WERAM Information


Tag Content
WERAM ID WERAM-Tub-0123
Ensembl Protein ID ENSTBEP00000013627.1
Gene Name KDM3A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSTBEG00000015669.1 ENSTBET00000015699.1 ENSTBEP00000013627.1
Status Unreviewed
Classification
Type Family E-value Score Start End
HDM JHDM2 5.10e-78 261.1 1062 1239
Organism Tupaia belangeri
Domain Profile
  HDM JHDM2

             JHDM2.txt   34 lateedrklgttnlhldvsdavnilvyvgilkkkwaeedlkellksieeeeldevtrkrvqdpkekpgalWhifaakdaekirelle 120 
l+t edrk+gttnlhldvsda+n++vyvgi+k+++++e+ e+lk+i+++++de+t+kr+ ++kekpgalWhi+aakd+ekire+l+
ENSTBEP00000013627.1 1062 LITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEE--EVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLK 1146
6899***********************************..********************************************** PP
JHDM2.txt 121 kvskeqgaevppdhdpihdqswyldrklrkrLfeeyGvegwtlvQklgdavlipagapHqvq..nlkscvkvaedFvsPEnvkecfr 205
kvs+eqg+e+p+dhdpihdqswyldr+lrkrL++eyGv+gw++vQ+lgd+v+ipagapHq + + +aedFvsPE+vk+cf+
ENSTBEP00000013627.1 1147 KVSEEQGQENPADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQARttAFSLFFLLAEDFVSPEHVKHCFW 1233
***********************************************************9872257777889*************** PP
JHDM2.txt 206 ltkeyr 211
lt+e+r
ENSTBEP00000013627.1 1234 LTQEFR 1239
****98 PP

Protein Sequence
(Fasta)
MVLTLGESWP VLVGKRFLSV SAADGGHDSW DVERVAEWPW LSGTIRAVSH TDVTKKDLKV 60
CVEFDGESWR KRRWIEVYSL PRRAFLVEHN LVLAERKSPE IPDRIVQWPA IMYRSLLDKA 120
GLGSITSVRF LGDQQRIFLS KDLLKPIQDV NSLRLSLMDN HNVSKEFQAL IVKHLDESHL 180
LQXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 240
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XCHKQSLPEE 300
LSSCLNTKPE ILRKPDVCKA GLLSSKSSQF GTGDLKILSE SKGGSIQAKT NTSQENRLEL 360
VPQPSPGLPK ECLSTKASKT ESEIANIPEL QKHLEHAPST SNVLLNKPEM KAGIQNGSPN 420
RCAEKKIEPS TLGCRSQNLK ESSIKVDNES CCTRSDNNLQ TVPSRKSVLS DPAKLKKLQQ 480
SGEAFVQDDS CVNIVAQLPK CRECRLDSLR KDKEQQKDSP VFCRFLYFRR LQFNKHGVLR 540
VEGFLTPNKY DSEAIGLWLP LTRNVVGTDL DTAKYILANI GDHFCQMVIS EKEAMSTIEP 600
HRQVAWKRAV KGVREMCDVC DTTIFNLHWV CPRCGFGVCV DCYRMKKKNC QQSAAYKTFS 660
WLRCVKSQIH EPENLMPTQI IPGKALYDVG DIVHSVRAKW GIKANCPCAT RQFKLFSKPI 720
SKEELKQASL AGEKPTLGAV LQQNPSVLEP MVVGGEAASK PAGSLKPACP ASASPLTWLA 780
DLTSGNVNKE NKEKQPTMPI LKNEIKCLPP LPPLSKSSTV LHTFNSTILT PVSNNNSGFL 840
RNLLNSSTGK TENGLKNTPK ILDDIFASLV QNKTSSSEAA KKPQGLTIKP SILGFDTPHY 900
WLCDNRLLCL QDPNNKSNWN VFRECWKQGQ PVMVSGVHHK LNTELWKPAS FRNEFGEQEV 960
DLVNCRTNEI ITGATVGDFW DGFEDVPXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 1020
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XLITPEDRKY GTTNLHLDVS 1080
DAANVMVYVG IPKGQCEQEE EVLKTIQDGD SDELTIKRFI EGKEKPGALW HIYAAKDTEK 1140
IREFLKKVSE EQGQENPADH DPIHDQSWYL DRSLRKRLHQ EYGVQGWAIV QFLGDVVFIP 1200
AGAPHQARTT AFSLFFLLAE DFVSPEHVKH CFWLTQEFRY LSQTHTNHED KLQ 1253
Nucleotide Sequence
(Fasta)
ATGGTGCTCA CGCTCGGAGA AAGTTGGCCG GTATTGGTCG GGAAGCGATT CCTCAGTGTG 60
TCCGCAGCCG ACGGCGGCCA CGACAGCTGG GACGTGGAGC GCGTCGCCGA GTGGCCCTGG 120
CTCTCCGGGA CCATTCGAGC TGTCTCCCAC ACCGACGTGA CCAAGAAGGA TCTGAAGGTG 180
TGTGTGGAGT TCGATGGGGA ATCTTGGAGG AAGAGAAGAT GGATAGAAGT CTACAGCCTT 240
CCAAGAAGAG CATTTTTAGT AGAGCATAAC TTGGTTTTGG CTGAACGAAA GTCGCCTGAA 300
ATTCCTGACC GAATTGTTCA GTGGCCTGCA ATAATGTACA GATCTCTGCT GGACAAAGCT 360
GGTTTGGGAT CCATAACTTC TGTTCGCTTT CTAGGAGATC AACAAAGAAT ATTTCTTTCT 420
AAAGATCTTT TGAAGCCTAT ACAGGATGTG AACAGTCTTC GACTTTCCCT TATGGATAAT 480
CATAACGTAA GCAAAGAATT TCAAGCTTTA ATTGTAAAAC ATTTGGATGA AAGTCATCTT 540
TTACAANNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 600
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 660
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 720
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 780
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 840
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNATGTCATA AGCAGAGTTT ACCAGAAGAA 900
CTTTCTTCCT GTCTAAATAC AAAGCCTGAA ATACTGAGAA AACCAGATGT CTGCAAAGCA 960
GGCTTACTCT CTTCAAAGTC CTCTCAGTTT GGAACTGGAG ACTTGAAAAT TCTGAGTGAA 1020
TCAAAAGGTG GCTCTATCCA AGCTAAGACA AATACTAGTC AGGAAAATAG ATTGGAATTG 1080
GTTCCACAAC CATCACCTGG CCTTCCTAAG GAGTGCTTAT CCACTAAGGC TTCAAAAACA 1140
GAATCGGAAA TTGCCAATAT TCCTGAACTG CAGAAGCACC TGGAACATGC ACCTTCCACG 1200
TCTAATGTCC TTTTAAATAA GCCAGAAATG AAAGCAGGTA TCCAAAATGG TAGCCCTAAT 1260
AGATGTGCAG AAAAAAAGAT AGAGCCTTCA ACCTTGGGTT GCCGGTCACA GAATTTAAAG 1320
GAATCGTCCA TAAAAGTAGA TAATGAAAGC TGTTGTACAA GAAGTGACAA TAATTTGCAA 1380
ACCGTCCCAT CCCGGAAGTC AGTTCTGTCA GACCCCGCCA AACTCAAGAA GCTGCAGCAG 1440
AGTGGAGAGG CCTTTGTGCA GGACGATTCC TGTGTGAACA TTGTTGCACA GCTGCCCAAG 1500
TGCCGGGAGT GTCGCCTGGA CAGTCTCCGC AAGGATAAGG AGCAGCAGAA GGACTCGCCT 1560
GTGTTTTGTC GCTTTCTTTA CTTCAGGAGG TTACAGTTCA ACAAACATGG TGTGTTACGG 1620
GTAGAAGGCT TCTTAACACC AAACAAATAT GACAGCGAAG CAATTGGCTT GTGGTTACCT 1680
TTAACCAGAA ACGTTGTGGG GACTGATTTG GACACAGCGA AGTATATCCT GGCCAACATC 1740
GGAGACCACT TCTGTCAAAT GGTGATTTCT GAAAAGGAAG CTATGTCAAC TATTGAGCCA 1800
CACAGACAGG TTGCTTGGAA ACGAGCCGTC AAAGGCGTTC GAGAAATGTG TGATGTGTGT 1860
GACACCACCA TTTTCAACCT GCACTGGGTG TGTCCTCGGT GTGGGTTTGG AGTGTGTGTG 1920
GATTGCTACC GGATGAAGAA GAAGAACTGC CAGCAGAGTG CAGCCTATAA GACTTTTTCG 1980
TGGCTGAGAT GTGTCAAAAG TCAGATCCAT GAACCAGAGA ACTTAATGCC TACACAGATC 2040
ATTCCAGGAA AAGCCCTCTA TGATGTTGGA GACATTGTTC ATTCTGTAAG AGCGAAGTGG 2100
GGAATAAAGG CAAATTGTCC CTGTGCAACC AGGCAGTTCA AACTCTTCTC AAAGCCCATC 2160
TCAAAGGAAG AGCTAAAACA GGCCTCCTTG GCTGGAGAGA AGCCGACTCT GGGTGCTGTG 2220
CTCCAGCAGA ACCCCTCAGT GTTGGAACCT ATGGTGGTGG GTGGGGAAGC TGCCTCCAAG 2280
CCAGCCGGCA GCCTGAAGCC TGCCTGTCCG GCCAGCGCAT CCCCTTTAAC CTGGCTGGCA 2340
GACCTGACCA GCGGGAATGT CAATAAGGAG AACAAGGAAA AACAACCAAC AATGCCAATT 2400
TTGAAGAATG AAATCAAATG CCTTCCACCC CTGCCCCCTT TAAGTAAATC CAGCACAGTC 2460
CTCCACACCT TTAACAGCAC AATTTTGACA CCTGTAAGCA ACAACAACTC TGGTTTCCTC 2520
CGCAACCTCT TGAATTCCTC TACAGGAAAG ACAGAAAATG GACTCAAGAA TACACCAAAA 2580
ATCCTCGATG ACATCTTTGC CTCTTTGGTA CAAAATAAGA CTTCTTCCTC CGAGGCAGCT 2640
AAGAAGCCTC AGGGACTGAC AATCAAGCCC AGCATCCTGG GCTTCGACAC CCCTCACTAC 2700
TGGCTGTGTG ATAACCGCCT GCTGTGCTTG CAGGACCCCA ACAACAAGAG CAACTGGAAC 2760
GTGTTCCGGG AGTGCTGGAA ACAAGGGCAG CCAGTGATGG TGTCGGGAGT GCACCACAAA 2820
TTGAACACTG AACTTTGGAA ACCCGCATCC TTCAGGAATG AGTTTGGCGA GCAGGAAGTC 2880
GACCTGGTTA ATTGTAGGAC CAATGAAATC ATCACGGGAG CCACAGTAGG AGACTTCTGG 2940
GATGGATTTG AAGATGTTCC AANNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 3000
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 3060
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 3120
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 3180
NGATTAATCA CTCCAGAAGA TCGGAAATAT GGAACGACGA ATCTTCACTT AGATGTATCA 3240
GATGCAGCTA ATGTCATGGT TTATGTGGGG ATTCCCAAAG GACAGTGTGA GCAAGAAGAA 3300
GAGGTCCTTA AAACCATCCA AGATGGAGAC TCTGATGAAC TCACAATAAA GCGATTTATT 3360
GAAGGAAAAG AGAAGCCAGG AGCCCTCTGG CACATTTATG CTGCTAAAGA CACAGAGAAA 3420
ATAAGAGAAT TCCTTAAAAA GGTATCAGAA GAACAAGGTC AAGAAAACCC AGCAGACCAT 3480
GATCCTATTC ATGATCAGAG TTGGTATTTA GACCGGTCGC TAAGAAAGCG TCTTCATCAA 3540
GAGTATGGCG TTCAAGGCTG GGCGATTGTA CAGTTTCTTG GGGATGTGGT ATTTATCCCA 3600
GCAGGAGCTC CACATCAGGC AAGAACCACT GCTTTTTCTT TATTCTTCTT ATTGGCTGAA 3660
GACTTTGTTT CTCCAGAGCA TGTAAAACAC TGCTTCTGGC TTACTCAGGA ATTCCGTTAT 3720
CTGTCACAGA CTCATACTAA CCACGAAGAT AAATTACAG
Sequence Source Ensembl
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Eqc-0035 ENSECAP00000005922.1 Equus caballus 90 0.0 1280
WERAM-Nol-0029 ENSNLEP00000003424.1 Nomascus leucogenys 90 0.0 1273
WERAM-Gog-0083 ENSGGOP00000006802.2 Gorilla gorilla 90 0.0 1272
WERAM-Poa-0107 ENSPPYP00000013616.2 Pongo abelii 90 0.0 1271
WERAM-Pat-0097 ENSPTRP00000042227.4 Pan troglodytes 90 0.0 1271
WERAM-Hos-0087 ENSP00000323659.5 Homo sapiens 90 0.0 1269
WERAM-Caj-0207 ENSCJAP00000022938.2 Callithrix jacchus 89 0.0 1268
WERAM-Aim-0108 ENSAMEP00000010467.1 Ailuropoda melanoleuca 89 0.0 1265
WERAM-Mim-0008 ENSMICP00000000704.1 Microcebus murinus 89 0.0 1261
WERAM-Mam-0113 ENSMMUP00000017247.2 Macaca mulatta 89 0.0 1259
WERAM-Caf-0086 ENSCAFP00000011182.3 Canis familiaris 88 0.0 1256
WERAM-Chs-0197 ENSCSAP00000012405.1 Chlorocebus sabaeus 89 0.0 1253
WERAM-Sus-0059 ENSSSCP00000008777.2 Sus scrofa 88 0.0 1243
WERAM-Mup-0099 ENSMPUP00000009177.1 Mustela putorius furo 87 0.0 1239
WERAM-Fec-0111 ENSFCAP00000009754.3 Felis catus 87 0.0 1238
WERAM-Mum-0192 ENSMUSP00000128789.1 Mus musculus 87 0.0 1234
WERAM-Cap-0195 ENSCPOP00000020827.1 Cavia porcellus 86 0.0 1232
WERAM-Tas-0095 ENSTSYP00000010010.1 Tarsius syrichta 88 0.0 1225
WERAM-Orc-0105 ENSOCUP00000008900.3 Oryctolagus cuniculus 87 0.0 1221
WERAM-Ptv-0098 ENSPVAP00000008907.1 Pteropus vampyrus 86 0.0 1218
WERAM-Ran-0048 ENSRNOP00000041218.4 Rattus norvegicus 86 0.0 1213
WERAM-Ict-0030 ENSSTOP00000002342.2 Ictidomys tridecemlineatus 85 0.0 1212
WERAM-Ova-0218 ENSOARP00000022207.1 Ovis aries 86 0.0 1212
WERAM-Dan-0108 ENSDNOP00000012864.3 Dasypus novemcinctus 86 0.0 1211
WERAM-Bot-0126 ENSBTAP00000018069.5 Bos taurus 86 0.0 1201
WERAM-Paa-0087 ENSPANP00000002284.1 Papio anubis 86 0.0 1193
WERAM-Soa-0085 ENSSARP00000008051.1 Sorex araneus 84 0.0 1192
WERAM-Otg-0117 ENSOGAP00000010248.2 Otolemur garnettii 85 0.0 1177
WERAM-Ocp-0022 ENSOPRP00000001989.2 Ochotona princeps 83 0.0 1166
WERAM-Tut-0121 ENSTTRP00000009851.1 Tursiops truncatus 83 0.0 1155
WERAM-Vip-0004 ENSVPAP00000000405.1 Vicugna pacos 82 0.0 1144
WERAM-Sah-0148 ENSSHAP00000015447.1 Sarcophilus harrisii 68 0.0 944
WERAM-Ora-0091 ENSOANP00000016437.2 Ornithorhynchus anatinus 68 0.0 936
WERAM-Myl-0036 ENSMLUP00000003044.2 Myotis lucifugus 80 0.0 931
WERAM-Mod-0072 ENSMODP00000027999.1 Monodelphis domestica 69 0.0 928
WERAM-Prc-0027 ENSPCAP00000002242.1 Procavia capensis 80 0.0 843
WERAM-Meg-0127 ENSMGAP00000013877.2 Meleagris gallopavo 63 0.0 843
WERAM-Tag-0135 ENSTGUP00000011149.1 Taeniopygia guttata 63 0.0 843
WERAM-Gaga-0143 ENSGALP00000036346.1 Gallus gallus 62 0.0 837
WERAM-Fia-0125 ENSFALP00000010570.1 Ficedula albicollis 62 0.0 835
WERAM-Pes-0047 ENSPSIP00000007045.1 Pelodiscus sinensis 63 0.0 808
WERAM-Mae-0016 ENSMEUP00000001330.1 Macropus eugenii 63 0.0 796
WERAM-Xet-0113 ENSXETP00000038986.2 Xenopus tropicalis 63 0.0 706
WERAM-Lac-0050 ENSLACP00000007100.1 Latimeria chalumnae 50 0.0 646
WERAM-Leo-0100 ENSLOCP00000013269.1 Lepisosteus oculatus 54 4e-165 580
WERAM-Loa-0020 ENSLAFP00000001269.3 Loxodonta africana 48 2e-151 534
WERAM-Anc-0075 ENSACAP00000007027.2 Anolis carolinensis 48 4e-151 533
WERAM-Anp-0111 ENSAPLP00000012780.1 Anas platyrhynchos 47 1e-149 528
WERAM-Asm-0165 ENSAMXP00000016507.1 Astyanax mexicanus 46 3e-145 513
WERAM-Orn-0157 ENSONIP00000016309.1 Oreochromis niloticus 45 5e-143 506
WERAM-Orla-0053 ENSORLP00000006841.1 Oryzias latipes 45 5e-143 506
WERAM-Gaa-0189 ENSGACP00000023958.1 Gasterosteus aculeatus 45 1e-142 505
WERAM-Pof-0098 ENSPFOP00000008824.2 Poecilia formosa 44 9e-141 499
WERAM-Xim-0102 ENSXMAP00000009010.1 Xiphophorus maculatus 44 4e-140 497
WERAM-Ten-0123 ENSTNIP00000013426.1 Tetraodon nigroviridis 44 1e-139 495
WERAM-Tar-0009 ENSTRUP00000002076.1 Takifugu rubripes 43 4e-138 490
WERAM-Dio-0016 ENSDORP00000002034.1 Dipodomys ordii 44 3e-133 474
WERAM-Ect-0040 ENSETEP00000003644.1 Echinops telfairi 40 1e-115 415
WERAM-Dar-0185 ENSDARP00000140909.1 Danio rerio 41 1e-113 409
WERAM-Gam-0134 ENSGMOP00000013905.1 Gadus morhua 40 2e-111 402
WERAM-Chh-0022 ENSCHOP00000002106.1 Choloepus hoffmanni 41 3e-107 387
WERAM-Pem-0103 ENSPMAP00000010459.1 Petromyzon marinus 37 1e-103 375
WERAM-Ere-0097 ENSEEUP00000009905.1 Erinaceus europaeus 94 3e-102 371
WERAM-Cii-0009 ENSCINP00000003397.3 Ciona intestinalis 58 1e-56 219
WERAM-Drm-0063 FBpp0081541 Drosophila melanogaster 57 4e-53 207
WERAM-Cis-0016 ENSCSAVP00000003200.1 Ciona savignyi 58 5e-52 204
WERAM-Met-0130 AES98174 Medicago truncatula 39 2e-28 126
WERAM-Brd-0081 BRADI3G36180.1 Brachypodium distachyon 36 6e-28 124
WERAM-Sot-0046 PGSC0003DMT400042379 Solanum tuberosum 36 3e-27 122
WERAM-Sob-0107 Sb07g020680.1 Sorghum bicolor 37 5e-27 121
WERAM-Prp-0116 EMJ12151 Prunus persica 43 7e-27 120
WERAM-Arl-0042 fgenesh2_kg.1__ 1301__ AT1G11950.1 Arabidopsis lyrata 37 1e-26 120
WERAM-Art-0009 AT1G11950.1 Arabidopsis thaliana 34 1e-26 120
WERAM-Zem-0051 GRMZM2G070885_P01 Zea mays 35 1e-26 119
WERAM-Sei-0105 Si028936m Setaria italica 34 2e-26 119
WERAM-Amt-0041 ERN17369 Amborella trichopoda 42 2e-26 119
WERAM-Lep-0100 LPERR09G06290.1 Leersia perrieri 35 2e-26 119
WERAM-Pot-0062 POPTR_0005s08460.1 Populus trichocarpa 38 7e-26 117
WERAM-Sol-0029 Solyc02g081010.1.1 Solanum lycopersicum 35 9e-26 117
WERAM-Tra-0279 Traes_6DS_BF9884650.1 Triticum aestivum 48 1e-25 116
WERAM-Aet-0029 EMT12717 Aegilops tauschii 48 2e-25 116
WERAM-Glm-0245 GLYMA19G12090.1 Glycine max 41 2e-25 116
WERAM-Thc-0081 EOY28779 Theobroma cacao 42 2e-25 115
WERAM-Brr-0170 Bra034494.1-P Brassica rapa 35 2e-25 115
WERAM-Bro-0002 Bo00957s030.1 Brassica oleracea 34 3e-25 115
WERAM-Tru-0016 TRIUR3_07101-P1 Triticum urartu 46 4e-25 115
WERAM-Orb-0104 OBART09G09130.1 Oryza barthii 34 4e-25 115
WERAM-Hov-0014 MLOC_13090.1 Hordeum vulgare 36 4e-25 114
WERAM-Orr-0107 ORUFI09G09860.1 Oryza rufipogon 34 6e-25 114
WERAM-Orni-0101 ONIVA09G08110.1 Oryza nivara 34 6e-25 114
WERAM-Orm-0094 OMERI09G07170.1 Oryza meridionalis 34 6e-25 114
WERAM-Ori-0112 BGIOSGA030706-PA Oryza indica 34 6e-25 114
WERAM-Orgl-0100 OGLUM09G09380.1 Oryza glumaepatula 34 6e-25 114
WERAM-Orp-0027 OPUNC02G35390.1 Oryza punctata 46 7e-25 114
WERAM-Orl-0059 KN539156.1_FGP008 Oryza longistaminata 34 8e-25 114
WERAM-Ors-0026 OS02T0828900-01 Oryza sativa 45 9e-25 114
WERAM-Orbr-0020 OB02G10630.1 Oryza brachyantha 43 1e-24 113
WERAM-Org-0029 ORGLA02G0333900.1 Oryza glaberrima 45 1e-24 113
WERAM-Mua-0058 GSMUA_Achr3P14190_001 Musa acuminata 44 1e-24 113
Created Date 25-Jun-2016