Tag |
Content |
WERAM ID |
WERAM-Mum-0192 |
Ensembl Protein ID |
ENSMUSP00000128789.1 |
Uniprot Accession |
Q6PCM1; KDM3A_MOUSE; Q2MJQ6; Q3TKW8; Q3UML3; Q6ZQ57; Q8K2J6; Q8K2K4; Q8R350 |
Genbank Protein ID |
NP_001033784.2; NP_766589.1; XP_006505327.1; XP_011239411.1 |
Protein Name |
Lysine-specific demethylase 3A |
Genbank Nucleotide ID |
NM_001038695.3; NM_173001.3; XM_006505264.2; XM_011241109.1 |
Gene Name |
KDM3A;JMJD1A/JHDM2A |
Ensembl Information |
|
Details |
Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
HDM |
JHDM2 |
Jmjc |
H3K9me1/2 |
K |
24362521 |
|
Status |
Reviewed |
Classification |
Type |
Family |
E-value |
Score |
Start |
End |
HDM |
JHDM2 |
8.70e-108 |
360.3 |
1075 |
1283 |
|
Organism |
Mus musculus |
NCBI Taxa ID |
10090 |
Functional Description (View)Functional Description
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation (By similarity). Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. |
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation (By similarity). Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
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Domain Profile |
HDM JHDM2
JHDM2.txt 1 eYckrdgklNLasklpknfvrpdlgPklynAyGlateedrklgttnlhldvsdavnilvyvgilkkkwaeedlkellksieeeelde 87 eY++rdgklNLas+lp++fvrpdlgPk+ynAyGl+t edrk+gttnlhldvsda+n++vyvgi+k+++++e+ e+l++i+++++de ENSMUSP00000128789.1 1075 EYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEE--EVLRTIQDGDSDE 1159 7***********************************************************************..************* PP JHDM2.txt 88 vtrkrvqdpkekpgalWhifaakdaekirellekvskeqgaevppdhdpihdqswyldrklrkrLfeeyGvegwtlvQklgdavlip 174 +t+kr+ ++kekpgalWhi+aakd+ekire+l+kvs+eqg+++p+dhdpihdqswyldr+lrkrL++eyGv+gw++vQ+lgd+v+ip ENSMUSP00000128789.1 1160 LTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQDNPADHDPIHDQSWYLDRSLRKRLYQEYGVQGWAIVQFLGDVVFIP 1246 *************************************************************************************** PP JHDM2.txt 175 agapHqvqnlkscvkvaedFvsPEnvkecfrltkeyr 211 agapHqv+nl+sc+kvaedFvsPE+vk+cf+lt+e+r ENSMUSP00000128789.1 1247 AGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFR 1283 ***********************************98 PP
|
Protein Sequence (Fasta) | MVLTLGESWP VLVGKRFLSL SAAEGNEGGQ DNWDLERVAE WPWLSGTIRA VSHTDVTKKD 60 LKVCVEFDGE SWRKRRWIDV YSLQRKAFLV EHNLVLAERK SPEVPEQVIQ WPAIMYKSLL 120 DKAGLGAITS VRFLGDQQSV FVSKDLLKPI QDVNSLRLSL TDNQTVSKEF QALIVKHLDE 180 SHLLQGDKNL VGSEVKIYSL DPSTQWFSAT VVHGNPSSKT LQVNCEEIPA LKIVDPALIH 240 VEVVHDNFVT CGNSTRTGAV KRKSSENNGS SVSKQAKSCS EASPSMCPVQ SVPTTVFKEI 300 LLGCTAATPS SKDPRQQNTP QAANSPPNIG AKLPQGCHKQ NLPEELSSCL NTKPEVPRTK 360 PDVCKEGLLS SKSSQVGAGD LKILSEPKGS CIQPKTNTDQ ESRLESAPQP VTGLPKECLP 420 AKTSSKAELD IATTPELQKH LEHAASTSDD LSDKPEVKAG VTSLNSCAEK KVEPSHLGSQ 480 SQNLKETSVK VDNESCCTRS SNKTQTPPAR KSVLTDPDKV RKLQQSGEAF VQDDSCVNIV 540 AQLPKCRECR LDSLRKDKDQ QKDSPVFCRF FHFRRLQFNK HGVLRVEGFL TPNKYDSEAI 600 GLWLPLTKNV VGTDLDTAKY ILANIGDHFC QMVISEKEAM STIEPHRQVA WKRAVKGVRE 660 MCDVCDTTIF NLHWVCPRCG FGVCVDCYRM KRKNCQQGAA YKTFSWIRCV KSQIHEPENL 720 MPTQIIPGKA LYDVGDIVHS VRAKWGIKAN CPCSNRQFKL FSKPALKEDL KQTSLSGEKP 780 TLGTMVQQSS PVLEPVAVCG EAASKPASSV KPTCPTSTSP LNWLADLTSG NVNKENKEKQ 840 LTMPILKNEI KCLPPLPPLN KPSTVLHTFN STILTPVSNN NSGFLRNLLN SSTAKTENGL 900 KNTPKILDDI FASLVQNKTS SDSSKRPQGL TIKPSILGFD TPHYWLCDNR LLCLQDPNNK 960 SNWNVFRECW KQGQPVMVSG VHHKLNTELW KPESFRKEFG EQEVDLVNCR TNEIITGATV 1020 GDFWDGFEDV PNRLKNDKEK EPMVLKLKDW PPGEDFRDMM PSRFDDLMAN IPLPEYTRRD 1080 GKLNLASRLP NYFVRPDLGP KMYNAYGLIT PEDRKYGTTN LHLDVSDAAN VMVYVGIPKG 1140 QCEQEEEVLR TIQDGDSDEL TIKRFIEGKE KPGALWHIYA AKDTEKIREF LKKVSEEQGQ 1200 DNPADHDPIH DQSWYLDRSL RKRLYQEYGV QGWAIVQFLG DVVFIPAGAP HQVHNLYSCI 1260 KVAEDFVSPE HVKHCFWLTQ EFRYLSQTHT NHEDKLQVKN VIYHAVKDAV AMLKASESSL 1320 GKP 1323Protein Fasta Sequence
>ENSMUSP00000128789.1|KDM3A;JMJD1A/JHDM2A|Mus musculus MVLTLGESWPVLVGKRFLSLSAAEGNEGGQDNWDLERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIDVYSLQRKAFLVEHNLVLAERKSPEVPEQVIQWPAIMYKSLLDKAGLGAITSVRFLGDQQSVFVSKDLLKPIQDVNSLRLSLTDNQTVSKEFQALIVKHLDESHLLQGDKNLVGSEVKIYSLDPSTQWFSATVVHGNPSSKTLQVNCEEIPALKIVDPALIHVEVVHDNFVTCGNSTRTGAVKRKSSENNGSSVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPSSKDPRQQNTPQAANSPPNIGAKLPQGCHKQNLPEELSSCLNTKPEVPRTKPDVCKEGLLSSKSSQVGAGDLKILSEPKGSCIQPKTNTDQESRLESAPQPVTGLPKECLPAKTSSKAELDIATTPELQKHLEHAASTSDDLSDKPEVKAGVTSLNSCAEKKVEPSHLGSQSQNLKETSVKVDNESCCTRSSNKTQTPPARKSVLTDPDKVRKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKDQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDSEAIGLWLPLTKNVVGTDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWIRCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPALKEDLKQTSLSGEKPTLGTMVQQSSPVLEPVAVCGEAASKPASSVKPTCPTSTSPLNWLADLTSGNVNKENKEKQLTMPILKNEIKCLPPLPPLNKPSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTAKTENGLKNTPKILDDIFASLVQNKTSSDSSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNTELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNDKEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLRTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQDNPADHDPIHDQSWYLDRSLRKRLYQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSLGKP
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Nucleotide Sequence (Fasta) | AAGTGTCGAG TCGCGAGCGA GTCCACGGCG GCTCCGAGGC CGCTCGGGGC GGGGATCGGT 60 CGCTGAGACG GGCCCTAGGC ACTAAGAGGG AGCCTTTTCT TTAACAGGGC GAGGGGACGA 120 ACACTTAGGC AAAAGCACTG GCGCCGCGGC TCAGTCCTCC CTTCTCTCTC TCAGTGTCCA 180 GCTTTGAAAG GGAGGAGCCC TTCCTGCTGG CGTGGAAACC ATGGTGCTCA CGCTCGGAGA 240 AAGTTGGCCA GTATTGGTGG GGAAGCGATT CCTCAGTCTG TCCGCAGCCG AAGGCAACGA 300 AGGCGGCCAG GACAACTGGG ACTTGGAGCG CGTTGCCGAG TGGCCCTGGC TGTCGGGGAC 360 CATTCGAGCT GTTTCCCACA CCGACGTTAC TAAGAAAGAC TTGAAGGTGT GTGTGGAGTT 420 TGATGGGGAG TCTTGGAGAA AGAGAAGATG GATAGATGTC TACAGCCTTC AGAGAAAAGC 480 ATTTTTAGTA GAGCATAACC TGGTTTTGGC AGAACGAAAA TCACCTGAAG TTCCTGAGCA 540 AGTTATTCAG TGGCCTGCAA TAATGTACAA ATCTCTTCTA GACAAAGCTG GCTTGGGAGC 600 CATAACTTCT GTTCGGTTTC TTGGAGATCA ACAAAGTGTA TTTGTTTCCA AAGACCTTTT 660 GAAACCTATA CAGGATGTTA ACAGTCTTCG GCTTTCCCTT ACTGATAATC AGACAGTCAG 720 TAAGGAATTT CAAGCTTTGA TTGTAAAACA TTTGGATGAA AGCCATCTTT TACAAGGTGA 780 CAAGAACCTT GTTGGTTCAG AAGTAAAAAT TTATAGCTTG GACCCATCTA CTCAGTGGTT 840 TTCAGCAACT GTTGTACATG GAAACCCATC ATCCAAAACT CTTCAAGTCA ACTGTGAGGA 900 GATTCCAGCA CTGAAAATTG TCGACCCAGC ACTGATTCAT GTTGAAGTTG TACATGACAA 960 CTTTGTGACA TGTGGTAATT CTACAAGAAC TGGAGCTGTA AAACGCAAGT CTTCTGAGAA 1020 TAACGGAAGT TCGGTTTCTA AACAAGCAAA ATCTTGTTCT GAGGCCTCTC CCAGTATGTG 1080 TCCTGTACAG TCTGTTCCCA CAACAGTGTT TAAGGAGATC CTGCTTGGCT GTACTGCAGC 1140 AACTCCATCT AGCAAGGACC CAAGACAGCA AAATACTCCC CAGGCAGCCA ATTCTCCACC 1200 TAACATTGGA GCAAAACTTC CTCAAGGATG TCATAAGCAG AACTTACCAG AAGAACTTTC 1260 TTCCTGTCTA AACACAAAAC CTGAAGTACC GAGAACAAAA CCAGATGTCT GCAAAGAAGG 1320 ATTACTTTCT TCAAAATCTT CTCAGGTTGG AGCTGGAGAC TTGAAAATTC TGAGTGAGCC 1380 CAAAGGTAGC TGTATCCAGC CTAAAACAAA CACTGATCAG GAGAGCAGAC TGGAGTCTGC 1440 TCCACAGCCA GTCACTGGCC TTCCAAAGGA GTGCTTGCCT GCAAAGACTT CCTCTAAGGC 1500 AGAACTGGAC ATTGCCACCA CTCCTGAACT GCAGAAGCAT CTAGAACATG CAGCTTCCAC 1560 ATCCGATGAC CTTTCAGATA AGCCAGAAGT GAAAGCAGGT GTCACTAGCC TTAATAGTTG 1620 TGCAGAAAAG AAGGTCGAAC CTTCACATTT AGGTTCCCAG TCACAGAATT TAAAGGAAAC 1680 TTCAGTAAAA GTAGATAATG AAAGCTGTTG TACAAGAAGC AGTAATAAAA CCCAGACTCC 1740 CCCAGCCCGG AAGTCAGTTT TGACAGACCC AGATAAAGTC AGGAAGCTGC AGCAGAGCGG 1800 AGAGGCCTTT GTTCAGGATG ACTCCTGTGT TAACATCGTG GCACAGCTGC CCAAGTGTCG 1860 GGAGTGTCGA CTAGACAGCC TGCGCAAGGA TAAGGACCAG CAGAAGGACT CTCCTGTGTT 1920 TTGTCGCTTT TTCCACTTCA GGAGATTACA ATTCAACAAG CATGGTGTGT TGCGGGTAGA 1980 AGGCTTCTTA ACACCAAACA AGTATGACAG TGAAGCGATT GGCTTGTGGC TGCCTTTGAC 2040 CAAAAATGTT GTGGGGACTG ATTTGGACAC AGCAAAATAT ATCCTGGCCA ATATTGGAGA 2100 CCACTTCTGT CAAATGGTGA TTTCTGAGAA GGAAGCTATG TCGACTATTG AGCCACACAG 2160 ACAGGTTGCT TGGAAACGAG CTGTCAAAGG AGTTAGAGAA ATGTGTGATG TGTGTGACAC 2220 AACCATTTTC AACCTGCACT GGGTGTGCCC TCGGTGTGGG TTTGGAGTAT GTGTAGATTG 2280 CTACCGGATG AAGAGGAAGA ACTGCCAACA GGGTGCTGCC TACAAGACTT TCTCTTGGAT 2340 AAGGTGTGTG AAGAGTCAGA TACATGAGCC TGAGAACCTG ATGCCCACAC AGATTATTCC 2400 TGGCAAAGCC CTCTACGATG TTGGAGACAT TGTGCATTCT GTCAGAGCAA AATGGGGCAT 2460 AAAGGCCAAT TGTCCCTGCT CCAACAGGCA GTTCAAGCTC TTCTCAAAGC CAGCCTTAAA 2520 GGAAGACCTG AAACAGACAT CCTTGTCTGG AGAAAAACCA ACTCTTGGGA CCATGGTCCA 2580 GCAAAGTTCC CCTGTTTTGG AGCCAGTGGC TGTGTGCGGG GAAGCAGCCT CCAAGCCAGC 2640 CAGCAGCGTG AAGCCCACCT GTCCCACCAG CACTTCACCT TTAAACTGGC TAGCTGACCT 2700 TACCAGTGGG AATGTCAACA AGGAGAATAA GGAAAAACAG CTGACTATGC CAATTTTAAA 2760 GAATGAAATC AAATGCCTTC CACCCTTGCC CCCTCTGAAC AAGCCCAGCA CAGTCCTCCA 2820 TACTTTTAAC AGCACCATCT TGACACCTGT GAGCAACAAT AATTCAGGTT TCCTTAGAAA 2880 TCTTTTGAAT TCATCCACAG CAAAGACAGA AAATGGATTG AAAAACACAC CCAAAATTCT 2940 TGATGACATC TTTGCCTCTT TGGTGCAAAA CAAGACTTCT TCTGATTCAT CCAAGAGGCC 3000 TCAAGGACTG ACAATCAAGC CTAGCATTCT TGGCTTTGAC ACTCCTCACT ACTGGCTGTG 3060 TGACAACCGC CTGCTGTGCT TGCAAGACCC CAACAATAAG AGCAATTGGA ATGTTTTTAG 3120 GGAATGCTGG AAACAAGGGC AGCCAGTGAT GGTGTCGGGC GTGCATCATA AATTAAACAC 3180 TGAACTCTGG AAACCCGAGT CCTTCAGAAA AGAGTTTGGT GAGCAGGAAG TAGACCTAGT 3240 CAATTGTAGG ACCAATGAAA TCATCACTGG AGCCACAGTC GGAGACTTCT GGGATGGATT 3300 TGAAGATGTT CCAAACCGTT TGAAAAACGA CAAAGAAAAA GAACCAATGG TGTTGAAACT 3360 TAAGGACTGG CCGCCAGGAG AAGACTTCAG AGACATGATG CCTTCCAGGT TTGATGATCT 3420 GATGGCCAAC ATTCCACTGC CTGAGTACAC CAGGCGAGAT GGCAAACTGA ACCTGGCTTC 3480 CAGACTGCCA AACTACTTTG TACGGCCAGA CCTGGGCCCC AAGATGTACA ATGCTTATGG 3540 ATTGATCACT CCAGAGGATC GGAAATATGG GACCACAAAT CTTCACTTAG ATGTATCTGA 3600 TGCAGCCAAT GTCATGGTTT ATGTGGGAAT TCCCAAAGGA CAGTGTGAAC AAGAAGAAGA 3660 AGTCCTTAGA ACCATCCAAG ATGGAGATTC TGATGAACTC ACAATCAAGA GATTTATTGA 3720 AGGAAAAGAG AAGCCAGGAG CCCTTTGGCA CATATATGCT GCTAAAGACA CAGAGAAGAT 3780 AAGAGAATTC CTTAAAAAGG TATCAGAGGA GCAGGGTCAA GACAACCCTG CAGACCATGA 3840 CCCTATCCAC GATCAGAGCT GGTATTTAGA CCGATCGCTG AGAAAGCGCC TCTATCAAGA 3900 GTACGGCGTG CAAGGCTGGG CTATTGTACA GTTTCTTGGG GATGTGGTGT TTATCCCAGC 3960 AGGAGCGCCA CATCAGGTTC ATAACTTATA CAGCTGTATC AAAGTGGCTG AAGACTTTGT 4020 GTCTCCAGAG CATGTTAAAC ACTGCTTCTG GCTTACTCAG GAATTCCGTT ACTTGTCACA 4080 GACTCATACC AACCATGAAG ATAAATTGCA GGTGAAAAAT GTTATCTACC ATGCAGTGAA 4140 AGATGCAGTT GCTATGCTGA AAGCCAGTGA ATCCAGTTTG GGCAAACCTT AACTCTTCTC 4200 TGCACAATGG AGATGAATTA TTGGCAGCTG ATCAAACTCT TCAGGCAGGA TTCCTGTGGA 4260 CTTTGAGATT TCCTGTTACC TCATCTTCTT TTTTAAAGTA CACCTGACTT GGGAGGGTAC 4320 TGTCTCTAAT GTATATTTCT AGTGTTTACA GACACTAAGT GTGTATATGT AGTAACTATT 4380 TACAGACCAC GCATCCTTAT ACTGTGACTT CACCTAGATC TTCTACCAAG CTGAAGACCC 4440 TGCTGGCTCT GAAACAATCC TTGCAGTTAC TCCCCAGCTG TTCGTCTGGA CAGCTCATTC 4500 AAGTGGATTT TTAACTATTA GGGATCACTG CGAAGTTTCG TTGGATTTTA TTTTATGTCC 4560 TTCAGAGCAC CCTCCCCCAC CCACTAGGGT CCAGAAGAGC AATGGAGGAA GTGACAGCTA 4620 ATGGTGCAGT TCTAAATATA TATTGCATAG GACTGGCATT ATATAGCAGA AATAACTACT 4680 GTATAATTCT TGGGGTTAAC CATCTTTAGT TAATGGAATT TTAATTTAAA TGAAGCTTTG 4740 CTAATTTTAA GTGGTAAGCA TTTTGCATTA AAATATTCCT ATAATATTTT GTCGCTGTTC 4800 TTTGTCCTTT ATTCTTTGTT TACTCTCTCG AAAATAAAAG GGCTAAACTA TTG
4854Nucleotide Fasta Sequence
>ENSMUSP00000128789.1|JHDM2|Mus musculus AAGTGTCGAGTCGCGAGCGAGTCCACGGCGGCTCCGAGGCCGCTCGGGGCGGGGATCGGTCGCTGAGACGGGCCCTAGGCACTAAGAGGGAGCCTTTTCTTTAACAGGGCGAGGGGACGAACACTTAGGCAAAAGCACTGGCGCCGCGGCTCAGTCCTCCCTTCTCTCTCTCAGTGTCCAGCTTTGAAAGGGAGGAGCCCTTCCTGCTGGCGTGGAAACCATGGTGCTCACGCTCGGAGAAAGTTGGCCAGTATTGGTGGGGAAGCGATTCCTCAGTCTGTCCGCAGCCGAAGGCAACGAAGGCGGCCAGGACAACTGGGACTTGGAGCGCGTTGCCGAGTGGCCCTGGCTGTCGGGGACCATTCGAGCTGTTTCCCACACCGACGTTACTAAGAAAGACTTGAAGGTGTGTGTGGAGTTTGATGGGGAGTCTTGGAGAAAGAGAAGATGGATAGATGTCTACAGCCTTCAGAGAAAAGCATTTTTAGTAGAGCATAACCTGGTTTTGGCAGAACGAAAATCACCTGAAGTTCCTGAGCAAGTTATTCAGTGGCCTGCAATAATGTACAAATCTCTTCTAGACAAAGCTGGCTTGGGAGCCATAACTTCTGTTCGGTTTCTTGGAGATCAACAAAGTGTATTTGTTTCCAAAGACCTTTTGAAACCTATACAGGATGTTAACAGTCTTCGGCTTTCCCTTACTGATAATCAGACAGTCAGTAAGGAATTTCAAGCTTTGATTGTAAAACATTTGGATGAAAGCCATCTTTTACAAGGTGACAAGAACCTTGTTGGTTCAGAAGTAAAAATTTATAGCTTGGACCCATCTACTCAGTGGTTTTCAGCAACTGTTGTACATGGAAACCCATCATCCAAAACTCTTCAAGTCAACTGTGAGGAGATTCCAGCACTGAAAATTGTCGACCCAGCACTGATTCATGTTGAAGTTGTACATGACAACTTTGTGACATGTGGTAATTCTACAAGAACTGGAGCTGTAAAACGCAAGTCTTCTGAGAATAACGGAAGTTCGGTTTCTAAACAAGCAAAATCTTGTTCTGAGGCCTCTCCCAGTATGTGTCCTGTACAGTCTGTTCCCACAACAGTGTTTAAGGAGATCCTGCTTGGCTGTACTGCAGCAACTCCATCTAGCAAGGACCCAAGACAGCAAAATACTCCCCAGGCAGCCAATTCTCCACCTAACATTGGAGCAAAACTTCCTCAAGGATGTCATAAGCAGAACTTACCAGAAGAACTTTCTTCCTGTCTAAACACAAAACCTGAAGTACCGAGAACAAAACCAGATGTCTGCAAAGAAGGATTACTTTCTTCAAAATCTTCTCAGGTTGGAGCTGGAGACTTGAAAATTCTGAGTGAGCCCAAAGGTAGCTGTATCCAGCCTAAAACAAACACTGATCAGGAGAGCAGACTGGAGTCTGCTCCACAGCCAGTCACTGGCCTTCCAAAGGAGTGCTTGCCTGCAAAGACTTCCTCTAAGGCAGAACTGGACATTGCCACCACTCCTGAACTGCAGAAGCATCTAGAACATGCAGCTTCCACATCCGATGACCTTTCAGATAAGCCAGAAGTGAAAGCAGGTGTCACTAGCCTTAATAGTTGTGCAGAAAAGAAGGTCGAACCTTCACATTTAGGTTCCCAGTCACAGAATTTAAAGGAAACTTCAGTAAAAGTAGATAATGAAAGCTGTTGTACAAGAAGCAGTAATAAAACCCAGACTCCCCCAGCCCGGAAGTCAGTTTTGACAGACCCAGATAAAGTCAGGAAGCTGCAGCAGAGCGGAGAGGCCTTTGTTCAGGATGACTCCTGTGTTAACATCGTGGCACAGCTGCCCAAGTGTCGGGAGTGTCGACTAGACAGCCTGCGCAAGGATAAGGACCAGCAGAAGGACTCTCCTGTGTTTTGTCGCTTTTTCCACTTCAGGAGATTACAATTCAACAAGCATGGTGTGTTGCGGGTAGAAGGCTTCTTAACACCAAACAAGTATGACAGTGAAGCGATTGGCTTGTGGCTGCCTTTGACCAAAAATGTTGTGGGGACTGATTTGGACACAGCAAAATATATCCTGGCCAATATTGGAGACCACTTCTGTCAAATGGTGATTTCTGAGAAGGAAGCTATGTCGACTATTGAGCCACACAGACAGGTTGCTTGGAAACGAGCTGTCAAAGGAGTTAGAGAAATGTGTGATGTGTGTGACACAACCATTTTCAACCTGCACTGGGTGTGCCCTCGGTGTGGGTTTGGAGTATGTGTAGATTGCTACCGGATGAAGAGGAAGAACTGCCAACAGGGTGCTGCCTACAAGACTTTCTCTTGGATAAGGTGTGTGAAGAGTCAGATACATGAGCCTGAGAACCTGATGCCCACACAGATTATTCCTGGCAAAGCCCTCTACGATGTTGGAGACATTGTGCATTCTGTCAGAGCAAAATGGGGCATAAAGGCCAATTGTCCCTGCTCCAACAGGCAGTTCAAGCTCTTCTCAAAGCCAGCCTTAAAGGAAGACCTGAAACAGACATCCTTGTCTGGAGAAAAACCAACTCTTGGGACCATGGTCCAGCAAAGTTCCCCTGTTTTGGAGCCAGTGGCTGTGTGCGGGGAAGCAGCCTCCAAGCCAGCCAGCAGCGTGAAGCCCACCTGTCCCACCAGCACTTCACCTTTAAACTGGCTAGCTGACCTTACCAGTGGGAATGTCAACAAGGAGAATAAGGAAAAACAGCTGACTATGCCAATTTTAAAGAATGAAATCAAATGCCTTCCACCCTTGCCCCCTCTGAACAAGCCCAGCACAGTCCTCCATACTTTTAACAGCACCATCTTGACACCTGTGAGCAACAATAATTCAGGTTTCCTTAGAAATCTTTTGAATTCATCCACAGCAAAGACAGAAAATGGATTGAAAAACACACCCAAAATTCTTGATGACATCTTTGCCTCTTTGGTGCAAAACAAGACTTCTTCTGATTCATCCAAGAGGCCTCAAGGACTGACAATCAAGCCTAGCATTCTTGGCTTTGACACTCCTCACTACTGGCTGTGTGACAACCGCCTGCTGTGCTTGCAAGACCCCAACAATAAGAGCAATTGGAATGTTTTTAGGGAATGCTGGAAACAAGGGCAGCCAGTGATGGTGTCGGGCGTGCATCATAAATTAAACACTGAACTCTGGAAACCCGAGTCCTTCAGAAAAGAGTTTGGTGAGCAGGAAGTAGACCTAGTCAATTGTAGGACCAATGAAATCATCACTGGAGCCACAGTCGGAGACTTCTGGGATGGATTTGAAGATGTTCCAAACCGTTTGAAAAACGACAAAGAAAAAGAACCAATGGTGTTGAAACTTAAGGACTGGCCGCCAGGAGAAGACTTCAGAGACATGATGCCTTCCAGGTTTGATGATCTGATGGCCAACATTCCACTGCCTGAGTACACCAGGCGAGATGGCAAACTGAACCTGGCTTCCAGACTGCCAAACTACTTTGTACGGCCAGACCTGGGCCCCAAGATGTACAATGCTTATGGATTGATCACTCCAGAGGATCGGAAATATGGGACCACAAATCTTCACTTAGATGTATCTGATGCAGCCAATGTCATGGTTTATGTGGGAATTCCCAAAGGACAGTGTGAACAAGAAGAAGAAGTCCTTAGAACCATCCAAGATGGAGATTCTGATGAACTCACAATCAAGAGATTTATTGAAGGAAAAGAGAAGCCAGGAGCCCTTTGGCACATATATGCTGCTAAAGACACAGAGAAGATAAGAGAATTCCTTAAAAAGGTATCAGAGGAGCAGGGTCAAGACAACCCTGCAGACCATGACCCTATCCACGATCAGAGCTGGTATTTAGACCGATCGCTGAGAAAGCGCCTCTATCAAGAGTACGGCGTGCAAGGCTGGGCTATTGTACAGTTTCTTGGGGATGTGGTGTTTATCCCAGCAGGAGCGCCACATCAGGTTCATAACTTATACAGCTGTATCAAAGTGGCTGAAGACTTTGTGTCTCCAGAGCATGTTAAACACTGCTTCTGGCTTACTCAGGAATTCCGTTACTTGTCACAGACTCATACCAACCATGAAGATAAATTGCAGGTGAAAAATGTTATCTACCATGCAGTGAAAGATGCAGTTGCTATGCTGAAAGCCAGTGAATCCAGTTTGGGCAAACCTTAACTCTTCTCTGCACAATGGAGATGAATTATTGGCAGCTGATCAAACTCTTCAGGCAGGATTCCTGTGGACTTTGAGATTTCCTGTTACCTCATCTTCTTTTTTAAAGTACACCTGACTTGGGAGGGTACTGTCTCTAATGTATATTTCTAGTGTTTACAGACACTAAGTGTGTATATGTAGTAACTATTTACAGACCACGCATCCTTATACTGTGACTTCACCTAGATCTTCTACCAAGCTGAAGACCCTGCTGGCTCTGAAACAATCCTTGCAGTTACTCCCCAGCTGTTCGTCTGGACAGCTCATTCAAGTGGATTTTTAACTATTAGGGATCACTGCGAAGTTTCGTTGGATTTTATTTTATGTCCTTCAGAGCACCCTCCCCCACCCACTAGGGTCCAGAAGAGCAATGGAGGAAGTGACAGCTAATGGTGCAGTTCTAAATATATATTGCATAGGACTGGCATTATATAGCAGAAATAACTACTGTATAATTCTTGGGGTTAACCATCTTTAGTTAATGGAATTTTAATTTAAATGAAGCTTTGCTAATTTTAAGTGGTAAGCATTTTGCATTAAAATATTCCTATAATATTTTGTCGCTGTTCTTTGTCCTTTATTCTTTGTTTACTCTCTCGAAAATAAAAGGGCTAAACTATTG
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Sequence Source |
Ensembl |
Keyword |
KW-0007--Acetylation KW-0010--Activator KW-0025--Alternative splicing KW-0156--Chromatin regulator KW-0181--Complete proteome KW-0963--Cytoplasm KW-0221--Differentiation KW-0223--Dioxygenase KW-0408--Iron KW-0479--Metal-binding KW-0539--Nucleus KW-0560--Oxidoreductase KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0744--Spermatogenesis KW-0804--Transcription KW-0805--Transcription regulation KW-0862--Zinc KW-0863--Zinc-finger --
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Interpro |
IPR003347--JmjC_dom
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PROSITE |
PS51184--JMJC
|
Pfam |
PF02373--JmjC
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0016020--C:membrane GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0050681--F:androgen receptor binding GO:0001047--F:core promoter binding GO:0051213--F:dioxygenase activity GO:0005506--F:iron ion binding GO:0003700--F:transcription factor activity, sequence-specific DNA binding GO:0000976--F:transcription regulatory region sequence-specific DNA binding GO:0030521--P:androgen receptor signaling pathway GO:0046293--P:formaldehyde biosynthetic process GO:0033169--P:histone H3-K9 demethylation GO:0036123--P:histone H3-K9 dimethylation GO:0009755--P:hormone-mediated signaling pathway GO:0008584--P:male gonad development GO:0051573--P:negative regulation of histone H3-K9 methylation GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0045893--P:positive regulation of transcription, DNA-templated GO:0010468--P:regulation of gene expression GO:2000736--P:regulation of stem cell differentiation GO:2000036--P:regulation of stem cell population maintenance GO:0001666--P:response to hypoxia GO:0007290--P:spermatid nucleus elongation GO:0007283--P:spermatogenesis GO:0006351--P:transcription, DNA-templated
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Orthology |
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Created Date |
25-Jun-2016 |