WERAM Information
Tag | Content | ||||||||||||
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WERAM ID | WERAM-Hos-0191 | ||||||||||||
Ensembl Protein ID | ENSP00000305918.6 | ||||||||||||
Uniprot Accession | Q15059; BRD3_HUMAN; B1APD9; Q4G5Y3; Q5T1R7; Q8N5M3; Q92645 | ||||||||||||
Genbank Protein ID | NP_031397.1; XP_006717354.1; XP_011517354.1 | ||||||||||||
Protein Name | Bromodomain-containing protein 3 | ||||||||||||
Genbank Nucleotide ID | NM_007371.3; XM_006717291.1; XM_011519052.1 | ||||||||||||
Gene Name | BRD3;ORFX;RING3L;KIAA0043 | ||||||||||||
Ensembl Information |
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Details |
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Status | Reviewed | ||||||||||||
Classification |
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Organism | Homo sapiens | ||||||||||||
NCBI Taxa ID | 9606 | ||||||||||||
Functional Description (View) |
Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene. | ||||||||||||
Domain Profile | Ac_Reader Bromodomain BROMO.txt 2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 |
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Protein Sequence (Fasta) | MSTATTVAPA GIPATPGPVN PPPPEVSNPS KPGRKTNQLQ YMQNVVVKTL WKHQFAWPFY 60 QPVDAIKLNL PDYHKIIKNP MDMGTIKKRL ENNYYWSASE CMQDFNTMFT NCYIYNKPTD 120 DIVLMAQALE KIFLQKVAQM PQEEVELLPP APKGKGRKPA AGAQSAGTQQ VAAVSSVSPA 180 TPFQSVPPTV SQTPVIAATP VPTITANVTS VPVPPAAAPP PPATPIVPVV PPTPPVVKKK 240 GVKRKADTTT PTTSAITASR SESPPPLSDP KQAKVVARRE SGGRPIKPPK KDLEDGEVPQ 300 HAGKKGKLSE HLRYCDSILR EMLSKKHAAY AWPFYKPVDA EALELHDYHD IIKHPMDLST 360 VKRKMDGREY PDAQGFAADV RLMFSNCYKY NPPDHEVVAM ARKLQDVFEM RFAKMPDEPV 420 EAPALPAPAA PMVSKGAESS RSSEESSSDS GSSDSEEERA TRLAELQEQL KAVHEQLAAL 480 SQAPVNKPKK KKEKKEKEKK KKDKEKEKEK HKVKAEEEKK AKVAPPAKQA QQKKAPAKKA 540 NSTTTAGRQL KKGGKQASAS YDSEEEEEGL PMSYDEKRQL SLDINRLPGE KLGRVVHIIQ 600 SREPSLRDSN PDEIEIDFET LKPTTLRELE RYVKSCLQKK QRKPFSASGK KQAAKSKEEL 660 AQEKKKELEK RLQDVSGQLS SSKKPARKEK PGSAPSGGPS RLSSSSSSES GSSSSSGSSS 720 DSSDSE 726 |
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Nucleotide Sequence (Fasta) | CCGGGGCCGG CGAGCCAAAG AGGAGCCGGC CGCGCGGGCC GGGAGGGGAC GGCCGCCGGA 60 GCCGCGAGGC CAACTGTCGC CTGGTTGGGC CCGGAAATGG GACGTCGCGC TTTCTCAGGG 120 AGCGTAGAAG CAGCCAGGGC CTCTCCAAGC CGCTGCTGTG ACAGAAAGTG AGTGAGCTGC 180 CGGAGGATGT CCACCGCCAC GACAGTCGCC CCCGCGGGGA TCCCGGCGAC CCCGGGCCCT 240 GTGAACCCAC CCCCCCCGGA GGTCTCCAAC CCCAGCAAGC CCGGCCGCAA GACCAACCAG 300 CTGCAGTACA TGCAGAATGT GGTGGTGAAG ACGCTCTGGA AACACCAGTT CGCCTGGCCC 360 TTCTACCAGC CCGTGGACGC AATCAAATTG AACCTGCCGG ATTATCATAA AATAATTAAA 420 AACCCAATGG ATATGGGGAC TATTAAGAAG AGACTAGAAA ATAATTATTA TTGGAGTGCA 480 AGCGAATGTA TGCAGGACTT CAACACCATG TTTACAAATT GTTACATTTA TAACAAGCCC 540 ACAGATGACA TAGTGCTAAT GGCCCAAGCT TTAGAGAAAA TTTTTCTACA AAAAGTGGCC 600 CAGATGCCCC AAGAGGAAGT TGAATTATTA CCCCCTGCTC CAAAGGGCAA AGGTCGGAAG 660 CCGGCTGCGG GAGCCCAGAG CGCAGGTACA CAGCAAGTGG CGGCCGTGTC CTCTGTCTCC 720 CCAGCGACCC CCTTTCAGAG CGTGCCCCCC ACCGTCTCCC AGACGCCCGT CATCGCTGCC 780 ACCCCTGTAC CAACCATCAC TGCAAACGTC ACGTCGGTCC CAGTCCCCCC AGCTGCCGCC 840 CCACCTCCTC CTGCCACACC CATCGTCCCC GTGGTCCCTC CTACGCCGCC TGTCGTCAAG 900 AAAAAGGGCG TGAAGCGGAA AGCAGACACA ACCACTCCCA CGACGTCGGC CATCACTGCC 960 AGCCGGAGTG AGTCGCCCCC GCCGTTGTCA GACCCCAAGC AGGCCAAAGT GGTGGCCCGG 1020 CGGGAGAGTG GTGGCCGCCC CATCAAGCCT CCCAAGAAGG ACCTGGAGGA CGGCGAGGTG 1080 CCCCAGCACG CAGGCAAGAA GGGCAAGCTG TCGGAGCACC TACGCTACTG CGACAGCATC 1140 CTCAGGGAGA TGCTATCCAA GAAGCACGCG GCCTACGCCT GGCCCTTCTA CAAGCCAGTG 1200 GATGCCGAGG CCCTGGAGCT GCACGACTAC CACGACATCA TCAAGCACCC GATGGACCTC 1260 AGCACCGTGA AAAGGAAGAT GGATGGCCGA GAGTACCCAG ACGCACAGGG CTTTGCTGCT 1320 GATGTCCGGC TGATGTTCTC GAATTGCTAC AAATACAATC CCCCAGACCA CGAGGTTGTG 1380 GCCATGGCCC GGAAGCTCCA GGACGTGTTT GAGATGAGGT TTGCCAAGAT GCCAGATGAG 1440 CCCGTGGAGG CACCGGCGCT GCCTGCCCCC GCGGCCCCCA TGGTGAGCAA GGGCGCTGAG 1500 AGCAGCCGTA GCAGTGAGGA GAGCTCTTCG GACTCAGGCA GCTCGGACTC GGAGGAGGAG 1560 CGGGCCACCA GGCTGGCGGA GCTGCAGGAG CAGCTGAAGG CCGTGCACGA GCAGCTGGCC 1620 GCCCTGTCTC AGGCCCCAGT AAACAAACCA AAGAAGAAGA AGGAGAAGAA GGAGAAGGAG 1680 AAGAAGAAGA AGGACAAGGA GAAGGAGAAG GAGAAGCACA AAGTGAAGGC CGAGGAAGAG 1740 AAGAAGGCCA AGGTGGCTCC GCCTGCCAAG CAGGCTCAGC AGAAGAAGGC TCCTGCCAAG 1800 AAGGCCAACA GCACGACCAC GGCCGGCAGA CAGCTGAAGA AAGGCGGCAA GCAGGCATCT 1860 GCCTCCTACG ACTCAGAGGA AGAGGAGGAG GGCCTGCCCA TGAGCTACGA TGAAAAGCGC 1920 CAGCTTAGCC TGGACATCAA CCGGCTGCCC GGGGAGAAGC TGGGCCGGGT AGTGCACATC 1980 ATCCAATCTC GGGAGCCCTC GCTCAGGGAC TCCAACCCCG ACGAGATAGA AATTGACTTT 2040 GAGACTCTGA AACCCACCAC TTTGCGGGAA CTGGAGAGAT ATGTCAAGTC TTGTTTACAG 2100 AAAAAGCAAA GGAAACCGTT CTCAGCAAGC GGGAAGAAAC AGGCAGCCAA GTCGAAAGAG 2160 GAGCTAGCTC AGGAAAAGAA GAAGGAGCTG GAAAAGCGTC TGCAGGATGT CAGCGGGCAG 2220 CTGAGCAGCA GCAAGAAGCC CGCCCGGAAA GAGAAGCCCG GCTCAGCACC CTCAGGGGGC 2280 CCGTCCAGGC TCAGCAGCAG CAGCTCCTCC GAGTCTGGGA GCAGCAGCTC CAGCGGGTCC 2340 AGCTCTGACA GCAGTGACTC AGAATGAACT GGCTTCGGAC AGAACAGGAC AGATGGATGT 2400 CGCACACGCC GAGACTCTGC CGTACCCCTC TGTGGTTCAT ATTACTACTT CTGTTCCATG 2460 GTGTGCAGGT CTGCTTCTTA ATTCAGTGTT ATGATATCTT CCAGTTTTTG CTTTCATAGG 2520 TCAGAGATCT ATCTTGTGTG TGCGTTAGAC TTGATGAGAA GGTGTGAACT CTGCAGAAAG 2580 TCTCTTCTTC ATCACTGAAT TCAGTCACTT GGAGATGACA ACTTCAAATG CTAACCCGAT 2640 GACCCCAGAA AACCGTGTGA GATTCGTACC GAAGAACCTT GTGGAATCCC TTTGCTTAGG 2700 CCCAACCTGG TCGATAGCTC GAGAAAGAAT TTTTTCCAAG GAAATGTCTC GGATATGGGT 2760 ACTGTATTTG AAAGCTGTTA GCTTTGTCAA CACGCATTGT CCTTGTCATT TGGGCCCCGA 2820 GCTCTGACCC TCGTGTCTGA CGCGGCCACC TCTTTCTGGA GGGGCTGAGG ACAGATGTGC 2880 CTGCTTGTGG AGACCAGGCT GGGCCTAAGC GAAGGGTCAT CGCAGCCCCA GCCCGGAGCG 2940 TGGAGCCCTT GGGGGGTGGT CGGGTGGGAT GTGCGTTCTC CGCTCGTGGT GATGTCAGGA 3000 GCTCCTCGGA GGGAACAGAG CGGCTGTGTA TGCAGCCTGC AGGTTTCCAT ACACTGAAGC 3060 TTTTACCTCA ACTTTAAAAA AAAAAAAAGA AGAAAAGATT TAAAAAAAAA AAAAAAGGAG 3120 ACTTTTTTTG TAAGGTTCGG CAATTTTCTA CGGAAGTCCA GCCCGCTGTG AGTCCCCGCC 3180 TGGCTAGCGC TGCCCCTGCT GCTGCTGCCG CGCCACCCTT GGGAACCACT TCCCGAGCTT 3240 ATGTGTATAT AAATAGTTAT TTATTAACAT CATTGGTCAT TTTTAAAAAA AAGAAAATAA 3300 GAAAAAACCG CAGAAGAAAT GCATTCACAC AGTCGCAGAG ATGCAGGCCT TGCCAGTGGT 3360 GTGCCGGGCG CGGGTCCTGT CTGGCGGCGG CCTGTCGTCT CCAGGTGCTA ACTCCTGCCA 3420 CCGCGCGGTG CTCACCCACG TCTGTTCGCG CGCTCGCCCC TGGGTTTGTT GGGTTTTTTG 3480 GTTTTTTTCT TTGTGGTTTT TTTTTTTTTT TTTTTTTGTA TGAAACTTGG AGGCTTACAG 3540 GTATAGACAG CTTTCAGCTA CAGCACATTC TAATTTTTTA TTTTGTTTAG TTCTTTTGTA 3600 TTCACTTCTG GTCTCTTTAA GACTGTTTTA AAAGAAATCA ATTTAGGGAA CCCCAGTTAT 3660 ATAATATAAA CTTTGTAATC TGAGAGAAAA AATGTATAGT AAATCTAAGT CTTGATTTTT 3720 AACTTTCTAT TGTAAAAAAT AATAATATAC AGAGTTTAAT AGAAGGTGAT GTTTTGGTTT 3780 TGTTTTCCCA GAGGCTGCCA TATGGTCTTT GAGTACGGGG ATGTCCCAAA CTGGCCCACC 3840 AATGAGCATG GCGGCTCCGG CCAGGAATGC CAGAGTTAGC CTCCCAGGCT TGCGGGTGGA 3900 CATGCCTGCT CCCTGCCAGC CTCCAGTGGC CTGGCCAGGC CCTCCCGAGC CTGTCTGCCC 3960 TCCCCAGGGG TGGAGGAGTC TCTGGGCCCC AGGAGGATTC CCTCCCGGAG ACTCGCACGG 4020 TGCTCCCTGC TCACGCGTTG TCACAGTTAG TCCGGAAATG ACTGAAACCA GGCATTCTCC 4080 CGGACCTCAG CGTGGGGGAG CCTCCAGGCA GACGCTGGGT ATGGAGCTGT GGTGTGGTCT 4140 GTCCTGTATG GTGGCCAGTG CTTTCTGCCA GCATTTCTGG ATGGATATAG GGACTATCAT 4200 TAGTATCCTA ATACACGGTG ATTTTAAAAC AACCATAAAA TTGATTCAGA GTCCACTGAC 4260 CCTTACAGAT GTAGGTATAC CCTTACTGGA GAGGGAACTC TGATGAGGAG ATGCTGGTAA 4320 ATTATCATTT TTTAAATTGC TGGTGAGTCT GACACTTGGT GAGTTTTCAG CCAGTTTGTT 4380 AAACTTTTAA TTAAGTTTTG TTTATAATAA AAATATAAAT GGATTTGAAA GTTTCCATTT 4440 TTTAAAGTTA CCCTCGTTTT CAAAGGTATT TTCTAAACAG ATCTTTAATG GACTATTTAA 4500 ACCGAATTTA AGGAATTCAC ACACGACAGT TGACAGGTCT TCACGCAGGC TGGTTGGTAA 4560 CGTGCTGCCA GCACAGGGCT GGGTGATACG TACACCCTAA GCCGGGGGTG CCTGGGGCTG 4620 GGGGGCGCTC CTTGCAATGC CCCTCCAGCC ACAGGGCAGT GAGGTGCTGC CTGTGTGAGC 4680 CGTCGGGGGA GCGGCCGGCT GTGGGGGCAG CGCAGCAGGA GCATCGTGGG GCCTTTCCTT 4740 CTCGGCTGGT TCTCTGTGAC GGTGGCGTCG GCTCGCCTCT GCTCCTTTCA TCTAGAAAGA 4800 AGCCACTGAC CCTGACAGCC CACGGCGGGT ACACTGAGCA GCTGCATTGG TGCTGTCACT 4860 TTTTTAAGGC TTTCTGTCCA GACTTCAACA CTGGTTTCTT TTCAGAGTTT CGAAGGATTA 4920 ATGACTTCCT CAGCGCCCTT GCTGGCGGGC TGAGGGTGAC AGTCACGTCC GTTTCTTCTG 4980 TATTAGAAGG CTGCGGTGAT TCAATTAGAT TGTCCCACTG CTGAGACCTG TAGGGCAGCT 5040 TCTAACATGC TTTTTTCAAG GGGAGAGGAG TAGTGACAAG TCGTGTGTCG GAATTGGATT 5100 TGAGAACACT CTGAATGACC CCTGGAGGCC GAGGGGGCAG GCTTCGGGCG TGAACTGAAC 5160 TCCAGACCCC TCTTTGTGTT GGGCAGTGTC ATCTTGCTTA CAAACTGTAA GACACATTTT 5220 TTTGTGTGTT TGTTTTTGTT GTTGTTCTTT TGCAGCACTC ACGCCTCTGA CAGTCTTTTG 5280 GGAAAGAGTA ACACCCACAT ACAGAATTTG TCACATCCAG AGTAGCACTG TTCCTTAATA 5340 CTGGCATAAT GCTTCCAGGA AGTTTTTCTT TTTTATATTT AAAATGTTAC TTTTCTGTAT 5400 GATGTGCATG CAAGTTTACC GTAACTTTTC TTAAACTTTT TAGTGCCGTT TCTAGTATAT 5460 TCCTGTAAAT GTCAGTTACT GAAAATGAGT CCAATGTAAG TAGTTTAGCT TGTTTATTGC 5520 AATGCTGGCC TCAACACAAC AGAATAAAAA TGGTAGAAAG TACTCTTTGA TGTTTCTGGT 5580 AATCATGGAC CCTTCTCCTG GGGCATTTGT TTTGTTTTCA TAATAAAAAG CAAAAAAAAA 5640 AAAAAAAAAA AA 5653 |
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Sequence Source | Ensembl | ||||||||||||
Keyword | KW-0002--3D-structure |
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Interpro | IPR001487--Bromodomain |
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PROSITE | |||||||||||||
Pfam | PF17035--BET |
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Gene Ontology | GO:0005634--C:nucleus |
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Orthology | |||||||||||||
Created Date | 25-Jun-2016 |