CTCGCAACAG CAACACCAGA GCTCTAAGAA AGGGAAGCTG 2460
TCAGAGCAGT TAAAGCACTG CAACGGCATC CTGAAGGAAC TGCTCTCAAA GAAGCACGCT 2520
GCCTACGCCT GGCCCTTCTA TAAGCCAGTG GACGCTTCTG CTCTTGGCCT TCATGATTAC 2580
CATGACATCA TTAAACACCC CATGGACCTC AGCACTGTCA AGCGGAAGAT GGAGAACCGT 2640
GACTACCGGG ATGCACAGGA GTTTGCTGCT GATGTACGGC TTATGTTCTC CAACTGCTAT 2700
AAGTACAATC CTCCAGACCA CGATGTTGTG GCTATGGCAC GAAAGTTGCA GGATGTGTTT 2760
GAGTTTCGCT ATGCCAAGAT GCCAGATGAG CCACTGGAAC CAGGACCTCT ACCAGTCTCT 2820
ACTGCCTTGC CTCCTGGGTT GACCAAATCC TCTTCAGAGT CCTCCAGTGA GGAAAGTAGC 2880
AGTGAGAGTT CCTCTGAGGA AGAGGAGGAG GAGGAAGAAG ATGAGGACGA GGAGGAGAGT 2940
GAAAGCTCAG ACTCTGAGGA GGAAAGGGCT CATCGCCTAG CAGAGCTGCA GGAGCAGCTT 3000
CGGGCAGTTC ATGAACAACT GGCTGCCCTG TCCCAGGGCC CAATATCTAA GCCCAAGCGG 3060
AAGAGAGAGA AAAAGGAAAA AAAGAAGAAA CGGAAGGCAG AGAAACATCG TGGCCGAATT 3120
GGGATCGATG AAGATGATAA GGGGCCTAGG GCACCTCGCC CACCTCAGCC CAAGAAATCT 3180
AAGAAAGCAG GTGGTGGGGG TAGCAATGCT ACTACACTCA GCCATCCTGG CTTTGGGACT 3240
TCCGGAGGAA GTAGCAACAA GCTACCTAAA AAGTCTCAAA AGACAGCTCC ACCTGTCCTT 3300
CCCACTGGCT ATGATTCTGA GGAGGAGGAA GAAAGCAGGC CCATGAGTTA TGATGAGAAG 3360
AGACAGTTAA GCCTGGATAT CAATAAGTTA CCTGGGGAAA AGCTGGGTCG AGTAGTACAT 3420
ATCATCCAAG CCAGGGAACC CTCTCTACGT GATTCAAATC CAGAAGAAAT TGAGATTGAT 3480
TTTGAAACAC TCAAGCCGTC CACACTTAGA GAGCTTGAGC GATATGTTTT ATCCTGCCTT 3540
CGAAAGAAAC CCCGGAAGCC CTACACTATT AGGAAACCTG TGGGAAAAAC AAAGGAGGAA 3600
CTGGCTTTGG AGAAGAAGCG GGAGCTAGAG AAGCGGTTGC AGGATGTCAG TGGACAGCTC 3660
AACTCCACCA AAAAGCCTCC CAAGAAAGCG AGTGAGAAGA CAGAGTCATC TGCACAGCAA 3720
GTGGCAGTGT CCCGTCTCAG TGCTTCTAGT TCCAGCTCAG ATTCCAGCTC CTCGTCGTCA 3780
TCTTCCTCTT CTTCAGACAC CAGCGATTCA GACTCGGGCT AAGGGGCCAG GCCAGATGGG 3840
GCAGGAAGGC TCCGCAGGAC CGGACCCCTG AACCACCCTT CCCCACTTTC CCTTGCTGTG 3900
ACGCTTCTTC ATCTCACCCC TCCATAGGAG AGCTGGCTCT GCAGTGGGGA GGAAGGCAGG 3960
GACATGGACA AAATACGATT GAATTCCTAG CCCTCTTGGG TGTGGTGTCC CTGTTGAGGA 4020
TGATGGGGGT GGGGCAAGGG TATGGGTGGG AGTGGGGATA GGCCTGGCAT AAAGCCCCCT 4080
GAGCTGTAGC TGTCCTGTTC ACTTCTAAGG GCCCTGTTTT GAGGTTTTAA TTTATTTAAG 4140
CTATGTGGTA AGGCTGGGGG TGTGTAGCCG TGGTCCTCCC TCCAGCTTCC ATGGGGAGGG 4200
AAGAAGAGGG AGCTCTTTTT GTTTTTTACA TTGACTTTTT TTTTCTACTT TTCCCTTTTA 4260
CTTCCACTCC ATTTGGGGCC TGGGGATTTT AGTCACCTCT CCAGTTGGCC CCAAGACTGT 4320
CTTTTCTTTC TTGAGTCTAA CATGTAAATA AAGAAAATAT TATTGAAGTT TTGA 4375
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR027353--NET_dom
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51525--NET
Pfam

PF17035--BET
PF00439--Bromodomain
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0070577--F:lysine-acetylated histone binding
GO:0016568--P:chromatin modification
GO:0006334--P:nucleosome assembly
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0004 ENSRNOP00000000535.4 Rattus norvegicus 99 0.0 1137
WERAM-Ict-0092 ENSSTOP00000009696.2 Ictidomys tridecemlineatus 95 0.0 1085
WERAM-Caj-0224 ENSCJAP00000040148.2 Callithrix jacchus 93 0.0 1080
WERAM-Pat-0149 ENSPTRP00000030782.4 Pan troglodytes 96 0.0 1078
WERAM-Gog-0065 ENSGGOP00000005721.2 Gorilla gorilla 93 0.0 1075
WERAM-Poa-0157 ENSPPYP00000019309.1 Pongo abelii 95 0.0 1075
WERAM-Hos-0255 ENSP00000372588.2 Homo sapiens 95 0.0 1075
WERAM-Loa-0152 ENSLAFP00000013518.3 Loxodonta africana 94 0.0 1074
WERAM-Eqc-0079 ENSECAP00000010277.1 Equus caballus 94 0.0 1074
WERAM-Mam-0211 ENSMMUP00000030455.2 Macaca mulatta 94 0.0 1071
WERAM-Mup-0018 ENSMPUP00000001938.1 Mustela putorius furo 95 0.0 1069
WERAM-Bot-0108 ENSBTAP00000014704.5 Bos taurus 94 0.0 1068
WERAM-Mim-0036 ENSMICP00000003366.1 Microcebus murinus 93 0.0 1067
WERAM-Aim-0029 ENSAMEP00000002041.1 Ailuropoda melanoleuca 94 0.0 1067
WERAM-Caf-0006 ENSCAFP00000001265.3 Canis familiaris 94 0.0 1067
WERAM-Sus-0016 ENSSSCP00000001595.1 Sus scrofa 94 0.0 1066
WERAM-Ova-0082 ENSOARP00000008629.1 Ovis aries 94 0.0 1065
WERAM-Tut-0048 ENSTTRP00000004025.1 Tursiops truncatus 94 0.0 1065
WERAM-Dan-0048 ENSDNOP00000004798.3 Dasypus novemcinctus 94 0.0 1058
WERAM-Otg-0077 ENSOGAP00000005790.2 Otolemur garnettii 90 0.0 1052
WERAM-Prc-0094 ENSPCAP00000008495.1 Procavia capensis 93 0.0 1048
WERAM-Cap-0031 ENSCPOP00000002556.2 Cavia porcellus 90 0.0 1040
WERAM-Paa-0136 ENSPANP00000012397.1 Papio anubis 89 0.0 1035
WERAM-Fec-0108 ENSFCAP00000008990.2 Felis catus 94 0.0 1035
WERAM-Dio-0036 ENSDORP00000004207.1 Dipodomys ordii 93 0.0 1030
WERAM-Tub-0130 ENSTBEP00000014498.1 Tupaia belangeri 89 0.0 1025
WERAM-Nol-0068 ENSNLEP00000008263.2 Nomascus leucogenys 94 0.0 1022
WERAM-Vip-0081 ENSVPAP00000007489.1 Vicugna pacos 94 0.0 1018
WERAM-Ptv-0132 ENSPVAP00000011321.1 Pteropus vampyrus 89 0.0 1009
WERAM-Sah-0013 ENSSHAP00000001287.1 Sarcophilus harrisii 88 0.0 995
WERAM-Mod-0128 ENSMODP00000017862.3 Monodelphis domestica 90 0.0 994
WERAM-Soa-0062 ENSSARP00000006154.1 Sorex araneus 93 0.0 951
WERAM-Ere-0096 ENSEEUP00000009790.1 Erinaceus europaeus 84 0.0 946
WERAM-Chh-0047 ENSCHOP00000005329.1 Choloepus hoffmanni 85 0.0 920
WERAM-Chs-0114 ENSCSAP00000005694.1 Chlorocebus sabaeus 97 0.0 816
WERAM-Ocp-0078 ENSOPRP00000006813.1 Ochotona princeps 96 0.0 808
WERAM-Orc-0025 ENSOCUP00000002687.2 Oryctolagus cuniculus 99 0.0 684
WERAM-Asm-0150 ENSAMXP00000014454.1 Astyanax mexicanus 57 0.0 648
WERAM-Gaga-0001 ENSGALP00000000211.4 Gallus gallus 78 3e-180 629
WERAM-Tas-0039 ENSTSYP00000004094.1 Tarsius syrichta 91 1e-179 627
WERAM-Xet-0111 ENSXETP00000037202.3 Xenopus tropicalis 71 7e-168 588
WERAM-Myl-0112 ENSMLUP00000009060.2 Myotis lucifugus 99 2e-167 587
WERAM-Dar-0210 ENSDARP00000129878.1 Danio rerio 59 5e-166 582
WERAM-Orn-0007 ENSONIP00000000922.1 Oreochromis niloticus 57 8e-160 561
WERAM-Meg-0092 ENSMGAP00000008728.2 Meleagris gallopavo 54 4e-158 556
WERAM-Lac-0022 ENSLACP00000003855.1 Latimeria chalumnae 55 1e-156 551
WERAM-Anc-0036 ENSACAP00000004148.2 Anolis carolinensis 78 1e-156 550
WERAM-Tar-0168 ENSTRUP00000035617.1 Takifugu rubripes 54 3e-155 546
WERAM-Ora-0083 ENSOANP00000013848.2 Ornithorhynchus anatinus 56 2e-128 457
WERAM-Pem-0020 ENSPMAP00000002717.1 Petromyzon marinus 66 2e-127 454
WERAM-Anp-0078 ENSAPLP00000009547.1 Anas platyrhynchos 54 3e-125 446
WERAM-Gaa-0134 ENSGACP00000017249.1 Gasterosteus aculeatus 60 6e-124 442
WERAM-Mae-0138 ENSMEUP00000013934.1 Macropus eugenii 87 5e-123 439
WERAM-Leo-0032 ENSLOCP00000005430.1 Lepisosteus oculatus 66 7e-123 439
WERAM-Ect-0061 ENSETEP00000006671.1 Echinops telfairi 89 1e-122 438
WERAM-Fia-0022 ENSFALP00000001679.1 Ficedula albicollis 60 3e-120 430
WERAM-Pof-0083 ENSPFOP00000007371.2 Poecilia formosa 63 1e-114 412
WERAM-Xim-0033 ENSXMAP00000003434.1 Xiphophorus maculatus 62 1e-112 405
WERAM-Tag-0083 ENSTGUP00000005921.1 Taeniopygia guttata 62 4e-112 403
WERAM-Ten-0212 ENSTNIP00000021345.1 Tetraodon nigroviridis 59 2e-109 394
WERAM-Pes-0120 ENSPSIP00000014231.1 Pelodiscus sinensis 63 7e-103 372
WERAM-Cii-0085 ENSCINP00000034825.1 Ciona intestinalis 53 4e-99 360
WERAM-Gam-0097 ENSGMOP00000009935.1 Gadus morhua 49 8e-81 299
WERAM-Cis-0028 ENSCSAVP00000005883.1 Ciona savignyi 47 1e-77 288
WERAM-Orla-0179 ENSORLP00000020845.1 Oryzias latipes 51 3e-71 267
Created Date 25-Jun-2016