| Tag |
Content |
| WERAM ID |
WERAM-Mum-0189 |
| Ensembl Protein ID |
ENSMUSP00000131871.1 |
| Uniprot Accession |
Q96EQ9; PRDM9_MOUSE; B8JJZ8; Q0D2N4
|
| Genbank Protein ID |
|
| Protein Name |
Histone-lysine N-methyltransferase PRDM9 |
| Genbank Nucleotide ID |
|
| Gene Name |
PRDM9 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HMT |
RIZ |
SET |
H3K4 |
K |
22028627
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HMT |
RIZ |
4.20e-43 |
147.7 |
250 |
362 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase. |
Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase.
|
| Domain Profile |
HMT RIZ
RIZ.txt 3 velaessipkeglgvya.kkkiekgekfGPfvGekkileeveenanekliweisedkgevkyivDasdeeksnWlryvnvArskeeqNL 90
+++++s ip++glgv++ +++++ g +fGP++G++ +e+ee+an++++w+i++ +++++y vD++de+++nW+ryvn+Ar++eeqNL
ENSMUSP00000131871.1 250 LRISPSGIPEAGLGVWNeASDLPVGLHFGPYEGQI---TEDEEAANSGYSWLITKGRNCYEY-VDGQDESQANWMRYVNCARDDEEQNL 334
7899*************99***************9...9999********************.************************** PP
RIZ.txt 91 aalqineqifYktikdIepdeELLvwyk 118
+a+q++++ifY+t++ I+p++ELLvwy+
ENSMUSP00000131871.1 335 VAFQYHRKIFYRTCRVIRPGCELLVWYG 362
***************************6 PP
|
Protein Sequence
(Fasta) | MSCTMNTNKL EENSPEEDTG KFEWKPKVKD EFKDISIYFS KEEWAEMGEW EKIRYRNVKR 60
NYKMLISIGL RAPRPAFMCY QRQAMKPQIN DSEDSDEEWT PKQQVSPPWV PFRVKHSKQQ 120
KESSRMPFSG ESNVKEGSGI ENLLNTSGSE HVQKPVSSLE EGNTSGQHSG KKLKLRKKNV 180
EVKMYRLRER KGLAYEEVSE PQDDDYLYCE KCQNFFIDSC PNHGPPLFVK DSMVDRGHPN 240
HSVLSLPPGL RISPSGIPEA GLGVWNEASD LPVGLHFGPY EGQITEDEEA ANSGYSWLIT 300
KGRNCYEYVD GQDESQANWM RYVNCARDDE EQNLVAFQYH RKIFYRTCRV IRPGCELLVW 360
YGDEYGQELG IKWGSKMKKG FTAGRELRTE IHPCLLCSLA FSSQKFLTQH MEWNHRTEIF 420
PGTSARINPK PGDPCSDQLQ EQHVDSQNKN DKASNEVKRK SKPRQRISTT FPSTLKEQMR 480
SEESKRTVEE LRTGQTTNTE DTVKSFIASE ISSIERQCGQ YFSDKSNVNE HQKTHTGEKP 540
YVCRECGRGF TQNSHLIQHQ RTHTGEKPYV CRECGRGFTQ KSDLIKHQRT HTGEKPYVCR 600
ECGRGFTQKS DLIKHQRTHT GEKPYVCREC GRGFTQKSVL IKHQRTHTGE KPYVCRECGR 660
GFTQKSVLIK HQRTHTGEKP YVCRECGRGF TAKSVLIQHQ RTHTGEKPYV CRECGRGFTA 720
KSNLIQHQRT HTGEKPYVCR ECGRGFTAKS VLIQHQRTHT GEKPYVCREC GRGFTAKSVL 780
IQHQRTHTGE KPYVCRECGR GFTQKSNLIK HQRTHTGEKP YVCRECGWGF TQKSDLIQHQ 840
RTHTREK 847Protein Fasta Sequence
>ENSMUSP00000131871.1|PRDM9|Mus musculus
MSCTMNTNKLEENSPEEDTGKFEWKPKVKDEFKDISIYFSKEEWAEMGEWEKIRYRNVKRNYKMLISIGLRAPRPAFMCYQRQAMKPQINDSEDSDEEWTPKQQVSPPWVPFRVKHSKQQKESSRMPFSGESNVKEGSGIENLLNTSGSEHVQKPVSSLEEGNTSGQHSGKKLKLRKKNVEVKMYRLRERKGLAYEEVSEPQDDDYLYCEKCQNFFIDSCPNHGPPLFVKDSMVDRGHPNHSVLSLPPGLRISPSGIPEAGLGVWNEASDLPVGLHFGPYEGQITEDEEAANSGYSWLITKGRNCYEYVDGQDESQANWMRYVNCARDDEEQNLVAFQYHRKIFYRTCRVIRPGCELLVWYGDEYGQELGIKWGSKMKKGFTAGRELRTEIHPCLLCSLAFSSQKFLTQHMEWNHRTEIFPGTSARINPKPGDPCSDQLQEQHVDSQNKNDKASNEVKRKSKPRQRISTTFPSTLKEQMRSEESKRTVEELRTGQTTNTEDTVKSFIASEISSIERQCGQYFSDKSNVNEHQKTHTGEKPYVCRECGRGFTQNSHLIQHQRTHTGEKPYVCRECGRGFTQKSDLIKHQRTHTGEKPYVCRECGRGFTQKSDLIKHQRTHTGEKPYVCRECGRGFTQKSVLIKHQRTHTGEKPYVCRECGRGFTQKSVLIKHQRTHTGEKPYVCRECGRGFTAKSVLIQHQRTHTGEKPYVCRECGRGFTAKSNLIQHQRTHTGEKPYVCRECGRGFTAKSVLIQHQRTHTGEKPYVCRECGRGFTAKSVLIQHQRTHTGEKPYVCRECGRGFTQKSNLIKHQRTHTGEKPYVCRECGWGFTQKSDLIQHQRTHTREK |
Nucleotide Sequence
(Fasta) | GACCCTGGAC CTCTCCAGTG AAATGTCCTG CACCATGAAC ACCAACAAGC TGGAAGAAAA 60
TAGTCCTGAA GAAGATACAG GGAAATTCGA GTGGAAACCC AAGGTCAAAG ATGAATTCAA 120
AGACATTTCC ATATACTTCT CCAAAGAAGA ATGGGCAGAG ATGGGAGAGT GGGAGAAAAT 180
TCGCTATAGA AATGTGAAAA GGAACTATAA AATGCTGATT TCAATAGGTC TCAGAGCCCC 240
TAGACCAGCT TTCATGTGTT ACCAAAGGCA AGCAATGAAA CCCCAAATAA ATGACAGTGA 300
GGATTCTGAT GAAGAGTGGA CACCTAAGCA ACAAGTCAGT CCTCCTTGGG TGCCTTTCCG 360
GGTGAAGCAC AGTAAACAGC AGAAGGAATC ATCTAGAATG CCATTTAGTG GTGAATCTAA 420
TGTGAAGGAA GGGTCTGGAA TAGAAAATTT GCTGAATACA AGTGGCTCAG AACACGTCCA 480
GAAACCAGTG TCCTCCCTTG AAGAAGGAAA TACCTCTGGA CAGCACTCTG GGAAAAAACT 540
GAAACTTAGG AAAAAGAACG TTGAAGTGAA AATGTACAGG CTGCGAGAGA GAAAGGGCCT 600
TGCCTATGAG GAGGTCAGCG AGCCTCAGGA TGATGACTAT CTCTATTGTG AGAAGTGCCA 660
GAATTTCTTC ATCGACAGTT GTCCCAACCA TGGGCCTCCT TTATTTGTAA AAGACAGTAT 720
GGTGGACAGG GGGCATCCCA ACCACTCAGT CCTCAGTCTG CCCCCTGGGC TAAGAATTAG 780
TCCATCGGGC ATCCCTGAAG CTGGACTTGG AGTATGGAAT GAAGCATCTG ATCTACCAGT 840
CGGTCTGCAC TTTGGCCCCT ATGAGGGTCA GATCACAGAG GATGAAGAGG CAGCCAACAG 900
TGGTTACTCC TGGCTGATTA CCAAGGGAAG AAACTGCTAT GAGTATGTGG ATGGACAGGA 960
CGAGTCCCAA GCCAACTGGA TGAGGTATGT GAACTGTGCC CGGGATGATG AAGAGCAGAA 1020
CCTGGTAGCC TTTCAATATC ACAGGAAAAT CTTCTATCGA ACCTGCCGGG TTATCAGACC 1080
AGGTTGTGAG CTTCTGGTCT GGTATGGGGA TGAGTACGGC CAGGAACTGG GCATTAAGTG 1140
GGGAAGCAAG ATGAAGAAAG GATTCACAGC AGGAAGAGAA CTAAGGACAG AAATTCATCC 1200
TTGTCTTTTG TGCTCTTTGG CCTTCTCAAG TCAGAAATTC CTCACTCAAC ATATGGAATG 1260
GAATCATCGC ACTGAAATCT TCCCAGGAAC ATCTGCAAGA ATAAATCCTA AACCAGGAGA 1320
TCCCTGTTCA GATCAGCTTC AGGAACAACA TGTTGATTCA CAGAACAAAA ATGACAAGGC 1380
CAGCAATGAA GTAAAAAGAA AATCCAAACC CAGGCAGAGG ATTTCAACAA CCTTTCCCAG 1440
CACACTCAAA GAACAAATGA GATCTGAGGA AAGTAAGAGA ACTGTGGAAG AGCTCAGAAC 1500
AGGCCAGACA ACAAATACAG AGGACACAGT CAAATCATTT ATTGCATCAG AAATCTCAAG 1560
TATTGAAAGA CAATGTGGGC AATATTTCAG TGATAAGTCA AATGTCAATG AGCACCAGAA 1620
GACACACACA GGGGAGAAGC CCTATGTTTG CAGGGAGTGT GGGCGGGGCT TTACACAGAA 1680
CTCACACCTC ATCCAGCACC AGAGGACACA CACAGGGGAG AAGCCCTATG TTTGCAGGGA 1740
GTGTGGGCGG GGCTTTACAC AGAAGTCAGA CCTCATCAAG CACCAGAGGA CACACACAGG 1800
GGAGAAGCCC TATGTTTGCA GGGAGTGTGG GCGGGGCTTT ACACAGAAGT CAGACCTCAT 1860
CAAGCACCAG AGGACACACA CAGGGGAGAA GCCCTATGTT TGCAGGGAGT GTGGGCGGGG 1920
CTTTACACAG AAGTCAGTCC TCATCAAGCA CCAGAGGACA CACACAGGGG AGAAGCCCTA 1980
TGTTTGCAGG GAGTGTGGGC GGGGCTTTAC ACAGAAGTCA GTCCTCATCA AGCACCAGAG 2040
GACACACACA GGGGAGAAGC CCTATGTTTG CAGGGAGTGT GGGCGGGGCT TTACAGCGAA 2100
GTCAGTCCTC ATCCAGCACC AGAGGACACA CACAGGGGAG AAGCCCTATG TTTGCAGGGA 2160
GTGTGGGCGG GGCTTTACAG CGAAGTCAAA CCTCATCCAG CACCAGAGGA CACACACAGG 2220
GGAGAAGCCC TATGTTTGCA GGGAGTGTGG GCGGGGCTTT ACAGCGAAGT CAGTCCTCAT 2280
CCAGCACCAG AGGACACACA CAGGGGAGAA GCCCTATGTT TGCAGGGAGT GTGGGCGGGG 2340
CTTTACAGCG AAGTCAGTCC TCATCCAGCA CCAGAGGACA CACACAGGGG AGAAGCCCTA 2400
TGTTTGCAGG GAGTGTGGGC GGGGCTTTAC ACAGAAGTCA AACCTCATCA AGCACCAGAG 2460
GACACACACA GGGGAGAAGC CCTATGTTTG CAGGGAGTGT GGGTGGGGCT TTACACAGAA 2520
GTCAGACCTC ATCCAGCACC AGAGGACACA TACAAGAGAG AAGTAATATA TTTTCGAAAA 2580
GAATGAGAAA GCCAACAGCA ATAAAACCAC ATCTCAACAA TTACAGGAAG ACAAATGTAG 2640
TCACTAAACA TCTGTTCTGC TAAAACTTCT AAGGAGTCTA CTGATTTTTA AAACTAGAAT 2700
ATAAAATGAC TAGAAAAGGG AATTAAATCC CCTTCTTTTT CTTTTCTTTT TCGGTTTTTA 2760
AAGACAGATT TCTCTGTGCA GTCTGGTTGT CCTAGAACTG TTTCTGTAGA CCAGGTTGGC 2820
CTCAAAATCA GAGTTGCTAG CTTCTGCCTC CCCAATACTA GGAGTAAAGC CCCATTGCAA 2880
ATTCTCATTT TCTTTCTTTT CTTTCTTTTC TTTCTTTTTT TTTTTTTTTT TTTTTGGTTT 2940
TTCGAGACAG GGTTTCTCTG TATAGCCCTG GCTGTCCTGG AACTCACGCT ATAGACCAGG 3000
CTGGCCTCGA ACTCTGAAAT CTGCCTGCCT CTGCCTCCCG AGTGCTGGGA TTAAAGGCAC 3060
CTGGCTACAA ATTCTCATTT TCAAGTGAGA TAAGTTAGAA AGAAAAACAA ACGAACAACC 3120
CCTCCTCAAA AACAAAACAA ACAAAAACAA ACTGTTAGGA GCGACCCTGT TTGAATGTTA 3180
GCTGCCTTGT CAGCCATAAG TGCTTACTTA CAAAGTCTTG GCCTTAGTGG AAAAGTATTA 3240
GCTTAGTTGA GATTTCTGTG GGAAAAAGTT GAGGCCTCTG TGGGAAAGTA CTACATAGAG 3300
TTCTGTTCCT CCTGCTGAAC TTTTTACCTA GCCAATATCC TGCTTTGGGG AACATGTACG 3360
TTCCCCCAGA AACAAAGCGA TTCTGCGTCA TCCCCCTACC CATACTCTGC TTCTGTGGGC 3420
ATAAAACCTG CCTGGGAATA ATAAAAATGT GACAGCTTGA
3461Nucleotide Fasta Sequence
>ENSMUSP00000131871.1|RIZ|Mus musculus
GACCCTGGACCTCTCCAGTGAAATGTCCTGCACCATGAACACCAACAAGCTGGAAGAAAATAGTCCTGAAGAAGATACAGGGAAATTCGAGTGGAAACCCAAGGTCAAAGATGAATTCAAAGACATTTCCATATACTTCTCCAAAGAAGAATGGGCAGAGATGGGAGAGTGGGAGAAAATTCGCTATAGAAATGTGAAAAGGAACTATAAAATGCTGATTTCAATAGGTCTCAGAGCCCCTAGACCAGCTTTCATGTGTTACCAAAGGCAAGCAATGAAACCCCAAATAAATGACAGTGAGGATTCTGATGAAGAGTGGACACCTAAGCAACAAGTCAGTCCTCCTTGGGTGCCTTTCCGGGTGAAGCACAGTAAACAGCAGAAGGAATCATCTAGAATGCCATTTAGTGGTGAATCTAATGTGAAGGAAGGGTCTGGAATAGAAAATTTGCTGAATACAAGTGGCTCAGAACACGTCCAGAAACCAGTGTCCTCCCTTGAAGAAGGAAATACCTCTGGACAGCACTCTGGGAAAAAACTGAAACTTAGGAAAAAGAACGTTGAAGTGAAAATGTACAGGCTGCGAGAGAGAAAGGGCCTTGCCTATGAGGAGGTCAGCGAGCCTCAGGATGATGACTATCTCTATTGTGAGAAGTGCCAGAATTTCTTCATCGACAGTTGTCCCAACCATGGGCCTCCTTTATTTGTAAAAGACAGTATGGTGGACAGGGGGCATCCCAACCACTCAGTCCTCAGTCTGCCCCCTGGGCTAAGAATTAGTCCATCGGGCATCCCTGAAGCTGGACTTGGAGTATGGAATGAAGCATCTGATCTACCAGTCGGTCTGCACTTTGGCCCCTATGAGGGTCAGATCACAGAGGATGAAGAGGCAGCCAACAGTGGTTACTCCTGGCTGATTACCAAGGGAAGAAACTGCTATGAGTATGTGGATGGACAGGACGAGTCCCAAGCCAACTGGATGAGGTATGTGAACTGTGCCCGGGATGATGAAGAGCAGAACCTGGTAGCCTTTCAATATCACAGGAAAATCTTCTATCGAACCTGCCGGGTTATCAGACCAGGTTGTGAGCTTCTGGTCTGGTATGGGGATGAGTACGGCCAGGAACTGGGCATTAAGTGGGGAAGCAAGATGAAGAAAGGATTCACAGCAGGAAGAGAACTAAGGACAGAAATTCATCCTTGTCTTTTGTGCTCTTTGGCCTTCTCAAGTCAGAAATTCCTCACTCAACATATGGAATGGAATCATCGCACTGAAATCTTCCCAGGAACATCTGCAAGAATAAATCCTAAACCAGGAGATCCCTGTTCAGATCAGCTTCAGGAACAACATGTTGATTCACAGAACAAAAATGACAAGGCCAGCAATGAAGTAAAAAGAAAATCCAAACCCAGGCAGAGGATTTCAACAACCTTTCCCAGCACACTCAAAGAACAAATGAGATCTGAGGAAAGTAAGAGAACTGTGGAAGAGCTCAGAACAGGCCAGACAACAAATACAGAGGACACAGTCAAATCATTTATTGCATCAGAAATCTCAAGTATTGAAAGACAATGTGGGCAATATTTCAGTGATAAGTCAAATGTCAATGAGCACCAGAAGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGCGGGGCTTTACACAGAACTCACACCTCATCCAGCACCAGAGGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGCGGGGCTTTACACAGAAGTCAGACCTCATCAAGCACCAGAGGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGCGGGGCTTTACACAGAAGTCAGACCTCATCAAGCACCAGAGGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGCGGGGCTTTACACAGAAGTCAGTCCTCATCAAGCACCAGAGGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGCGGGGCTTTACACAGAAGTCAGTCCTCATCAAGCACCAGAGGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGCGGGGCTTTACAGCGAAGTCAGTCCTCATCCAGCACCAGAGGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGCGGGGCTTTACAGCGAAGTCAAACCTCATCCAGCACCAGAGGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGCGGGGCTTTACAGCGAAGTCAGTCCTCATCCAGCACCAGAGGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGCGGGGCTTTACAGCGAAGTCAGTCCTCATCCAGCACCAGAGGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGCGGGGCTTTACACAGAAGTCAAACCTCATCAAGCACCAGAGGACACACACAGGGGAGAAGCCCTATGTTTGCAGGGAGTGTGGGTGGGGCTTTACACAGAAGTCAGACCTCATCCAGCACCAGAGGACACATACAAGAGAGAAGTAATATATTTTCGAAAAGAATGAGAAAGCCAACAGCAATAAAACCACATCTCAACAATTACAGGAAGACAAATGTAGTCACTAAACATCTGTTCTGCTAAAACTTCTAAGGAGTCTACTGATTTTTAAAACTAGAATATAAAATGACTAGAAAAGGGAATTAAATCCCCTTCTTTTTCTTTTCTTTTTCGGTTTTTAAAGACAGATTTCTCTGTGCAGTCTGGTTGTCCTAGAACTGTTTCTGTAGACCAGGTTGGCCTCAAAATCAGAGTTGCTAGCTTCTGCCTCCCCAATACTAGGAGTAAAGCCCCATTGCAAATTCTCATTTTCTTTCTTTTCTTTCTTTTCTTTCTTTTTTTTTTTTTTTTTTTTTGGTTTTTCGAGACAGGGTTTCTCTGTATAGCCCTGGCTGTCCTGGAACTCACGCTATAGACCAGGCTGGCCTCGAACTCTGAAATCTGCCTGCCTCTGCCTCCCGAGTGCTGGGATTAAAGGCACCTGGCTACAAATTCTCATTTTCAAGTGAGATAAGTTAGAAAGAAAAACAAACGAACAACCCCTCCTCAAAAACAAAACAAACAAAAACAAACTGTTAGGAGCGACCCTGTTTGAATGTTAGCTGCCTTGTCAGCCATAAGTGCTTACTTACAAAGTCTTGGCCTTAGTGGAAAAGTATTAGCTTAGTTGAGATTTCTGTGGGAAAAAGTTGAGGCCTCTGTGGGAAAGTACTACATAGAGTTCTGTTCCTCCTGCTGAACTTTTTACCTAGCCAATATCCTGCTTTGGGGAACATGTACGTTCCCCCAGAAACAAAGCGATTCTGCGTCATCCCCCTACCCATACTCTGCTTCTGTGGGCATAAAACCTGCCTGGGAATAATAAAAATGTGACAGCTTGA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
--
|
| Interpro |
IPR001909--KRAB
IPR003655--Krueppel-associated_box-rel
IPR001214--SET_dom
IPR019041--SSXRD_motif
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
|
| PROSITE |
PS50806--KRAB_RELATED
PS50280--SET
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
|
| Pfam |
PF01352--KRAB
PF00856--SET
PF09514--SSXRD
PF00096--zf-C2H2
|
| Gene Ontology |
GO:0005694--C:chromosome
GO:0005654--C:nucleoplasm
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0046872--F:metal ion binding
GO:0010844--F:recombination hotspot binding
GO:0043565--F:sequence-specific DNA binding
GO:0051568--P:histone H3-K4 methylation
GO:0034968--P:histone lysine methylation
GO:0016571--P:histone methylation
GO:0006311--P:meiotic gene conversion
GO:0060903--P:positive regulation of meiosis I
GO:0010845--P:positive regulation of reciprocal meiotic recombination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
