| Tag |
Content |
| WERAM ID |
WERAM-Scp-0024 |
| Ensembl Protein ID |
SPBC16D10.07c.1:pep |
| Uniprot Accession |
O94640; SIR2_SCHPO; Q6H8I3
|
| Genbank Protein ID |
NP_001018840.1
|
| Protein Name |
NAD-dependent histone deacetylase sir2 |
| Genbank Nucleotide ID |
NM_001022423.2
|
| Gene Name |
SIR2;SPBC16D10.07c |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H4K16 |
K |
12867036
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
2.30e-85 |
284.1 |
148 |
430 |
|
| Organism |
Schizosaccharomyces pombe |
| NCBI Taxa ID |
284812 |
Functional Description
(View)Functional Description
Involved in silencing within the mating-type region, at the telomeres, and according to PubMed:12867036 also within centromeric DNA regions. Required for the localization of swi6 to the telomeres, silent mating type region, and according to PubMed:12867036 to the centromeric DNA regions. According to PubMed:15545655 not required for the localization of swi6 to centromeric foci. Deacetylates histone H3 on 'Lys-9' and 'Lys-16' of histone H4. This has a direct role in heterochromatin assembly. |
Involved in silencing within the mating-type region, at the telomeres, and according to PubMed:12867036 also within centromeric DNA regions. Required for the localization of swi6 to the telomeres, silent mating type region, and according to PubMed:12867036 to the centromeric DNA regions. According to PubMed:15545655 not required for the localization of swi6 to centromeric foci. Deacetylates histone H3 on 'Lys-9' and 'Lys-16' of histone H4. This has a direct role in heterochromatin assembly.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 2 klakllkkskkivvltGAGiStsaGIPDFRsseGlysklkkeelpspeaifdldffrkdpkvfyalakelyp.lgsakPtktHyflaele 90
++++llkk+k++vvl+GAGiSts GI DFRs++G+y++l+++ l++p+++fd+++fr++p++fy++a++l+p +++++P+ H f+++le
SPBC16D10.07c.1:pep 148 DVVNLLKKAKNVVVLVGAGISTSLGILDFRSDNGFYARLARHGLSEPSEMFDIHTFRENPEIFYTFARDLLPeTNHYSPS--HAFIRLLE 235
7899****************************************************************************..******** PP
SIR2.txt 91 kkgkllrlytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCekC....................... 157
kk+kl++l+tQNiD+Le+k+gl+++k++++HGs+ata+C+kCk++++++e+ e+++++ +v+ C++C
SPBC16D10.07c.1:pep 236 KKNKLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSELYEDIRNQ-RVSYCNECgkpplklrrvgqnkkekhyfsdg 324
**********************************************************.9****************************** PP
SIR2.txt 158 ...........kgvlkpdivffgenlpeefleeveed.lkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevkadkladlkll 235
g++kpdi+ffge+lp++f+++v + l+e+dll+++GtSlkv+pv++l+ ++++ ++p++++++++v+ ++++d+++l
SPBC16D10.07c.1:pep 325 dsesseddlaqPGIMKPDITFFGEALPDSFFNKVGSGeLEETDLLICIGTSLKVAPVSELI-SVIPPTTPQIYISRTPVR-HTQFDVNFL 412
**********88*********************988659**********************.******************.99*****99 PP
SIR2.txt 236 gd.cdevveellkllgle 252
+ cd+v+ e++k++g+
SPBC16D10.07c.1:pep 413 SPyCDWVIVEICKRAGWL 430
866************996 PP
|
Protein Sequence
(Fasta) | MASNPLDNNM PTTPVEEKIP VASYSPSSSG SSSGASLLVD IMCGSKETED EEVDSDEWDK 60
PETENISDLD ERSEMVRYLR ASGYAKFLEK YLIEEELPVR SILKKLGINL PSALEEFEDI 120
DLLPLLKEVL KREVARRIKL PHFNTFEDVV NLLKKAKNVV VLVGAGISTS LGILDFRSDN 180
GFYARLARHG LSEPSEMFDI HTFRENPEIF YTFARDLLPE TNHYSPSHAF IRLLEKKNKL 240
STLFTQNIDN LEKKTGLSDN KIIQCHGSFA TATCIKCKHK VDGSELYEDI RNQRVSYCNE 300
CGKPPLKLRR VGQNKKEKHY FSDGDSESSE DDLAQPGIMK PDITFFGEAL PDSFFNKVGS 360
GELEETDLLI CIGTSLKVAP VSELISVIPP TTPQIYISRT PVRHTQFDVN FLSPYCDWVI 420
VEICKRAGWL NELQALCDLP ECHSGSKTRA FETDLDIKFE EPSTYHITST TNGSC 475Protein Fasta Sequence
>SPBC16D10.07c.1:pep|SIR2;SPBC16D10.07c|Schizosaccharomyces pombe
MASNPLDNNMPTTPVEEKIPVASYSPSSSGSSSGASLLVDIMCGSKETEDEEVDSDEWDKPETENISDLDERSEMVRYLRASGYAKFLEKYLIEEELPVRSILKKLGINLPSALEEFEDIDLLPLLKEVLKREVARRIKLPHFNTFEDVVNLLKKAKNVVVLVGAGISTSLGILDFRSDNGFYARLARHGLSEPSEMFDIHTFRENPEIFYTFARDLLPETNHYSPSHAFIRLLEKKNKLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSELYEDIRNQRVSYCNECGKPPLKLRRVGQNKKEKHYFSDGDSESSEDDLAQPGIMKPDITFFGEALPDSFFNKVGSGELEETDLLICIGTSLKVAPVSELISVIPPTTPQIYISRTPVRHTQFDVNFLSPYCDWVIVEICKRAGWLNELQALCDLPECHSGSKTRAFETDLDIKFEEPSTYHITSTTNGSC |
Nucleotide Sequence
(Fasta) | CATGGTTCAA AGCAACGTTT AAATTAACAA GTTGTATAGT TAAACTTATA CAGTGCTTTG 60
CTTCTAATAG CCATTATTAC CAGGAAATAA CGAGATCACA GTTGCCCGCA TACCATTAAG 120
CTAACGAAAC TTTACTGCAC TAAACAAGAG ACTAGCTTTT CGTAATTGTA ATAAGACTTA 180
TCGAAAAGTT GAACCAGAGA TCTTCAGTTC AGTAGATCAT TGCCTTTCTC AAACGAAGCT 240
TTAATTTATA CTTCCTTAAA AATAATTGAT TAGTCATATT TTCATGTTAT ACAAACTCTG 300
TCATGGCTTC CAATCCGCTA GATAATAATA TGCCGACGAC TCCCGTTGAG GAAAAAATTC 360
CAGTCGCTAG TTATTCTCCT AGCTCTTCTG GTAGTAGTTC CGGTGCTAGT TTACTAGTAG 420
ATATTATGTG CGGCAGTAAA GAAACTGAGG ATGAAGAGGT TGATTCTGAT GAATGGGATA 480
AACCAGAAAC AGAAAACATA AGTGATTTGG ATGAACGATC CGAAATGGTC AGATATTTAA 540
GGGCTTCAGG CTATGCGAAA TTCTTGGAGA AATATTTAAT AGAAGAAGAG TTGCCTGTAC 600
GATCGATTTT AAAAAAACTT GGAATCAATT TGCCTAGTGC ACTTGAAGAG TTTGAAGACA 660
TAGATTTACT TCCTTTGCTG AAGGAAGTTT TAAAACGTGA GGTTGCTAGG AGAATCAAAC 720
TTCCACATTT TAATACCTTT GAAGATGTTG TTAATTTATT GAAAAAAGCT AAAAATGTTG 780
TCGTCCTTGT TGGGGCAGGC ATAAGTACAA GTTTGGGAAT TTTAGATTTC CGTTCAGACA 840
ATGGTTTTTA TGCCCGTTTG GCACGCCATG GATTATCGGA ACCTTCTGAA ATGTTTGATA 900
TCCATACGTT TAGAGAAAAT CCAGAAATTT TTTATACTTT TGCTAGAGAT CTTTTGCCGG 960
AGACGAATCA TTATTCCCCC TCGCATGCCT TCATTAGATT GCTTGAAAAG AAGAATAAAT 1020
TATCAACATT GTTTACCCAA AATATAGACA ATTTGGAAAA AAAGACTGGA CTCTCCGATA 1080
ACAAAATTAT TCAATGTCAT GGGTCTTTTG CTACCGCAAC TTGTATCAAA TGCAAGCACA 1140
AGGTGGATGG ATCGGAGTTA TATGAAGACA TAAGAAATCA AAGAGTTTCT TACTGCAATG 1200
AATGCGGAAA ACCACCCTTA AAATTAAGAA GAGTCGGTCA AAATAAAAAA GAGAAACATT 1260
ATTTTTCAGA TGGTGATAGT GAATCTTCTG AAGATGATCT AGCTCAACCT GGGATTATGA 1320
AACCTGATAT CACATTTTTT GGGGAAGCCT TACCGGATTC TTTCTTTAAC AAAGTCGGGA 1380
GTGGTGAGCT TGAAGAGACT GATTTATTAA TTTGTATTGG AACTTCTTTA AAAGTGGCTC 1440
CTGTTTCAGA ACTCATCAGT GTTATTCCTC CTACTACTCC TCAGATTTAC ATTTCGAGGA 1500
CTCCTGTTCG TCATACCCAA TTCGATGTAA ATTTTCTAAG TCCTTATTGT GATTGGGTTA 1560
TTGTGGAGAT TTGTAAACGT GCTGGATGGC TGAATGAATT ACAAGCGCTT TGCGATTTAC 1620
CTGAGTGTCA TAGTGGTTCC AAAACGCGAG CTTTCGAAAC GGATTTGGAT ATAAAATTTG 1680
AGGAGCCCAG CACCTATCAT ATCACGAGCA CAACAAACGG TAGTTGTTAA TTTTAGGACT 1740
GATCGATCTA TCGAAGTTGA ATGTAGAAGC AAATATATTA TATACATATA TCGAGTATGA 1800
GAGCCAGATT ATTGGACATT AACTTATTAT CCGTTTGAGA CTTCTTAGTT TTGTAAGTGC 1860
CATTGTTAAA AACTGTTTTT TCTCTTCGCA CCTAATGTTT AAATCTGCTA AACTGGGTGA 1920
AAACACATTA AAACAAGTTA TAATACATTT TACAATACCA AGGACTGTGT AATTAGTAAA 1980
TGAACATTGA AGCAAATTAC ATTCATAGGC TATGCAAAAT TAGCTACTTT TTTAAGCATA 2040
GTAAATCAGT GAAAATGACA CAATTATTAT TTAAAATTGA AAGATTGATT GGTACATATC 2100
AATACAACCA ATGAAGCATC TAATTGTACG ATACTAAAGA GAAACAACTG AAAACGGAC
2160
Nucleotide Fasta Sequence
>SPBC16D10.07c.1:pep|SIR2|Schizosaccharomyces pombe
CATGGTTCAAAGCAACGTTTAAATTAACAAGTTGTATAGTTAAACTTATACAGTGCTTTGCTTCTAATAGCCATTATTACCAGGAAATAACGAGATCACAGTTGCCCGCATACCATTAAGCTAACGAAACTTTACTGCACTAAACAAGAGACTAGCTTTTCGTAATTGTAATAAGACTTATCGAAAAGTTGAACCAGAGATCTTCAGTTCAGTAGATCATTGCCTTTCTCAAACGAAGCTTTAATTTATACTTCCTTAAAAATAATTGATTAGTCATATTTTCATGTTATACAAACTCTGTCATGGCTTCCAATCCGCTAGATAATAATATGCCGACGACTCCCGTTGAGGAAAAAATTCCAGTCGCTAGTTATTCTCCTAGCTCTTCTGGTAGTAGTTCCGGTGCTAGTTTACTAGTAGATATTATGTGCGGCAGTAAAGAAACTGAGGATGAAGAGGTTGATTCTGATGAATGGGATAAACCAGAAACAGAAAACATAAGTGATTTGGATGAACGATCCGAAATGGTCAGATATTTAAGGGCTTCAGGCTATGCGAAATTCTTGGAGAAATATTTAATAGAAGAAGAGTTGCCTGTACGATCGATTTTAAAAAAACTTGGAATCAATTTGCCTAGTGCACTTGAAGAGTTTGAAGACATAGATTTACTTCCTTTGCTGAAGGAAGTTTTAAAACGTGAGGTTGCTAGGAGAATCAAACTTCCACATTTTAATACCTTTGAAGATGTTGTTAATTTATTGAAAAAAGCTAAAAATGTTGTCGTCCTTGTTGGGGCAGGCATAAGTACAAGTTTGGGAATTTTAGATTTCCGTTCAGACAATGGTTTTTATGCCCGTTTGGCACGCCATGGATTATCGGAACCTTCTGAAATGTTTGATATCCATACGTTTAGAGAAAATCCAGAAATTTTTTATACTTTTGCTAGAGATCTTTTGCCGGAGACGAATCATTATTCCCCCTCGCATGCCTTCATTAGATTGCTTGAAAAGAAGAATAAATTATCAACATTGTTTACCCAAAATATAGACAATTTGGAAAAAAAGACTGGACTCTCCGATAACAAAATTATTCAATGTCATGGGTCTTTTGCTACCGCAACTTGTATCAAATGCAAGCACAAGGTGGATGGATCGGAGTTATATGAAGACATAAGAAATCAAAGAGTTTCTTACTGCAATGAATGCGGAAAACCACCCTTAAAATTAAGAAGAGTCGGTCAAAATAAAAAAGAGAAACATTATTTTTCAGATGGTGATAGTGAATCTTCTGAAGATGATCTAGCTCAACCTGGGATTATGAAACCTGATATCACATTTTTTGGGGAAGCCTTACCGGATTCTTTCTTTAACAAAGTCGGGAGTGGTGAGCTTGAAGAGACTGATTTATTAATTTGTATTGGAACTTCTTTAAAAGTGGCTCCTGTTTCAGAACTCATCAGTGTTATTCCTCCTACTACTCCTCAGATTTACATTTCGAGGACTCCTGTTCGTCATACCCAATTCGATGTAAATTTTCTAAGTCCTTATTGTGATTGGGTTATTGTGGAGATTTGTAAACGTGCTGGATGGCTGAATGAATTACAAGCGCTTTGCGATTTACCTGAGTGTCATAGTGGTTCCAAAACGCGAGCTTTCGAAACGGATTTGGATATAAAATTTGAGGAGCCCAGCACCTATCATATCACGAGCACAACAAACGGTAGTTGTTAATTTTAGGACTGATCGATCTATCGAAGTTGAATGTAGAAGCAAATATATTATATACATATATCGAGTATGAGAGCCAGATTATTGGACATTAACTTATTATCCGTTTGAGACTTCTTAGTTTTGTAAGTGCCATTGTTAAAAACTGTTTTTTCTCTTCGCACCTAATGTTTAAATCTGCTAAACTGGGTGAAAACACATTAAAACAAGTTATAATACATTTTACAATACCAAGGACTGTGTAATTAGTAAATGAACATTGAAGCAAATTACATTCATAGGCTATGCAAAATTAGCTACTTTTTTAAGCATAGTAAATCAGTGAAAATGACACAATTATTATTTAAAATTGAAAGATTGATTGGTACATATCAATACAACCAATGAAGCATCTAATTGTACGATACTAAAGAGAAACAACTGAAAACGGAC
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0520--NAD
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0779--Telomere
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR007654--NAD-dep_histone_deAcase_SIR2_N
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF04574--DUF592
PF02146--SIR2
|
| Gene Ontology |
GO:0034507--C:chromosome, centromeric outer repeat region
GO:0000781--C:chromosome, telomeric region
GO:0031934--C:mating-type region heterochromatin
GO:0000790--C:nuclear chromatin
GO:0031618--C:nuclear pericentric heterochromatin
GO:1902377--C:nuclear rDNA heterochromatin
GO:1990707--C:nuclear subtelomeric heterochromatin
GO:0005634--C:nucleus
GO:0030869--C:RENT complex
GO:0004407--F:histone deacetylase activity
GO:0031078--F:histone deacetylase activity (H3-K14 specific)
GO:1990162--F:histone deacetylase activity (H3-K4 specific)
GO:0032129--F:histone deacetylase activity (H3-K9 specific)
GO:0034739--F:histone deacetylase activity (H4-K16 specific)
GO:0070403--F:NAD+ binding
GO:0046969--F:NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970--F:NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0008270--F:zinc ion binding
GO:0006342--P:chromatin silencing
GO:0030702--P:chromatin silencing at centromere
GO:1990141--P:chromatin silencing at centromere outer repeat region
GO:0030466--P:chromatin silencing at silent mating-type cassette
GO:0006348--P:chromatin silencing at telomere
GO:0006281--P:DNA repair
GO:0016575--P:histone deacetylation
GO:1990596--P:histone H3-K4 deacetylation
GO:1990619--P:histone H3-K9 deacetylation
GO:0061647--P:histone H3-K9 modification
GO:1990679--P:histone H4-K12 deacetylation
GO:1990678--P:histone H4-K16 deacetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0031453--P:positive regulation of heterochromatin assembly
GO:0070198--P:protein localization to chromosome, telomeric region
GO:0051570--P:regulation of histone H3-K9 methylation
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
