| Tag |
Content |
| WERAM ID |
WERAM-Sac-0024 |
| Ensembl Protein ID |
YJR119C |
| Uniprot Accession |
P47156; JHD2_YEAST; D6VWT8
|
| Genbank Protein ID |
NP_012653.1
|
| Protein Name |
Histone demethylase JHD2 |
| Genbank Nucleotide ID |
NM_001181777.1
|
| Gene Name |
JHD2 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDM |
JHDM2 |
Jmjc |
H3K4me3 |
K |
23091032
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| Me_Reader |
PHD |
4.10e-13 |
47.8 |
237 |
634 |
|
| Organism |
Saccharomyces cerevisiae |
| NCBI Taxa ID |
559292 |
Functional Description
(View)Functional Description
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated H3 'Lys-4'. |
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated H3 'Lys-4'.
|
| Domain Profile |
Me_Reader PHD
PHD.txt 3 iClvCgkddegekemvqCdeCddwfHlkCvklplsslpegkswyCpsC 50
C+vC+k+++ ++ + Cd+Cd+ fH++C+++pl+++p+g +w+C++C
YJR119C 237 ACIVCRKTNDPKR-TILCDSCDKPFHIYCLSPPLERVPSG-DWICNTC 282
7****99999987.**************************.******* PP
PHD.txt 13 gekemvqCdeCd 24
+e++ + C++C+
YJR119C 623 DEEYDIFCSQCK 634
333456666665 PP
|
Protein Sequence
(Fasta) | MEEIPALYPT EQEFKNPIDY LSNPHIKRLG VRYGMVKVVP PNGFCPPLSI DMENFTFQPR 60
IQNLENLDLK NRCRLFFMKQ LNNFKRSVKD PSKLILREPY TIVEYSDSTH ASEILKKKVY 120
FYDVFSELIK DNRTLTDTTQ SFRRKLKFRD ISQLRGDISL WRTISKKFNV PIGLLKEIFE 180
KYIASYYIFL HSLNENVHTA LHADQYPKSL LSDDEDDFDL GPDSNSGSDF EEDDDDACIV 240
CRKTNDPKRT ILCDSCDKPF HIYCLSPPLE RVPSGDWICN TCIVGNGYYG FTQDTHDYSL 300
PEFQEYCKRQ NSRLLPARKL SIDELEEMFW SLVTKNRRSS LTTVKYGADI HNELPGQITG 360
FPTREFIPKN INGDELIDYL KYCDHPMNLT NLPMAHNSLL PLFKRNISGM TIPWIYIGSL 420
FSTFCWHMED QYTLSANYQH EGDPKVWYSI PESGCTKFND LLNDMSPDLF IKQPDLLHQL 480
VTLISPYDPN FKKSGIPVYK AVQKPNEYII TFPKCYHAGF NTGYNFNEAV NFTIDFWLPY 540
GFGAITDYKL TQKACVFDMF DLMINVLDKY NKDTLLFNDA FVRQCYSSLI VFYNTELKRI 600
RKIQAIVPRT TLLEVHTDPN DEDEEYDIFC SQCKTICSIA FVLRKNNYDS IRTYKRHKKN 660
HLSIRQWNEL STTDSKVSIL CTQDYLKSIQ NLNNSDGEEP YIDDELYFTK SLKDIDSLIK 720
QVGVKLDR 728Protein Fasta Sequence
>YJR119C|JHD2|Saccharomyces cerevisiae
MEEIPALYPTEQEFKNPIDYLSNPHIKRLGVRYGMVKVVPPNGFCPPLSIDMENFTFQPRIQNLENLDLKNRCRLFFMKQLNNFKRSVKDPSKLILREPYTIVEYSDSTHASEILKKKVYFYDVFSELIKDNRTLTDTTQSFRRKLKFRDISQLRGDISLWRTISKKFNVPIGLLKEIFEKYIASYYIFLHSLNENVHTALHADQYPKSLLSDDEDDFDLGPDSNSGSDFEEDDDDACIVCRKTNDPKRTILCDSCDKPFHIYCLSPPLERVPSGDWICNTCIVGNGYYGFTQDTHDYSLPEFQEYCKRQNSRLLPARKLSIDELEEMFWSLVTKNRRSSLTTVKYGADIHNELPGQITGFPTREFIPKNINGDELIDYLKYCDHPMNLTNLPMAHNSLLPLFKRNISGMTIPWIYIGSLFSTFCWHMEDQYTLSANYQHEGDPKVWYSIPESGCTKFNDLLNDMSPDLFIKQPDLLHQLVTLISPYDPNFKKSGIPVYKAVQKPNEYIITFPKCYHAGFNTGYNFNEAVNFTIDFWLPYGFGAITDYKLTQKACVFDMFDLMINVLDKYNKDTLLFNDAFVRQCYSSLIVFYNTELKRIRKIQAIVPRTTLLEVHTDPNDEDEEYDIFCSQCKTICSIAFVLRKNNYDSIRTYKRHKKNHLSIRQWNELSTTDSKVSILCTQDYLKSIQNLNNSDGEEPYIDDELYFTKSLKDIDSLIKQVGVKLDR |
Nucleotide Sequence
(Fasta) | ATGGAGGAAA TTCCTGCCCT GTATCCAACG GAACAAGAAT TCAAAAATCC GATCGATTAT 60
CTCTCTAACC CCCACATTAA AAGGCTTGGT GTACGATATG GTATGGTCAA GGTCGTACCA 120
CCAAACGGGT TCTGCCCGCC ACTTTCTATT GATATGGAAA ATTTTACTTT TCAACCAAGA 180
ATTCAAAATC TGGAGAACCT AGACCTGAAA AATAGGTGTA GGCTATTTTT TATGAAACAG 240
TTAAATAATT TTAAAAGATC CGTTAAGGAT CCATCGAAAC TTATACTTAG GGAACCTTAT 300
ACGATTGTAG AATATTCAGA TTCTACTCAT GCATCGGAAA TACTAAAAAA AAAAGTGTAC 360
TTTTATGACG TTTTCTCTGA ACTAATAAAA GACAATCGGA CACTTACTGA CACTACACAG 420
TCATTCAGGC GAAAATTGAA ATTTAGAGAT ATTTCCCAAT TAAGAGGCGA CATCAGTCTA 480
TGGAGGACCA TTTCTAAAAA ATTCAACGTA CCAATCGGCT TGTTAAAGGA AATTTTTGAG 540
AAATATATTG CCTCATACTA CATATTTCTT CATTCACTGA ACGAGAACGT GCACACGGCG 600
CTGCATGCTG ACCAGTATCC AAAATCCTTA TTAAGTGATG ACGAGGACGA TTTCGATCTT 660
GGGCCAGATT CGAATTCTGG GTCGGATTTT GAGGAGGACG ATGATGATGC TTGTATTGTT 720
TGTCGCAAGA CAAATGATCC AAAAAGAACA ATTTTATGTG ATTCATGTGA CAAACCATTC 780
CATATATATT GTTTATCACC ACCTTTGGAA CGTGTTCCCT CTGGCGATTG GATTTGTAAC 840
ACTTGTATCG TCGGAAACGG ATATTACGGA TTCACTCAGG ACACGCATGA CTATTCTCTA 900
CCAGAGTTTC AAGAATATTG TAAACGTCAA AATTCAAGGT TATTACCAGC ACGAAAACTG 960
TCTATAGATG AGTTGGAAGA GATGTTTTGG AGCTTAGTGA CCAAGAATCG TCGCAGTTCA 1020
TTAACGACAG TTAAATACGG TGCTGACATA CATAACGAAT TGCCAGGTCA AATTACCGGC 1080
TTTCCGACGA GAGAATTTAT ACCCAAAAAT ATAAATGGGG ACGAATTGAT AGACTACCTC 1140
AAATATTGCG ATCATCCTAT GAATTTAACT AACTTGCCTA TGGCTCATAA TTCGCTATTA 1200
CCGTTATTTA AAAGAAATAT TTCTGGCATG ACTATTCCTT GGATTTACAT AGGCTCCTTA 1260
TTTTCCACAT TTTGTTGGCA TATGGAAGAT CAGTATACCC TAAGTGCTAA CTATCAACAT 1320
GAAGGTGACC CTAAGGTCTG GTACAGCATT CCCGAATCGG GATGTACGAA ATTCAACGAT 1380
CTATTAAATG ATATGTCACC AGACTTATTT ATCAAACAAC CAGACCTACT GCATCAGCTA 1440
GTGACTTTAA TATCTCCGTA CGATCCAAAT TTCAAGAAAT CAGGTATTCC TGTGTACAAA 1500
GCTGTGCAAA AGCCCAACGA ATATATTATC ACGTTTCCTA AATGTTACCA TGCTGGTTTT 1560
AATACAGGTT ATAATTTTAA TGAAGCTGTC AATTTTACTA TAGATTTCTG GCTACCATAT 1620
GGATTTGGTG CGATTACGGA TTATAAATTA ACTCAGAAAG CATGTGTTTT TGATATGTTT 1680
GATTTAATGA TCAATGTTTT GGACAAGTAC AATAAAGATA CTCTATTGTT CAATGATGCT 1740
TTTGTTAGGC AATGTTACTC TTCATTGATC GTCTTTTATA ATACTGAATT AAAACGCATA 1800
CGGAAAATTC AGGCCATTGT ACCACGGACA ACTCTTTTGG AGGTGCATAC TGATCCAAAC 1860
GATGAAGATG AGGAATACGA TATATTTTGT TCCCAATGTA AGACTATATG TTCAATAGCC 1920
TTTGTATTGC GAAAGAATAA CTATGATTCA ATTAGAACGT ATAAAAGACA CAAGAAAAAC 1980
CATTTAAGTA TTAGGCAGTG GAATGAACTA TCCACGACGG ACAGTAAAGT GAGTATCCTG 2040
TGTACGCAGG ATTACTTAAA ATCAATACAA AACTTGAACA ATAGCGACGG TGAAGAACCT 2100
TATATTGACG ATGAATTGTA TTTCACTAAG TCTTTGAAGG ATATTGACTC TTTAATAAAG 2160
CAAGTTGGTG TTAAGTTAGA TAGATAG
2188Nucleotide Fasta Sequence
>YJR119C|PHD|Saccharomyces cerevisiae
ATGGAGGAAATTCCTGCCCTGTATCCAACGGAACAAGAATTCAAAAATCCGATCGATTATCTCTCTAACCCCCACATTAAAAGGCTTGGTGTACGATATGGTATGGTCAAGGTCGTACCACCAAACGGGTTCTGCCCGCCACTTTCTATTGATATGGAAAATTTTACTTTTCAACCAAGAATTCAAAATCTGGAGAACCTAGACCTGAAAAATAGGTGTAGGCTATTTTTTATGAAACAGTTAAATAATTTTAAAAGATCCGTTAAGGATCCATCGAAACTTATACTTAGGGAACCTTATACGATTGTAGAATATTCAGATTCTACTCATGCATCGGAAATACTAAAAAAAAAAGTGTACTTTTATGACGTTTTCTCTGAACTAATAAAAGACAATCGGACACTTACTGACACTACACAGTCATTCAGGCGAAAATTGAAATTTAGAGATATTTCCCAATTAAGAGGCGACATCAGTCTATGGAGGACCATTTCTAAAAAATTCAACGTACCAATCGGCTTGTTAAAGGAAATTTTTGAGAAATATATTGCCTCATACTACATATTTCTTCATTCACTGAACGAGAACGTGCACACGGCGCTGCATGCTGACCAGTATCCAAAATCCTTATTAAGTGATGACGAGGACGATTTCGATCTTGGGCCAGATTCGAATTCTGGGTCGGATTTTGAGGAGGACGATGATGATGCTTGTATTGTTTGTCGCAAGACAAATGATCCAAAAAGAACAATTTTATGTGATTCATGTGACAAACCATTCCATATATATTGTTTATCACCACCTTTGGAACGTGTTCCCTCTGGCGATTGGATTTGTAACACTTGTATCGTCGGAAACGGATATTACGGATTCACTCAGGACACGCATGACTATTCTCTACCAGAGTTTCAAGAATATTGTAAACGTCAAAATTCAAGGTTATTACCAGCACGAAAACTGTCTATAGATGAGTTGGAAGAGATGTTTTGGAGCTTAGTGACCAAGAATCGTCGCAGTTCATTAACGACAGTTAAATACGGTGCTGACATACATAACGAATTGCCAGGTCAAATTACCGGCTTTCCGACGAGAGAATTTATACCCAAAAATATAAATGGGGACGAATTGATAGACTACCTCAAATATTGCGATCATCCTATGAATTTAACTAACTTGCCTATGGCTCATAATTCGCTATTACCGTTATTTAAAAGAAATATTTCTGGCATGACTATTCCTTGGATTTACATAGGCTCCTTATTTTCCACATTTTGTTGGCATATGGAAGATCAGTATACCCTAAGTGCTAACTATCAACATGAAGGTGACCCTAAGGTCTGGTACAGCATTCCCGAATCGGGATGTACGAAATTCAACGATCTATTAAATGATATGTCACCAGACTTATTTATCAAACAACCAGACCTACTGCATCAGCTAGTGACTTTAATATCTCCGTACGATCCAAATTTCAAGAAATCAGGTATTCCTGTGTACAAAGCTGTGCAAAAGCCCAACGAATATATTATCACGTTTCCTAAATGTTACCATGCTGGTTTTAATACAGGTTATAATTTTAATGAAGCTGTCAATTTTACTATAGATTTCTGGCTACCATATGGATTTGGTGCGATTACGGATTATAAATTAACTCAGAAAGCATGTGTTTTTGATATGTTTGATTTAATGATCAATGTTTTGGACAAGTACAATAAAGATACTCTATTGTTCAATGATGCTTTTGTTAGGCAATGTTACTCTTCATTGATCGTCTTTTATAATACTGAATTAAAACGCATACGGAAAATTCAGGCCATTGTACCACGGACAACTCTTTTGGAGGTGCATACTGATCCAAACGATGAAGATGAGGAATACGATATATTTTGTTCCCAATGTAAGACTATATGTTCAATAGCCTTTGTATTGCGAAAGAATAACTATGATTCAATTAGAACGTATAAAAGACACAAGAAAAACCATTTAAGTATTAGGCAGTGGAATGAACTATCCACGACGGACAGTAAAGTGAGTATCCTGTGTACGCAGGATTACTTAAAATCAATACAAAACTTGAACAATAGCGACGGTGAAGAACCTTATATTGACGATGAATTGTATTTCACTAAGTCTTTGAAGGATATTGACTCTTTAATAAAGCAAGTTGGTGTTAAGTTAGATAGATAG
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR003347--JmjC_dom
IPR003349--JmjN
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
|
| PROSITE |
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
|
| Pfam |
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0051213--F:dioxygenase activity
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0034649--F:histone demethylase activity (H3-monomethyl-K4 specific)
GO:0008270--F:zinc ion binding
GO:0071041--P:antisense RNA transcript catabolic process
GO:0000183--P:chromatin silencing at rDNA
GO:0016577--P:histone demethylation
GO:0034720--P:histone H3-K4 demethylation
GO:1904388--P:negative regulation of ncRNA transcription associated with protein coding gene TSS/TES
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060623--P:regulation of chromosome condensation
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
