Arabidopsis thaliana      HMT      SUV39

※ SUV39 family introduction

    SUV39: The Su(var)3-9 gene was originally identified in a genetic screen as a suppressor of position effect variegation in Drosophila. This was the first hint that the Su(var)3-9 protein might be involved in regulating chromatin structure. In mice, there are two highly related homologues of the Drosophila Su(var)3-9, Suv39h1 and Suv39h2. Following the identification of Suv39h1 as a lysine methyltransferase capable of methylating Lys9 of histone H3 (H3K9), confirmation that this protein can modulate chromatin architecture came with the finding that it creates a specific binding site for the heterochromatin protein HP1. As Suv39h1 and HP1 interact, it is thought that Suv39h1 methylating H3 K9, and then HP1 binding to the methylated H3, forms a positive feedback loop allowing HP1 and H3 K9 methylation to spread along chromatin, generating repressive heterochromatin in the process. (1)

Reference
1. Schneider R, Bannister AJ, Kouzarides T.Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem Sci.2002;27(8):396-402. PMID: 12151224.



There are 15 genes.  Reviewed (15 or Unreviewed (0

No.StatusWERAM IDGene/Alias Name
1
WERAM-Art-0003
SUVR1
2
WERAM-Art-0013
SUVH7; SET17; SDG17
3
WERAM-Art-0027
SUVH3; SET19; SDG19
4
WERAM-Art-0037
SUVH10; SET11; SDG11
5
WERAM-Art-0041
SUVH6
6
WERAM-Art-0043
SUVR5
7
WERAM-Art-0044
SUVH8; SDG21; SET21
8
WERAM-Art-0050
SUVH2; SET3; SDG3
9
WERAM-Art-0053
SUVH5
10
WERAM-Art-0063
SUVR3
11
WERAM-Art-0064
SUVR4
12
WERAM-Art-0099
SUVH9; SDG22
13
WERAM-Art-0116
SUVH1; SET32; SDG32
14
WERAM-Art-0123
SUVH4; SET33; KYP; SDG33
15
WERAM-Art-0136
SUVR2