WERAM Information

Tag Content
WERAM ID WERAM-Ran-0088
Ensembl Protein ID ENSRNOP00000018861.5
Uniprot Accession C6ZII9; C6ZII9_RAT
Genbank Protein ID
Protein Name Protein Sirt3
Genbank Nucleotide ID
Gene Name SIRT3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000013828.7 ENSRNOT00000018861.6 ENSRNOP00000018861.5
Details
Type Family Domain Substrates AA References (PMIDs)
HDAC SIR2 Deacetylase sirtuin-type H3K14 K 26692487
Status Reviewed
Classification
Type Family E-value Score Start End
HDAC SIR2 1.10e-93 313.8 48 303
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional Description
(View)
Domain Profile
  HDAC SIR2
              SIR2.txt   2 klakllk..kskkivvltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyfla 87 
                           ++a+ll+   ++++vv++GAGiSt +GIPDFRs ++Glys+l+++++p+peaif+l ff ++pk+f++lakelyp g+++P+++Hyfl+
  ENSRNOP00000018861.5  48 DVAELLRtrACSRVVVMVGAGISTPSGIPDFRSpGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFTLAKELYP-GHYRPNVAHYFLR 135
                           57777776689****************************************************************.************* PP
              SIR2.txt  88 elekkgkllrlytQNiDgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCekCkgvlkpdivffgenlpeef 176
                           +l++k++llrlytQNiDgLer++g++++klve+HGs+  a+Ct C+++fp+e i+++++a+ +vp+C+ C+gv+kpdivffge+lp++f
  ENSRNOP00000018861.5 136 LLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGSFVSATCTVCRRSFPGEDIRADVMAD-RVPRCPVCTGVVKPDIVFFGEQLPARF 223
                           *************************************************************.9************************** PP
              SIR2.txt 177 leeveedlkeadlllvlGtSlkvepvaslvkkavkkkvpvllvnleevk....adkladlkllgdcdevveellkllgleee 254
                           l +v +d++ adlll+lGtSl+vep+asl  + v+k+vp+ll+n++ v+    + +++d+++lgd+ + ve+l++llg+++e
  ENSRNOP00000018861.5 224 LLHV-ADFALADLLLILGTSLEVEPFASLS-ESVQKSVPRLLINRDLVGsfalSPRRKDVVQLGDVVQGVERLVDLLGWTQE 303
                           ****.899**********************.********************999*************************985 PP
Protein Sequence
(Fasta)		MALSCRLVLA ALRLWGPGGG RRPISLSVGA SGGFGCGGHS EKKLSLQDVA ELLRTRACSR 60
VVVMVGAGIS TPSGIPDFRS PGSGLYSNLQ QYDIPYPEAI FELGFFFHNP KPFFTLAKEL 120
YPGHYRPNVA HYFLRLLHDK ELLLRLYTQN IDGLERASGI PASKLVEAHG SFVSATCTVC 180
RRSFPGEDIR ADVMADRVPR CPVCTGVVKP DIVFFGEQLP ARFLLHVADF ALADLLLILG 240
TSLEVEPFAS LSESVQKSVP RLLINRDLVG SFALSPRRKD VVQLGDVVQG VERLVDLLGW 300
TQELQDLIQR ENGKLDGQDG
Nucleotide Sequence
(Fasta)		AGAGCATCAT GGCGCTGAGC TGTCGACTGG TATTGGCCGC GCTCAGACTG TGGGGTCCGG 60
GAGGTGGGAG AAGGCCCATA TCCCTCTCTG TGGGAGCCTC AGGCGGCTTT GGATGTGGAG 120
GACACAGTGA GAAGAAGCTG TCTCTGCAGG ACGTAGCTGA GCTGCTTCGG ACCAGAGCCT 180
GCAGTAGGGT TGTGGTCATG GTGGGGGCTG GCATCAGCAC ACCCAGTGGT ATCCCAGACT 240
TCAGATCCCC AGGGAGTGGC CTCTACAGCA ACCTTCAGCA GTATGACATC CCGTACCCTG 300
AGGCCATCTT TGAACTAGGC TTCTTTTTTC ACAACCCCAA GCCCTTTTTC ACGTTGGCCA 360
AGGAGCTGTA CCCTGGGCAC TACAGGCCCA ATGTCGCTCA CTACTTCCTT CGGCTGCTTC 420
ACGACAAGGA GCTGCTTCTG CGGCTCTACA CACAGAACAT CGACGGGCTT GAGAGAGCAT 480
CTGGTATCCC TGCCTCAAAG CTGGTTGAAG CTCATGGGTC CTTTGTATCA GCTACGTGCA 540
CGGTCTGTCG AAGGTCCTTC CCAGGGGAAG ACATACGGGC TGACGTGATG GCAGACAGGG 600
TGCCCCGCTG CCCTGTCTGT ACTGGCGTTG TGAAACCTGA CATTGTGTTC TTTGGGGAGC 660
AGCTGCCAGC AAGGTTCTTA CTACATGTGG CTGATTTCGC CTTGGCAGAT CTGCTACTCA 720
TTCTTGGGAC CTCCCTGGAG GTGGAGCCTT TTGCCAGCTT GTCTGAATCG GTACAGAAAT 780
CAGTGCCCCG ACTGCTCATC AATCGAGACT TGGTGGGGTC CTTTGCTCTG AGTCCTCGAA 840
GGAAAGATGT GGTCCAGCTA GGGGATGTAG TCCAGGGTGT GGAAAGGCTG GTGGACCTCC 900
TGGGGTGGAC ACAAGAGCTG CAGGATCTCA TCCAGCGGGA AAATGGAAAG CTGGATGGAC 960
AGGACGGATA AGACAGACTA TGGCTTACTT CTTCACCTGC GGGAAAGTCG CACAGGAGAT 1020
CATCCTATTC CCAGGGAGAC CTCATGTCTG AAAACAGCTC CGACAGGTTT ACAAACATGG 1080
GCCAGACCAC AACATGTGTC CTGGGCAGTA GTCCCAAGGC TGCCTTTGTT AAGGCTGACC 1140
AGGGACCTTT ACCCTTGGGG CCATGTGTTA CCATACAAAG GAGCTCCACG TGTGTGCTCT 1200
GTCCACCCAT CACTGCTGAA GCTTGCAGTA CAGTGCTGCT TTCTGACAGA GGCCTTAGTT 1260
ACCAAGAGGG CAGGGCAGCA TGCCCATCGC TAGACAGCTG ATACGCTAGG CTAATCTAGC 1320
ATGTTGGTCG GTAAAGTGGC ATCTTTAACT GAAAAATCAT TTTTCGCATG AAATAAATTT 1380
AGT 1384
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0732--Signal
--
Interpro

IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR017328--Sirtuin_class_I
IPR026590--Ssirtuin_cat_dom
PROSITE

PS50305--SIRTUIN
Pfam

PF02146--SIR2
Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0019899--F:enzyme binding
GO:0070403--F:NAD+ binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0008270--F:zinc ion binding
GO:0009060--P:aerobic respiration
GO:0007568--P:aging
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:2000757--P:negative regulation of peptidyl-lysine acetylation
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0034983--P:peptidyl-lysine deacetylation
GO:0032024--P:positive regulation of insulin secretion
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Mum-0070 ENSMUSP00000026559.7 Mus musculus 95 1e-112 403
WERAM-Gog-0146 ENSGGOP00000012824.2 Gorilla gorilla 86 2e-112 402
WERAM-Ict-0131 ENSSTOP00000013488.2 Ictidomys tridecemlineatus 83 4e-112 401
WERAM-Hos-0139 ENSP00000372191.4 Homo sapiens 85 8e-112 400
WERAM-Poa-0191 ENSPPYP00000022355.1 Pongo abelii 85 2e-111 399
WERAM-Orc-0194 ENSOCUP00000019306.2 Oryctolagus cuniculus 79 3e-111 398
WERAM-Paa-0056 ENSPANP00000005782.1 Papio anubis 82 1e-110 397
WERAM-Sus-0110 ENSSSCP00000015488.2 Sus scrofa 77 1e-110 396
WERAM-Nol-0170 ENSNLEP00000018956.1 Nomascus leucogenys 84 2e-110 395
WERAM-Chs-0140 ENSCSAP00000007481.1 Chlorocebus sabaeus 83 9e-110 394
WERAM-Mod-0192 ENSMODP00000026476.2 Monodelphis domestica 81 3e-108 389
WERAM-Tub-0067 ENSTBEP00000008310.1 Tupaia belangeri 84 3e-108 389
WERAM-Eqc-0017 ENSECAP00000002534.1 Equus caballus 85 1e-107 386
WERAM-Cap-0199 ENSCPOP00000018954.1 Cavia porcellus 83 2e-107 385
WERAM-Bot-0022 ENSBTAP00000002648.3 Bos taurus 81 5e-107 384
WERAM-Ova-0092 ENSOARP00000009476.1 Ovis aries 81 5e-106 381
WERAM-Mup-0089 ENSMPUP00000008357.1 Mustela putorius furo 83 7e-106 380
WERAM-Caf-0076 ENSCAFP00000009649.3 Canis familiaris 79 1e-105 380
WERAM-Dan-0202 ENSDNOP00000027446.1 Dasypus novemcinctus 81 1e-104 376
WERAM-Aim-0043 ENSAMEP00000003493.1 Ailuropoda melanoleuca 82 2e-104 376
WERAM-Ptv-0186 ENSPVAP00000016701.1 Pteropus vampyrus 81 3e-104 375
WERAM-Mim-0058 ENSMICP00000005750.1 Microcebus murinus 78 3e-104 375
WERAM-Soa-0118 ENSSARP00000011447.1 Sorex araneus 77 4e-104 375
WERAM-Fec-0035 ENSFCAP00000002455.2 Felis catus 78 3e-103 372
WERAM-Otg-0196 ENSOGAP00000020777.1 Otolemur garnettii 81 5e-103 371
WERAM-Pes-0119 ENSPSIP00000014160.1 Pelodiscus sinensis 75 8e-102 367
WERAM-Anc-0180 ENSACAP00000017235.2 Anolis carolinensis 73 9e-102 367
WERAM-Anp-0145 ENSAPLP00000015403.1 Anas platyrhynchos 76 8e-101 364
WERAM-Gaga-0047 ENSGALP00000006674.4 Gallus gallus 75 8e-101 363
WERAM-Meg-0026 ENSMGAP00000002050.2 Meleagris gallopavo 74 2e-100 362
WERAM-Sah-0089 ENSSHAP00000010517.1 Sarcophilus harrisii 79 2e-95 346
WERAM-Fia-0142 ENSFALP00000011956.1 Ficedula albicollis 79 2e-94 342
WERAM-Tag-0102 ENSTGUP00000007081.1 Taeniopygia guttata 79 2e-92 336
WERAM-Loa-0217 ENSLAFP00000022559.1 Loxodonta africana 81 7e-92 334
WERAM-Lac-0044 ENSLACP00000006675.2 Latimeria chalumnae 65 2e-89 326
WERAM-Leo-0013 ENSLOCP00000002849.1 Lepisosteus oculatus 67 1e-88 323
WERAM-Caj-0061 ENSCJAP00000010311.1 Callithrix jacchus 85 1e-87 320
WERAM-Dar-0078 ENSDARP00000051972.5 Danio rerio 68 2e-87 319
WERAM-Mam-0066 ENSMMUP00000011129.2 Macaca mulatta 87 4e-87 318
WERAM-Tut-0151 ENSTTRP00000012839.1 Tursiops truncatus 73 3e-86 315
WERAM-Orn-0188 ENSONIP00000019610.1 Oreochromis niloticus 67 5e-86 315
WERAM-Asm-0068 ENSAMXP00000007378.1 Astyanax mexicanus 66 1e-84 310
WERAM-Gaa-0170 ENSGACP00000020749.1 Gasterosteus aculeatus 69 2e-84 309
WERAM-Pof-0013 ENSPFOP00000001321.2 Poecilia formosa 69 9e-84 307
WERAM-Gam-0078 ENSGMOP00000008397.1 Gadus morhua 66 4e-83 305
WERAM-Xim-0222 ENSXMAP00000018428.1 Xiphophorus maculatus 67 4e-82 301
WERAM-Orla-0002 ENSORLP00000000105.1 Oryzias latipes 67 3e-81 299
WERAM-Tar-0146 ENSTRUP00000031533.1 Takifugu rubripes 71 5e-80 295
WERAM-Xet-0176 ENSXETP00000058774.1 Xenopus tropicalis 62 8e-75 277
WERAM-Pem-0044 ENSPMAP00000005386.1 Petromyzon marinus 60 2e-73 273
WERAM-Ere-0056 ENSEEUP00000004763.1 Erinaceus europaeus 78 2e-71 266
WERAM-Ten-0144 ENSTNIP00000015099.1 Tetraodon nigroviridis 56 1e-70 263
WERAM-Cii-0083 ENSCINP00000033928.1 Ciona intestinalis 54 6e-67 251
WERAM-Cis-0064 ENSCSAVP00000014791.1 Ciona savignyi 51 4e-66 248
WERAM-Myl-0011 ENSMLUP00000000900.2 Myotis lucifugus 50 9e-63 237
WERAM-Drm-0067 FBpp0310647 Drosophila melanogaster 53 1e-62 237
WERAM-Trv-0012 EHK19002 Trichoderma virens 52 2e-62 236
WERAM-Trr-0018 EGR46788 Trichoderma reesei 53 6e-62 234
WERAM-Pat-0091 ENSPTRP00000018763.5 Pan troglodytes 49 7e-62 234
WERAM-Tas-0032 ENSTSYP00000003226.1 Tarsius syrichta 89 1e-61 233
WERAM-Pytr-0009 EDU41553 Pyrenophora triticirepentis 49 2e-60 230
WERAM-Mao-0040 MGG_17827T0 Magnaporthe oryzae 51 3e-60 229
WERAM-Zyt-0001 Mycgr3P100618 Zymoseptoria tritici 50 1e-59 227
WERAM-Pyt-0039 EFQ86136 Pyrenophora teres 49 3e-59 226
WERAM-Asn-0005 CADANIAP00000554 Aspergillus nidulans 50 3e-59 225
WERAM-Aso-0005 CADAORAP00000633 Aspergillus oryzae 49 4e-58 222
WERAM-Asf-0024 CADAFLAP00010064 Aspergillus flavus 49 4e-58 222
WERAM-Ocp-0048 ENSOPRP00000004238.2 Ochotona princeps 52 7e-58 221
WERAM-Lem-0007 CBY02082 Leptosphaeria maculans 50 8e-58 221
WERAM-Asfu-0013 CADAFUAP00003392 Aspergillus fumigatus 52 9e-58 221
WERAM-Scp-0042 SPCC132.02.1:pep Schizosaccharomyces pombe 48 1e-57 221
WERAM-Asni-0009 CADANGAP00002892 Aspergillus niger 50 2e-57 220
WERAM-Lab-0008 EDR12994 Laccaria bicolor 47 3e-57 219
WERAM-Gag-0013 GGTG_03219T0 Gaeumannomyces graminis 49 4e-57 219
WERAM-Asc-0030 CADACLAP00006830 Aspergillus clavatus 50 6e-57 218
WERAM-Fuo-0021 FOXG_06023P0 Fusarium oxysporum 49 6e-57 218
WERAM-Ast-0036 CADATEAP00009630 Aspergillus terreus 49 7e-57 218
WERAM-Miv-0009 MVLG_01362T0 Microbotryum violaceum 46 2e-56 216
WERAM-Coi-0005 EAS35645 Coccidioides immitis 48 2e-56 216
WERAM-Usm-0036 UM05892P0 Ustilago maydis 52 5e-56 215
WERAM-Cag-0026 CAG62123 Candida glabrata 43 4e-55 212
WERAM-Scs-0014 EDN99996 Sclerotinia sclerotiorum 48 7e-55 211
WERAM-Asg-0028 AAS54472 Ashbya gossypii 44 1e-54 210
WERAM-Caa-0033 KGT64755 Candida albicans 45 3e-54 209
WERAM-Nec-0006 EFNCRP00000000764 Neurospora crassa 50 4e-54 209
WERAM-Scj-0005 EEB06048 Schizosaccharomyces japonicus 48 4e-54 208
WERAM-Kop-0007 CAY68156 Komagataella pastoris 47 1e-53 207
WERAM-Crn-0031 AAW44797 Cryptococcus neoformans 43 3e-53 206
WERAM-Spr-0042 CBQ70931 Sporisorium reilianum 52 7e-53 204
WERAM-Sac-0046 YPL015C Saccharomyces cerevisiae 39 8e-52 201
WERAM-Dio-0012 ENSDORP00000001437.1 Dipodomys ordii 46 1e-50 197
WERAM-Pug-0030 EFP89251 Puccinia graminis 47 2e-50 196
WERAM-Kll-0027 CAG98291 Kluyveromyces lactis 41 5e-49 192
WERAM-Mel-0010 EGG12163 Melampsora laricipopulina 49 7e-48 188
WERAM-Mae-0115 ENSMEUP00000010974.1 Macropus eugenii 55 1e-47 187
WERAM-Chg-0025 EAQ89546 Chaetomium globosum 45 1e-47 187
WERAM-Ved-0011 EGY21147 Verticillium dahliae 45 4e-47 186
WERAM-Cae-0022 R11A8.4a Caenorhabditis elegans 44 5e-43 172
WERAM-Ect-0047 ENSETEP00000005080.1 Echinops telfairi 39 1e-42 171
WERAM-Osl-0012 ABO98065 Ostreococcus lucimarinus 51 1e-42 171
WERAM-Cym-0017 CML119CT Cyanidioschyzon merolae 42 8e-37 151
WERAM-Vip-0121 ENSVPAP00000010985.1 Vicugna pacos 42 7e-35 145
WERAM-Yal-0031 CAG78100 Yarrowia lipolytica 40 2e-31 133
Created Date 25-Jun-2016