WERAM Information

Tag Content
WERAM ID WERAM-Hos-0177
Ensembl Protein ID ENSP00000296682.3
Uniprot Accession Q9NQV7; PRDM9_HUMAN; B4DX22; Q27Q50
Genbank Protein ID NP_001297143.1; NP_064612.2
Protein Name Histone-lysine N-methyltransferase PRDM9
Genbank Nucleotide ID NM_001310214.1; NM_020227.3
Gene Name PRDM9;PFM6;MSBP3;ZNF899;MEISETZ
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164256.10 ENST00000296682.3 ENSP00000296682.3
ENSG00000164256.10 ENST00000635252.1 ENSP00000489227.1
Details
Type Family Domain Substrates AA References (PMIDs)
HMT RIZ SET H3K4 K 25537518; 20951770
Status Reviewed
Classification
Type Family E-value Score Start End
HMT RIZ 1.10e-42 147.2 246 358
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View)		 Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).
Domain Profile
  HMT RIZ
            RIZ.txt   3 velaessipkeglgvya.kkkiekgekfGPfvGekkileeveenanekliweisedkgevkyivDasdeeksnWlryvnvArskeeqNLaal 93 
                        +++ +s ip++glgv++ +++++ g +fGP++G++   +e+ee+an++++w+i++ +++++y vD++d++++nW+ryvn+Ar++eeqNL+a+
  ENSP00000296682.3 246 LRIGPSGIPQAGLGVWNeASDLPLGLHFGPYEGRI---TEDEEAANNGYSWLITKGRNCYEY-VDGKDKSWANWMRYVNCARDDEEQNLVAF 333
                        68999************999**************9...9999********************.***************************** PP
            RIZ.txt  94 qineqifYktikdIepdeELLvwyk 118
                        q+++qifY+t++ I+p++ELLvwy+
  ENSP00000296682.3 334 QYHRQIFYRTCRVIRPGCELLVWYG 358
                        ************************6 PP
Protein Sequence
(Fasta)		MSPEKSQEES PEEDTERTER KPMVKDAFKD ISIYFTKEEW AEMGDWEKTR YRNVKRNYNA 60
LITIGLRATR PAFMCHRRQA IKLQVDDTED SDEEWTPRQQ VKPPWMALRV EQRKHQKGMP 120
KASFSNESSL KELSRTANLL NASGSEQAQK PVSPSGEAST SGQHSRLKLE LRKKETERKM 180
YSLRERKGHA YKEVSEPQDD DYLYCEMCQN FFIDSCAAHG PPTFVKDSAV DKGHPNRSAL 240
SLPPGLRIGP SGIPQAGLGV WNEASDLPLG LHFGPYEGRI TEDEEAANNG YSWLITKGRN 300
CYEYVDGKDK SWANWMRYVN CARDDEEQNL VAFQYHRQIF YRTCRVIRPG CELLVWYGDE 360
YGQELGIKWG SKWKKELMAG REPKPEIHPC PSCCLAFSSQ KFLSQHVERN HSSQNFPGPS 420
ARKLLQPENP CPGDQNQEQQ YPDPHSRNDK TKGQEIKERS KLLNKRTWQR EISRAFSSPP 480
KGQMGSCRVG KRIMEEESRT GQKVNPGNTG KLFVGVGISR IAKVKYGECG QGFSVKSDVI 540
THQRTHTGEK LYVCRECGRG FSWKSHLLIH QRIHTGEKPY VCRECGRGFS WQSVLLTHQR 600
THTGEKPYVC RECGRGFSRQ SVLLTHQRRH TGEKPYVCRE CGRGFSRQSV LLTHQRRHTG 660
EKPYVCRECG RGFSWQSVLL THQRTHTGEK PYVCRECGRG FSWQSVLLTH QRTHTGEKPY 720
VCRECGRGFS NKSHLLRHQR THTGEKPYVC RECGRGFRDK SHLLRHQRTH TGEKPYVCRE 780
CGRGFRDKSN LLSHQRTHTG EKPYVCRECG RGFSNKSHLL RHQRTHTGEK PYVCRECGRG 840
FRNKSHLLRH QRTHTGEKPY VCRECGRGFS DRSSLCYHQR THTGEKPYVC REDE 894
Nucleotide Sequence
(Fasta)		CTCTGAGAGA ACGCCCGGCC AGGGTGAACG CCGCGGCAGG AGAGCACGGG AGATTGTGAA 60
GAGCATGGGG AGCCTTTGTC GTGCAGCGTG AAACCCTTGA GCCTTTGGCC TAGGAGCTGG 120
GAGACTCAGG GCCCTTCTCA CACTCAGAAT TGGAGCAGGG CCTTCTAGAC AGTCCCAGCA 180
CCATGAGCCC TGAAAAGTCC CAAGAGGAGA GCCCAGAAGA AGACACAGAG AGAACAGAGC 240
GGAAGCCCAT GGTCAAAGAT GCCTTCAAAG ACATTTCCAT ATACTTCACC AAGGAAGAAT 300
GGGCAGAGAT GGGAGACTGG GAGAAAACTC GCTATAGGAA TGTGAAAAGG AACTATAATG 360
CACTGATTAC TATAGGTCTC AGAGCCACTC GACCAGCTTT CATGTGTCAC CGAAGGCAGG 420
CCATCAAACT CCAGGTGGAT GACACAGAAG ATTCTGATGA AGAATGGACC CCTAGGCAGC 480
AAGTCAAACC TCCTTGGATG GCCTTAAGAG TGGAACAGCG TAAACACCAG AAGGGAATGC 540
CCAAGGCGTC ATTCAGTAAT GAATCTAGTT TGAAAGAATT GTCAAGAACA GCAAATTTAC 600
TGAATGCAAG TGGCTCAGAG CAGGCTCAGA AACCAGTGTC CCCTTCTGGA GAAGCAAGTA 660
CCTCTGGACA GCACTCAAGA CTAAAACTGG AACTCAGGAA GAAGGAGACT GAAAGAAAGA 720
TGTATAGCCT GCGAGAAAGA AAGGGTCATG CATACAAAGA GGTCAGCGAG CCGCAGGATG 780
ATGATTACCT CTATTGTGAG ATGTGTCAGA ACTTCTTCAT TGACAGCTGT GCTGCCCATG 840
GGCCCCCTAC ATTTGTAAAG GACAGTGCAG TGGACAAGGG GCACCCCAAC CGTTCAGCCC 900
TCAGTCTGCC CCCAGGGCTG AGAATTGGGC CATCAGGCAT CCCTCAGGCT GGGCTTGGAG 960
TATGGAATGA GGCATCTGAT CTGCCGCTGG GTCTGCACTT TGGCCCTTAT GAGGGCCGAA 1020
TTACAGAAGA CGAAGAGGCA GCCAACAATG GATACTCCTG GCTGATCACC AAGGGGAGAA 1080
ACTGCTATGA GTATGTGGAT GGAAAAGATA AATCCTGGGC CAACTGGATG AGGTATGTGA 1140
ACTGTGCCCG GGATGATGAA GAGCAGAACC TGGTGGCCTT CCAGTACCAC AGGCAGATCT 1200
TCTATAGAAC CTGCCGAGTC ATTAGGCCAG GCTGTGAACT GCTGGTCTGG TATGGGGATG 1260
AATACGGCCA GGAACTGGGC ATCAAGTGGG GCAGCAAGTG GAAGAAAGAG CTCATGGCAG 1320
GGAGAGAACC AAAGCCAGAG ATCCATCCAT GTCCCTCATG CTGTCTGGCC TTTTCAAGTC 1380
AGAAATTTCT CAGTCAACAT GTAGAACGCA ATCACTCCTC TCAGAACTTC CCAGGACCAT 1440
CTGCAAGAAA ACTCCTCCAA CCAGAGAATC CCTGCCCAGG GGATCAGAAT CAGGAGCAGC 1500
AATATCCAGA TCCACACAGC CGTAATGACA AAACCAAAGG TCAAGAGATC AAAGAAAGGT 1560
CCAAACTCTT GAATAAAAGG ACATGGCAGA GGGAGATTTC AAGGGCCTTT TCTAGCCCAC 1620
CCAAAGGACA AATGGGGAGC TGTAGAGTGG GAAAAAGAAT AATGGAAGAA GAGTCCAGAA 1680
CAGGCCAGAA AGTGAATCCA GGGAACACAG GCAAATTATT TGTGGGGGTA GGAATCTCAA 1740
GAATTGCAAA AGTCAAGTAT GGAGAGTGTG GACAAGGTTT CAGTGTTAAA TCAGATGTTA 1800
TTACACACCA AAGGACACAT ACAGGGGAGA AGCTCTACGT CTGCAGGGAG TGTGGGCGGG 1860
GCTTTAGCTG GAAGTCACAC CTCCTCATTC ACCAGAGGAT ACACACAGGG GAGAAGCCCT 1920
ATGTCTGCAG GGAGTGTGGG CGGGGCTTTA GCTGGCAGTC AGTCCTCCTC ACTCACCAGA 1980
GGACACACAC AGGGGAGAAG CCCTATGTCT GCAGGGAGTG TGGGCGGGGC TTTAGCCGGC 2040
AGTCAGTCCT CCTCACTCAC CAGAGGAGAC ACACAGGGGA GAAGCCCTAT GTCTGCAGGG 2100
AGTGTGGGCG GGGCTTTAGC CGGCAGTCAG TCCTCCTCAC TCACCAGAGG AGACACACAG 2160
GGGAGAAGCC CTATGTCTGC AGGGAGTGTG GGCGGGGCTT TAGCTGGCAG TCAGTCCTCC 2220
TCACTCACCA GAGGACACAC ACAGGGGAGA AGCCCTATGT CTGCAGGGAG TGTGGGCGGG 2280
GCTTTAGCTG GCAGTCAGTC CTCCTCACTC ACCAGAGGAC ACACACAGGG GAGAAGCCCT 2340
ATGTCTGCAG GGAGTGTGGG CGGGGCTTTA GCAATAAGTC ACACCTCCTC AGACACCAGA 2400
GGACACACAC AGGGGAGAAG CCCTATGTCT GCAGGGAGTG TGGGCGGGGC TTTCGCGATA 2460
AGTCACACCT CCTCAGACAC CAGAGGACAC ACACAGGGGA GAAGCCCTAT GTCTGCAGGG 2520
AGTGTGGGCG GGGCTTTAGA GATAAGTCAA ACCTCCTCAG TCACCAGAGG ACACACACAG 2580
GGGAGAAGCC CTATGTCTGC AGGGAGTGTG GGCGGGGCTT TAGCAATAAG TCACACCTCC 2640
TCAGACACCA GAGGACACAC ACAGGGGAGA AGCCCTATGT CTGCAGGGAG TGTGGGCGGG 2700
GCTTTCGCAA TAAGTCACAC CTCCTCAGAC ACCAGAGGAC ACACACAGGG GAGAAGCCCT 2760
ACGTCTGCAG GGAGTGTGGG CGGGGCTTTA GCGATAGGTC AAGCCTCTGC TATCACCAGA 2820
GGACACACAC AGGGGAGAAG CCCTACGTCT GCAGGGAGGA TGAGTAAGTC ATTAGTAATA 2880
AAACCTCATC TCAATAGCCA CAAAAAGACA AATGTGGTCA CCACACACTT GCACACCCCA 2940
GCTGTGAGGT GGCTTCAGCG GAAGTCTGCT GACCCCTTAT ATTCCCCGAG AGTATAAAGA 3000
GATCGGAAAT AACTGATTAA ACAAATCCGC CACTTTCATG ACTAGAGATG AGGAAGAACA 3060
AGGGATAGTT CTGTAAGTGT TCGGGGGACA TCAGCATGTG TGGTTCTTTC CCGCACTGAT 3120
CCCCTCCATT TTTTGTTTGT TTTTTTGCCT CCTGTTCTAA TAAATTTTGT CTCCATACAA 3180
ATCTGAACCC CAAGTGTGTA CCTCATTCTT CCCTTATCAC TGAAGGCAAG AAGAGTCCAG 3240
AAGGGCCACA GAGAACTCAT GTGTTCAGCT CAAGACTCCA CAGGAATTCA ACCCCCAGAA 3300
AGACATAAAC TTGGAGTCCG TCTGGTTTAA TTATTGGAGA ATCGATTCCC AAGTCCAGGA 3360
AGAGAAATGT AAGATTCTAG AAAGTCGCAG CAGGAAAGGG AGTTCCCTGG TCTCCTGGGA 3420
AGTGTGGCTT CTTCTCCTAA TGGACACCTC TCCTCTGCTG CCATACTCTC CCTTGGCTCC 3480
CCAGTCTCCT CTCCTGATCT CCTCCAATCT CTGTAGCCCA AGATGTGAAA GCCAGACAAG 3540
AACACGCGTG TGTGTATATA TGTGTTCGGG TGTGGGGGTA TGTGCCCTCC GTGTAGGTAA 3600
CTGTGTGAGT GTGGGGGGTT TCAAGGGTGT GTTAGGAACA ACGCTCAAAA TCCTAAGGAA 3660
ACTGAACACT CGAACGAAGG ATTCTTAGCA A 3692
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
Interpro

IPR001909--KRAB
IPR003655--Krueppel-associated_box-rel
IPR001214--SET_dom
IPR019041--SSXRD_motif
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
PROSITE

PS50806--KRAB_RELATED
PS50280--SET
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF01352--KRAB
PF00856--SET
PF09514--SSXRD
PF00096--zf-C2H2
PF13912--zf-C2H2_6
Gene Ontology

GO:0005694--C:chromosome
GO:0005654--C:nucleoplasm
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:0034968--P:histone lysine methylation
GO:0006311--P:meiotic gene conversion
GO:0010845--P:positive regulation of reciprocal meiotic recombination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Poa-0137 ENSPPYP00000017162.1 Pongo abelii 94 0.0 1507
WERAM-Caj-0109 ENSCJAP00000019231.2 Callithrix jacchus 86 0.0 1493
WERAM-Paa-0092 ENSPANP00000006501.1 Papio anubis 89 0.0 1464
WERAM-Chs-0202 ENSCSAP00000013264.1 Chlorocebus sabaeus 91 0.0 1241
WERAM-Bot-0024 ENSBTAP00000047652.2 Bos taurus 70 0.0 1226
WERAM-Mum-0189 ENSMUSP00000131871.1 Mus musculus 73 0.0 1224
WERAM-Sus-0183 ENSSSCP00000023246.1 Sus scrofa 76 0.0 1149
WERAM-Dan-0153 ENSDNOP00000019431.1 Dasypus novemcinctus 74 0.0 1145
WERAM-Prc-0084 ENSPCAP00000007153.1 Procavia capensis 66 0.0 1107
WERAM-Ran-0144 ENSRNOP00000060531.1 Rattus norvegicus 70 0.0 1102
WERAM-Dio-0007 ENSDORP00000000987.1 Dipodomys ordii 70 0.0 1080
WERAM-Mam-0029 ENSMMUP00000005026.2 Macaca mulatta 87 0.0 1022
WERAM-Otg-0200 ENSOGAP00000015635.1 Otolemur garnettii 67 0.0 968
WERAM-Orc-0183 ENSOCUP00000016681.2 Oryctolagus cuniculus 75 0.0 958
WERAM-Mup-0073 ENSMPUP00000006803.1 Mustela putorius furo 75 0.0 885
WERAM-Mim-0047 ENSMICP00000004601.1 Microcebus murinus 82 0.0 875
WERAM-Soa-0002 ENSSARP00000000218.1 Sorex araneus 74 0.0 817
WERAM-Pes-0005 ENSPSIP00000002371.1 Pelodiscus sinensis 49 0.0 806
WERAM-Pat-0067 ENSPTRP00000014513.3 Pan troglodytes 93 0.0 655
WERAM-Gog-0206 ENSGGOP00000017242.1 Gorilla gorilla 97 0.0 644
WERAM-Myl-0115 ENSMLUP00000009197.2 Myotis lucifugus 72 0.0 631
WERAM-Fec-0044 ENSFCAP00000003508.2 Felis catus 78 0.0 631
WERAM-Aim-0022 ENSAMEP00000001535.1 Ailuropoda melanoleuca 77 2e-179 627
WERAM-Ocp-0132 ENSOPRP00000013913.2 Ochotona princeps 61 2e-179 626
WERAM-Chh-0045 ENSCHOP00000005073.1 Choloepus hoffmanni 75 2e-154 543
WERAM-Eqc-0097 ENSECAP00000011324.1 Equus caballus 89 2e-149 527
WERAM-Ova-0031 ENSOARP00000004225.1 Ovis aries 74 5e-135 479
WERAM-Loa-0175 ENSLAFP00000017573.2 Loxodonta africana 76 1e-129 461
WERAM-Mod-0198 ENSMODP00000031611.2 Monodelphis domestica 64 1e-129 461
WERAM-Ora-0057 ENSOANP00000008625.2 Ornithorhynchus anatinus 41 3e-127 454
WERAM-Tas-0082 ENSTSYP00000008295.1 Tarsius syrichta 57 2e-99 361
WERAM-Lac-0137 ENSLACP00000015755.1 Latimeria chalumnae 60 2e-79 295
WERAM-Tag-0028 ENSTGUP00000001982.1 Taeniopygia guttata 30 1e-73 275
WERAM-Tut-0128 ENSTTRP00000010427.1 Tursiops truncatus 30 2e-72 271
WERAM-Meg-0110 ENSMGAP00000011137.1 Meleagris gallopavo 30 3e-72 271
WERAM-Orn-0032 ENSONIP00000003899.1 Oreochromis niloticus 30 4e-72 270
WERAM-Xim-0168 ENSXMAP00000013864.1 Xiphophorus maculatus 30 7e-72 270
WERAM-Anp-0121 ENSAPLP00000013678.1 Anas platyrhynchos 30 9e-72 269
WERAM-Orla-0174 ENSORLP00000020343.1 Oryzias latipes 30 5e-71 266
WERAM-Leo-0089 ENSLOCP00000011948.1 Lepisosteus oculatus 31 2e-70 264
WERAM-Nol-0097 ENSNLEP00000011114.2 Nomascus leucogenys 30 2e-70 264
WERAM-Tar-0166 ENSTRUP00000035409.1 Takifugu rubripes 30 5e-68 256
WERAM-Dar-0015 ENSDARP00000106969.1 Danio rerio 30 5e-67 253
WERAM-Ptv-0137 ENSPVAP00000011602.1 Pteropus vampyrus 30 2e-66 252
WERAM-Xet-0015 ENSXETP00000004492.3 Xenopus tropicalis 29 6e-64 243
WERAM-Ere-0093 ENSEEUP00000009413.1 Erinaceus europaeus 30 1e-60 232
WERAM-Pem-0083 ENSPMAP00000008984.1 Petromyzon marinus 54 2e-58 225
WERAM-Gaga-0111 ENSGALP00000019484.4 Gallus gallus 28 2e-58 224
WERAM-Vip-0075 ENSVPAP00000006917.1 Vicugna pacos 29 1e-54 212
WERAM-Cap-0142 ENSCPOP00000011596.2 Cavia porcellus 30 7e-52 203
WERAM-Ten-0069 ENSTNIP00000008627.1 Tetraodon nigroviridis 27 2e-42 172
WERAM-Ect-0147 ENSETEP00000016463.1 Echinops telfairi 29 3e-38 157
WERAM-Fia-0094 ENSFALP00000007850.1 Ficedula albicollis 28 2e-32 139
WERAM-Gam-0122 ENSGMOP00000012899.1 Gadus morhua 25 2e-32 139
WERAM-Caf-0212 ENSCAFP00000031903.3 Canis familiaris 28 6e-32 137
WERAM-Sah-0097 ENSSHAP00000011079.1 Sarcophilus harrisii 27 7e-32 137
WERAM-Anc-0027 ENSACAP00000003308.3 Anolis carolinensis 28 2e-30 132
WERAM-Tub-0069 ENSTBEP00000008639.1 Tupaia belangeri 39 5e-28 124
WERAM-Ict-0141 ENSSTOP00000014774.2 Ictidomys tridecemlineatus 39 2e-26 119
WERAM-Mae-0001 ENSMEUP00000000039.1 Macropus eugenii 41 2e-26 118
WERAM-Asm-0040 ENSAMXP00000005078.1 Astyanax mexicanus 38 2e-26 118
WERAM-Pof-0234 ENSPFOP00000019495.1 Poecilia formosa 40 5e-26 117
WERAM-Gaa-0023 ENSGACP00000003553.1 Gasterosteus aculeatus 40 5e-25 114
Created Date 25-Jun-2016