WERAM Information

Tag Content
WERAM ID WERAM-Art-0050
Ensembl Protein ID AT2G33290.1
Uniprot Accession O22781; SUVH2_ARATH
Genbank Protein ID NP_180887.1
Protein Name Histone-lysine N-methyltransferase family member SUVH2
Genbank Nucleotide ID NM_128889.2
Gene Name SUVH2;SET3;SDG3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT2G33290 AT2G33290.1 AT2G33290.1
Details
Type Family Domain Substrates AA References (PMIDs)
HMT SUV39 SET H3K9; H4K20 K 20703330; 15659850
Status Reviewed
Classification
Type Family E-value Score Start End
HMT SUV39 5.40e-33 114.9 496 638
Organism Arabidopsis thaliana
NCBI Taxa ID 3702
Functional Description
(View)		 Histone methyltransferase family member. According to PubMed:15775980, it is required for normal methylation of 'Lys-9' and 'Lys-27' of histone H3, 'Lys-20' of H4, and cytosine, but PubMed:19043555 see no significant effect on histone methylation when the gene is mutated. According to PubMed:19043555, the protein does not bind S-adenosyl-L-methionine and lacks methyltransferase activity. Instead, it may function downstream of DRM2 in RNA-directed DNA methylation, binding to methylated DNA and recruiting DNA-directed RNA polymerase V to chromatin (PubMed:24463519). Plays a central role in gene silencing.
Domain Profile
  HMT SUV39
    SUV39.txt   2 rLqvfktenkGwGvrclddiakgsFvciyaGeiltddeaekegleegdeyladldskesv..enlkegyesdvplssdssntrqekdkeeseyiidak 97 
                  rL+vf+++++GwGvr+ld i++g+F+c+yaG ++t+ +ae    ++gd +++  + ++++  +   +++  d         + ++ +    ++ +d +
  AT2G33290.1 496 RLEVFRSKETGWGVRTLDLIEAGAFICEYAGVVVTRLQAEIL-SMNGDVMVYPGRFTDQWrnWGDLSQVYPD-------FVRPNYPSLPPLDFSMDVS 585
                  8**************************************988.67777777777776666224444444444.......477899999********** PP
    SUV39.txt  98 kegnvgrflnHscspNlfvqnvfvdthdlrfprvafFaskrikagtELtwdYg 150
                  ++ nv+++++Hs +pN++vq v++d+++l+fprv++Fa ++i++  EL+ dYg
  AT2G33290.1 586 RMRNVACYISHSKEPNVMVQFVLHDHNHLMFPRVMLFALENISPLAELSLDYG 638
                  ****************************************************6 PP
Protein Sequence
(Fasta)		MSTLLPFPDL NLMPDSQSST AGTTAGDTVV TGKLEVKSEP IEEWQTPPSS TSDQSANTDL 60
IAEFIRISEL FRSAFKPLQV KGLDGVSVYG LDSGAIVAVP EKENRELIEP PPGFKDNRVS 120
TVVVSPKFER PRELARIAIL GHEQRKELRQ VMKRTRMTYE SLRIHLMAES MKNHVLGQGR 180
RRRSDMAAAY IMRDRGLWLN YDKHIVGPVT GVEVGDIFFY RMELCVLGLH GQTQAGIDCL 240
TAERSATGEP IATSIVVSGG YEDDEDTGDV LVYTGHGGQD HQHKQCDNQR LVGGNLGMER 300
SMHYGIEVRV IRGIKYENSI SSKVYVYDGL YKIVDWWFAV GKSGFGVFKF RLVRIEGQPM 360
MGSAVMRFAQ TLRNKPSMVR PTGYVSFDLS NKKENVPVFL YNDVDGDQEP RHYEYIAKAV 420
FPPGIFGQGG ISRTGCECKL SCTDDCLCAR KNGGEFAYDD NGHLLKGKHV VFECGEFCTC 480
GPSCKSRVTQ KGLRNRLEVF RSKETGWGVR TLDLIEAGAF ICEYAGVVVT RLQAEILSMN 540
GDVMVYPGRF TDQWRNWGDL SQVYPDFVRP NYPSLPPLDF SMDVSRMRNV ACYISHSKEP 600
NVMVQFVLHD HNHLMFPRVM LFALENISPL AELSLDYGLA DEVNGKLAIC N 651
Nucleotide Sequence
(Fasta)		TTGAGACAAC CTCGAAGTAA TGCAAACACT TTAAGGCCGG ATCCGATTCG TGACCCGAAT 60
AGTTTCCGGA TTCGGAGCCC AGGTGTTGTT TCTGTCTTCG GTTCATTGGG AAGGATGAGT 120
ACATTGTTAC CATTTCCTGA CCTCAACCTC ATGCCGGATT CTCAATCCTC CACCGCCGGA 180
ACCACAGCCG GCGACACTGT AGTCACCGGA AAGTTAGAAG TGAAATCGGA ACCAATTGAG 240
GAATGGCAAA CTCCACCATC GTCTACCTCC GATCAATCAG CCAATACCGA TCTCATCGCC 300
GAGTTTATTC GTATCTCAGA GCTCTTCCGC TCGGCATTCA AGCCACTGCA GGTCAAAGGA 360
TTAGACGGAG TCTCCGTATA CGGATTGGAT TCTGGTGCCA TCGTTGCTGT ACCGGAGAAA 420
GAAAACCGGG AATTGATTGA ACCGCCTCCA GGATTTAAGG ATAATCGAGT CTCCACCGTC 480
GTTGTCTCGC CGAAATTCGA GAGACCGAGA GAGCTAGCGA GAATTGCAAT TCTAGGTCAT 540
GAACAACGGA AGGAACTCCG ACAAGTCATG AAACGAACTA GGATGACTTA TGAGTCTCTT 600
CGGATTCATC TAATGGCGGA GAGTATGAAG AATCATGTAC TTGGTCAAGG GCGTAGACGG 660
AGGAGCGATA TGGCGGCTGC GTATATAATG AGGGATCGGG GACTGTGGTT GAACTATGAT 720
AAGCACATAG TTGGTCCAGT CACAGGGGTT GAAGTAGGGG ATATATTCTT CTACCGTATG 780
GAATTGTGTG TGCTGGGCTT ACACGGCCAG ACACAAGCCG GGATTGATTG TTTAACGGCT 840
GAACGGAGCG CCACTGGAGA GCCTATAGCT ACCAGCATTG TTGTCTCAGG TGGTTATGAG 900
GATGATGAAG ATACAGGAGA TGTTTTGGTT TATACTGGTC ACGGTGGTCA GGATCATCAA 960
CACAAGCAGT GTGATAACCA GAGGCTAGTA GGTGGGAATC TGGGAATGGA GAGAAGTATG 1020
CACTACGGTA TCGAGGTACG TGTGATTAGA GGTATTAAGT ATGAGAACAG TATAAGCTCG 1080
AAGGTGTATG TATATGATGG TTTGTATAAG ATAGTAGATT GGTGGTTTGC TGTGGGGAAG 1140
TCTGGTTTTG GGGTTTTTAA ATTTAGGTTA GTAAGAATTG AAGGGCAACC GATGATGGGC 1200
AGTGCGGTAA TGAGGTTTGC ACAAACTCTT AGAAATAAGC CATCGATGGT TAGGCCTACT 1260
GGTTATGTTA GCTTTGACCT TTCTAACAAG AAGGAGAATG TACCCGTGTT TCTATATAAT 1320
GATGTAGATG GTGATCAAGA ACCGAGACAT TATGAGTACA TTGCAAAAGC TGTCTTTCCT 1380
CCTGGAATTT TTGGTCAGGG GGGGATCAGC AGGACTGGCT GCGAGTGTAA GCTCTCTTGT 1440
ACTGATGATT GTCTCTGTGC AAGGAAGAAC GGTGGTGAGT TTGCATATGA TGATAACGGG 1500
CATCTATTGA AAGGAAAGCA TGTGGTATTT GAATGTGGGG AATTCTGCAC TTGTGGTCCG 1560
AGCTGTAAGA GCCGTGTGAC ACAGAAGGGA TTGAGGAACA GGCTAGAGGT TTTCAGATCG 1620
AAGGAAACCG GTTGGGGTGT CAGGACACTT GATCTAATTG AAGCTGGTGC TTTCATATGC 1680
GAATATGCAG GTGTAGTTGT CACGAGACTT CAAGCCGAGA TTCTGTCAAT GAATGGGGAT 1740
GTTATGGTCT ATCCTGGTCG GTTCACAGAC CAATGGCGTA ACTGGGGTGA TTTATCTCAA 1800
GTATACCCAG ATTTTGTTAG GCCGAATTAT CCATCTCTCC CTCCACTGGA TTTCTCAATG 1860
GATGTGTCAA GGATGAGGAA CGTGGCTTGC TACATTAGTC ACAGCAAAGA ACCAAATGTG 1920
ATGGTGCAAT TTGTTTTGCA TGACCACAAT CACCTGATGT TCCCCCGTGT GATGCTTTTT 1980
GCGCTGGAGA ATATCTCACC GTTGGCCGAG CTAAGCCTGG ATTACGGCTT GGCAGATGAA 2040
GTGAACGGCA AGCTCGCCAT CTGCAACTAG TTTTTACAAA GTTTGTTTTT GTGCTATAGC 2100
TTGAGCCTTG AGATGGAGAA AATTTTGATC AAAGCCTTTC TCTGCTCGTT TGTTGTTATG 2160
TCTTCCAACC TTTCTGTGAA GCAAGAATGG GAGGCATGGT CGGTGAGTGT TCTGCATCCA 2220
TTTTTTGGGG GTAAAAACTT CTCTTTGTCA AATGTGTTTG TACTTTTGTT CTGTTATTAA 2280
TGTACTGAAA TTTTTGTATG TTTCTCTCTC CCCCTTATGT TAGAGCTTAA GCTGATATAT 2340
2341
Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
--
Interpro

IPR025794--Hist-Lys_N-MeTrfase_plant
IPR007728--Pre-SET_dom
IPR015947--PUA-like_domain
IPR001214--SET_dom
IPR003105--SRA_YDG
PROSITE

PS50867--PRE_SET
PS51575--SAM_MT43_SUVAR39_2
PS50280--SET
PS51015--YDG
Pfam

PF05033--Pre-SET
PF02182--SAD_SRA
PF00856--SET
Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0005720--C:nuclear heterochromatin
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0042054--F:histone methyltransferase activity
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008270--F:zinc ion binding
GO:0016571--P:histone methylation
GO:0040029--P:regulation of gene expression, epigenetic
Orthology
WERAM ID Ensembl Protein ID Species Identity E-value Score
WERAM-Arl-0128 scaffold_401902.1 Arabidopsis lyrata 93 0.0 1235
WERAM-Thc-0056 EOY06233 Theobroma cacao 58 0.0 807
WERAM-Brr-0113 Bra021840.1-P Brassica rapa 60 0.0 795
WERAM-Bro-0083 Bo4g181770.1 Brassica oleracea 61 0.0 788
WERAM-Pot-0114 POPTR_0010s07480.1 Populus trichocarpa 62 0.0 781
WERAM-Prp-0044 EMJ28171 Prunus persica 58 0.0 779
WERAM-Viv-0026 VIT_05s0049g02220.t01 Vitis vinifera 57 0.0 778
WERAM-Sol-0118 Solyc09g090810.1.1 Solanum lycopersicum 54 0.0 730
WERAM-Sot-0005 PGSC0003DMT400003956 Solanum tuberosum 54 0.0 725
WERAM-Glm-0079 GLYMA07G19420.1 Glycine max 54 0.0 696
WERAM-Met-0016 KEH40794 Medicago truncatula 55 0.0 661
WERAM-Brd-0015 BRADI1G29010.1 Brachypodium distachyon 53 0.0 645
WERAM-Lep-0075 LPERR07G10390.1 Leersia perrieri 53 0.0 644
WERAM-Orb-0074 OBART07G12290.1 Oryza barthii 57 0.0 642
WERAM-Ori-0084 BGIOSGA025596-PA Oryza indica 57 0.0 641
WERAM-Orp-0072 OPUNC07G10970.1 Oryza punctata 52 0.0 640
WERAM-Ors-0067 OS07T0435900-01 Oryza sativa 57 0.0 639
WERAM-Orm-0070 OMERI07G09810.1 Oryza meridionalis 57 0.0 638
WERAM-Orr-0076 ORUFI07G12410.1 Oryza rufipogon 57 0.0 636
WERAM-Orgl-0071 OGLUM07G11790.1 Oryza glumaepatula 57 0.0 636
WERAM-Tra-0051 Traes_2AS_A204857F71.1 Triticum aestivum 56 4e-180 629
WERAM-Hov-0102 MLOC_71915.1 Hordeum vulgare 51 6e-180 628
WERAM-Tru-0091 TRIUR3_32787-P1 Triticum urartu 56 4e-179 625
WERAM-Sei-0110 Si029125m Setaria italica 55 3e-178 622
WERAM-Sob-0021 Sb02g010210.1 Sorghum bicolor 55 7e-175 611
WERAM-Orbr-0083 OB07G18500.1 Oryza brachyantha 61 2e-174 610
WERAM-Zem-0021 GRMZM2G025924_P01 Zea mays 55 6e-173 605
WERAM-Orl-0087 KN539973.1_FGP004 Oryza longistaminata 61 3e-171 599
WERAM-Mua-0084 GSMUA_Achr5P13120_001 Musa acuminata 46 2e-164 577
WERAM-Amt-0043 ERN15731 Amborella trichopoda 52 8e-150 528
WERAM-Org-0094 ORGLA08G0193900.1 Oryza glaberrima 47 1e-124 444
WERAM-Orni-0096 ONIVA09G01180.1 Oryza nivara 47 2e-124 443
WERAM-Sem-0004 EFJ22703 Selaginella moellendorffii 40 3e-93 340
WERAM-Aet-0062 EMT00374 Aegilops tauschii 37 4e-93 339
WERAM-Php-0129 PP1S9_150V6.1 Physcomitrella patens 42 1e-88 325
Created Date 25-Jun-2016