WERAM Information

Tag Content
WERAM ID WERAM-Mum-0082
Ensembl Protein ID ENSMUSP00000128812.1
Uniprot Accession Q8K2F0; BRD3_MOUSE; Q8C665; Q8CAX7; Q9JI25
Genbank Protein ID NP_001107045.1; NP_001107046.1; NP_075825.3
Protein Name Bromodomain-containing protein 3
Genbank Nucleotide ID NM_001113573.1; NM_001113574.1; NM_023336.4
Gene Name BRD3;Fsrg2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026918.16 ENSMUST00000164296.7 ENSMUSP00000128812.1
ENSMUSG00000026918.16 ENSMUST00000028282.14 ENSMUSP00000028282.8
ENSMUSG00000026918.16 ENSMUST00000077737.12 ENSMUSP00000076918.6
ENSMUSG00000026918.16 ENSMUST00000113941.8 ENSMUSP00000109574.2
ENSMUSG00000026918.16 ENSMUST00000154316.7 ENSMUSP00000114422.1
ENSMUSG00000026918.16 ENSMUST00000138693.7 ENSMUSP00000115755.1
ENSMUSG00000026918.16 ENSMUST00000147736.1 ENSMUSP00000122009.1
Details
Type Family Domain Substrates AA References (PMIDs)
Ac_Reader Bromodomain Bromodomain K 23420887
Status Reviewed
Classification
Type Family E-value Score Start End
Ac_Reader Bromodomain 1.20e-55 186.9 51 396
Organism Mus musculus
NCBI Taxa ID 10090
Functional Description
(View)		 Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription of the CCND1 gene (By similarity). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets.
Domain Profile
  Ac_Reader Bromodomain
             BROMO.txt   2 ehevsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                           +h++++pF +pvd+  l++pdY++iik+Pmd+ tik+rle+++Y+s++e+++D++ +f+N++ yn++ +++
  ENSMUSP00000128812.1  51 KHQFAWPFYQPVDAIkLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDI 121
                           79*****************************************************************9987 PP
             BROMO.txt   4 evsepFrepvdpq.leipdYydiikePmdLstikerleegnYsspeefvkDvrlifnNakaynenkssv 71 
                            +++pF +pvd++ le++dY+diik+PmdLst+k+++++++Y +++ f++D+rl+f+N+++yn+++++v
  ENSMUSP00000128812.1 328 AYAWPFYKPVDAEaLELHDYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEV 396
                           679***************************************************************998 PP
Protein Sequence
(Fasta)		MSTTAAAPTG IPAVPGPVNP PPPEVSNPSK PGRKTNQLQY MQNVVVKTLW KHQFAWPFYQ 60
PVDAIKLNLP DYHKIIKNPM DMGTIKKRLE NNYYWSASEC MQDFNTMFTN CYIYNKPTDD 120
IVLMAQALEK IFLQKVAQMP QEEVELLPPA PKGKGRKPAA GAQNAGSQQV AAVSSVSPAT 180
PFQNIPPTVS QTPVIAATPV PTITANVTSV PVPPPAAPPP PATPIVPVVP PTPPVVKKKG 240
VKRKADTTTP TTSAITASRS ESPPPLSEPK QAKVVARRES GGRPIKPPKK DLEDGEVPQH 300
AGKKGKLSEH LRHCDSILRE MLSKKHAAYA WPFYKPVDAE ALELHDYHDI IKHPMDLSTV 360
KRKMDSREYP DAQGFAADIR LMFSNCYKYN PPDHEVVAMA RKLQDVFEMR FAKMPDEPME 420
APALPAPTAP IVSKGAESSR SSEESSSDSG SSDSEEERAT RLAELQEQLK AVHEQLAALS 480
QAPVNKPKKK KEKKEKEKKK KDKDKDKEKE KHKAKSEEEK KAKAAPAAKQ AQQKKAPTKK 540
ANSTTTASRQ LKKGGKQASA SYDSEEEEEG LPMSYDEKRQ LSLDINRLPG EKLGRVVHII 600
QSREPSLRDS NPDEIEIDFE TLKPTTLREL ERYVKSCLQK KQRKPLSTSG KKQAAKSKEE 660
LAQEKKKELE KRLQDVSGQL NSKKPTKKEK SGSAPSGGPS RLSSSSSSES ASSSSSGSSS 720
DSSDSE 726
Nucleotide Sequence
(Fasta)		TGACTAAGCT GCCAGAGGAT GTCCACTACA GCGGCTGCCC CCACGGGGAT CCCGGCAGTC 60
CCGGGCCCCG TGAACCCTCC CCCACCTGAG GTCTCCAACC CCAGCAAGCC CGGGCGAAAG 120
ACTAACCAAC TGCAGTACAT GCAGAATGTA GTGGTGAAGA CACTCTGGAA ACATCAGTTT 180
GCCTGGCCTT TCTACCAGCC TGTGGATGCA ATCAAGCTGA ACCTGCCTGA TTATCATAAA 240
ATAATAAAAA ACCCAATGGA CATGGGGACT ATCAAGAAGA GACTAGAAAA TAATTATTAT 300
TGGAGTGCCA GTGAGTGTAT GCAGGACTTC AACACCATGT TTACAAACTG TTATATTTAT 360
AATAAGCCCA CAGATGATAT AGTGCTAATG GCCCAGGCCT TAGAGAAAAT CTTTCTGCAG 420
AAAGTGGCCC AGATGCCTCA GGAGGAAGTT GAACTATTGC CCCCTGCTCC AAAGGGCAAA 480
GGCCGGAAGC CAGCTGCAGG AGCCCAAAAT GCAGGTTCCC AACAAGTGGC AGCTGTGTCT 540
TCGGTCTCCC CAGCAACCCC CTTCCAGAAC ATACCCCCCA CCGTGTCCCA GACACCCGTC 600
ATTGCCGCTA CCCCTGTACC AACCATCACT GCAAACGTCA CGTCAGTTCC AGTCCCCCCA 660
CCCGCTGCAC CGCCTCCTCC TGCGACACCC ATCGTCCCTG TGGTCCCTCC CACACCGCCT 720
GTAGTCAAGA AAAAGGGCGT GAAGCGGAAA GCAGACACAA CCACACCCAC AACATCTGCC 780
ATCACTGCCA GCCGGAGTGA GTCTCCCCCA CCACTTTCAG AGCCCAAGCA AGCCAAGGTA 840
GTGGCCCGAA GGGAGAGCGG GGGCCGCCCC ATCAAACCTC CCAAGAAGGA CCTGGAAGAT 900
GGTGAGGTCC CACAGCACGC GGGTAAAAAG GGAAAACTGT CCGAGCACCT GCGGCACTGT 960
GACAGCATCC TCCGGGAGAT GCTGTCCAAG AAGCATGCTG CCTATGCGTG GCCCTTTTAC 1020
AAGCCAGTGG ACGCGGAGGC GCTGGAGCTG CATGACTACC ATGACATCAT CAAGCACCCC 1080
ATGGACCTCA GCACGGTCAA AAGGAAGATG GATAGCCGAG AGTACCCAGA TGCACAGGGC 1140
TTTGCTGCTG ATATCCGGTT AATGTTCTCG AATTGTTATA AGTACAACCC TCCAGACCAC 1200
GAAGTGGTGG CCATGGCCAG GAAGCTCCAG GATGTGTTTG AGATGAGGTT TGCCAAGATG 1260
CCCGATGAGC CCATGGAGGC GCCTGCGCTG CCCGCTCCCA CGGCCCCCAT CGTGAGCAAG 1320
GGGGCTGAGA GCAGCCGCAG TAGTGAGGAG AGCTCTTCAG ATTCAGGCAG CTCAGACTCA 1380
GAAGAGGAGC GAGCCACTCG GCTGGCTGAG CTGCAGGAGC AGCTGAAGGC CGTGCACGAA 1440
CAGCTGGCTG CCTTGTCTCA GGCCCCAGTG AACAAACCAA AGAAGAAGAA AGAGAAGAAG 1500
GAAAAGGAAA AGAAGAAGAA AGACAAGGAC AAAGACAAAG AGAAGGAGAA GCACAAGGCC 1560
AAGTCTGAGG AGGAGAAGAA GGCCAAGGCA GCCCCAGCAG CCAAGCAGGC CCAGCAGAAA 1620
AAGGCTCCCA CCAAGAAGGC CAACAGCACA ACCACAGCCA GCAGACAGCT CAAGAAGGGC 1680
GGCAAGCAGG CATCTGCGTC CTATGACTCA GAGGAAGAGG AGGAGGGCCT GCCCATGAGC 1740
TATGATGAAA AGCGACAACT TAGCCTTGAC ATCAACCGGC TGCCCGGCGA GAAGCTAGGG 1800
CGTGTGGTGC ACATCATTCA GTCTCGGGAG CCCTCGCTTC GGGACTCAAA CCCAGACGAG 1860
ATTGAGATTG ACTTTGAGAC CCTGAAGCCA ACCACGCTGC GGGAACTGGA GAGATATGTC 1920
AAGTCTTGTT TACAAAAAAA GCAGAGGAAA CCATTGTCAA CAAGCGGGAA GAAGCAGGCA 1980
GCCAAATCGA AAGAGGAGCT AGCTCAGGAG AAGAAAAAGG AGCTGGAGAA GCGGCTGCAG 2040
GATGTCAGTG GACAACTGAA CAGCAAAAAA CCCACTAAGA AAGAGAAGTC CGGCTCAGCT 2100
CCCTCAGGAG GCCCATCAAG GCTCAGCAGT AGCAGCTCCT CTGAGTCTGC GAGCAGTAGC 2160
TCCAGTGGAT CGAGCTCCGA CAGCAGTGAC TCAGAGTGAA CTCGGACTGG GACAGAGCTG 2220
GACAGATGGA CGTGGTGCAC GCCAACGCAG TGTCCCCTCC TATGGTTTTC TTTTACTTCA 2280
GTGTTATGAT CTCTTCCAGC TGTGCTCCAG TAGGGCGGAG AGCCTCGCAC GTGCACCAGA 2340
CCCCATGAGA GGGCCGAGCT CTGCGAGGGG GAAATGCCTT TGCAGCTCCA TTTAGTTGTT 2400
TGGAGACTGC TCCTGGGATG CTAACCTGAT GGCCATAGAC ACGGTGGGCT GGAGGCGTGG 2460
CTGGATCTGC CCAATCCTTC CTCAGGACCA GCCTCTCCCT TAGTAACTTG AAGGAAGCTT 2520
TGCAAGGGTG TTTCTCTGGA ATGGGTTCTG TGTTTGAAAG CTGTTAGAAC ACTAACCAGC 2580
AGGTTACTTC TCTCCGCAGG GGCTGAAGAC AGATGTGTCA GCCCATGGGA ACCAGCCTGG 2640
GCCCTAGTGG AGGGTCCTGG TAGCTGCAGA CCAGAGCCTC ACACCTCTGG GTTGGGTGTG 2700
GAGGAAGAGG GGTACTGAGT TCCCTGGTCC TTTGGCTGTG TGTGCAGCGT GCAGATTTCG 2760
GGACACCGAA ACTTTTACCT CAACTTAAGG G 2792
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
--
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR027353--NET_dom
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51525--NET
Pfam

PF17035--BET
PF00439--Bromodomain
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0070577--F:lysine-acetylated histone binding
GO:0016568--P:chromatin modification
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Ran-0047 ENSRNOP00000059977.2 Rattus norvegicus 95 0.0 869
WERAM-Dio-0124 ENSDORP00000011896.1 Dipodomys ordii 92 0.0 850
WERAM-Eqc-0172 ENSECAP00000019196.1 Equus caballus 94 0.0 849
WERAM-Tut-0064 ENSTTRP00000005012.1 Tursiops truncatus 92 0.0 848
WERAM-Ere-0086 ENSEEUP00000008250.1 Erinaceus europaeus 94 0.0 840
WERAM-Myl-0058 ENSMLUP00000004658.2 Myotis lucifugus 92 0.0 838
WERAM-Caf-0204 ENSCAFP00000029360.4 Canis familiaris 94 0.0 825
WERAM-Bot-0103 ENSBTAP00000013992.5 Bos taurus 92 0.0 822
WERAM-Caj-0105 ENSCJAP00000003948.2 Callithrix jacchus 94 0.0 818
WERAM-Pat-0180 ENSPTRP00000036845.4 Pan troglodytes 92 0.0 816
WERAM-Loa-0079 ENSLAFP00000005884.3 Loxodonta africana 94 0.0 815
WERAM-Hos-0191 ENSP00000305918.6 Homo sapiens 92 0.0 815
WERAM-Gog-0161 ENSGGOP00000014161.2 Gorilla gorilla 92 0.0 813
WERAM-Aim-0129 ENSAMEP00000011812.1 Ailuropoda melanoleuca 94 0.0 806
WERAM-Mod-0111 ENSMODP00000016422.4 Monodelphis domestica 92 0.0 803
WERAM-Ora-0029 ENSOANP00000004526.3 Ornithorhynchus anatinus 89 0.0 802
WERAM-Anp-0067 ENSAPLP00000008292.1 Anas platyrhynchos 88 0.0 793
WERAM-Sah-0154 ENSSHAP00000015966.1 Sarcophilus harrisii 90 0.0 789
WERAM-Ect-0114 ENSETEP00000012589.1 Echinops telfairi 86 0.0 783
WERAM-Gaga-0026 ENSGALP00000004217.3 Gallus gallus 88 0.0 782
WERAM-Anc-0026 ENSACAP00000003167.3 Anolis carolinensis 84 0.0 781
WERAM-Dan-0036 ENSDNOP00000003814.2 Dasypus novemcinctus 92 0.0 780
WERAM-Meg-0076 ENSMGAP00000000015.2 Meleagris gallopavo 86 0.0 772
WERAM-Tag-0083 ENSTGUP00000005921.1 Taeniopygia guttata 86 0.0 748
WERAM-Fec-0058 ENSFCAP00000005302.3 Felis catus 90 0.0 743
WERAM-Pes-0120 ENSPSIP00000014231.1 Pelodiscus sinensis 91 0.0 711
WERAM-Ptv-0084 ENSPVAP00000007791.1 Pteropus vampyrus 84 0.0 701
WERAM-Ict-0138 ENSSTOP00000014229.2 Ictidomys tridecemlineatus 94 0.0 652
WERAM-Chs-0186 ENSCSAP00000011661.1 Chlorocebus sabaeus 96 0.0 639
WERAM-Otg-0057 ENSOGAP00000004075.2 Otolemur garnettii 96 0.0 638
WERAM-Cap-0014 ENSCPOP00000001618.2 Cavia porcellus 96 0.0 635
WERAM-Nol-0151 ENSNLEP00000016301.1 Nomascus leucogenys 96 0.0 632
WERAM-Poa-0188 ENSPPYP00000022145.2 Pongo abelii 96 0.0 632
WERAM-Sus-0039 ENSSSCP00000006159.2 Sus scrofa 96 1e-180 630
WERAM-Paa-0215 ENSPANP00000002889.1 Papio anubis 96 3e-180 629
WERAM-Mup-0137 ENSMPUP00000012092.1 Mustela putorius furo 95 7e-180 628
WERAM-Ocp-0076 ENSOPRP00000006773.1 Ochotona princeps 92 9e-179 624
WERAM-Mam-0037 ENSMMUP00000007224.2 Macaca mulatta 96 2e-178 623
WERAM-Asm-0058 ENSAMXP00000006999.1 Astyanax mexicanus 74 2e-153 540
WERAM-Dar-0016 ENSDARP00000107943.2 Danio rerio 71 6e-151 532
WERAM-Fia-0022 ENSFALP00000001679.1 Ficedula albicollis 86 2e-146 517
WERAM-Leo-0032 ENSLOCP00000005430.1 Lepisosteus oculatus 77 9e-135 478
WERAM-Prc-0094 ENSPCAP00000008495.1 Procavia capensis 61 3e-133 473
WERAM-Ova-0082 ENSOARP00000008629.1 Ovis aries 60 4e-133 472
WERAM-Mim-0036 ENSMICP00000003366.1 Microcebus murinus 60 1e-132 471
WERAM-Vip-0081 ENSVPAP00000007489.1 Vicugna pacos 60 4e-131 466
WERAM-Tub-0130 ENSTBEP00000014498.1 Tupaia belangeri 58 6e-125 446
WERAM-Orc-0025 ENSOCUP00000002687.2 Oryctolagus cuniculus 61 3e-116 416
WERAM-Soa-0062 ENSSARP00000006154.1 Sorex araneus 58 3e-111 400
WERAM-Orn-0007 ENSONIP00000000922.1 Oreochromis niloticus 64 9e-106 382
WERAM-Pem-0081 ENSPMAP00000008773.1 Petromyzon marinus 55 6e-100 362
WERAM-Chh-0047 ENSCHOP00000005329.1 Choloepus hoffmanni 50 2e-90 330
WERAM-Xet-0123 ENSXETP00000042370.3 Xenopus tropicalis 76 4e-90 330
WERAM-Lac-0189 ENSLACP00000021483.1 Latimeria chalumnae 82 1e-89 328
WERAM-Mae-0045 ENSMEUP00000004128.1 Macropus eugenii 96 1e-83 308
WERAM-Orla-0179 ENSORLP00000020845.1 Oryzias latipes 55 1e-74 278
WERAM-Tas-0039 ENSTSYP00000004094.1 Tarsius syrichta 64 1e-71 268
WERAM-Ten-0212 ENSTNIP00000021345.1 Tetraodon nigroviridis 68 6e-69 259
WERAM-Xim-0033 ENSXMAP00000003434.1 Xiphophorus maculatus 67 1e-67 255
WERAM-Pof-0083 ENSPFOP00000007371.2 Poecilia formosa 64 2e-67 254
WERAM-Gam-0180 ENSGMOP00000017708.1 Gadus morhua 67 4e-66 250
WERAM-Gaa-0003 ENSGACP00000000131.1 Gasterosteus aculeatus 67 1e-65 248
WERAM-Tar-0168 ENSTRUP00000035617.1 Takifugu rubripes 96 4e-64 243
WERAM-Drm-0012 FBpp0071074 Drosophila melanogaster 75 1e-52 205
Created Date 25-Jun-2016