| Tag |
Content |
| WERAM ID |
WERAM-Mum-0070 |
| Ensembl Protein ID |
ENSMUSP00000026559.7 |
| Uniprot Accession |
Q8R104; SIR3_MOUSE; B9W0A9; C6ZII7; Q9EPA8
|
| Genbank Protein ID |
NP_001120823.1; NP_001171275.1; NP_071878.2
|
| Protein Name |
NAD-dependent protein deacetylase sirtuin-3 |
| Genbank Nucleotide ID |
NM_001127351.1; NM_001177804.1; NM_022433.2
|
| Gene Name |
SIRT3;Sir2l3 |
| Ensembl Information |
|
| Details |
| Type |
Family |
Domain |
Substrates |
AA |
References (PMIDs) |
| HDAC |
SIR2 |
Deacetylase sirtuin-type |
H3K14 |
K |
23835326
|
|
| Status |
Reviewed |
| Classification |
| Type |
Family |
E-value |
Score |
Start |
End |
| HDAC |
SIR2 |
7.00e-91 |
305.6 |
1 |
240 |
|
| Organism |
Mus musculus |
| NCBI Taxa ID |
10090 |
Functional Description
(View)Functional Description
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. |
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.
|
| Domain Profile |
HDAC SIR2
SIR2.txt 16 ltGAGiStsaGIPDFRs.seGlysklkkeelpspeaifdldffrkdpkvfyalakelyplgsakPtktHyflaelekkgkllrlytQNi 103
++GAGiSt +GIPDFRs ++Glys+l+++++p+peaif+l ff ++pk+f++lakelyp g+++P++tHyfl++l++k++llrlytQNi
ENSMUSP00000026559.7 1 MVGAGISTPSGIPDFRSpGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYP-GHYRPNVTHYFLRLLHDKELLLRLYTQNI 88
79*********************************************************.***************************** PP
SIR2.txt 104 DgLerkaglkedklvelHGslatasCtkCkkefpreeikeklkakekvpkCekCkgvlkpdivffgenlpeefleeveedlkeadlllv 192
DgLer++g++++klve+HG++ ta+Ct C+++fp+e i+++++a+ +vp+C+ C+gv+kpdivffge+lp++fl ++ +d++ adlll+
ENSMUSP00000026559.7 89 DGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWADVMAD-RVPRCPVCTGVVKPDIVFFGEQLPARFLLHM-ADFALADLLLI 175
*********************************************.9*****************************9.899******** PP
SIR2.txt 193 lGtSlkvepvaslvkkavkkkvpvllvnleevk....adkladlkllgdcdevveellkllgleee 254
lGtSl+vep+asl +av+k+vp+ll+n++ v+ + +++d+++lgd+ + ve+l++llg+++e
ENSMUSP00000026559.7 176 LGTSLEVEPFASLS-EAVQKSVPRLLINRDLVGpfvlSPRRKDVVQLGDVVHGVERLVDLLGWTQE 240
**************.************************************************985 PP
|
Protein Sequence
(Fasta) | MVGAGISTPS GIPDFRSPGS GLYSNLQQYD IPYPEAIFEL GFFFHNPKPF FMLAKELYPG 60
HYRPNVTHYF LRLLHDKELL LRLYTQNIDG LERASGIPAS KLVEAHGTFV TATCTVCRRS 120
FPGEDIWADV MADRVPRCPV CTGVVKPDIV FFGEQLPARF LLHMADFALA DLLLILGTSL 180
EVEPFASLSE AVQKSVPRLL INRDLVGPFV LSPRRKDVVQ LGDVVHGVER LVDLLGWTQE 240
LLDLMQRERG KLDGQDR 257Protein Fasta Sequence
>ENSMUSP00000026559.7|SIRT3;Sir2l3|Mus musculus
MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLILGTSLEVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLDLMQRERGKLDGQDR |
Nucleotide Sequence
(Fasta) | ACTTCCGCTA AACTTCTCCC GGGTTTCTGG CCCTGCCCTT GAGGCATTAA AGAGTAGAGG 60
TGCCTGGGGA CAGCTAGCCA CTGACTGGTC ACGTAGCCTC AAGCCTGCAG ACTTGGGTCC 120
TCTGAAACCG GATGGCGTTT GGCGAGGACT AGTGTTACAG GTGGGAGAAG GCCCATATCC 180
CTCTGTGTGG GAGCCTCAGG CGGCTTTGGA GGTGGAGGAA GCAGTGAGAA GAAGTTTTCT 240
CTGCAGGATG TAGCTGAGCT GCTTCGGACC AGAGCCTGCA GTAGGGTGGT GGTCATGGTG 300
GGGGCCGGCA TCAGCACACC CAGTGGCATC CCGGACTTCA GATCCCCAGG GAGCGGCCTC 360
TACAGCAACC TTCAGCAGTA TGACATCCCG TACCCTGAAG CCATCTTTGA ACTTGGCTTT 420
TTCTTTCACA ACCCCAAGCC CTTTTTCATG TTGGCCAAGG AGCTGTACCC TGGGCACTAC 480
AGGCCCAATG TCACTCACTA CTTCCTGAGG CTCCTCCACG ACAAGGAGCT GCTTCTGCGG 540
CTCTATACAC AGAACATCGA CGGGCTTGAG AGAGCATCTG GGATCCCTGC CTCAAAGCTG 600
GTTGAAGCCC ACGGGACCTT TGTAACAGCT ACATGCACGG TCTGTCGAAG GTCCTTCCCA 660
GGGGAAGACA TATGGGCTGA TGTGATGGCG GACAGGGTGC CCCGCTGCCC TGTCTGTACT 720
GGCGTTGTGA AACCCGACAT TGTGTTCTTT GGGGAGCAGC TGCCTGCAAG GTTCCTACTC 780
CATATGGCTG ACTTCGCTTT GGCAGATCTG CTACTCATTC TTGGGACCTC CCTGGAGGTG 840
GAGCCTTTTG CCAGCTTGTC TGAAGCAGTA CAGAAATCAG TGCCCCGACT GCTCATCAAT 900
CGAGACTTGG TGGGGCCGTT CGTTCTGAGT CCTCGAAGGA AAGATGTGGT CCAGCTAGGG 960
GATGTAGTTC ATGGTGTGGA AAGGCTGGTG GACCTCCTGG GGTGGACACA AGAACTGCTG 1020
GATCTTATGC AGCGGGAACG TGGCAAGCTG GATGGACAGG ACAGATAAGA CTATGGCTTC 1080
TTCACCTGGG GAAGTCACAC AGCAGATCAT CCTATGTCCA GCAAGACTTC ATGCCTGAAG 1140
ACAGCTCCAA CACGTTTACA AACATGAACC AGACCACAAC ATGTGGCCTG GACAGTGGTC 1200
CTCCGAGGCT GCCTTTGGAA AGGCTGACCA GGGATGTCTA CCCTTGGGGC CCCTCCATGT 1260
GTGCGCCCTG TCCACCTCAT CACTGCTGAA GGTGTAGTGC AGGTGCTGCT TTCTGCAGCG 1320
GCCCTTAAGT TATCACGAGG GCAGCACAGC ACGCCCGTCG CCAGGCAGGC GATGCACTAG 1380
GGCAATCTAG CATGTTGATC GGTAAAGTGG CATCTTTAAC TACAACATCA TTTCTTGCAT 1440
GAAATAAACT TAGTATAAAA A
1462Nucleotide Fasta Sequence
>ENSMUSP00000026559.7|SIR2|Mus musculus
ACTTCCGCTAAACTTCTCCCGGGTTTCTGGCCCTGCCCTTGAGGCATTAAAGAGTAGAGGTGCCTGGGGACAGCTAGCCACTGACTGGTCACGTAGCCTCAAGCCTGCAGACTTGGGTCCTCTGAAACCGGATGGCGTTTGGCGAGGACTAGTGTTACAGGTGGGAGAAGGCCCATATCCCTCTGTGTGGGAGCCTCAGGCGGCTTTGGAGGTGGAGGAAGCAGTGAGAAGAAGTTTTCTCTGCAGGATGTAGCTGAGCTGCTTCGGACCAGAGCCTGCAGTAGGGTGGTGGTCATGGTGGGGGCCGGCATCAGCACACCCAGTGGCATCCCGGACTTCAGATCCCCAGGGAGCGGCCTCTACAGCAACCTTCAGCAGTATGACATCCCGTACCCTGAAGCCATCTTTGAACTTGGCTTTTTCTTTCACAACCCCAAGCCCTTTTTCATGTTGGCCAAGGAGCTGTACCCTGGGCACTACAGGCCCAATGTCACTCACTACTTCCTGAGGCTCCTCCACGACAAGGAGCTGCTTCTGCGGCTCTATACACAGAACATCGACGGGCTTGAGAGAGCATCTGGGATCCCTGCCTCAAAGCTGGTTGAAGCCCACGGGACCTTTGTAACAGCTACATGCACGGTCTGTCGAAGGTCCTTCCCAGGGGAAGACATATGGGCTGATGTGATGGCGGACAGGGTGCCCCGCTGCCCTGTCTGTACTGGCGTTGTGAAACCCGACATTGTGTTCTTTGGGGAGCAGCTGCCTGCAAGGTTCCTACTCCATATGGCTGACTTCGCTTTGGCAGATCTGCTACTCATTCTTGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGTCTGAAGCAGTACAGAAATCAGTGCCCCGACTGCTCATCAATCGAGACTTGGTGGGGCCGTTCGTTCTGAGTCCTCGAAGGAAAGATGTGGTCCAGCTAGGGGATGTAGTTCATGGTGTGGAAAGGCTGGTGGACCTCCTGGGGTGGACACAAGAACTGCTGGATCTTATGCAGCGGGAACGTGGCAAGCTGGATGGACAGGACAGATAAGACTATGGCTTCTTCACCTGGGGAAGTCACACAGCAGATCATCCTATGTCCAGCAAGACTTCATGCCTGAAGACAGCTCCAACACGTTTACAAACATGAACCAGACCACAACATGTGGCCTGGACAGTGGTCCTCCGAGGCTGCCTTTGGAAAGGCTGACCAGGGATGTCTACCCTTGGGGCCCCTCCATGTGTGCGCCCTGTCCACCTCATCACTGCTGAAGGTGTAGTGCAGGTGCTGCTTTCTGCAGCGGCCCTTAAGTTATCACGAGGGCAGCACAGCACGCCCGTCGCCAGGCAGGCGATGCACTAGGGCAATCTAGCATGTTGATCGGTAAAGTGGCATCTTTAACTACAACATCATTTCTTGCATGAAATAAACTTAGTATAAAAA
|
| Sequence Source |
Ensembl |
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0520--NAD
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0862--Zinc
--
|
| Interpro |
IPR029035--DHS-like_NAD/FAD-binding_dom
IPR003000--Sirtuin
IPR026591--Sirtuin_cat_small_dom
IPR017328--Sirtuin_class_I
IPR026590--Ssirtuin_cat_dom
|
| PROSITE |
PS50305--SIRTUIN
|
| Pfam |
PF02146--SIR2
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005743--C:mitochondrial inner membrane
GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0070403--F:NAD+ binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0008270--F:zinc ion binding
GO:0009060--P:aerobic respiration
GO:0070932--P:histone H3 deacetylation
GO:2000757--P:negative regulation of peptidyl-lysine acetylation
GO:0034983--P:peptidyl-lysine deacetylation
GO:0006476--P:protein deacetylation
|
| Orthology |
|
| Created Date |
25-Jun-2016 |
