| Tag |
Content |
| WERAM ID |
WERAM-Drm-0063 |
| Ensembl Protein ID |
FBpp0081541 |
| Uniprot Accession |
Q9VHC5; Q9VHC5_DROME
|
| Genbank Protein ID |
NP_001287255.1; NP_788611.1
|
| Protein Name |
JmjC domain-containing histone demethylase 2, isoform A |
| Genbank Nucleotide ID |
NM_001300326.1; NM_176434.2
|
| Gene Name |
KDM3B;CG31123;CG8165;JHDM2 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDM |
JHDM2 |
Jmjc |
H3K9 |
K |
26207949
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDM |
JHDM2 |
1.20e-97 |
326.2 |
358 |
806 |
|
| Organism |
Drosophila melanogaster |
| NCBI Taxa ID |
7227 |
Functional Description
(View) |
|
| Domain Profile |
HDM JHDM2
JHDM2.txt 117 ellekvskeqgaevppdh 134
e ++++ ke + ++ + +
FBpp0081541 358 EVIQDMIKESQLKQHTSY 375
333333333333222221 PP
JHDM2.txt 1 eYckrdgklNLasklpknfvrpdlgPklynAyGlateedrklgttnlhldvsdavnilvyvgilkkkwaeedlkellksieeeeldevtrkrvqdpke 98
eY+ r+g+lN+as+lpk+fv pdlgPk+ynAyG a + d+ gttnlhld+sdavni+vyvgi+++ +++ ++++++k+ie +++d++tr+r+q+p++
FBpp0081541 598 EYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSALHPDK--GTTNLHLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDV 693
7***************************************..******************************************************** PP
JHDM2.txt 99 kpgalWhifaakdaekirellekvskeqgaevppdhdpihdqswyldrklrkrLfeeyGvegwtlvQklgdavlipagapHqvqnlkscvkvaedFvs 196
pgalWhif+a+da+kir+ll++v+ e+g++ +pdhdpihdq+wyld+klr+rLf+eyGveg+ +vQ+lgdav+ipagapHqvqnl++c+kvaedFvs
FBpp0081541 694 LPGALWHIFPARDADKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGAPHQVQNLHNCIKVAEDFVS 791
************************************************************************************************** PP
JHDM2.txt 197 PEnvkecfrltkeyr 211
PEn+++c++lt+e+r
FBpp0081541 792 PENITHCYHLTHEFR 806
*************98 PP
|
Protein Sequence
(Fasta) | MSQKELAALV ATRTSRKRTI SSTSFSISTR TDPKSIIEIH IFNDSLPIKR ACCEVENPTL 60
KAEQRVQQEE ESLGQVPPLT EEEQQRHDEF RNSGSIFLQD LPCFKLQQAQ PIAGSSPIPK 120
CRECRRRNLA TTEGEPSSVS DVYCRFYEFR RLQFNENGEL CVVGFPNPYS EPSPEDIAIW 180
QPDKNTPPTS GYMDIQVCRY ILLHAGDQFC YIWHQEAEAL SLHQNTDGTI AWKKAVKGTR 240
EICDVCDTTL FNYHWTCRKC GFGVCLDCVK DRKEGLRLRR AENAAQKGCD EYHWLLCSDP 300
SGPQEHVLTE LMLTQIIAGD ALNVLGRLLH EVRTLWQVPQ VCGCLLSKQA IEDAQSKEVI 360
QDMIKESQLK QHTSYSSLAS EQKVHQQQRL DQLHATKLEF ARELGVDYVP GRVWTKETLG 420
KDPITTAFDN LKHINFLRKG LAGLRRFLPP RTMTFAYSTQ LAPGVPHEFL CDGRLLRLTD 480
AMHPDNRVLF QEVWKCGQPV MISEVARSLN LDLWHPQAFC RDFGDKPNDL INCLNGNLVP 540
NQPMRHFWEG FQCMTKRLPD AYGKPMLLKL KDWPPGDDFA EILPTRFADL MKGLPMPEYT 600
LRTGNLNIAS CLPKMFVPPD LGPKMYNAYG SALHPDKGTT NLHLDISDAV NIMVYVGIPQ 660
DGDTRPQMAA TQKAIEIGGC DYITRARCQS PDVLPGALWH IFPARDADKI RDLLNRVTLE 720
KGFRLEPDHD PIHDQNWYLD DKLRARLFKE YGVEGHPIVQ CLGDAVFIPA GAPHQVQNLH 780
NCIKVAEDFV SPENITHCYH LTHEFRRLSH SHTNHEDKLQ IKNIIYHAIK DCCTILTRAV 840
DERLNAELTK LNAD 854Protein Fasta Sequence
>FBpp0081541|KDM3B;CG31123;CG8165;JHDM2|Drosophila melanogaster
MSQKELAALVATRTSRKRTISSTSFSISTRTDPKSIIEIHIFNDSLPIKRACCEVENPTLKAEQRVQQEEESLGQVPPLTEEEQQRHDEFRNSGSIFLQDLPCFKLQQAQPIAGSSPIPKCRECRRRNLATTEGEPSSVSDVYCRFYEFRRLQFNENGELCVVGFPNPYSEPSPEDIAIWQPDKNTPPTSGYMDIQVCRYILLHAGDQFCYIWHQEAEALSLHQNTDGTIAWKKAVKGTREICDVCDTTLFNYHWTCRKCGFGVCLDCVKDRKEGLRLRRAENAAQKGCDEYHWLLCSDPSGPQEHVLTELMLTQIIAGDALNVLGRLLHEVRTLWQVPQVCGCLLSKQAIEDAQSKEVIQDMIKESQLKQHTSYSSLASEQKVHQQQRLDQLHATKLEFARELGVDYVPGRVWTKETLGKDPITTAFDNLKHINFLRKGLAGLRRFLPPRTMTFAYSTQLAPGVPHEFLCDGRLLRLTDAMHPDNRVLFQEVWKCGQPVMISEVARSLNLDLWHPQAFCRDFGDKPNDLINCLNGNLVPNQPMRHFWEGFQCMTKRLPDAYGKPMLLKLKDWPPGDDFAEILPTRFADLMKGLPMPEYTLRTGNLNIASCLPKMFVPPDLGPKMYNAYGSALHPDKGTTNLHLDISDAVNIMVYVGIPQDGDTRPQMAATQKAIEIGGCDYITRARCQSPDVLPGALWHIFPARDADKIRDLLNRVTLEKGFRLEPDHDPIHDQNWYLDDKLRARLFKEYGVEGHPIVQCLGDAVFIPAGAPHQVQNLHNCIKVAEDFVSPENITHCYHLTHEFRRLSHSHTNHEDKLQIKNIIYHAIKDCCTILTRAVDERLNAELTKLNAD |
Nucleotide Sequence
(Fasta) | ATAGTATAAT TTCAGCATCG ACTTGTTGGC CAGCTCTAGT TGCGCTTCGC TCAGTGCTAA 60
TGAAAAATCG AATTTTTCGC TTCAAATCGA CTGAAGTTTA CACGGGCTAA AGTATTACAG 120
AAGTTTGGCT CAAGCCATTA CACAACATGC AATAAGTAAA TACAGAGGAG CTAAAATGTC 180
GCAAAAAGAA TTGGCGGCTC TGGTTGCCAC GAGAACGAGT CGCAAACGCA CCATATCCTC 240
GACCTCATTC TCTATTTCCA CTCGCACTGA TCCAAAATCC ATCATAGAGA TACACATATT 300
CAATGACTCC TTGCCCATAA AAAGAGCTTG CTGCGAAGTG GAGAATCCAA CTTTAAAAGC 360
GGAACAGCGA GTGCAGCAGG AAGAAGAGAG CCTGGGCCAA GTGCCGCCGC TGACCGAGGA 420
AGAGCAGCAG CGGCACGATG AGTTCCGAAA TAGTGGTTCG ATATTCCTGC AGGATTTGCC 480
CTGCTTTAAG CTGCAGCAGG CACAGCCGAT AGCAGGATCA TCACCCATTC CCAAGTGTCG 540
GGAGTGCAGA AGAAGAAATT TGGCTACAAC AGAGGGCGAA CCCAGTTCAG TTAGCGACGT 600
TTACTGCCGG TTCTACGAGT TCCGACGCCT TCAGTTCAAT GAGAATGGAG AGCTGTGCGT 660
GGTTGGCTTC CCAAATCCCT ACAGCGAGCC CTCACCAGAG GACATCGCCA TTTGGCAGCC 720
GGATAAAAAT ACACCGCCGA CCAGCGGTTA CATGGATATA CAGGTTTGCA GGTACATCCT 780
ACTCCATGCC GGCGACCAGT TCTGCTATAT TTGGCACCAG GAAGCAGAGG CTTTAAGTTT 840
GCATCAGAAT ACGGACGGAA CCATTGCCTG GAAGAAGGCC GTAAAAGGAA CACGAGAGAT 900
TTGCGACGTG TGTGACACCA CATTGTTCAA CTACCATTGG ACTTGCCGCA AGTGCGGCTT 960
TGGAGTGTGT CTGGACTGCG TTAAAGATCG CAAGGAGGGA TTGCGACTGC GGCGAGCGGA 1020
GAACGCTGCC CAAAAGGGAT GCGATGAGTA CCACTGGCTG CTCTGCAGCG ACCCCAGTGG 1080
CCCACAGGAG CACGTCCTTA CCGAGCTGAT GCTAACACAG ATCATAGCCG GAGATGCCCT 1140
CAACGTCTTG GGCAGGCTGC TGCACGAGGT TCGTACTTTG TGGCAGGTGC CACAGGTCTG 1200
CGGCTGCCTT CTGAGCAAGC AAGCGATTGA AGATGCACAA TCAAAGGAAG TGATCCAGGA 1260
TATGATTAAG GAGTCTCAGC TGAAGCAGCA CACCAGCTAC TCGTCGCTGG CCTCCGAGCA 1320
GAAGGTGCAC CAGCAACAGC GCCTCGATCA ACTGCACGCC ACGAAGTTGG AGTTTGCCAG 1380
AGAGCTAGGT GTAGATTATG TTCCAGGTCG AGTGTGGACC AAGGAAACCT TGGGAAAGGA 1440
TCCAATAACA ACGGCGTTTG ATAATTTGAA GCACATTAAT TTTCTGAGAA AGGGATTGGC 1500
CGGCTTGAGA AGGTTTCTTC CACCAAGGAC CATGACTTTT GCTTACTCCA CTCAGTTGGC 1560
TCCAGGAGTT CCTCACGAGT TTCTGTGCGA TGGCAGACTG CTTAGACTCA CCGATGCCAT 1620
GCATCCGGAT AATCGAGTTC TTTTCCAGGA GGTTTGGAAA TGCGGCCAGC CAGTTATGAT 1680
TTCGGAGGTG GCTCGCTCTT TGAACTTAGA CTTATGGCAT CCACAAGCCT TTTGCCGGGA 1740
CTTTGGCGAC AAGCCCAATG ATCTTATTAA TTGCCTGAAT GGCAATCTGG TGCCCAATCA 1800
GCCAATGCGA CACTTTTGGG AGGGTTTTCA GTGCATGACC AAGCGTCTGC CAGATGCATA 1860
TGGCAAGCCA ATGCTCTTAA AGCTTAAGGA TTGGCCGCCG GGTGATGATT TTGCCGAAAT 1920
ACTGCCCACC AGGTTTGCTG ATTTGATGAA GGGACTGCCC ATGCCGGAGT ACACACTTCG 1980
CACGGGAAAC CTTAACATAG CTAGCTGCTT ACCCAAGATG TTTGTGCCAC CAGACTTAGG 2040
ACCCAAAATG TACAACGCAT ATGGCTCAGC ATTGCACCCC GACAAGGGTA CAACCAATCT 2100
TCACTTGGAC ATTTCGGATG CAGTGAACAT AATGGTTTAT GTGGGAATAC CCCAGGATGG 2160
GGACACGAGA CCTCAGATGG CGGCCACGCA GAAAGCCATA GAAATTGGCG GATGCGATTA 2220
CATCACTAGA GCTCGTTGCC AATCGCCAGA TGTATTACCC GGAGCACTTT GGCACATCTT 2280
TCCAGCTCGC GATGCAGACA AAATAAGAGA TTTACTTAAC CGCGTGACCC TGGAGAAGGG 2340
TTTCCGTCTG GAGCCGGATC ACGATCCAAT TCACGATCAG AATTGGTACT TGGACGACAA 2400
GTTGCGAGCT CGTTTATTCA AAGAGTATGG CGTGGAGGGG CATCCGATTG TCCAGTGCTT 2460
GGGCGACGCA GTCTTTATAC CAGCTGGCGC CCCACATCAG GTTCAAAATC TCCACAACTG 2520
TATTAAGGTG GCCGAGGATT TTGTATCGCC GGAAAATATC ACGCACTGCT ATCATCTAAC 2580
TCACGAGTTT AGAAGGCTTT CGCACTCGCA CACAAATCAC GAGGACAAGC TTCAGATCAA 2640
GAATATTATC TACCATGCCA TCAAGGACTG TTGCACCATC CTGACCAGAG CTGTGGATGA 2700
GAGACTTAAT GCGGAATTAA CCAAGCTAAA TGCAGATTAG AATTTTCTTA CCTTTTAGTT 2760
TTTTTCAACT ATTTAACATT TATTATTATT TTTTAAGATC AAAAATTGTC AAATATTCAA 2820
TAAATACTTA CTTAGAACT
Nucleotide Fasta Sequence
>FBpp0081541|JHDM2|Drosophila melanogaster
ATAGTATAATTTCAGCATCGACTTGTTGGCCAGCTCTAGTTGCGCTTCGCTCAGTGCTAATGAAAAATCGAATTTTTCGCTTCAAATCGACTGAAGTTTACACGGGCTAAAGTATTACAGAAGTTTGGCTCAAGCCATTACACAACATGCAATAAGTAAATACAGAGGAGCTAAAATGTCGCAAAAAGAATTGGCGGCTCTGGTTGCCACGAGAACGAGTCGCAAACGCACCATATCCTCGACCTCATTCTCTATTTCCACTCGCACTGATCCAAAATCCATCATAGAGATACACATATTCAATGACTCCTTGCCCATAAAAAGAGCTTGCTGCGAAGTGGAGAATCCAACTTTAAAAGCGGAACAGCGAGTGCAGCAGGAAGAAGAGAGCCTGGGCCAAGTGCCGCCGCTGACCGAGGAAGAGCAGCAGCGGCACGATGAGTTCCGAAATAGTGGTTCGATATTCCTGCAGGATTTGCCCTGCTTTAAGCTGCAGCAGGCACAGCCGATAGCAGGATCATCACCCATTCCCAAGTGTCGGGAGTGCAGAAGAAGAAATTTGGCTACAACAGAGGGCGAACCCAGTTCAGTTAGCGACGTTTACTGCCGGTTCTACGAGTTCCGACGCCTTCAGTTCAATGAGAATGGAGAGCTGTGCGTGGTTGGCTTCCCAAATCCCTACAGCGAGCCCTCACCAGAGGACATCGCCATTTGGCAGCCGGATAAAAATACACCGCCGACCAGCGGTTACATGGATATACAGGTTTGCAGGTACATCCTACTCCATGCCGGCGACCAGTTCTGCTATATTTGGCACCAGGAAGCAGAGGCTTTAAGTTTGCATCAGAATACGGACGGAACCATTGCCTGGAAGAAGGCCGTAAAAGGAACACGAGAGATTTGCGACGTGTGTGACACCACATTGTTCAACTACCATTGGACTTGCCGCAAGTGCGGCTTTGGAGTGTGTCTGGACTGCGTTAAAGATCGCAAGGAGGGATTGCGACTGCGGCGAGCGGAGAACGCTGCCCAAAAGGGATGCGATGAGTACCACTGGCTGCTCTGCAGCGACCCCAGTGGCCCACAGGAGCACGTCCTTACCGAGCTGATGCTAACACAGATCATAGCCGGAGATGCCCTCAACGTCTTGGGCAGGCTGCTGCACGAGGTTCGTACTTTGTGGCAGGTGCCACAGGTCTGCGGCTGCCTTCTGAGCAAGCAAGCGATTGAAGATGCACAATCAAAGGAAGTGATCCAGGATATGATTAAGGAGTCTCAGCTGAAGCAGCACACCAGCTACTCGTCGCTGGCCTCCGAGCAGAAGGTGCACCAGCAACAGCGCCTCGATCAACTGCACGCCACGAAGTTGGAGTTTGCCAGAGAGCTAGGTGTAGATTATGTTCCAGGTCGAGTGTGGACCAAGGAAACCTTGGGAAAGGATCCAATAACAACGGCGTTTGATAATTTGAAGCACATTAATTTTCTGAGAAAGGGATTGGCCGGCTTGAGAAGGTTTCTTCCACCAAGGACCATGACTTTTGCTTACTCCACTCAGTTGGCTCCAGGAGTTCCTCACGAGTTTCTGTGCGATGGCAGACTGCTTAGACTCACCGATGCCATGCATCCGGATAATCGAGTTCTTTTCCAGGAGGTTTGGAAATGCGGCCAGCCAGTTATGATTTCGGAGGTGGCTCGCTCTTTGAACTTAGACTTATGGCATCCACAAGCCTTTTGCCGGGACTTTGGCGACAAGCCCAATGATCTTATTAATTGCCTGAATGGCAATCTGGTGCCCAATCAGCCAATGCGACACTTTTGGGAGGGTTTTCAGTGCATGACCAAGCGTCTGCCAGATGCATATGGCAAGCCAATGCTCTTAAAGCTTAAGGATTGGCCGCCGGGTGATGATTTTGCCGAAATACTGCCCACCAGGTTTGCTGATTTGATGAAGGGACTGCCCATGCCGGAGTACACACTTCGCACGGGAAACCTTAACATAGCTAGCTGCTTACCCAAGATGTTTGTGCCACCAGACTTAGGACCCAAAATGTACAACGCATATGGCTCAGCATTGCACCCCGACAAGGGTACAACCAATCTTCACTTGGACATTTCGGATGCAGTGAACATAATGGTTTATGTGGGAATACCCCAGGATGGGGACACGAGACCTCAGATGGCGGCCACGCAGAAAGCCATAGAAATTGGCGGATGCGATTACATCACTAGAGCTCGTTGCCAATCGCCAGATGTATTACCCGGAGCACTTTGGCACATCTTTCCAGCTCGCGATGCAGACAAAATAAGAGATTTACTTAACCGCGTGACCCTGGAGAAGGGTTTCCGTCTGGAGCCGGATCACGATCCAATTCACGATCAGAATTGGTACTTGGACGACAAGTTGCGAGCTCGTTTATTCAAAGAGTATGGCGTGGAGGGGCATCCGATTGTCCAGTGCTTGGGCGACGCAGTCTTTATACCAGCTGGCGCCCCACATCAGGTTCAAAATCTCCACAACTGTATTAAGGTGGCCGAGGATTTTGTATCGCCGGAAAATATCACGCACTGCTATCATCTAACTCACGAGTTTAGAAGGCTTTCGCACTCGCACACAAATCACGAGGACAAGCTTCAGATCAAGAATATTATCTACCATGCCATCAAGGACTGTTGCACCATCCTGACCAGAGCTGTGGATGAGAGACTTAATGCGGAATTAACCAAGCTAAATGCAGATTAGAATTTTCTTACCTTTTAGTTTTTTTCAACTATTTAACATTTATTATTATTTTTTAAGATCAAAAATTGTCAAATATTCAATAAATACTTACTTAGAACT
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
--
|
| Interpro |
IPR003347--JmjC_dom
|
| PROSITE |
PS51184--JMJC
|
| Pfam |
PF02373--JmjC
|
| Gene Ontology |
GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0032452--F:histone demethylase activity
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0008168--F:methyltransferase activity
GO:0016577--P:histone demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0031937--P:positive regulation of chromatin silencing
GO:2001020--P:regulation of response to DNA damage stimulus
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
